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ADVANCES INPERITONEAL DIALYSIS2003

Advances in

Peritoneal

Dialysis/2003

Selected papers from the

Twenty-Third Annual Conference

on Peritoneal Dialysis

Seattle, Washington

March 2003

Volume 19

Editor

Ramesh Khanna, MD

Associate Editors

Madhukar Misra, MD

Karl D. Nolph, MD

Dimitrios G. Oreopoulos, MD

Barbara F. Prowant, RN, MS

Zbylut J. Twardowski, MD

Editorial Assistant

Claire Oser

© PERITONEAL DIALYSIS PUBLICATIONS INC. 2003

© Peritoneal Dialysis Publications Inc. 2003

Printed in Canada by Multimed Inc.

ISSN 1197-8554

ISBN 0-9691349-7-5

Canadian Cataloguing in Publication Data

Conference on Peritoneal Dialysis (23rd; 2003:

Seattle, Washington)

Advances in peritoneal dialysis 2003

“Volume 19.”

Includes bibliographical references and index.

ISSN 1197-8554

ISBN 0-9691349-7-5

1. Peritoneal dialysis - Congresses. 2. Continuous

ambulatory peritoneal dialysis - Congresses.

I. Khanna, Ramesh, II. Title.

RC901.7.P48C2305 617.4 '61059 C94-390030-1

Advances in Peritoneal Dialysis is abstracted in

Index Medicus and Index to Scientific and Technical

Proceedings and ISI/ISTP + B online database.

Subscriptions, orders or change of address:

