ageLOC Sciencein review

18 Total Patents

3 Awards Received

8 Published Scientific Articles

14 Oral Presentations

26 Scientific Posters

AGELOC SCIENCE IS A GLOBAL PHENOMENON

Barcelona, Spain

Berlin, Germany

Bangkok, Thailand

New York, NY USA

“Nu Skin, with ageLOC science, stands apart from the competition because our approach is based upon 30 years of breakthrough anti-aging research. Our research continues to gain recognition and is validated through presentations at global scientific conferences.”—Joe Chang, Ph.D.

Santa Barbara, CA

Anaheim, CA USA

Helsinki, Finland

Les Diablerets, Switzerland

Tokyo, Japan

Singapore

Taipei, Taiwan

Hangzhou, China

Wuhan, ChinaHong Kong, China

Sapporo, Japan

Siena, Italy

Corvallis, OR USA

Paris, France

Washington D.C, USA

Ventura, CA

New Orleans,

LA USA

Phoenix, AZ USA

Buenos Aires, Argentina

Brussels, Belgium

Atlanta, GA, USA

ageLOC Science 2011 Timeline

FEBRUARY

PublishedArticle in Cosmetics and ToiletriesPresented at American Academy of Dermatology’s 69th Annual Meeting

Presentedat Gordon Research Conference

2 Presentedat Fifth International Symposium on Health and the Environment

MARCH2011

“This research identifying groups of genes and genetic pathways that change in expression as we age is essential to building our proprietary ageLOC science that targets the sources of aging.”— Joseph Chang, Ph.D., Nu Skin Chief Scientific Officer and Executive VP of Product Development

APRIL

4 Presented at Federation of American Societies of Experimental Biology

MAY JUNE

Presentedat Society for Investigative DermatologyAwardedUtah Innovation Award for ageLOC Vitality: Natural Products Category

Presented Gene Expression Research in Paris, France

2011

ReleasedThe Aging Myth, a book by Joseph Chang, Ph.D.

JULY

Presented at Tenth Symposium of Mycology SocietiesPublishedArticle in Central China Agriculture University Journal

SEPTEMBER OCTOBER

PresentedR2 Research at Second International Conference on Environmental Stressors in Biology and Medicine Launched Nutritional Product ageLOC R2

Presented at Linus Pauling Institute Diet and Optimum Health Conference2 Presentedat European Society for Dermatological ResearchFiledPatent on R2

2011

The Aging MythBecame a New York Times Best Seller

Published Online article in Dermatological SurgeryPresented at International Federation of Societies of Cosmetic Chemists

NOVEMBER

Presentedat Fourth International Conference and Exhibition for Nutraceuticals and Functional FoodsPresented at 2011 International Conference on Food Factors

DECEMBER

Presentedat Society of Cosmetic Chemists Annual Scientific Seminar

Presentedat New TCM Product Development and Industrial Development Strategy SummitPublishedArticle in Zhejiang University Journal

2011

Nu Skin AcquiredLifeGen Technologies

ageLOC Science Publications and Presentations

Patents Awards

FULL LIST

Multiple Patents in the following categories:

Licensed Patents-Pending on Formulation or Ingredients Nu Skin-Developed Patents-Pending on Formulation or Ingredients Licensed Patent on Method Nu Skin-Developed Patent-Pending on Method

Angela Mastaloudis, Senior Scientist, Received the DSM Nutraceutical Research Award

Remona Gopaul, Associate Senior Scientist, Named Young Scientist of the Year by the Society of Cosmetic Chemists

Nu Skin Awarded Utah Innovation Award for ageLOC Vitality: Natural Products category, 2011

2011 Published Articles

FULL LIST

February 2011Gopaul, R., Knaggs, H., Wickett, R. “A Review of Genomic Techniques in Cosmetic Testing.” Cosmetics & Toiletries. February 2011, pp. 112-117.

July 2011Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J. “CordyMax Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” Proceeding of the 10th Symposium of Mycology Societies Across Taiwan Strait, Central China Agriculture University Publishing. 2011, pp 255-256.

