agenti patogeni in bolile infectioase(1)

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Boli infectioase Boli infectioase Microorganisme Microorganisme Coloratia Gram: cristal violet si rosu safranina. Gram (+) – albastre Gram (-) - rosii

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Page 1: Agenti Patogeni in Bolile Infectioase(1)

Boli infectioaseBoli infectioase

MicroorganismeMicroorganisme

Coloratia Gram: cristal violet si rosu safranina.

Gram (+) – albastre

Gram (-) - rosii

Page 2: Agenti Patogeni in Bolile Infectioase(1)

AntraxAntrax

Bacil, Gram (+), aerob, sporulat, ce produce infectii cutanate, digestive, pulmonare si meningeale

Page 3: Agenti Patogeni in Bolile Infectioase(1)

Corinebacterium difteriaeCorinebacterium difteriae

Bacil Gram (+), non-sporulat, aerob, cu dispozitie in “litere chinezesti”, colonii de tip S, produce exotoxine, determina difteria (faringo-laringiana si cutanata)

Page 4: Agenti Patogeni in Bolile Infectioase(1)

Haemophilus InfluenzaeHaemophilus Influenzae

Bacil Gram (-), non-sporulat, aerob, cu activitate endotoxinica prin LPS din peretele bacterian, produce pneumonie, meningita (la copil); H. Ducrey produce sancrul moale

Page 5: Agenti Patogeni in Bolile Infectioase(1)

Klebsiella PneumoniaeKlebsiella Pneumoniae

Bacil Gram (-), incapsulat, colonii M, din genul Enterobacteriaceae, produce pneumonie la imunosupresati, alcoolici (“bloc negru pulmonar”), si infectii urinare

Page 6: Agenti Patogeni in Bolile Infectioase(1)

Meningococ (Neisseria Meningitidis)Meningococ (Neisseria Meningitidis)

Coc Gram (-), incapsulat, dispus in diplo, aerob, colonii M, produce meningita purulenta la adult; Coc Gram (-), incapsulat, dispus in diplo, aerob, colonii M, produce meningita purulenta la adult; colonizeaza nasofaringele si are pili cu care se ataseaza de celulele epiteliale non-ciliatecolonizeaza nasofaringele si are pili cu care se ataseaza de celulele epiteliale non-ciliate

Page 7: Agenti Patogeni in Bolile Infectioase(1)

PneumococPneumococ

Coc Gram (+), aerob, incapsulat, lanceolat, dispus in diplo, colonii M, produce pneumonia franca lobara la adult; disemineaza prin porii lui Cohn de la o alveola la alta

Page 8: Agenti Patogeni in Bolile Infectioase(1)

StafilococStafilococ

Coc Gram (+), aerob, colonii S, coagulaza (+), dispus in gramezi, produce infectii cutanate (furuncule, carbuncule), pneumonie (abcese pulmonare, cu empiem si pneumatocele), endocardita

Page 9: Agenti Patogeni in Bolile Infectioase(1)

Cat scratch disease, HE, 10x Cat scratch disease, HE, 10x

Granulom nespecific compus dintr-o zona centrala cu necroza supurativa si o zona perifierica cu celule epitelioide in palisada, determinat de bacili Gram (-) ce colonizeaza ghearele de pisica

Page 10: Agenti Patogeni in Bolile Infectioase(1)

Mycobacterium TuberculosisMycobacterium TuberculosisBacil acid-alcoolo rezistent, Ziehl Neelsen pozitiv, colonii R, aerob, izolat sau in gramezi, intra- sau extracelular, are un perete ceros ce contine acizi micolici si lipoarabinomanan, ce interactioneaza cu receptori TLR2

Page 11: Agenti Patogeni in Bolile Infectioase(1)

BK – Ziehl NeelsenBK – Ziehl Neelsen

Extracelular in alveolele pulmonare, Z-N, 100x, imersie

Intracelular intr-o celula Langhans, Z-N, 100x, imersie

Page 12: Agenti Patogeni in Bolile Infectioase(1)