Peritoneal Dialysis Publications Inc.,

399 Bathurst St.,

Toronto, Ontario Canada M5T 2S8

or call (416) 603-7974

Fax (416) 603-8127

Contents

Preface ix

Past Special Recognition Award Winners x

Outstanding Abstract Awards 2003 xi

Past Outstanding Abstract Award Winners xi

Part One

Peritoneal Kinetics and Anatomy

Viability of, and Basic Fibroblast Growth Factor

Secretion by, Human Peritoneal Mesothelial Cells

Cultured with Various Components of Peritoneal

Dialysis Fluid

Satoshi Ogata, Noriaki Yorioka, Kei Kiribayashi,

Takayuki Naito, Masatoshi Kuratsune, Yoji

Nishida 2

Diffusion Correction of Sodium Sieving Applicable

in a Peritoneal Equilibration Test

Wytske M. Westra, Watske Smit, Machteld M. Zweers,

Dirk G. Struijk, Raymond T. Krediet 6

Effects of Antihypertensive Drugs on Peritoneal

Vessels in Hypertensive Dogs with Mild Renal

Insufficiency

Yuji Ishida, Koji Tomori, Hidetomo Nakamoto, Hiroe

Imai, Hiromichi Suzuki 10

Glucose and Mannitol Have Different Effects on

Peritoneal Morphology in Chronically Dialyzed Rats

Arkadiusz Styszynski, Beata Kwiatkowska, Katarzyna

Wieczorowska–Tobis, Andrzej Breborowicz,

Dimitrios G. Oreopoulos 15

Morphologic Changes in the Liver of Dialyzed

Rats—Preliminary Observations

Katarzyna Wieczorowska–Tobis, Renata Brelinska,

Andrzej Breborowicz, Dimitrios G. Oreopoulos 20

The Effect of Dwell Time on Dialysate Cancer

Antigen 125 Appearance Rates in Patients on

Continuous Ambulatory Peritoneal Dialysis

Sema Akman, Roos van Westrhenen, Dirk R. De

Waart, Johan K. Hiralall, Machteld M. Zweers,

Raymond T. Krediet 24

Intraperitoneal and Subcutaneous Pharmacokinetics

of Low Molecular Weight Heparin in Continuous

Ambulatory Peritoneal Dialysis Patients

Aykut Sifil, Cem Mermut, Yavuz Yenicerioglu, Caner

Cavdar, Mukaddes Gumustekin, Ali Celik, Faize

Yuksel, Taner Camsari 28

Part Two

Clinical Experiences

Clinical Experience with Tamoxifen in Peritoneal

Fibrosing Syndromes

Gloria del Peso, M. Auxiliadora Bajo, Fernando Gil,

Abelardo Aguilera, Silvia Ros, Olga Costero, M. Jose

Castro, Rafael Selgas 32

Volume Expansion and Sodium Balance in Peritoneal

Dialysis Patients. Part I: Recent Concepts in

Pathogenesis

Mukesh Khandelwal, Jatin Kothari, Murali Krishnan,

Vassilis Liakopoulos, Efstathia Tziviskou, Krishna

Sahu, Carole Chatalalsingh, Joanne Bargman,

Dimitrios Oreopoulos 36

Volume Expansion and Sodium Balance in Perito-

neal Dialysis Patients. Part II: Newer Insights in

Management

Mukesh Khandelwal, Jatin Kothari, Murali Krishnan,

Vassilis Liakopoulos, Efstathia Tziviskou, Krishna

Sahu, Carole Chatalalsingh, Joanne Bargman,

Dimitrios Oreopoulos 44

Short Peritoneal Equilibration Test: Impact of Pre-

ceding Dwell Time

Zbylut J. Twardowski, Barbara F. Prowant, Harold

L. Moore, Ling Chang Lou, Elizabeth White, Kerry

Farris 53

A Selective Angiotensin Receptor Antagonist,

Valsartan, Produced Regression of Left Ventricular

Hypertrophy Associated with a Reduction of Arterial

Stiffness

Hiromichi Suzuki, Hidetomo Nakamoto, Hirokazu

Okada, Soichi Sugahara, Yoshihiko Kanno 59

vi Contents

Dialysate Interleukin-15 Concentration and Ultrafil-

tration Capacity in Patients Undergoing Peritoneal

Dialysis

Alicja E. Grzegorzewska, Monika Mlot 67

A Partial Explanation for the Surprising ADEMEX

Result

Denis E. Pagé, Greg Knoll 73

Long-Term Automated Peritoneal Dialysis in Patients

with Refractory Congestive Heart Failure

Ana M. Ortiz, Pamela A. Acosta, Ramón Corbalan,

Jorge E. Jalil 77

Cost Savings from Peritoneal Dialysis Therapy Time

Extension Using Icodextrin

David W. Johnson, Kaia Vincent, Sophie Blizzard,

Markus Rumpsfeld, Paul Just 81

Improving Adequacy of Peritoneal Dialysis in ESRD

Network 5 (Maryland; Washington, DC; Virginia;

West Virginia)

Todd Gehr, Filitsa Bender, Jeffrey Fink, Paul Light,

Karen Elliott, Christie Shield, Mary Turner, Cathy

Mays, Joan Parrish, Nancy Armistead 86

Incremental Dialysis with Automated Peritoneal

Dialysis

Loris Neri, Giusto Viglino, Agnese Cappelletti,

Carmen Gandolfo, Sara Barbieri 93

Longitudinal Changes of Peritoneal Function

Calculated by Personal Dialysis Capacity in a Patient

After Long-Term Continuous Ambulatory Peritoneal

Dialysis

Hidetomo Nakamoto, Hiroshi Takane, Soichi

Sugahara, Yoshihiko Kanno, Hirokazu Okada,

Tadashi Yamamoto, Hiromichi Suzuki 97

Re-evaluation of Adequate Dose in Japanese Perito-

neal Dialysis Patients

Akihiro C. Yamashita, Makoto Ishizaki, Masahiko

Nakamoto, Hideki Kawanishi, Hiroyuki

Hamada 103

Successful Development and Application of a

Strategic Dialysis Planning Model (RENPLAN)

Peter Rutherford, Paul Forte 106

Nightly Intermittent Peritoneal Dialysis to Initiate

Peritoneal Dialysis

Santhanam Ramalakshmi, Judith Bernardini, Beth

Piraino 111

Health Literacy Affects Peritoneal Dialysis Perfor-

mance and Outcomes

Myra A. Kleinpeter 115

Questionnaire to Peritoneal Dialysis Patients Under-

going Combined Therapy (Peritoneal Dialysis and

Hemodialysis)

