advances in handheld raman and ftir chemical identification
TRANSCRIPT
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The world leader in serving science
Michael Hargreaves
Advances in Handheld Raman and FTIR Chemical Identification
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Meeting Growing Needs in Many Applications
Accelerating
Lab to Field
Metal Alloy ID
• Recycling, PMI,
fabrication, QC/QA
Regulatory
• Lead paint, environmental,
consumer product safety
(lead in toys)
Safety & Security
• Explosives identification,
unknown threat screening
Mining
• Exploration, ore grading,
ore trading
Pharma/Chem
• Raw Material ID,
counterfeit drugs
Narcotics
• Crime scene investigation,
local police, border agents
• New application
• Building Awareness
Food/Feed/Ag
• Moisture, fat, protein for
feed producers
• New application
• Developing Markets
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Overview
• Handheld Raman & FTIR history
• Science recap
• Thermo Scientific™ FirstDefender™, TruDefender™, and
TruNarc™ Analyzers
• Thermo Scientific™ Gemini™ Analyzer
• New features
• New hardware
• GUI overview
• Summary
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Elite Users Worldwide: 8,500+ Units Deployed Military EOD & CBRNE, Customs, Police Forensics, Fire HAZMAT units: • Key U.S. Customers
• U.S. Military (Air Force, Army, Navy, Marine Corp, National Guard)
• Department of Justice – ATF and FBI
• Department of Homeland Security – Customs & TSA
• Department of State
• Global users:
• Australian Defense Force & Federal Police
• Chinese Public Security Bureau (PSB)
• German Bundespolizei
• Japanese Ministry of Defense (MOD)
• Indian Police & Mumbai Airport
• Indonesian National Police & National Narcotics Agency (BNN)
• Royal Norwegian Ministry of Defense
• Singapore HSA & Civil Defense
• South Korean National Police & Presidential Security Service
• United Kingdom Ministry of Defense (MOD)
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A Legacy of Innovation
TruDefender™ FTi
TruDefender™ FT
FirstDefender ™ (2005)
TruScreen™ TSA QPL
ECAC, Type A
TruDefender™ FT FirstDefender™ RM/RMX
TruScreen™ TSA QPL
ECAC, Type A
TruDefender™ FTi
TruNarc™
FirstDefender™ (2005)
TruDefender™ FTX/i Gemini™
2007 2008 2009 2010 2011 2012 2013 2014 2015
Raman Spectrometer
• First handheld for S&S
• Chemometric software
• Ultra compact low power laser
FTIR Spectrometer
• First ever handheld
• Michelson interferometer
• Sealed ATR
Generation II Raman
• 5X Faster, 50% smaller
• Integrated optical components
• Robot integration
Counter-Narcotics
• Purpose-built for law enforcement
• Fluorescence solution
• Pay-per-scan option
Software & Hardware
Advancements
• Customizable screening algorithms
• GSM wireless
• Tagging
• Improved anvil
Elite 2-in-1 Raman & FTIR
• First and only 2-in-1 handheld
• Motorized FTIR anvil
• Scan assist
• Touchscreen
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Of Interest?
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Raman & FTIR Spectroscopy
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Complementary Technologies
FTIR Raman
Dark colored solids
Fluorescent
samples
Through sealed
transparent
containers
Pressure
sensitive
substances
Samples
diluted in water
Light colored solids
FTIR + Raman
together serve as
complementary
tests for many
samples
Two-in-one Analyzer!
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Typical Spectra
0 500 1000 1500 2000 2500 3000
EAM2201
MAM2201
AM2201
Raman Shift ∆cm-1
Molecular “fingerprint” of the molecule
AM2201
MAM2201
EAM2201
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• Organic Chemicals
• Narcotics
• TICs & TIMs
• Explosives
• Inorganic Chemicals
• Mineral acids (such as sulfuric and nitric acid)
• Oxides (such as titanium dioxide)
• Sulfates, phosphates, perchlorates, and carbonates
• CANNOT identify
• Pure metals
• Biologicals
• Trace detection/identification (Note Type-H kit)
Technology Capabilities (FTIR & Raman)
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Gunpowder
smokeless
powder
nitroglycerin
TATP
RDX
PETN
RAMAN
500 1000 1500 2000 2500
Raman shift (D cm-1)
fluorescent/heat
fluorescent/heat
FT-IR
1000 1500 2000 2500 3000 3500 4000
wavenumbers (cm-1)
pressure sensitivity
Complementary Nature of Raman & FTIR
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Dec 25, 2009 – Northwest Flight #253
“AhuraFD machines were put to their most important test
Friday night when federal authorities called for help
analyzing the chemicals ... onboard Northwest Airlines
Flight 253.”
