adverse drug interactions

A Handbook for Prescribers

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A Handbook for Prescribers

Lakshman Karalliedde DA FRCAVisiting Senior Lecturer, Department of Public Health Sciences,Kings College London School of Medicine;Consultant Medical Toxicologist, Health Protection Agency,London, UK

Simon F.J. Clarke DA FRCS(Ed) FCEMConsultant Emergency Medicine Physician, Frimley Park NHS Foundation Trust, UK;Honorary Consultant Medical Toxicologist, Chemical Hazards and Poisons Division (London), Health Protection Agency, UK

Ursula Collignon BPharm MRPharmSSenior Pharmacist, Guys & St Thomas NHS Foundation Trust, London, UK

Janaka Karalliedde MBBS MRCPClinical Lecturer in Diabetes and Endocrinology, Kings CollegeLondon School of Medicine, Kings College London, UK

First published in Great Britain in 2010 byHodder Arnold, an imprint of Hodder Education, an Hachette UK company, 338 Euston Road, London NW1 3BHhttp://www.arnoldpublishers.com/http://www.hoddereducation.com

2010 Karalliedde, Clarke, Collignon and Karalliedde

All rights reserved. Apart from any use permitted under UK copyright law, this publicationmay only be reproduced, stored or transmitted, in any form, or by any means with priorpermission in writing of the publishers or in the case of reprographic production inaccordance with the terms of licences issued by the Copyright Licensing Agency. In theUnited Kingdom such licences are issued by the Copyright Licensing Agency: Saffron House,610 Kirby Street, London EC1N 8TS

Whilst the advice and information in this book are believed to be true and accurate at thedate of going to press, neither the authors nor the publisher can accept any legalresponsibility or liability for any errors or omissions that may be made. In particular (butwithout limiting the generality of the preceding disclaimer) every effort has been made tocheck drug dosages; however it is still possible that errors have been missed. Furthermore,dosage schedules are constantly being revised and new side-effects recognized. For thesereasons the reader is strongly urged to consult the drug companies printed instructionsbefore administering any of the drugs recommended in this book.

British Library Cataloguing in Publication DataA catalogue record for this book is available from the British Library

Library of Congress Cataloging-in-Publication DataA catalog record for this book is available from the Library of Congress

ISBN 9780340927694

1 2 3 4 5 6 7 8 9 10

Commissioning Editor: Philip ShawProject Editor: Joanna SilmanProduction Controller: Karen DyerIndexer: Jan Ross

Typeset in 9/10.5 pt ITC Garamond Light BT by Macmillan Publishing Solutions, Chennai, IndiaPrinted and bound in India

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About the authors ............................................................................................................................... ix

Preface ............................................................................................................................................................ x

Acknowledgements ............................................................................................................................ xi

Abbreviations ......................................................................................................................................... xii

Index of drug names ........................................................................................................................ xiii

Introduction .................................................................................. lx

Clinical features of some adverse drug interactions ............. lxix

Part 1 Cardiovascular drugs ......................................................... 1Introduction .................................................................................................................................. 1Aliskiren .......................................................................................................................................... 7Antiarrhythmics ........................................................................................................................... 8Antihypertensives and heart failure drugs .................................................................. 34Antiplatelet drugs ................................................................................................................... 54Beta-blockers ............................................................................................................................. 62Calcium channel blockers ..................................................................................................... 78Cardiac glycosides .................................................................................................................... 98Diuretics ..................................................................................................................................... 107Ivabradine ................................................................................................................................. 119Lipid-lowering drugs ............................................................................................................ 120Nitrates ....................................................................................................................................... 130Peripheral vasodilators ....................................................................................................... 133Potassium channel activators ........................................................................................... 137Selective phosphodiesterase inhibitors ....................................................................... 138Sympathomimetics ................................................................................................................ 138

Part 2 Drugs acting on the nervous system ............................ 147Introduction ............................................................................................................................. 147Antidementia drugs ............................................................................................................. 155Antidepressants ...................................................................................................................... 156Antiemetics .............................................................................................................................. 203Antiepileptics .......................................................................................................................... 209Antimigraine drugs .............................................................................................................. 228Antiobesity drugs .................................................................................................................. 236Antiparkinsons drugs ......................................................................................................... 239Antipsychotics ......................................................................................................................... 251Anxiolytics and hypnotics .................................................................................................. 263CNS stimulants ........................................................................................................................ 274Drug dependence therapies ............................................................................................. 279Drugs used to treat neuromuscular diseases and movement disorders ....... 283

CONTENTS

Part 3 Anticancer and immunomodulating drugs .................. 287Introduction ............................................................................................................................. 287Cytotoxics .................................................................................................................................. 289Hormones and hormone antagonists .......................................................................... 346Other immunomodulating drugs ................................................................................... 350

Part 4 Anticoagulants ............................................................... 389Introduction ............................................................................................................................. 389Anticoagulants oral .......................................................................................................... 390Anticoagulants parenteral ............................................................................................. 399Thrombolytics .......................................................................................................................... 401

Part 5 Antidiabetic drugs ......................................................... 403Introduction ............................................................................................................................. 403Insulin ......................................................................................................................................... 405Metformin ................................................................................................................................ 413Sulphonylureas ....................................................................................................................... 421Other diabetic drugs ............................................................................................................ 433

Part 6 Other endocrine drugs ................................................... 453Bisphosphonates ................................................................................................................... 454Danazol ..................................................................................................................................... 454Desmopressin .......................................................................................................................... 454Diazoxide .................................................................................................................................. 454Dutasteride .............................................................................................................................. 454Female sex hormones .......................................................................................................... 454Gestrinone ................................................................................................................................ 454Glucagon ................................................................................................................................... 454Nandrolone .............................................................................................................................. 455Somatropin (growth hormone) ...................................................................................... 455Steroid replacement therapy ........................................................................................... 455Strontium ranelate ............................................................................................................... 455Testosterone ............................................................................................................................ 455Thyroid hormones ................................................................................................................ 456Trilostane .................................................................................................................................. 458

Part 7 Analgesics ....................................................................... 459Introduction ............................................................................................................................. 459Acetaminophen ...................................................................................................................... 461Nefopam .................................................................................................................................... 461Non-steroidal anti-inflammatory drugs (NSAIDs) ................................................... 462Opioids ....................................................................................................................................... 470Paracetamol ............................................................................................................................. 479

Part 8 Musculoskeletal drugs ................................................... 481Introduction ............................................................................................................................. 481Antigout drugs ....................................................................................................................... 482Drugs affecting bone metabolism ................................................................................. 488

CONTENTS

vi

Drugs treating inflammatory arthropathies .......................................................... 488Skeletal muscle relaxants ................................................................................................ 488

Part 9 Anaesthetic drugs .......................................................... 492Introduction .......................................................................................................................... 492Anaesthetics general ..................................................................................................... 494Anaesthetics local ........................................................................................................... 498Anticholinesterases ........................................................................................................... 502Antimuscarinics ................................................................................................................... 502Benzodiazepines ................................................................................................................. 502Dantrolene ............................................................................................................................ 502Muscle relaxants depolarizing and non-depolarizing ................................... 502Opioids .................................................................................................................................... 505

Part 10 Drugs to treat infections ............................................. 506Introduction .......................................................................................................................... 506Antibiotics aminoglycosides ...................................................................................... 510Antibiotics beta-lactams .............................................................................................. 513Antibiotics macrolides .................................................................................................. 515Antibiotics penicillins .................................................................................................... 525Antibiotics quinolones ................................................................................................. 526Antibiotics rifamycins ................................................................................................... 532Antibiotics sulphonamides ......................................................................................... 541Antibiotics tetracyclines ............................................................................................... 546Other antibiotics ................................................................................................................. 549Antifungal drugs ................................................................................................................ 561Antimalarials ........................................................................................................................ 580Other antiprotozoals ........................................................................................................ 592Antivirals antiretrovirals .............................................................................................. 596Antivirals other ................................................................................................................ 628