Yukiko Igarashi, Eriko Watanabe, Sachiko

Mukaiyama, Kazuko Iwaya, Yuko Doumen, Misaki

Moriishi, Hideki Kawanishi 120

Telemedicine System Using a Cellular Telephone for

Continuous Ambulatory Peritoneal Dialysis Patients

Hidetomo Nakamoto, Atsushi Kawamoto, Yoshimasa

Tanabe, Yoshinori Nakagawa, Eiichi Nishida, Takashi

Akiba, Hiromichi Suzuki 124

Complications of Peritoneal Dialysis Related to

Increased Intra-abdominal Pressure

Adit S. Mahale, Atul Katyal, Ramesh Khanna 130

Gastric Angiodysplasia in Patients Undergoing

Maintenance Dialysis

Koji Tomori, Hidetomo Nakamoto, Syuhei Kotaki,

Yuji Ishida, Hiroshi Takane, Hironori Nemoto,

Yoshihiko Kanno, Soichi Sugahara, Hirokazu Okada,

Hiromichi Suzuki 136

Once-Weekly Hemodialysis Helps Continuous

Ambulatory Peritoneal Dialysis Patients Who Have

Insufficient Solute Removal

Yoshihiko Kanno, Hiromichi Suzuki, Hidetomo

Nakamoto, Hirokazu Okada, Soichi Sugahara 143

Peritoneal Dialysis Versus Hemodialysis: A Five-

Year Comparison of Survival and Effects on the

Cardiovascular System, Erythropoiesis, and Calcium

Metabolism

Toshihiko Suzuki, Yoshihiko Kanno, Hidetomo

Nakamoto, Hirokazu Okada, Soichi Sugahara,

Hiromichi Suzuki 148

Attitudes of Chinese Chief Nephrologists Toward

Dialysis Modality Selection

Li-jia Zhao, Tao Wang 155

viiContents

The BDI and the SF36: Which Tool to Use to Screen

for Depression?