TBC - PCRTBC - PCR

Migrare electroforetica pentru DNA-BK: liniile 1, 2, 5, 6, 7, 8 pozitive; liniile 3, 4, 9 negative, in centru markeri de marime

Page 13: Agenti Patogeni in Bolile Infectioase(1)

Granulom TBCGranulom TBC

HE, 4x, granulom specific cu necroza cazeoasa, celule gigante multinucleate Langhans, celule epitelioide si limfocite

Page 14: Agenti Patogeni in Bolile Infectioase(1)

Limfocite CD4+, 40xLimfocite CD4+, 40x

Page 15: Agenti Patogeni in Bolile Infectioase(1)

Limfocite CD8+, 40x Limfocite CD8+, 40x

Page 16: Agenti Patogeni in Bolile Infectioase(1)

Epitelioide, CD68+, 40xEpitelioide, CD68+, 40x

Page 17: Agenti Patogeni in Bolile Infectioase(1)

Celule LanghansCelule Langhans

Page 18: Agenti Patogeni in Bolile Infectioase(1)

Celule gigante multinucleate, HE, 40xCelule gigante multinucleate, HE, 40x

De corp strain In sarcoidoza (corpi asteroizi Schaumann)

Page 19: Agenti Patogeni in Bolile Infectioase(1)

Lues, VDRL +, HE, 10x, 40xLues, VDRL +, HE, 10x, 40xTreponema Pallidum, spirocheta Gram (-), mobila, cu aspect helicoidal, anaeroba (dar poate folosi glucoza prin oxidare), creste in culturi celulare, patogen strict uman

Page 20: Agenti Patogeni in Bolile Infectioase(1)

Chist hidatic, HE, 10x, 40xChist hidatic, HE, 10x, 40xEchinococcus Granulosus, vierme lat cu un cap – scolex (cu 4 discuri de suctiune si 2 randuri de carlige) si un corp numit strobila ce contine 3 segmente numite proglote (una matura, una imatura si una gravida). Produce chiste uniloculare in plamani, ficat si creier, delimitate de o membrana anhista, care contin un lichid limpede “ca apa de izvor” si nisip hidatic. Are ca gazde intermediare caninele si ierbivorele

Page 21: Agenti Patogeni in Bolile Infectioase(1)

Trichinella Spiralis, HE, 40x, 10xTrichinella Spiralis, HE, 40x, 10xAre ca gazda intermediara porcul; larvele inchistate ajunse in duoden sau jejun, trec in forma adulta, strabat mucoasa in sange si colonizeaza muschii striati (mm. extrinseci ai globului ocular, deltoidul, gastrocnemianul, pectoralii, intercostalii), unde trec in forma larvara si se inchisteaza putandu-se calcifica. Apare un granulom cu celule eozinofile si epitelioide

Page 22: Agenti Patogeni in Bolile Infectioase(1)

Aspergillus Fumigatus, PAS, 20x Aspergillus Fumigatus, PAS, 20x Fungi in forma vegetativa, cu miceliu compus din filamente (hife) cu capete de fructificare, in plaman

Page 23: Agenti Patogeni in Bolile Infectioase(1)

Candida AlbicansCandida Albicans

Spori, frotiu cervico-vaginal, col. Pap, 40x

Spori, frotiu cervico-vaginal, col. Pap, 100x, imersie

Page 24: Agenti Patogeni in Bolile Infectioase(1)

Criptococcus NeoformansCriptococcus Neoformans

Fung cu capsula polizaharidica (ce inhiba fagocitoza) si fenoloxidaza (converteste compusii fenolici in melanina), produce pneumonie atipica si meningita la cei cu SIDA

Page 25: Agenti Patogeni in Bolile Infectioase(1)

Apararea antiviralaApararea antivirala