Part 11 Drugs acting on the gastrointestinal tract ................. 633Introduction .......................................................................................................................... 633Antacids .................................................................................................................................. 634Antidiarrhoeals ................................................................................................................... 636Antiemetics ........................................................................................................................... 637Antimuscarinics ................................................................................................................... 637Drugs affecting bile .......................................................................................................... 637Drugs used to treat inflammatory bowel disease ............................................... 637H2 receptor blockers ......................................................................................................... 638Pancreatin .............................................................................................................................. 648Proton pump inhibitors ................................................................................................... 649Sucralfate ............................................................................................................................... 654Tripotassium dicitratobismuthate .............................................................................. 655

Part 12 Respiratory drugs ......................................................... 656Introduction .......................................................................................................................... 656Antihistamines ..................................................................................................................... 658

CONTENTS

vii

Bronchodilators ................................................................................................................... 662Doxapram .............................................................................................................................. 673Leukotriene receptor antagonists .............................................................................. 673

Part 13 Metabolic drugs ............................................................ 675Agalsidase .............................................................................................................................. 676Laronidase ............................................................................................................................. 676Penicillamine ........................................................................................................................ 676Sodium phenylbutyrate ................................................................................................... 676Trientine ................................................................................................................................. 676

Part 14 Drugs used in obstetrics and gynaecology ................ 677Danazol ................................................................................................................................... 678Ergometrine .......................................................................................................................... 678Female hormones ............................................................................................................... 678Gestrinone ............................................................................................................................. 684Mifepristone ......................................................................................................................... 684Oxytocics ................................................................................................................................ 684Prostaglandins ..................................................................................................................... 684Raloxifene .............................................................................................................................. 685Tibolone ................................................................................................................................. 685

Part 15 Urological drugs ............................................................ 686Urinary retention ............................................................................................................... 687Urinary incontinence ........................................................................................................ 687Erectile dysfunction ........................................................................................................... 688Urinary alkalization ........................................................................................................... 690

Part 16 Drugs of abuse .............................................................. 691Cannabis ................................................................................................................................. 692Amphetamines .................................................................................................................... 699Ecstasy (MDMA) .................................................................................................................. 701Cocaine ................................................................................................................................... 703Heroin ...................................................................................................................................... 704Hallucinogens ...................................................................................................................... 704Gamma hydroxybutyric acid ......................................................................................... 704Amyl nitrite ........................................................................................................................... 704

Part 17 Miscellaneous ................................................................ 705Introduction .......................................................................................................................... 705Alcohol .................................................................................................................................... 713Grapefruit juice ................................................................................................................... 720Minerals .................................................................................................................................. 733Herbal drugs ......................................................................................................................... 742

Part 18 Over-the-counter drugs ................................................ 760Introduction .......................................................................................................................... 760

CONTENTS

viii

ix

ABOUT THE AUTHORS

Lakshman Karalliedde is currently Visiting Senior Lecturer at the Division ofPublic Health Sciences, Kings College London School of Medicine, Kings College,London, UK; and Senior Collaborator at the South Asian Clinical ToxicologyResearch Collaboration, Faculty of Medicine, University of Peradeniya, Sri Lanka.He is also Consultant Medical Toxicologist, Chemical Hazards & Poisons Division(London), Health Protection Agency, UK.

Dr Karalliedde was formerly Senior Lecturer and Honorary Consultant Anaesthetistat the United Medical & Dental Schools of Guys & St Thomas Hospitals, London,UK; and Medical Toxicologist at Guys Poisons Unit and National PoisonsInformation Service, Guys & St Thomas NHS Foundation Trust, London, UK.

Simon F. J. Clarke is Consultant Emergency Medicine Physician, Frimley ParkNHS Foundation Trust, UK; and Honorary Consultant Medical Toxicologist,Chemical Hazards and Poisons Division (London), Health Protection Agency, UK.

Ursula Collignon is Senior Pharmacist at Guys & St Thomas NHS FoundationTrust, London, UK.

Janaka Karalliedde is Clinical Lecturer in Diabetes and Endocrinology in theCardiovascular Division, Kings College London School of Medicine, Kings CollegeLondon, UK.

PREFACE

Thirteen years ago, the journal of the American Medical Association (JAMA 1996)reported that 108, 000 Americans died in hospital from adverse drug reactions and2.2 million Americans had reactions to FDA approved medications. In the UK anestimated 1.6 million bed days are due to in-patient adverse drug reactions and upto 6.5% of new patient admissions may be related to an adverse drug reaction.Recent estimates suggest that adverse drug reactions cost the NHS in England inexcess of 637 million annually.

In 2009, in the UK, drugs are increasingly available over the counter and on-linewithout prescription. Furthermore, there is widespread use of numerous herbalmedicines from relatively under-regulated suppliers and the constituents of suchproducts are often not known. This clinical reality of the widespread use of potentmedicines be they allopathic or traditional showed us the need for a practicalhands-on guide that aims to be a compact, succinct and accessible source ofinformation for practitioners, prescribers and the public about adverse druginteractions.

We are aware that there are numerous sources of information available toprescribers, pharmacists and users about adverse drug interactions and that newdrug interactions are reported on a regular basis. This makes it difficult for the busypracticing health-care professional to keep up with the related literature. We haveaimed to produce a user-friendly resource that not only describes the potentialinteractions themselves, but also gives practical advice about what clinical featuresto look out for, what to do to try to minimize their occurrence, and what to do ifthey occur. We aim to produce a source of information that can be used within thetime frame of a consultation, to provide some guidance to prescribers, dispensersand users to minimize the risk of a drug interaction occurring.

Thus, this book intends to provide a source of easily accessible and conciseinformation and guidance to busy prescribers, dispensers and users to minimizethis avoidable or preventable hazard.

Note: The views expressed in this book are those of the authors, and notnecessarily those of the Health Protection Agency.

x

ACKNOWLEDGEMENTS

The authors thank the following people for their specialized input which hascontributed to this book:

Indika Gawarammana, Senior Lecturer in Medicine and Consultant Physician,Director of Clinical Research South Asian Clinical Toxicology ResearchCollaboration, Faculty of Medicine, University of Peradeniya, Sri Lanka; andConjoint Senior Lecturer in Toxicology, University of Newcastle, Australia. Heassisted LK in editing the book.

Edwin Chandraharan, Consultant Obstetrician and Gynaecologist, St GeorgesHealth Care NHS Trust, London, UK.

SAM Kularatne, Professor of Medicine, Faculty of Medicine, University ofPeradeniya, Sri Lanka.

Karen Sturgeon, Medical Toxicology Information Service, Guys and St ThomasNHS Foundation Trust, London, UK.

Anomi Panditharatne, Division of Ophthalmology, University College LondonHospital, London, UK.

Thilak Jayalath, Senior Lecturer in Medicine, Faculty of Medicine, University ofPeradeniya, Sri Lanka.

Jean Sugathadasa, General Practitioner, London.