Laura Troidle, Diane Wuerth, Susan Finkelstein, Alan

Kliger, Fred Finkelstein 159

Promoting Use of Home Dialysis

Mahendra Agraharkar, Mathew Patlovany, Sharon

Henry, Becky Bonds 163

Part Three

Host Defenses and Infection

Histologic Criteria for Diagnosing Encapsulating

Peritoneal Sclerosis in Continuous Ambulatory

Peritoneal Dialysis Patients

Kazuho Honda, Kosaku Nitta, Shigeru Horita, Misao

Tsukada, Mitsuyo Itabashi, Hiroshi Nihei, Takashi

Akiba, Hideaki Oda 169

Encapsulating Peritoneal Sclerosis–Like Findings in

a Hemodialysis Patient Without a History of Perito-

neal Dialysis

Hideki Kawanishi, Hiroshi Watanabe, Misaki

Moriishi, Schinichiro Tsuchiya 176

Role of Adhesion Molecules in the Progression of

Peritoneal Sclerosis

Hiroe Imai, Hidetomo Nakamoto, Rie Fukushima,

Yuji Ishida, Yasuhiro Yamanouchi, Hiromichi

Suzuki 180

Peritoneal Effluent Markers of Inflammation in

Patients Treated with Icodextrin-Based and Glucose-

Based Dialysis Solutions

Alena Parikova, Machteld M. Zweers, Dirk G. Struijk,

Raymond T. Krediet 186

Severe Peritoneal Mononucleosis Associated with

Icodextrin Use in Continuous Ambulatory Peritoneal

Dialysis

Juan Martín, Gabriela Sansone, Antonio Cirugeda,

José A. Sánchez–Tomero, Cecilia Muñoz, Rafael

Selgas 191

Strategies for Intervention in and Prevention of

Biofilm-Related Infection in Peritoneal Dialysis

Patients

Mrinal K. Dasgupta 195

The Effects of Weekly Mupirocin Application on

Infections in Continuous Ambulatory Peritoneal

Dialysis Patients

Müjdat Zeybel, Ayse Özder, Canan Sanlidag, Serkan

Yildiz, Caner Cavdar, Rifki Ersoy, Ali Celik, Taner

Camsari 198

Fivefold Reduction in Peritonitis Using a Multi-

faceted Continuous Quality Initiative Program

Diane Borg, Anupkumar Shetty, Deborah Williams,

Mark D. Faber 202

Part Four

Metabolism and Nutrition

Normalization of Protein Nitrogen Appearance by

Various Size Indicators in Patients on Continuous

Peritoneal Dialysis

Antonios H. Tzamaloukas, Glen H. Murata, Dorothy

J. Vanderjagt, Karen S. Servilla, Robert H. Glew 207

Body Composition Evaluation in Peritoneal Dialysis

Patients Using Anthropometric Formulas Estimating

Body Water


J. Vanderjagt, Karen S. Servilla, Robert H.

Glew 212

Weight Status Classification of Patients on

Continuous Peritoneal Dialysis


J. Vanderjagt, Karen S. Servilla, Robert H.

Glew 217

Differences in Clinical and Laboratory Data of

Peritoneal Dialysis Patients Selected According to

Body Mass Index

Alicja E. Grzegorzewska, Irena Mariak 222

The Effect of Intraperitoneal 22-Oxacalcitriol on

Secondary Hyperparathyroidism in Continuous

Ambulatory Peritoneal Dialysis Patients (IPOX

Study)

Minoru Kubota, Yuki Iwanaga, Nozomi

Ishiguro 227

Severe Hyperparathyroidism Despite Paricalcitol

Therapy: One-Year Follow-Up

Suhail B. Shuja, Rasib M. Raja 231

viii Contents

Midpeliq Reduces Glucose Load

Noritomo Itami, Yaushige Tsuji, Yoshio Katsuki, Seiji

Ohira 236

Malnutrition–Inflammation Syndrome Is Associated

with Endothelial Dysfunction in Peritoneal Dialysis

Patients

Abelardo Aguilera, José A. Sánchez–Tomero, María

A. Bajo, Maria L. Ruiz–Caravaca, Vicente Alvarez,

Gloria del Peso, Angel Herranz, Maria V. Cuesta,

María J. Castro, Rafael Selgas 240

Serum Concentration of Haptoglobin, Adequacy of

Peritoneal Dialysis, and Nutrition Status of Patients

With and Without Diabetes on Peritoneal Dialysis

Malgorzata Sucharzewska–Tomczak, Alicja E.

Grzegorzewska, Magdalena Leander 246

Part Five

Catheters and Connectors

Analysis of Factors Predicting Survival of a Second

Peritoneal Dialysis Catheter

Krishna M. Sahu, Aziz Walele, Vasilis Liakopoulos,

Joanne M. Bargman 252

Is It Safe to Simultaneously Remove and Replace

Infected Peritoneal Dialysis Catheters? Review of the

Literature and Suggested Guidelines

Amit Mitra, Isaac Teitelbaum 255

Does Endoluminal Brushing Eliminate the Need for

Catheter Removal in Peritoneal Dialysis Patients with

Persistent Peritonitis?

Nejat Aksu, Önder Yavascan, Orhan D. Kara, Hakan

Erdogan, Murat Kangin 260

Part Six

Pediatrics

The Peritoneal Membrane: A Dynamic Dialysis

Membrane in Children

Michel Fischbach, Börje Haraldsson, Pauline Helms,

Stéphanie Danner, Vincent Laugel, Joëlle

Terzic 265

Outcome in Children on Chronic Peritoneal Dialysis

Osman Dönmez, Sefaye Aladag, Nuray Cigerdelen,

Söhret Kocak 269

Adequacy and Nutrition in Pediatric Peritoneal

Dialysis

Maria A. Delucchi, Eugenio E. Rodriguez, Erick D.

Diaz, Rodrigo C. Villegas 273

Subject Index 279

Author Index 282

Instructions to Authors, inside back cover

Preface

The 23rd Annual Dialysis Conference took place in

Seattle, Washington, March 2 – 4, 2003, under the

chairmanship of Karl D. Nolph. We express our

warmest thanks to the chair and his team of

professionals, who helped organize another

excellent meeting attended by approximately 2,500

participants. The Continuing Medical Education

(CME) team deserves all the kudos for their smooth

organizational skills—they made everything

happen.