November 2011Li, C., Tan, N., Barger, J., Zhang, Y., Ferguson, S., Prolla, T., Zhu, J. “Combined use of ageLOC whole-gene expression profiling technology and mouse lifespan test in anti-aging herbal product study.” Proceeding of New TCM Products Innovation and Industrial Development Summit, Zhejiang University Publishing, Hangzhou. 27 Nov. 2011. (in press)

December 2011Chang, A., Lingala, B., Chang, T., Kern, D., Wood, S., Toyoda, H., Knaggs, H. “An Exploratory Study to Determine the Association Between Assessed Facial Skin Aging and Plasma Isoprostane Levels in Middle-Aged Japanese Women.” Article first published online: 5 Dec. 2011 Dermatological Surgery. http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2011.02235.x/abstract

2011 Oral PresentationsJune 2011“Transcriptional biomarkers of calorie restriction and their modulation by dietary interventions.” Invited Speaker: Free Radicals, Nutrition and Aging: From Fundamental Aspects to Clinical Applications. Paris, France, June 15-17, 2011. Barger, J.

July 2011“CordyMax Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” The 10th Symposium of Mycology Societies Across Taiwan Strait, Wuhan, China, July 17, 2011. Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J. September 2011“Transcriptional biomarkers of calorie restriction in adipose tissue and modulation by dietary interventions.” Invited Speaker: Linus Pauling Institute Diet and Optimum Health Conference. Corvallis, OR, September 13-16, 2011. Barger, J.

October 2011“A unique nutritional formulation to promote cellular protection and purification via induction of the Nrf2-mediated ARE/Phase II detoxification pathways.” Invited Speaker: Second International Conference on Environmental Stressors in Biology and Medicine. Centro Didattico, Policlinico Le Scotte Siena, Italy. October 5-7, 2011. Mastaloudis, A.

November 2011“Restructuring of the ECM in Human Skin by Equol: A Plant and Soy-Derived Isoflavonoid.” Gene Expression and Protein Evidence presented at the 4th International Conference and Exhibition for Nutraceuticals and Functional Foods, Sapporo, Japan, November 2011. Gopaul, R., Knaggs, H., Lephart, E. “Whole-gene transcriptional profiling to detect aging-associated mitochondria dysfunction and to develop an anti-aging product.” Invited Speaker: The 2011 International Conference on Food Factors, Taiwan, November 20-23, 2011. Zhu, J., Dong, Y., Barger, J., Lu, J., Tan, N., Prolla, T., Weindruch, R., Bartlett, M. “Combination of ageLOC biochip whole-gene expression profiling and mouse lifespan test in CM anti-aging study.” Invited Speaker: Summit

 “Combination of ageLOC biochip whole-gene expression profiling and mouse lifespan test in CM anti-aging study.” Invited Speaker: Summit of New TCM product Development and Industrial Development Strategy, Hangzhou, China, November 25-27, 2011. Li, C., Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J.

FULL LIST

Posters 2011

FULL LIST

February 2011“Exploratory Study to Assess Association of Skin Aging with Plasma Isoprostane Levels in Healthy Middle-Aged Japanese Women.” The American Academy of Dermatology’s 69th Annual Meeting, February 2011, New Orleans, LA. Chang, A., Chang, T., Lingala, B., Kern, D., Wood, S., Toyoda, H., Knaggs, H.

March 2011“A PCR-based screen to identify natural compounds with the ability to influence Nrf2-mediated transcriptional induction of detoxification/antioxidant genes.” Gordon Research Conference: Oxidative Stress & Disease. Emerging Research Areas in the Study of Oxidative Stress and Disease. March 13-18, 2011, Ventura, CA. Mastaloudis, A., Barger, J., Prolla, T., Weindruch, R., Ferguson, S., Wood, S. “Cordyceps sinensis Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” Progress in Nutrition 2011. The 5th International Symposium, “Promoting Good Health and Developing a Sustainable Environment,” Hong Kong, March 10-11, 2011. Zhu, J., Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M. “ageLOC Vitality improves exercise endurance, glucose metabolism and antioxidant capacity in an aging model.” Progress in Nutrition 2011. The 5th International Symposium, “Promoting Good Health and Developing a Sustainable Environment,” Hong Kong, March 10-11, 2011. Zhu, J., Yang, J., Dong, Y., Zhao, C., Wu, Z., Zhang, Y., Tan, N., Lu, J., Bartlett, M.

April 2011“The lifespan-prolonging effect of Cordyceps sinensis Cs-4 in normal mice and its molecular mechanisms.” FASEB J 2011 25(1): 599.1. FASEB EB2011, Washington, DC, Apr. 10, 2011. Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J. “ageLOC Vitality improves endurance exercise, exercise glucose metabolism and antioxidant capacity in an aging model.” FASEB J 2011 25(1): 1049.2. FASEB EB2011, Washington, DC, Apr. 12, 2011. Yang, J., Dong, Y., Zhao, C., Wu, Z., Zhang, Y., Tan, N., Lu, J., Bartlett, M., Zhu, J. “Cordyceps sinensis Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” FASEB J 2011 25(1): 1090.13. FASEB EB2011, Washington, DC, Apr. 13, 2011. Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J.  “An ageLOC Vitality formula improves endurance exercise in aged mice and energy metabolism in muscle mitochondria.” FASEB J 2011 25(1): 1114.9. FASEB EB2011, Washington, DC, Apr. 13, 2011. Dong, Y., Lu, J., Yang, J., Zhao, C., Tan, N., Wu, Z., Zhang, Y., Gao, L., Bartlett, M., Zhu, J.