LK wishes to thank Ajayakumar Anandibhai Patel (B Pharmacy, Kings CollegeLondon), Karen Hogan, Penelope Dixie, Angela Dillaway and Louise Dowlingfor their assistance and advice. He is also very appreciative of the continuingencouragement of Philip Shaw at Hodder Arnold, without which the book wouldnot have seen its completion.

xi

ABBREVIATIONS

xii

5-HT 5-hydroxytryptamineACE angiotensin-converting enzymeACh acetylcholineADH antidiuretic hormoneAIDS acquired immune deficiency

syndromeAPTT activated partial thromboplastin

timeATP adenosine triphosphateAUC area under the curveAV atrioventricularBCG Bacille Calmette-GuerinBP blood pressureBZD benzodiazepineCHM Commission on Human

MedicinesCHMP Committee for Medical Products

for Human UseCK creatine kinaseCNS central nervous systemCSF cerebrospinal fluidCSM Committee on Safety of

MedicinesCYP cytochrome P450ECG electrocardiogramFBC full blood countFDA Food and Drug AdministrationGABA gamma-amino butyric acidGTN glyceryl trinitrateHbA1c glycated haemoglobinHIV human immunodeficiency virusIL interleukin

INR international normalized ratioLFT liver function testMAO monoamine oxidaseMAOI monoamine oxidase inhibitorMDMA methylenedioxymethamphetamineMRP multidrug resistance-associated

proteinMSG monosodium glutamateNICE National Institute for Health and

Clinical ExcellenceNMDA N-methyl-D-aspartateNNRTI non-nucleoside reverse

transcriptase inhibitorNSAID non-steroidal anti-inflammatory

drugOATP organic anion-transporting

polypeptideOTC over-the-counterP-gp P-glycoproteinPR pulse ratePRN as required (pro re nata)RNA ribonucleic acidSNRI serotoininnorepinephrine

(noradrenaline) reuptake inhibitorSSRI selective serotonin reuptake

inhibitorTCA tricyclic antidepressantTFT thyroid function testTSH thyroid-stimulating hormoneU&Es urea and electrolytesUDPGT uridine diphosphate glucuronosyl

transferase

xiii

INDEX OF DRUG NAMES

This index lists page numbers where the named drug appears as the primary drugin the interaction. Where interactions are in the book for a group of drugs (e.g. aceinhibitors), individual drug names in this index are referenced to the group (e.g. forfosinopril the reader is directed to see ace inhibitors). Herbal drugs (other thanSt. Johns wort) are not listed here. The contents list gives the full page range for aparticular drug group or category.

Drug (primary) Page Part of the Book Category Subcategory (drug groups only)

abacavir 603, 611 10. Drugs to treatinfections

Antivirals antiretrovirals

Nucleoside reversetranscriptaseinhibitors

abciximab seeglycoproteinIIb/IIIainhibitors 61

acarbose 433437 5. Antidiabetic drugs Other antidiabeticdrugs

acebutolol 66 1. Cardiovascular drugs Beta-blockers

acemetacin see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

acenocoumarol seeanticoagul-ants oral390399

acetaminophen seeparacetamol

acetazolamide 107108 1. Cardiovascular drugs Diuretics Carbonic anhydraseinhibitors

aciclovir 628, 629 10. Drugs to treatinfections

Antivirals other

acitretin 382 3. Anticancer andimmunomodulatingdrugs

Otherimmunomodulatingdrugs

actinomycin D seedactinomycin

adalimumab 351 3. Anticancer andimmunomodulatingdrugs


INDEX OF DRUG NAMES

xiv


adefovirdipivoxil

630 10. Drugs to treatinfections

Antivirals other

adenosine 8 1. Cardiovascular drugs Antiarrhythmics

adrenaline seeepinephrine

agalsidase beta 676 13. Metabolic drugs Agalsidase beta

alcohol 713719 17. Miscellaneous drugs Alcohol

aldesleukin seeinterleukin-2

alendronate 454 6. Other endocrine drugs Bisphosphonates

alfentanil 476, 478 7. Analgesics Opioids

alimemazine 660 12. Respiratory drugs Antihistamines

aliskiren 7 1. Cardiovascular drugs Aliskiren

allopurinol 482483 8. Musculoskeletaldrugs

Antigout drugs

allopurinol 739 17. Miscellaneousdrugs

Minerals Other drug-mineralinteractions

almotriptan 230, 231,232, 233,234, 235

2. Drugs acting on thenervous system

Antimigraine drugs 5-HT1 agonists triptans

alprostadil 684 14. Drugs used inobstetrics andgynaecology

Prostaglandins

alteplase seethrombolytics401402

amantadine 239240 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

ambrisentan seevasodilatorantihypert-ensives 35,36, 37, 38,41, 42,4453

amikacin seeaminogly-cosides510513

amiloride 113 1. Cardiovascular drugs Diuretics Potassium-sparingdiuretics andaldosteroneantagonists

aminophylline see theo-phyllines,655

INDEX OF DRUG NAMES

xv


amiodarone 914 1. Cardiovascular drugs Antiarrhythmics

amisulpride 253 2. Drugs acting on thenervous system

Antipsychotics

amitriptyline 183, 187,188, 189


Antidepressants Tricyclicantidepressants

amlodipine see calciumchannelblockers7898

ammoniumchloride

690 15. Urological drugs Urinaryalkalinization

amobarbital seebarbiturates(asantiepilep-tics)211214

amoxapine 187 2. Drugs acting on thenervous system


amoxycillin seepenicillins525

amphetamines 699700 16. Drugs of abuse

amphotericin 561562 10. Drugs to treatinfections

Antifungal drugs

ampicillin 525, 526 10. Drugs to treatinfections

Antibiotics Penicillins

amprenavir 620, 622,626

10. Drugs to treatinfections


Protease inhibitors

amyl nitrite 704 16. Drugs of abuse Amyl nitrite

anakinra 352 3. Anticancer andimmunomodulatingdrugs


anastrazole 346 3. Anticancer andimmunomodulatingdrugs

Hormones andhormoneantagonists

antacids 634636 11. Drugs acting on thegastrointestinal tract

apomorphine 249, 250 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Dopaminergics

apraclonidine see sympa-thomimetics138

aprazolam 264, 265,266, 268,269


Anxiolytics andhypnotics

Benzodiazepines

INDEX OF DRUG NAMES

xvi


aprepitant 203204 2. Drugs acting on thenervous system

Antiemetics

aripiprazole 253, 255,257, 259


Antipsychotics

arsenic trioxide 290 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

artemether 580581 10. Drugs to treatinfections

Antimalarials

asparaginase see crisan-taspase

aspirin 5457 1. Cardiovascular drugs Antiplatelet drugs

astemizole 661 12. Respiratory drugs Antihistamines

atazanavir 620, 621,622, 623,626, 628



Protease inhibitors

atenolol 66 1. Cardiovascular drugs Beta-blockers

atomoxetine 274276 2. Drugs acting on thenervous system

CNS stimulants

atorvastatin 125, 126,128

1. Cardiovascular drugs Lipid-lowering drugs Statins

atovaquone 582 10. Drugs to treatinfections

Antimalarials

atracurium see musclerelaxants depolarising,non-depolarising502505

atropine 240, 241,243


AntiParkinsonsdrugs

Antimuscarinics

azapropazone see non-steroidalanti-inflammat-ory drugs(NSAIDs)462270

azathioprine 352355 3. Anticancer andimmunomodulatingdrugs


azithromycin 515, 516,522


Antibiotics Macrolides

azithromycin 739 17. Miscellaneousdrugs


INDEX OF DRUG NAMES

xvii


baclofen 488, 489,490, 491

8. Musculoskeletaldrugs

Skeletal musclerelaxants

balsalazide seeaminosali-cylates 351

bambuterol 665 12. Respiratory drugs Bronchodilators Beta-2 agonists

bemiparin see antico-agulants parenteral,399

bendroflumethi-azide

seethiazides116119

benperidol seeantipsy-chotics251263

betamethasone see corti-costeroids367374

betaxolol 66 1. Cardiovascular drugs Beta-blockers

bethanechol seeantimus-carinics240247

bexarotene 291 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

bezafibrate seefibrates123125

bicalutamide 346 3. Anticancer andimmunomodulatingdrugs


bisoprolol 66 1. Cardiovascular drugs Beta-blockers

bivalirudin seehirudins339, 401

bleomycin 291 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

bortezomib 291 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

bosentan 41, 51, 52 1. Cardiovascular drugs Antihypertensives andheart failure drugs