The present volume includes a collection of

interesting peritoneal dialysis–related manuscripts

from the 23rd Annual Dialysis Conference. The

manuscripts were solicited from the invited speakers

and from contributors selected to give slide and poster

presentations during the conference. The manuscripts

were peer-reviewed, and those reflecting innovative

concepts and current interests in peritoneal dialysis

were chosen for publication. Advances in Peritoneal

Dialysis is abstracted in the Index Medicus, the Index

to Scientific and Technical Proceedings, and the

ISI/ISTP +B online database.

Preparations for the 24th Annual Dialysis

Conference, which is to be held in San Antonio,

Texas, February 9 – 11, 2004, are now underway. As

always, early registrants receive special discounts.

For information, visit our Web site at

www.muhealth.org/~dialysis, or contact the CME

office at the University of Missouri–Columbia at

(573) 882-4105.

The Editors

Each year the Annual Conference on Peritoneal

Dialysis recognizes those individuals who have

made significant contributions to the field of peri-

toneal dialysis. Each honoree receives a plaque

commemorating his or her pioneering work over

the years.

Special Recognition AwardWinners

1989

Jack W. Moncrief, MD

Austin, Texas, USA

Robert Popovich, PhD

Austin, Texas, USA

1990

Dimitrios G. Oreopoulos, MD

Toronto, Ontario, Canada

Nancy Gallagher, BSN, RN, CNN

Tacoma, Washington, USA

1991

Fred Boen, MD

The Netherlands

1992

Russell Palmer, MD

Vancouver, British Columbia, Canada

1993

John Maher, MD

Bethesda, Maryland, USA

1994

Rosario Maiorca, MD

Brescia, Italy

1995

Umberto Buoncristiani, MD

Perugia, Italy

Sharron Izatt, RN


1996

Giuseppe LaGreca, MD

Vicenza, Italy

1997

James W. Dobbie, MD

Edinburgh, Scotland

1998

Jonas Bergström, MD

Huddinge, Sweden

1999

Raymond Krediet, MD

Amsterdam, The Netherlands

2000

Lazaro Gotloib, MD

Afula, Israel

2001

Stephen Vas, MD


2002

Norman Lasker, MD

Philadelphia, Pennsylvania, USA

2003

Ram Gokal, MD

Manchester, England

Every year the first author of the outstanding abstract

submitted to the Annual Conference on Peritoneal

Dialysis and the first author of the outstanding abstract

in the Nursing category are awarded a plaque and

cash award on behalf of the International Society for

Peritoneal Dialysis. The awards are presented to the

recipient during the conference.

Since 1990, the first authors of the two best

submitted abstracts in the field of pediatrics also

receive a plaque and cash award; these winners are

also listed below. Baxter Healthcare Corporation

sponsors these two pediatric awards.

Here is a list of award winners and their affiliated

institutions.

1987

Andrzej Breborowicz (ISPD)

Toronto Western Hospital, Toronto, Canada

and Department of Pathophysiology

Medical Academy, Poznan, Poland

1988

Francesco Quarello (ISPD)

The Department of Nephrology

University of Torino, N.A.M. Hospital, Torino, Italy

1989

Eleni Stylianou (ISPD)

Renal Medicine, Royal Infirmary

Cardiff, Wales, United Kingdom

1990

Andrzej Breborowicz (ISPD)

Toronto Western Hospital, Toronto, Canada

and Department of Pathophysiology

Medical Academy, Poznan, Poland

Eileen D. Brewer (Pediatrics)

Department of Pediatrics

University of Utah and Baylor College of Medicine

Ching-Yuang Lin (Pediatrics)


Veterans General Hospital, Taipei, Taiwan, ROC

1991

Dennis Finbar Geary (Pediatrics)

The Hospital for Sick Children


Juergen Rainer Klein (ISPD)

Department of Nephrology

University of Ulm, Ulm, Germany

Dirk G. Struijk (ISPD)


Academic Medical Center, University of Amsterdam


Bradley A. Warady (Pediatrics)

The Children’s Mercy Hospital

Kansas City, Missouri

1992

Marie-Jose Fernandez–Reyes (ISPD)

Hospital La Paz, Madrid, Spain

Outstanding Abstract Awards

2003

Roberto Pecoits–Filho, MD, PhD (ISPD)

Karolinska Institutet

Stockholm, Sweden

Sara Jane Harte, RGN (ISPD–Nursing)