May 2011“Association of skin aging severity with blood isoprostane levels in healthy middle-aged Japanese women.” Society for Investigative Dermatology (SID) May 2011, J. Invest Dermatol 131. S. 85 (2011). Chang, T., Lingala, B., Kern, D., Wood, S., Toyoda, H., Knaggs, H., Chang, A.

July 2011“CordyMax Cs-4 restores aging-associated changes in gene expression and extends lifespan in normal aged mice.” Proceeding of the 10th Symposium of Mycology Societies cross Taiwan Strait, Central China Agriculture University. 2011, pp 255-256. Oral presentation at: The 10th Symposium of Mycology Societies Cross Taiwan Strait, Wuhan, China, July 17, 2011. Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J.

September 2011“A Multifactorial Approach to Addressing Body Appearance Aging.” European Society for Dermatological Research (ESDR) September 2011, J. Invest Dermatol 131. S. 54 (2011). Knaggs, H., Kern, D., Gopaul, R., Langerveld, A. “A Multifactorial Gene Expression Approach to Understanding Skin Aging.” J. Invest Dermatol 131. S. 57, September 2011. Knaggs, H., Kern, D., Bartlett, M., Wood, S., Mastaloudis, A., Ferguson, S., Langerveld, A. “A Systematic Approach to Evaluate and Rank Natural Ingredients Based on Their Ability to Oppose Age-Related Changes in Gene Expression.” Linus Pauling Institute Diet and Optimum Health Conference. Corvallis, OR. September 13-16, 2011. Wood, S., Mastaloudis, A., Barger, J., Prolla, T., Weindruch, R.

Posters 2011

FULL LIST

October 2011“A unique blend of natural compounds with the ability to oppose age-related changes in gene expression related to dysregulation of removal of cellular debris, cellular detoxification, antioxidant protection and inflammatory balance.” Second International Conference on Environmental Stressors in Biology and Medicine. October 5-7, 2011, Centro Didattico, Policlinico Le Scotte Siena, Italy. Mastaloudis, A., Barger, J., Prolla, T., Weindruch, R., Bartlett, M., Wood, S.

November 2011“Combination of ageLOC biochip whole-gene expression profiling and mouse lifespan test in CM anti-aging study.” Proceeding of Summit of New TCM product Development and Industrial Development Strategy, China J Chinese Materia Medica Publishing. 2011. Li, C.L., Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J.Invited Speaker at: Summit of New TCM product Development and Industrial Development Strategy, Hangzhou, China, November 25-27, 2011.  “Whole-gene transcriptional profiling to detect aging-associated mitochondria dysfunction and to develop an anti-aging product.” Proceeding of 2011 International Conference on Food Factors. Zhu, J.S., Dong, Y.Z., Barger, J.L., Lu, J.H., Tan, N.Z., Prolla, T.A., Weindruch, R., Bartlett, M.Invited Speaker at: The 2011 International Conference on Food Factors, Taiwan, November 20-23, 2011.

December 2011“Influencing the Expression of Genes Associated with Skin Inflammation by Combining Narcissus Tazetta Bulb Extract and Schizandra Chinensis Fruit Extract—an in vitro Analysis.” Society of Cosmetic Chemists Annual Scientific Seminar, New York, NY, December 2011. Gopaul, R., Knaggs, H., Kern, D.

“So Why Don’t I Look Younger?” International Federation of Societies of Cosmetic Chemists, Bangkok, Thailand, December 14-15, 2011. Kern, D., Chang, A., Wood, S., Gopaul, R., Lephart, J., Knaggs, H.

summaryWe believe Nu Skin’s ongoing research, combined with the acquisition of LifeGen Technologies, will deepen the company’s understanding of gene expression and its impact on reversing the effects of aging even later in life.

With our exclusive focus on identifying, targeting, and resetting Youth Gene Clusters, we believe ageLOC science is the answer to anti-aging. It’s a scientific breakthrough that goes beyond the signs to target the ultimate sources of aging.

For more information about ageLOC science, please visit ageloc.com.