VasodilatorAntihypertensives

INDEX OF DRUG NAMES

xviii


brimonidine seesympatho-mimetics138

bromocriptine 244, 247,250


AntiParkinsonsdrugs

Dopaminergics

bumetanide see loopdiuretics109

bupivacaine 500 9. Anaesthetic drugs Anaesthetics local

buprenorphine 476 7. Analgesics Opioids

bupropion 279281 2. Drugs acting on thenervous system

Drug dependencetherapies

buspirone 270272 2. Drugs acting on thenervous system


busulfan 291293 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

butobarbital seebarbiturates(asantiepilep-tics)211214

cabergoline 244, 247 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Dopaminergics

calcium 733734 17. Miscellaneousdrugs

Minerals

calciumlevofolinate

307 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

candesartan see angio-tensin-IIreceptorantagonists34, 35, 26,27, 38, 39,41, 42, 43,44, 46, 48,49, 51, 52

cannabis 692699 16. Drugs of abuse Cannabis

capecitabine 293, 306 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

capreomycin 511 10. Drugs to treatinfections

Antibiotics Aminoglycosides

INDEX OF DRUG NAMES

xix


captopril see ACEinhibitors 34,35, 36, 37, 38,39, 40, 42, 43,46, 48, 49, 50,51, 52, 53

carbamazepine 209, 215219,222


Antiepileptics

carbamazepine 740 17. Miscellaneousdrugs


carboplatin 331 3. Anticancer andimmunomodulating drugs

Cytotoxics

carisoprodol 491 8. Musculoskeletaldrugs


carmustine 293 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

carvedilol 66, 73 1. Cardiovascular drugs Beta-blockers

caspofungin 576 10. Drugs to treatinfections

Antifungal drugs

cefaclor seecephalosporins513514

cefadroxil seecephalosporins513514

cefalexin seecephalosporins513514

cefixime seecephalosporins513514

cefotaxime seecephalosporins513514

cefpodoxime 513 10. Drugs to treatinfections

Antibiotics Beta-lactams:Cephalosporins

cefradine seecephalosporins513514

ceftazidime seecephalosporins513514

ceftriaxone seecephalosporins513514

INDEX OF DRUG NAMES

xx


cefuroxime 513 10. Drugs to treatinfections

Antibiotics Beta-lactams:Cephalosporins

celecoxib 469 7. Analgesics Non-steroidal anti-inflammatory drugs(NSAIDs)

celiprolol see beta-blockers6377

cetirizine see anti-histamines658662

chloral hydrate 272 2. Drugs acting on thenervous system


chlorambucil 293 3. Anticancer andimmunomodulating drugs

Cytotoxics

chloramphenicol 549550 10. Drugs to treatinfections

Other antibiotics

chlordiazepoxide 266 2. Drugs acting on thenervous system


Benzodiazepines

chlormethiazole 272 2. Drugs acting on thenervous system


chloroquine 583, 584,585


Antimalarials

chlorphenamine 659, 661 12. Respiratory drugs Antihistamines

chlorpheniramine 660 12. Respiratory drugs Antihistamines

chlorpromazine 254, 257,259, 260,261, 262


Antipsychotics

chlorpropamide 423, 431 5. Antidiabetic drugs Sulphonylureas

chlortalidone see thiazides116119

ciclosporin 355367 3. Anticancer andimmunomodulatingdrugs


cidofovir 631 10. Drugs to treatinfections

Antivirals other

cilastin (withimipenem)


Antibiotics Beta-lactams

cilazapril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

INDEX OF DRUG NAMES

xxi


cilostazol 133134 1. Cardiovascular drugs Peripheral vasodilators

cimetidine 638, 639,640, 641,642, 643,644, 645,646, 647,648

11. Drugs acting on thegastrointestinal tract

H2 receptor blockers

cinacalcet 734 17. Miscellaneous drugs Minerals

cinnarizine see anti-histamines658662

ciprofibrate see fibrates123125

ciprofloxacin 527, 528,529, 530,531


Antibiotics Quinolones

ciprofloxacin 740 17. Miscellaneousdrugs


cisatracurium

cisplatin 329330 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

citalopram seeselectiveserotoninreuptakeinhibitors(SSRIs)168179

clarithromycin 515, 516,517, 518,519, 520,521, 522,523, 524



clemastine see anti-histamines658662

clindamycin 551 10. Drugs to treatinfections

Other antibiotics

clobazam seebenzodi-azepines(BZDs)264270

clomipramine 183,187,188, 189



INDEX OF DRUG NAMES

xxii


clonazepam 266 2. Drugs acting on thenervous system


Benzodiazepines

clonidine 42 1. Cardiovascular drugs Antihypertensivesand heart failuredrugs

Centrally actingantihypertensives

clopidogrel 5859 1. Cardiovascular drugs Antiplatelet drugs

clozapine 252, 253,254, 255,256, 259,260, 261,262


Antipsychotics

clozapine 740 17. Miscellaneousdrugs


cocaine 703704 16. Drugs of abuse Cocaine

codeine 476 7. Analgesics Opioids

colchicine 483484 8. Musculoskeletal drugs Antigout drugs

colesevelam see anionexchangeresins120123

colestipol 740

colestyramine 740

colistin 551552 10. Drugs to treatinfections

Other antibiotics

cortisone see cortico-steroids367374

co-trimoxazole 542,543544,545, 546


Antibiotics Sulphonamides

crisantaspase 294 3. Anticancer andimmunomodulating drugs

Cytotoxics

cyclizine see anti-histamines658662

cyclopenthiazide seethiazides116119

cyclopentolate see anti-muscarinics240247

cyclophosphamide 294295 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

cycloserine 552 10. Drugs to treatinfections

Other antibiotics

INDEX OF DRUG NAMES

xxiii


cyproheptadine 659, 661 12. Respiratory drugs Antihistamines

cytarabine 296 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

dacarbazine 296 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

dactinomycin 296 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

dalfopristin 558559 10. Drugs to treatinfections

Other antibiotics

dalteparin seeheparins400401

danaparoid seeheparins400401

danazol 678 14. Drugs used inobstetrics andgynaecology

Danazol

dantrolene 490, 491 8. Musculoskeletaldrugs


dapsone 552553 10. Drugs to treatinfections

Other antibiotics

daptomycin 553 10. Drugs to treatinfections

Other antibiotics

darifenacin 241, 242 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Antimuscarinics

darunavir seeproteaseinhibitors611628

dasatinib 297 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

daunorubicin 297 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

deflazacort seecortico-steroids367374

demeclocycline seetetracyclines546549

INDEX OF DRUG NAMES

xxiv


desflurane seeanaesthetics general494, 496,497

desipramine 183, 190 2. Drugs acting on thenervous system


desloratadine see anti-histamines658662

desmopressin 454 6. Other endocrine drugs Desmopressin

dexamethasone 368, 369,371

3. Anticancer andimmunomodulatingdrugs


Corticosteroids

dexamfetamine 146 1. Cardiovascular drugs Sympathomimeticsdexibuprofen see non-

steroidalanti-inflammatorydrugs(NSAIDs)462470

dexketoprofen see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

dextromethorphan 473 7. Analgesics Opioids

diamorphine see opioids470479

diazepam 264, 265,266, 267,268, 269



Benzodiazepines

diazoxide 41 1. Cardiovascular drugs Antihypertensivesand heart failuredrugs

VasodilatorAntihypertensives

diclofenac see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

INDEX OF DRUG NAMES

xxv


dicycloverine see anti-muscarinics240247

didanosine 603, 604,605, 606,607, 609,610, 611




digitoxin 98107 1. Cardiovascular drugs Cardiac glycosides

digoxin 99107 1. Cardiovascular drugs Cardiac glycosides

dihydrocodeine 476 7. Analgesics Opioids

diltiazem 90, 91, 92,93, 94

1. Cardiovascular drugs Calcium channelblockers

dipipanone see opioids470479

dipivefrine seesympatho-mimetics138

dipyridamole 5960 1. Cardiovascular drugs Antiplatelet drugs

disodiumetidronate

seebisphospho-nates 454

disodiumpamidronate

seebisphospho-nates 454

disopyramide 1518 1. Cardiovascular drugs Antiarrhythmics

distigmine seeantimus-carinics240247

disulfiram 282283 2. Drugs acting on thenervous system


dobutamine seesympatho-mimetics138

docetaxel 297299 3. Anticancer andimmunomodulating drugs

Cytotoxics

dolasetron see 5-HT3antagonists207209

domperidone 204, 205,206


Antiemetics

donepezil 285 2. Drugs acting on thenervous system

Neuromuscular andmovement disorders

Parasympathomimetics

INDEX OF DRUG NAMES

xxvi


dopamine seesympatho-mimetics138

dopexamine seesympatho-mimetics138

dosulepin see tricyclicantidepres-sants180191

doxazosin see alphablockers34, 35, 47,48, 50, 51

doxapram 673 12. Respiratory drugs Doxapram

doxepin 187 2. Drugs acting on thenervous system


doxorubicin 299301 3. Anticancer andimmunomodulating drugs

Cytotoxics

doxycycline 546, 547,548


Antibiotics Tetracyclines

duloxetine 197, 198,199


Antidepressants

dutasteride 687 15. Urological drugs Urinary retention

edrophonium seeparasympa-thomimetics283285

efavirenz 596, 597,598, 599,600, 601,602



Non-nucleosidereverse transcriptaseinhibitors (NNRTIs)