Barts and the London NHS Trust

London, England

Douglas L. Blowey, MD (Pediatrics)

Children’s Mercy Hospital


Mini Michael, MBBS, FRACP (Pediatrics)

Baylor College of Medicine

Houston, Texas

Past Outstanding Abstract

Award Winners

Awards

Alan R. Watson (Pediatrics)

City Hospital

Nottingham, England

1993

Masataka Honda (Pediatrics)

Tokyo Metropolitan Children’s Hospital

Tokyo, Japan

Brian J.R. Junor (ISPD)

Western Infirmary

Glasgow, Scotland

Frederick M. Kouri (Pediatrics)



1994

Gregory A. Done (Pediatrics)

Director Pediatric Dialysis/Special Care Areas

Texas Children’s Hospital

Houston, Texas

Roelof Ewout Reddingius (Pediatrics)


Sint Radboud Hospital

Nijmegen, The Netherlands

Bengt Rippe (ISPD)


University Hospital, Lund, Sweden

1995

Reinhard Brunkhorst (ISPD)

Medical School of Hannover

Hannover, Germany

Kathleen M. Reilly (Pediatrics)

Children’s National Medical Center

Washington, D.C

Cornelis Hendrik Schröder (Pediatrics)


University of Nijmegen

Nijmegen, The Netherlands

Ren Gao Ye (ISPD)

National Institute of Kidney

First Affiliated Hospital

Guangzhou, PR China

1996

Sheila Coakley (Pediatrics)

Jackson Memorial Medical Center

Miami, Florida

Alberto Carlo Edefonti (Pediatrics)

Clinica Pediatrica, Milano, Italy

Masaaki Nakayama (ISPD)

Jeiki University School, Tokyo, Japan

1997

Linda L. Jones (Pediatrics)



Ching-Yuang Lin (ISPD)

Veterans General Hospital, Taipei, Taiwan

Franz S. Schaefer (Pediatrics)

University Children’s Hospital

Heidelberg, Germany

Mae Squires–Graham (ISPD–Nursing)

Kingston General Hospital

Kingston, Ontario, Canada

Michelle Anne Zilber (ISPD–Nursing)

Gambro Healthcare, St. Louis, Missouri

1998

M.A.M. Mateijsen

Academic Medical Center

University of Amsterdam, The Netherlands

Sema Akman (Pediatrics)

Akdeniz University Medical Faculty

Departments of Pediatric Nephrology

Antalya, Turkey

Janet E. Coleman (Pediatrics)

Nottingham City Hospital

Nottingham, United Kingdom

1999

Alberdina Willemina de Boer (Pediatrics)

Onze Lieve Vrouwe Gasthuis


Reinhard R. Brunkhorst (ISPD)

Medical School Hannover, Hannover, Germany

Lee Ann Douglas (Pediatrics)

Children’s Hospital, University of Texas Medical

Branch, Galveston, Texas

Linda Turnbull (ISPD–Nursing)

Foothills Medical Centre, Calgary, Alberta, Canada

2000

Rudi de Waart (ISPD)



Atul Sharma (Pediatrics)

The Montreal Children’s Hospital

Montreal, Quebec, Canada

Paule Comtois (Pediatrics)

The Montreal Children’s Hospital

Montreal, Quebec, Canada

Lynda N. Newman (ISPD–Nursing)

University Hospitals of Cleveland

Cleveland, Ohio

2001

Joanne M. Bargman (ISPD)

University of Toronto, Toronto, Ontario, Canada

Wei-Kin Gong (Pediatrics)

National University of Singapore, Singapore

Mitsuko N. Pierre (Pediatrics)

UCLA/Da Vita Pediatric Dialysis Center

Los Angeles, California

Mary Kathryn Hrinya (ISPD–Nursing)

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania

2002

Roos van Westrhenen (ISPD)


The Netherlands

Pei-Pei Foong (Pediatrics)

Shaw NKF-CMI Children’s Kidney Center

Singapore

Susanne Haas (Pediatrics)

University Children’s Hospital

Heidelberg, Germany

Maria Luongo (ISPD–Nursing)

Massachusetts General Hospital

Boston, Massachusetts

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