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Intervet

• Intervet develops and sells veterinary products(vaccines and pharmaceuticals)

• Intervet is represented by 54 commercial companies in 53 countries worldwide

• Intervet has approximately 5,200 employees

• Intervet has 13 R&D and 18 production sites

• Annual investment in R&D exceeds 10% of sales• More than 15% of Intervet’s total workforce in R&D• 13 R&D sites spread around the globe• Major research sites:

Germany:Antiparasitic and anti-infective product discovery and development

France:Specialized pharmaceutical productdevelopment

Centers in NL, UK and US:Bacterial, viral and parasitic vaccine projects

Centers in Norway and Singapore:advanced aquatic animal health products

Research at Intervet

Pioneers of Aquatic Animal Health since 1985Pioneers of Aquatic Animal Health since 1985Pioneers of Aquatic Animal Health since 1985

Intervet Aquatic Animal HealthIntervet Aquatic Animal Health

Aquatic Animal Developmental Diversity

Temperature / Salinity

Aquatic Animal Developmental Aquatic Animal Developmental DiversityDiversity

Temperature / SalinityTemperature / Salinity

Milkfish/ShrimpMulletBrackish

Salmon Asian sea bassBass/BreamMarine

Trout Catfish/TilapiaCarp/EelsFresh

0 - 16 °C 12 - 25 °C 20 - 32 °C

Based on this extreme diversity, Intervet has set up two specialized R&D centres

Based on this extreme diversity, Intervet has set up two specialized R&D centres

Intervet’s Aquatic Animal Health

NorwayColdwater Fish

The NetherlandsHeadquarters

SingaporeTropical Fish

Vaccines - Endocrines - Antiparasitics

Pioneers of Aquatic Animal Health since 1985Pioneers of Aquatic Animal Health since 1985

Matre Research Station

Matre Research Station

Intervet Norbio Singapore Pte. Ltd.(January 2000)

Intervet Norbio Singapore Pte. Ltd.(January 2000)

Dedicated to disease research and product development for aquatic animal health in the Asia-Pacific region

Dedicated to disease research and product development for aquatic animal health in the Asia-Pacific region

The team in Singapore

Major activities at Intervet Norbio Singapore

• R&D• Disease diagnosis, including the detection and identification

of new emerging pathogens• Vaccine development for economically important fish

diseases (bacterial and viral vaccines)• Development of high quality and safe pharmaceuticals for

responsible use in aquaculture

• Technical support• Regional epidemiological disease investigations• Education of fish and shrimp farmers to improve husbandry

and health practices• Technical support to farmers• Marketing support to Intervet local companies

Hatchery

Sex-reversal

1 g 10 g 100 g 1 kg0 g

Path

ogen

Phas

eNursery Pre-grow-out Grow-out

Flavobacterium columnare

RLOEdwardsiella tarda

IridovirusStreptococcus spp. (Sa; Si)

Saprolegnia & Branchiomyces

Nocardia seriolae

Trichodina & Dactylogyrus

Nodavirus?

Note: importance of the disease is roughly in proportion to the size of the arrow bars

Major Diseases Affecting Tilapiaduring the Farming Cycle

0 DOC 45 DOC 80DOC 140DOC 400DOC

0g 1 g 15 g 100 g 3.5 kg

Hatchery phase

(ponds/tanks)

Nursery phase

(tanks)

Pre-grow-out

(small cages)

Grow-out

(Big cages)

Diseases in Asian seabass

Disease cycle

VNN

Big Belly

10 DOC

30DOC

0.3-0.5g

<0.1g

Iridovirus

Tenacibaculum maritimum

Streptococcus iniae

Benedeniaparasites

Best vaccine application method

Immersion Injection

5g

20g

0 DOC 45 DOC 80DOC 140DOC 400DOC

0g 1 g 15 g 100 g 3.5 kg

Hatchery phase

(ponds/tanks)

Nursery phase

(tanks)

Pre-grow-out

(small cages)

Grow-out

(Big cages)

Diseases in Asian seabass

Disease cycle

VNN

Big Belly

10 DOC

30DOC

0.3-0.5g

<0.1g

Iridovirus

Tenacibaculum maritimum

Streptococcus iniae

Benedeniaparasites

Best vaccine application method

Immersion Injection

5g

20g

0 DOC 45 DOC 80DOC 140DOC 400DOC

0g 1 g 15 g 100 g 3.5 kg

Hatchery phase

(ponds/tanks)

Nursery phase

(tanks)

Pre-grow-out

(small cages)

Grow-out

(Big cages)

Diseases in Asian seabass

Disease cycle

VNN

Big Belly

10 DOC

30DOC

0.3-0.5g

<0.1g

Iridovirus

Tenacibaculum maritimum

Streptococcus iniae

Benedeniaparasites

Best vaccine application method

Immersion Injection

5g

20g

0 DOC 45 DOC 80DOC 140DOC 400DOC

0g 1 g 15 g 100 g 3.5 kg

Hatchery phase

(ponds/tanks)

Nursery phase

(tanks)

Pre-grow-out

(small cages)

Grow-out

(Big cages)

Diseases in Asian seabass

Disease cycle

VNN

Big Belly

10 DOC

30DOC

0.3-0.5g

<0.1g

Iridovirus

Tenacibaculum maritimum

Streptococcus iniae

Benedeniaparasites

Best vaccine application method

Immersion Injection

5g

20g

BacteriologyBacteriology

VirologyVirology BiochemistryBiochemistry

DiagnosisDiagnosis

Pilot Production Lab

1,300 L research tanks

Highlights of Intervet Norbio Singapore

• 2000: Intervet Norbio Singapore, first and only private aquatic animal health (AAH) R&D centre established.

• 2003: Intervet participated in the task force for Koi Herpes Virus on request from NACA (Network of Aquaculture Centres in Asia-Pacific) and the Indonesian government.

• 2004: Intervet Norbio Singapore is recognized as a regional resource centre by NACA.

• 2005: Introduction of Intervet's first fish vaccine in Japan, • Norvax® Vibrio mono, an immersion vaccine

against • Vibrio (Listonella) anguillarum infections of

Japanese yellowtail.

• 2005: Introduction of Intervet's first Asian fish vaccine outside Japan, Norvax® Strep Si, an immersion and injection vaccine against Streptococcus iniae infections in warmwater fish.

Other Regional Activities

• Serving as member of the NACA Aquatic Animal Health Advisory Group

• Participation in disease epidemiology study with local universities/institutes/agencies (e.g. P.R. China, Indonesia, Malaysia, Thailand).

• Sponsorship for DAA and CAA

• Trainings, e.g. AVA tilapia course (Singapore), MOA fish diseases and diagnosis (PRC), NACA grouper training course (Indonesia)

• Weekly Asian Aquatic Animal Newsletter

• …

Websites

• www.intervet.com/aah/singapore.asp

• www.thefishsite.com/

Potential collaboration among Intervet, NACA and other organizations

• What we can give:– Knowledge/facility in aquatic animal health

(diseases, diagnosis and health management)

– Solution for sustainable aquaculture –vaccines

– Funding

• What we want to take:– Source of epidemiology data– Facilitation of field trials– Support on vaccination program as part of

health management practice: education