eletriptan 230, 231,232, 233,234, 235



emtricitabine 609, 610 10. Drugs to treatinfections


Nucleoside reversetranscriptase inhibitors

enalapril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

INDEX OF DRUG NAMES

xxvii


enoxaparin seeheparins400401

enoximone 138 1. Cardiovascular drugs Selectivephosphodiesteraseinhibitors

entacapone 245, 249,250


AntiParkinsonsdrugs

Dopaminergics

ephedrine seesympatho-mimetics138

epinephrine 142 1. Cardiovascular drugs Sympathomimetics

epinephrine(local anaestheticswith)

499 9. Anaesthetic drugs Anaesthetics local

epirubicin 301302 3. Anticancer andimmunomodulating drugs

Cytotoxics

eplerenone seepotassium-sparingdiureticsandaldosteroneantagonists112115

eprosartan seeangiotensin-II receptorantagonists34, 35, 26,27, 38, 39,41, 42, 43,44, 46, 48,49, 51, 52

eptifibatide seeglycoproteinIIb/IIIainhibitors 61

ergotamine 229 2. Drugs acting on thenervous system

Antimigraine drugs Ergot derivatives

erlotinib 302 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

ertapenem 514 10. Drugs to treatinfections


INDEX OF DRUG NAMES

xxviii


erythromycin 515, 516,517, 518,519, 520,521, 522,523, 524



escitalopram 177 2. Drugs acting on thenervous system

Antidepressants Selective serotoninreuptake inhibitors(SSRIs)

esmolol see beta-blockers6377

esomeprazole 650, 652 11. Drugs acting on thegastrointestinal tract

Proton pumpinhibitors

estradiol 680 14. Drugs used inobstetrics andgynaecology

Female hormones Oestrogens

estramustine 302 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

etanercept 374 3. Anticancer andimmunomodulatingdrugs


ethambutol 553 10. Drugs to treatinfections

Other antibiotics

ethambutol 741 17. Miscellaneousdrugs


ethosuximide 209, 219 2. Drugs acting on thenervous system

Antiepileptics

ethylestradiol 680 14. Drugs used inobstetrics andgynaecology

Female hormones Oestrogens

etodolac see non-steroidalanti-inflammat-ory drugs(NSAIDs)462470

etomidate seeanaesthetics general494, 496,497

etoposide 303304 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

INDEX OF DRUG NAMES

xxix


etoricoxib see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

etravirine see non-nucleosidereversetranscriptaseinhibitors(NNRTIs)603

ezetimibe 123, 127 1. Cardiovascular drugs Lipid-lowering drugs

famotidine 640, 642,644, 647



felodipine 93 1. Cardiovascular drugs Calcium channelblockers

fenbufen see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

fenofibrate seefibrates123125

fenoprofen see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

fenoterol see beta-2agonists662665

fentanyl 476, 478 7. Analgesics Opioids

fexofenadine 660, 662 12. Respiratory drugs Antihistamines

flecainide 1822 1. Cardiovascular drugs Antiarrhythmics

flucloxacillin seepenicillins525

INDEX OF DRUG NAMES

xxx


fluconazole 563, 564,566, 567,568, 569,571, 573,574, 575


Antifungal drugs Azoles

flucytosine 577 10. Drugs to treatinfections

Antifungal drugs

fludarabine 304 3. Anticancer andimmunomodulating drugs

Cytotoxics

flurbiprofen see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

fluoride 734 17. Miscellaneousdrugs

Minerals

fluorouracil 304306 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

fluoxetine 170, 175,177


Antidepressants Selective serotoninreuptake inhibitors

flupentixol 254 2. Drugs acting on thenervous system

Antipsychotics

fluphenazine 254 2. Drugs acting on thenervous system

Antipsychotics

flurazepam seebenzodi-azepines(BZDs)264270

flutamide 346 3. Anticancer andimmunomodulating drugs

Hormones andhormone antagonists

fluvastatin 129 1. Cardiovascular drugs Lipid-lowering drugs Statins

fluvoxamine 171, 172,173, 175,176, 177,178, 179



folinate 307 3. Anticancer andimmunomodulating drugs

Cytotoxics

fondaparinux 399 4. Anticoagulants Anticoagulants parenteral

formoterol see beta-2agonists662665

INDEX OF DRUG NAMES

xxxi


fosamprenavir see proteaseinhibitors611628

foscarnetsodium


Antivirals other

fosinopril see ACEinhibitors 34,35, 36, 37,38, 39, 40,42, 43, 46,48, 49, 50,51, 52, 53

fosphenytoin 220225

frovatriptan see 5-HT1agonists triptans230236

furosemide see loopdiuretics 109

fusidic acid 553 10. Drugs to treatinfections

Other antibiotics

gabapentin 219 2. Drugs acting on thenervous system

Antiepileptics

galantamine 283, 284 2. Drugs acting on thenervous system



ganciclovir 629, 630 10. Drugs to treatinfections

Antivirals other

gemcitabine 307 3. Anticancer andimmunomodulating drugs

Cytotoxics

gemfibrozil 123, 124 1. Cardiovascular drugs Lipid-lowering drugs Fibrates

gentamicin 510 10. Drugs to treatinfections


gestrinone 684 14. Drugs used inobstetrics andgynaecology

Gestrinone

glibenclamide seesulphony-lureas421423

glicazide seesulphony-lureas421423

glimepiride 423, 432 5. Antidiabetic drugs Sulphonylureas

glipizide 423, 424,427, 432

5. Antidiabetic drugs Sulphonylureas

INDEX OF DRUG NAMES

xxxii


glipizide 740 17. Miscellaneousdrugs


glucagon 454 6. Other endocrinedrugs

Glucagon

glyceryltrinitrate

see nitrates130133

glycopyrronium 240 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Antimuscarinics

gold 374 3. Anticancer andimmunomodulatingdrugs


granisetron see 5-HT3antagonists207209

grapefruit juice 720732 17. Miscellaneous drugs Grapefruit juice

griseofulvin 577579 10. Drugs to treatinfections

Antifungal drugs

guanethidine 35, 39 1. Cardiovascular drugs Antihypertensivesand heart failuredrugs

adrenergic neuroneblocking drugs

haloperidol 253, 254,255, 258,259, 260,261, 262


Antipsychotics

halothane 495, 496,497

9. Anaesthetic drugs Anaesthetics general

heparin seeheparins400401

homatropine see anti-muscarinics240247

hydralazine seevasodilatorantihyper-tensives35, 36, 37,38, 41, 42,4453

hydrocortisone see cortico-steroids367374

hydroxycarbamide 307 3. Anticancer andimmunomodulating drugs

Cytotoxics

hydroxychloro-quine

583, 584 10. Drugs to treatinfections

Antimalarials

INDEX OF DRUG NAMES

xxxiii


hydroxycobalamin see vitaminB12

hydroxyurea seehydroxy-carbamide

hydroxyzine 658, 659,660

12. Respiratory drugs Antihistamines

hyoscine seeantimus-carinics240247

ibandronate seebisphospho-nates 454

ibuprofen see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

idarubicin 308 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

ifosfamide 308309 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

iloprost seevasodilatorantihyper-tensives35, 36, 37,38, 41, 42,4453

imatinib 310315 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

imidapril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

imipenem withcilastin



INDEX OF DRUG NAMES

xxxiv


imipramine 183, 187,188, 190



indapamide see thiazides116119

indinavir 621, 623,625, 628



Protease inhibitors

indometacin 462, 469 7. Analgesics Non-steroidal anti-inflammatory drugs(NSAIDs)

