advice for young scientists luis a. nunes amaral howard hughes medical institute dept. of chemical...
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Advice for young scientists
Luis A. Nunes AmaralHoward Hughes Medical Institute
Dept. of Chemical and Biological EngineeringDept. of Medicine
Northwestern Institute on Complex Systems
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Challenges
Getti
ng
Funded
Doing Great
Research
Becoming
Known
Comunicating
Well Often
&
Puzzle borrowed from http://masenomathscamp.net
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Apprenticeship
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If it was only that simple…
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Detecting great research
Citations are the currency of science
Eugene Garfield (ISI)
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Total citations are a result of…
Stringer, Sales-Pardo & Amaral, PLoS One 3, e1683 (2008) 6
q = Scientific field +Authors’ reputation +Authors’ prior work in field + Timeliness/Relevance to peers +Originality of problem + Originality of approach + Unexpectedness of results +Significance of results + Strength of evidence + Quality of exposition +Quality of figures + …
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Suggesting that:
Stringer, Sales-Pardo & Amaral, PLoS One 3, e1683 (2008) 7
Number of citations to papers published by a researcher or in a journal may be normally (or, perhaps, log-normally) distributed.
Papers by a given researcher may receive a typical number of citations.
Papers published in a given journals may also receive a typical number of citations.
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Journal citation distribution
Stringer, Sales-Pardo & Amaral, PLoS One 3, e1683 (2008)
Journal of Biological Chemistry
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What can one do to succeed?
Getti
ng
Funded
Doing Great
Research
Becoming
Known
Comunicating
Well Often
&
Puzzle borrowed from http://masenomathscamp.net
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Data-driven approach
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Framingham Heart Study
Research Milestones1960 Cigarette smoking found to increase the risk of heart disease1961 Cholesterol level, blood pressure, and electrocardiogram
abnormalities found to increase the risk of heart disease1967 Physical activity found to reduce the risk of heart disease and obesity to increase the risk of heart disease1970 High blood pressure found to increase the risk of stroke1976 Menopause found to increase the risk of heart disease1978 Psychosocial factors found to affect heart disease1988 High levels of HDL cholesterol found to reduce risk of death
5,209 men and women between the ages of 30 and 62Extensive physical examinations and lifestyle interviews repeated every two years
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What can one do to succeed?
Getti
ng
Funded
Doing Great
Research
Becoming
Known
Comunicating
Well Often
&
Puzzle borrowed from http://masenomathscamp.net
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Doing great research
When does discovery/innovation occur?
What can one do to foster discovery?
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Christopher Columbus never abandoned the belief that he had reached Asia.
Right place, right time
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Right place, right time
Upon returning from his August vacation, Alexander Fleming discovered that a fungus of the Penicillium genus had, by chance, contaminated a bacterial culture, killing the closest colonies.
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Gregor Mendel had been trained in mathematics and learned how to design experiments and analyze data.
Botanists of Mendel's time were not accustomed to statistics and so couldn't recognize the importance of Mendel's discovery.
Knowledge transfer
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John von Neumann made important contributions in quantum physics, computer science, economics and many mathematical fields.
Von Neumann developed the mathematical basis of game theory, but “…had von Neumann and Morgenstern never met, it seems unlikely that game theory would have been developed."
Knowledge transfer
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Doing great research
When does discovery/innovation occur?
What can one do to foster discovery?
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What can one do?
Leave my comfort zone • Team work
Mentor and be mentored• Does mentor fecundity correlate with other
measures of academic productivity and recognition?
• Does mentor fecundity impact fecundity of protégés?
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Teams
Guimera, Uzzi, Spiro & Amaral, Science 308, 697 (2005) 20
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Team characteristics
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Measuring team size
Team size is 192
Team size is 2 (actually 4)
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Measuring diversity
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Measuring expertise
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Data
Field Period Teams Agents Journals
Broadway 1877-1990 2,258 4,113 ----
Socialpsychology 1955-2004 16,526 23,029 7
Economics 1955-2004 14,870 23,236 9
Ecology 1955-2004 26,888 38,609 10
Astronomy 1955-2004 30,552 30,192 6
Guimera, Uzzi, Spiro & Amaral, Science 308, 697 (2005) 25
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Team size
Guimera, Uzzi, Spiro & Amaral, Science 308, 697 (2005) 26
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Team characteristics
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p probability of a team member being an incumbent
q tendency to repeat past collaborations rather than initiate new ones
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Impact increases with
Increasing experience of team members
Decreasing probability of repeating collaborations
Increasing size of community
Guimera, Uzzi, Spiro & Amaral, Science 308, 697 (2005) 28
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What can one do?
Leave my comfort zone • Team work
Mentor and be mentored• Does mentor fecundity correlate with other
measures of academic productivity and recognition?
• Does mentor fecundity impact fecundity of protégés?
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Large longitudinal database
Studied career of 7,259 mathematicians who obtained their Ph.D. between 1900 and 1960
Malmgren, Ottino, Amaral, Nature (2010) 30
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Proxies of academic success
469 members of NAS4,447 mathematicians with publication counts7,259 mathematicians with fecundity counts
Malmgren, Ottino, Amaral, Nature (2010) 31
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What can one do?
Leave my comfort zone • Team work
Mentor and be mentored• Does mentor fecundity correlate with other
measures of academic productivity and recognition?
• Does mentor fecundity impact fecundity of protégés?
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Fecundity of protégés
k<3 3≤k < 10 K ≥10
1st third of career 37% larger --- 29% larger
2nd third of career 37% larger --- ---
3rd third of career 37% larger --- 31% smaller
Malmgren, Ottino, Amaral, Nature (in press) 33
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Take home messages
Eat your vegetables Avoid saturated fat Exercise Collaborate broadly and
often
Choose mentors broadly and wisely