indoramin see alphablockers34, 35, 47,48, 50, 51

infliximab 375 3. Anticancer andimmunomodulatingdrugs


inositol seeperipheralvasodilators133136

insulin 405412 5. Antidiabetic drugs Insulin

interferon 375 3. Anticancer andimmunomodulatingdrugs


interferon alfa 375 3. Anticancer andimmunomodulatingdrugs


interferon alpha 375 3. Anticancer andimmunomodulatingdrugs


interferongamma

375 3. Anticancer andimmunomodulatingdrugs


interleukin-2 376 3. Anticancer andimmunomodulatingdrugs


ipratropium 241, 242 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Antimuscarinics

irbesartan 41 1. Cardiovascular drugs Antihypertensivesand heart failuredrugs

Angiotensin-IIreceptor antagonists

irinotecan 315316 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

INDEX OF DRUG NAMES

xxxv


isocarboxacid seemonoamineoxidaseinhibitors(MAOIs)

isoflurane seeanaesthet-ics general494, 496,497

isometheptene seesympatho-mimetics138

isoniazid 553554 10. Drugs to treatinfections

Other antibiotics

isoprenaline seesympatho-mimetics138

isosorbidedinitrate

see nitrates130133

isosorbidemononitrate

see nitrates130133

isradipine see calciumchannelblockers7898

itraconazole 564, 565,566, 567,568, 569,570, 571,572, 573,574, 575,576



ivabradine 119120 1. Cardiovascular drugs Ivabradine

kaolin 636 11. Drugs acting on thegastrointestinal tract

Antidiarrhoeals

ketamine 494, 495,498

9. Anaesthetic drugs Anaesthetics general

ketoconazole 563, 564,565, 566,567, 568,569, 570,571, 572,573, 574,575



INDEX OF DRUG NAMES

xxxvi


ketoprofen see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

ketotifen 661 12. Respiratory drugs Antihistamines

labetalol 68 1. Cardiovascular drugs Beta-blockers

lacidipine 93 1. Cardiovascular drugs Calcium channelblockers

lamivudine 605, 608,610




lamotrigine 210, 219 2. Drugs acting on thenervous system

Antiepileptics

lanreotide 346347 3. Anticancer andimmunomodulatingdrugs


lansoprazole 649, 653,654



laronidase 676 13. Metabolic drugs Laronidase

leflunomide 377378 3. Anticancer andimmunomodulatingdrugs


lepirudin see hirudins339, 401

lercanidipine 93 1. Cardiovascular drugs Calcium channelblockers

letrozole 347 3. Anticancer andimmunomodulatingdrugs


levamisole 592593 10. Drugs to treatinfections

Other antiprotozoals

levobupivacaine seeanaesthetics local 498

levocetirizine see anti-histamines658662

levodopa 244, 245,247, 248,249, 250


AntiParkinsonsdrugs

Dopaminergics

levodopa 741 17. Miscellaneousdrugs


INDEX OF DRUG NAMES

xxxvii


levofloxacin 529 10. Drugs to treatinfections


levofloxacin 740 17. Miscellaneousdrugs


levomepromazine see anti-psychotics251263

levothyroxine see thyroidhormones456458

lidocaine 498, 499,501, 502

9. Anaesthetic drugs Anaesthetics local

linezolid seemonoamineoxidaseinhibitors(MAOIs)

liothyronine see thyroidhormones456458

lisinopril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

lithium 156159 2. Drugs acting on thenervous system

Antidepressants

lofepramine see tricyclicantidepres-sants180191

lofexidine 283 2. Drugs acting on thenervous system


lomustine 316 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

loperamide 637 11. Drugs acting on thegastrointestinal tract

Antidiarrhoeals

lopinavir 621, 622,625



Protease inhibitors

loprazolam see benzo-diazepines(BZDs)264270

INDEX OF DRUG NAMES

xxxviii


loratadine 661, 662 12. Respiratory drugs Antihistamines

lorazepam 266 2. Drugs acting on thenervous system


Benzodiazepines

lormetazepam see benzo-diazepines(BZDs)264270

losartan 36 1. Cardiovascular drugs Antihypertensivesand heart failuredrugs

Angiotensin-IIreceptor antagonists

lovastatin 126, 128 1. Cardiovascular drugs Lipid-lowering drugs Statins

LSD seehallucino-gens 704

lumefantrine 580581 10. Drugs to treatinfections

Antimalarials

lymecycline seetetracyclines546549

magnesium 734735 17. Miscellaneousdrugs

Minerals

maprotiline 188 2. Drugs acting on thenervous system


MDMA 701703 16. Drugs of abuse Methylenedioxymethamphetamine(MDMA, Ecstasy)

mebendazole 593 10. Drugs to treatinfections


mefenamic acid see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

mefloquine 585587 10. Drugs to treatinfections

Antimalarials

meloxicam see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

INDEX OF DRUG NAMES

xxxix


melphalan 316 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

memantine 155 2. Drugs acting on thenervous system

Antidementia drugs

mepacrine 593 10. Drugs to treatinfections


meprobamate 272 2. Drugs acting on thenervous system


meptazinol see opioids470479

mercaptopurine 317 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

meropenem 514 10. Drugs to treatinfections


mesalazine seeaminosali-cylates 351

mesna 317 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

metaraminol seesympatho-mimetics138

metformin 413421 5. Antidiabetic drugs Metforminmethadone 470, 476,

4777. Analgesics Opioids

methenamine 555 10. Drugs to treatinfections

Other antibiotics

methocarbamol 489, 490 8. Musculoskeletaldrugs


methotrexate 318325 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

methyldopa 38, 39 1. Cardiovascular drugs Antihypertensivesand heart failuredrugs


methylphenidate 146 1. Cardiovascular drugs Sympathomimetics

methylpredni-solone

see cortico-steroids367374

methysergide 229 2. Drugs acting on thenervous system

Antimigraine drugs Ergot derivatives

INDEX OF DRUG NAMES

xl


metoclopramide 204, 205,206


Antiemetics

metolazone seethiazides116119

metoprolol 64, 66,67, 70

1. Cardiovascular drugs Beta-blockers

metronidazole 555557 10. Drugs to treatinfections

Other antibiotics

mexiletine 2225 1. Cardiovascular drugs Antiarrhythmics

mianserin see tricyclicantidepres-sants180191

miconazole 567, 568,569, 574,575



midazolam 264, 265,266, 267,269



Benzodiazepines

mifepristone 684 14. Drugs used inobstetrics andgynaecology

Mifepristone

milrinone 138 1. Cardiovascular drugs Selectivephosphodiesteraseinhibitors

minocycline seetetracyclines546549

minoxidil seevasodilatorantihyper-tensives 35,36, 37, 38,41, 42,4453

mirtazapine 199200 2. Drugs acting on thenervous system

Antidepressants

mitomycin 325 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

mitotane 326 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

mitoxantrone 326 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

INDEX OF DRUG NAMES

xli


mivacurium see musclerelaxants depolarising,non-depolarising502505

mizolastine 658, 660,661


moclobemide 165, 166,168


Antidepressants Monoamine oxidaseinhibitors

modafinil 276279 2. Drugs acting on thenervous system

CNS stimulants

moexipril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

montelukast 674 12. Respiratory drugs Leukotriene receptorantagonists

moracizine 25 1. Cardiovascular drugs Antiarrhythmics

morphine 473, 474 7. Analgesics Opioids

moxifloxacin 526 10. Drugs to treatinfections


moxisylyte 135 1. Cardiovascular drugs Peripheralvasodilators

moxonidine see centrallyactinghyperten-sives 38, 39,40, 4247,50, 53

1. Cardiovascular drugs Antihypertensivesand heart failuredrugs


mycophenolate 379381 3. Anticancer andimmunomodulatingdrugs


nabumetone see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

nadolol see beta-blockers6377

INDEX OF DRUG NAMES

xlii


naftidrofuryl seeperipheralvasodilators133136

nalidixic acid 527, 529 10. Drugs to treatinfections


nandrolone 455 6. Other endocrinedrugs

Nandrolone

naproxen 469 7. Analgesics Non-steroidalanti-inflammatorydrugs (NSAIDs)

naratriptan see 5-HT1agonists triptans230236

natalizumab 381382 3. Anticancer andimmunomodulatingdrugs


nateglinide 437447 5. Antidiabetic drugs Other antidiabeticdrugs

Meglitinidederivatives

nebivolol see beta-blockers6377

nefopam 461462 7. Analgesics Nefopam

nelfinavir 621, 622,623, 625



Protease inhibitors

neomycin 510, 511 10. Drugs to treatinfections


neostigmine 283, 284 2. Drugs acting on thenervous system



nevirapine 596, 598,599, 601,602, 603



Non-nucleosidereverse transcriptaseinhibitors (NNRTIs)

nicardipine 93 1. Cardiovascular drugs Calcium channelblockers

nicorandil seepotassiumchannelactivators137138

nifedipine 92, 93, 94, 98

1. Cardiovascular drugs Calcium channelblockers

nimodipine see calciumchannelblockers7898

INDEX OF DRUG NAMES

xliii


nisoldipine 93 1. Cardiovascular drugs Calcium channelblockers

nitrazepam see benzodi-azepines(BZDs)264270

nitrofurantoin 557 10. Drugs to treatinfections

Other antibiotics

nitrofurantoin 740 17. Miscellaneousdrugs


nitrous oxide 494 9. Anaesthetic drugs Anaesthetics general

nizatidine 647 11. Drugs acting on thegastrointestinal tract


noradrenaline (see norepi-nephrine)

norepinephrine seesympatho-mimetics138

norethisterone 683 14. Drugs used inobstetrics andgynaecology

Female hormones Progestogens

norfloxacin 528, 529,530



nortriptyline 183, 187 2. Drugs acting on thenervous system


octreotide 347 3. Anticancer andimmunomodulatingdrugs


oestrogens 678682 14. Drugs used inobstetrics andgynaecology

Female hormones

ofloxacin 529 10. Drugs to treatinfections


ofloxacin 740 17. Miscellaneousdrugs


olanzapine 254, 255,256, 257,259, 261,262


Antipsychotics

INDEX OF DRUG NAMES

xliv


olmesartan seeangiotensin-II receptorantagonists34, 35, 26,27, 38, 39,41, 42, 43,44, 46, 48,49, 51, 52

olsalazine see amino-salicylates351

omeprazole 649, 650,651, 652,653



ondansetron 208,209 2. Drugs acting on thenervous system

Antiemetics 5-HT3 antagonists

orlistat 236237 2. Drugs acting on thenervous system

Antiobesity drugs

orphenadrine see antimus-carinics240247

oseltamivir 632 10. Drugs to treatinfections

Antivirals other

oxaliplatin seecytotoxics289

oxazepam 266 2. Drugs acting on thenervous system


Benzodiazepines

oxcarbazepine 210, 219 2. Drugs acting on thenervous system

Antiepileptics

oxprenolol see beta-blockers6377

oxycodone see opioids470479

oxymetazoline seesympatho-mimetics138

oxytetracycline seetetracyclines546549

oxytocin seeoxytocics684

INDEX OF DRUG NAMES

xlv


paclitaxel 326328 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

paliperidone see anti-psychotics251263

palonosetron see 5-HT3antagonists207209

pancreatin 648 11. Drugs acting on thegastrointestinal tract

Pancreatin

pancuronium 504 9. Anaesthetic drugs Muscle relaxants depolarising, non-depolarising

pantoprazole see protonpumpinhibitors649654

papaveretum see opioids470479

paracetamol 479480 7. Analgesics Paracetamol

parecoxib 462, 468 7. Analgesics Non-steroidal anti-inflammatory drugs(NSAIDs)

paroxetine 172, 173,175, 177,178



pemetrexed 328 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

penicillamine 382 3. Anticancer andimmunomodulatingdrugs


penicillamine 741 17. Miscellaneousdrugs


penicillin V 525 10. Drugs to treatinfections


pentamidine 595 10. Drugs to treatinfections


pentamidineisetionate



pentazocine see opioids470479

pentostatin 328 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

INDEX OF DRUG NAMES

xlvi


pentoxifylline 136 1. Cardiovascular drugs Peripheral vasodilators

pergolide 247 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Dopaminergics

pericyazine see anti-psychotics251263

perindopril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

perphenazine 254, 255,262


Antipsychotics

pethidine 473, 475,477, 478

7. Analgesics Opioids

phenelzine 160, 165 2. Drugs acting on thenervous system

Antidepressants Monoamine oxidaseinhibitors

phenindione see antico-agulants oral390399

phenobarbital see barbitu-rates (asantiepilep-tics)211214

phenoperidine 473 7. Analgesics Opioids

phenothiazines 251, 252,253, 255,256, 258,261, 262


Antipsychotics

phenoxybenza-mine

see alphablockers34, 35, 47,48, 50, 51

phentolamine see alphablockers34, 35, 47,48, 50, 51

phenylephrine seesympatho-mimetics138

INDEX OF DRUG NAMES

xlvii


phenylpropanolamine

seesympatho-mimetics138

phenytoin 210,220225


Anticonvulsants

phenytoin 740 17. Miscellaneousdrugs


pilocarpine 284 2. Drugs acting on thenervous system



pimozide 251, 252,253, 254,255, 256,259, 261,262


Antipsychotics

pindolol 69 1. Cardiovascular drugs Beta-blockers

pioglitazone 447452 5. Antidiabetic drugs Other antidiabeticdrugs

Thiazolidinediones

piperacillin 525 10. Drugs to treatinfections


pipotiazine see anti-psychotics251263

piracetam 285 2. Drugs acting on thenervous system


piroxicam see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

pizotifen 236 2. Drugs acting on thenervous system

Antimigraine drugs

porfimer 333 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

posaconazole 563, 565,566, 567,569, 570,572, 573,574, 575



potassium 736737 17. Miscellaneousdrugs

Minerals

pramipexole 248, 249 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Dopaminergics

INDEX OF DRUG NAMES

xlviii


pravastatin see statins125129

prazosin see alphablockers34, 35, 47,48, 50, 51

prednisolone 741

prilocaine 499 9. Anaesthetic drugs Anaesthetics local

primaquine 587 10. Drugs to treatinfections

Antimalarials

primidone 740 2. Drugs acting on thenervous system

Antiepileptics

probenecid 484486 8. Musculoskeletal drugs Antigout drugs

procainamide 2628 1. Cardiovascular drugs Antiarrhythmics

procaine 498, 501,502

9. Anaesthetic drugs Anaesthetics local

procarbazine 334338 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

prochlorperazine 261 2. Drugs acting on thenervous system

Antipsychotics

procyclidine 241 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Antimuscarinics

progesterones 662663 14. Drugs used inobstetrics andgynaecology

Female hormones Progestogens

proguanil 587588 10. Drugs to treatinfections

Antimalarials

promazine see anti-psychotics251263

promethazine 660 12. Respiratory drugs Antihistamines

propafenone 2933 1. Cardiovascular drugs Antiarrhythmics

propanolol 66, 67, 68,69, 71, 74

1. Cardiovascular drugs Beta-blockers

propantheline 242 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Antimuscarinics

propofol 495 9. Anaesthetic drugs Anaesthetics general

pseudoephedrine seesympatho-mimetics138

pyrazinamide 557 10. Drugs to treatinfections

Other antibiotics

INDEX OF DRUG NAMES

xlix


pyridostigmine 283, 284 2. Drugs acting on thenervous system



pyrimethamine 588589 10. Drugs to treatinfections

Antimalarials

quetiapine see anti-psychotics251263

quinagolide seedopamin-ergics243250

quinapril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

quinine 590592 10. Drugs to treatinfections

Antimalarials

quinupristin 558559 10. Drugs to treatinfections

Other antibiotics

rabeprazole see protonpumpinhibitors649654

raloxifene 685 14. Drugs used inobstetrics andgynaecology

Raloxifene

raltitrexed 338 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

ramipril see ACEinhibitors34, 35, 36,37, 38, 39,40, 42, 43,46, 48, 49,50, 51, 52,53

ranitidine 638, 642,643, 644,646, 647,648



rasagiline 244, 245,246, 250


AntiParkinsonsdrugs

Dopaminergics

INDEX OF DRUG NAMES

l


reboxetine 201 2. Drugs acting on thenervous system

Antidepressants

repaglinide 437447 5. Antidiabetic drugs Other antidiabeticdrugs

Meglitinidederivatives

reteplase seethrombolytics401402

ribavirin 632 10. Drugs to treatinfections

Antivirals other

rifabutin 536, 537,538, 539,540, 541


Antibiotics Rifamycins

rifampicin 532, 533,534, 535,536, 537,538, 539,540, 541



rifapentine 537 10. Drugs to treatinfections


riluzole 286 2. Drugs acting on thenervous system


rimonabant 237238 2. Drugs acting on thenervous system

Antiobesity drugs

risedronate seebisphospho-nates 454

risperidone 254, 255,256, 259,262


Antipsychotics

ritonavir 614, 621,622, 624,625



Protease inhibitors

rituximab 383 3. Anticancer andimmunomodulatingdrugs


rivastigmine seeparasympa-thomimetics283285

rizatriptan 231, 234 2. Drugs acting on thenervous system


rocuronium see musclerelaxants depolarising,non-depolarising502205

INDEX OF DRUG NAMES

li


ropinirole 244, 246,249


AntiParkinsonsdrugs

Dopaminergics

ropivacaine 500, 501 9. Anaesthetic drugs Anaesthetics local

rosiglitazone 447452 5. Antidiabetic drugs Other antidiabeticdrugs

Thiazolidinediones

rosuvastatin 126 1. Cardiovascular drugs Lipid-lowering drugs Statins

rotigoline seedopamin-ergics243250

salbutamol 664, 665 12. Respiratory drugs Bronchodilators Beta-2 agonists

salmeterol see beta-2agonists662665

saquinavir 613, 621,624, 625,626



Protease inhibitors

secobarbital see barbitu-rates (asantiepilep-tics)211214

selegiline 244, 245,246, 249,250


AntiParkinsonsdrugs

Dopaminergics

sertindole 253, 255,259, 260,262


Antipsychotics

sertraline 169, 170,174, 175,177, 178



sevelamer 737 17. Miscellaneous drugs Minerals

sevoflurane seeanaesthetics general494, 496,497

sibutramine 238239 2. Drugs acting on thenervous system

Antiobesity drugs

sildenafil 688, 689 15. Urological drugs Erectile dysfunction Phosphodiesterasetype 5 inhibitors

simvastatin 125, 126,127, 128

1. Cardiovascular drugs Lipid-lowering drugs Statins

sirolimus 383385 3. Anticancer andimmunomodulatingdrugs


INDEX OF DRUG NAMES

lii


sitaxentan seevasodilatorantihyper-tensives35, 36, 37,38, 41, 42,4453

sodiumbicarbonate

690 15. Urological drugs Urinaryalkalinization

sodiumclodronate

454 6. Other endocrinedrugs

Bisphosphonates

sodiumnitroprusside

seevasodilatorantihyper-tensives35, 36, 37,38, 41, 42,4453

sodium oxybate 273 2. Drugs acting on thenervous system


sodiumphenylbutyrate

676 13. Metabolic drugs Sodiumphenylbutyrate

sodiumpolystyrenesulphonate

735736 17. Miscellaneousdrugs

Minerals Polystyrenesulphonate resins

solifenacin 242 2. Drugs acting on thenervous system

AntiParkinsonsdrugs

Antimuscarinics

somatropin 455 6. Other endocrinedrugs

Somatropin

sorafenib 339 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

sotalol 6263 1. Cardiovascular drugs Beta-blockers

spironolactone seepotassium-sparingdiureticsandaldosteroneantagonists112115

St Johns Wort 191195 2. Drugs acting on thenervous system

Antidepressants

stavudine 603, 604,606, 610




INDEX OF DRUG NAMES

liii


streptokinase seethrombolytics401402

streptomycin 511 10. Drugs to treatinfections


strontium ranelate 455 6. Other endocrine drugs Strontium ranelate

sucralfate 654 11. Drugs acting on thegastrointestinal tract

Sucralfate

sulfadiazine 541 10. Drugs to treatinfections


sulfamethoxazole/trimethoprim

542,543544,545, 546



sulfasalazine seeaminosali-cylates 351

sulfinpyrazone 486487 8. Musculoskeletal drugs Antigout drugs

sulindac see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

sulpiride 253, 255,263


Antipsychotics

sumatriptan 231 2. Drugs acting on thenervous system


sunitinib 339 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

suxamethonium 503, 504,505

9. Anaesthetic drugs

tacrolimus 385388 3. Anticancer andimmunomodulatingdrugs


tadalafil 688, 689 15. Urological drugs Erectile dysfunction Phosphodiesterasetype 5 inhibitors

tamoxifen 348349 3. Anticancer andimmunomodulatingdrugs


tegafur 339 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

teicoplanin 559 10. Drugs to treatinfections

Other antibiotics

INDEX OF DRUG NAMES

liv


telbivudine 632 10. Drugs to treatinfections

Antivirals other

telithromycin 515, 516,518, 519,520, 522,523



telmisartan seeangiotensin-II receptorantagonists34, 35, 26,27, 38, 39,41, 42, 43,44, 46, 48,49, 51, 52

temazepam 266 2. Drugs acting on thenervous system


Benzodiazepines

temoporfin 339 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

tenecteplase seethrombolytics401402

tenofovir 605, 606,608, 609,610




tenoxicam see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

terazosin see alphablockers34, 35, 47,48, 50, 51

terbinafine 579 10. Drugs to treatinfections

Antifungal drugs

terbutaline 662 12. Respiratory drugs Bronchodilators Beta-2 agonists

terfenadine 658, 660,661, 662


testosterone 455456 6. Other endocrinedrugs

Testosterone

tetrabenazine 286 2. Drugs acting on thenervous system


INDEX OF DRUG NAMES

lv


tetracycline 546, 547,548


Antibiotics Tetracyclines

thalidomide 388 3. Anticancer andimmunomodulatingdrugs


theophylline 665673 12. Respiratory drugs Bronchodilators Theophyllines

thioguanine seetioguanine

thiopentone 494, 495 9. Anaesthetic drugs Anaesthetics general

thioridazine 262 2. Drugs acting on thenervous system

Antipsychotics

thiotepa 339 3. Anticancer andimmunomodulatingdrugs

Cytotoxics

tiaprofenic acid see non-steroidalanti-inflammatorydrugs(NSAIDs)462470

tibolone 685 14. Drugs used inobstetrics andgynaecology

Tibolone

tigecycline seetetracyclines546549

tiludronate seebisphospho-nates 454

timolol 67, 69, 71 1. Cardiovascular drugs Beta-blockers

tinidazole 595 10. Drugs to treatinfections


tinzaparin see heparins400401

tioguan

adverse drug interactions

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