“Using the AhuraFD machine, officials were able to
confirm… that the chemical was PETN.”
“It's great to be able to identify what the FBI was looking
at and to have it whenever we need it.”
- Lt. Dan Ross, Warren Fire Department
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Oct 29, 2010 – Printer Cartridge Cargo Incident
Dubai: AhuraFD used to
identify suspicious
materials in the field, which
was communicated to time-
sensitive related site in the
UK. Chemicals identified
include:
• PETN: 300 to 400 grams
(primary explosive)
• Lead azide: 5 grams
(detonator)
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Nov 2011 – “Bomb Factory” in Escondido, CA
• Following detonation in yard, responders find hundreds
of unknown chemicals and explosives
• FirstDefender RMX used as primary chemical ID
tool throughout response
• Largest known cache of HMTD in the US found in home
• Decision was made to burn home based on quantity
and variety of materials
Photos courtesy of County of San Diego, DEH-HIRT
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Sept 24, 2012 – Acid Attack, San Diego
• Suspect threw unknown liquid at female victim after
altercation, causing pain and burning, San Diego HazMat
team responds.
• TruDefender FTi identifed the liquid as concentrated
sulfuric acid at 4 different sites.
• Data transmitted wirelessly to Thermo Scientific
reachback support, who confirmed the identification.
• Due to overwhelming evidence, suspect pled guilty to
assault with a caustic chemical and aggravated mayhem.
Photos courtesy of County of San Diego, DEH-HIRT
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High-Risk Precursors – Priority & Opportunity
• Precursors tend
to travel farther
than finished
Products
• More opportunity
for interdiction T
ime
Distance
Legal manufacture of
precursor materials
Manufacture
of Illicit
product
Subversion
to illicit intent
Opportunities
for interdiction
HME/Narcotic
Required for Success:
Training/SOPs
Intelligence
Technology in the field
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TruNarc: Narcotics Identification capability
TruNarc CAN Identify:
• Cocaine
• Heroin
• Ketamine
• Methamphetamine
• MDMA (ecstasy)
• Synthetic Cannabinoids
• In ‘bulk’ and after sprayed on
leaves
• GHB / GBL
• Morphine
• PCP
• Oxycodone (high and low
dose)
• Methadone
• MDPV
Simple, quick, accurate test
with easy to interpret results
TruNarc CANNOT Identify:
• Marijuana / Hashish / LSD / Opium
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EMCDDA website
0 500 1000 1500 2000 2500 3000
MDP2P methyl glycidate
APAAN (Aqueous Solution)
alpha-Acetylphenylacetonitrile
(APAAN)
Raman Shift ∆cm-1
UNODC Global Smart Update
Narcotic Precursors
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Dutch Police APAAN Seizure
• Following the discovery of a warehouse filled
with APAAN on Jan 29, Dutch law
enforcement investigated transportation
methods, resulting in a truck found on Feb 27.
• AhuraFD (a.k.a. FirstDefender) immediately
identified the truck’s contents as10,000 kg of
APAAN, a pre-precursor in the field.
Truck with APAAN found Feb 27 APAAN operating pilot - Jan29
APAAN BMK Amphetamine
Methamphetamine
AhuraFD result screen – tweeted by Dutch Police
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Synthetic Cathinones
EMCDDA image
500 1000 1500 2000 2500 3000 3500 4000
Pentedrone hydrochloride
3,4-Methylenedioxypyrovalerone hydrochloride
(MDPV)
Mephedrone hydrochloride
3,4-Dimethylethcathinone hydrochloride
4-Fluoromethcathinone hydrochloride
Wavenumber /cm-1
EMCDDA data
FTIR spectra
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Synthetic Cannabinoids
0 500 1000 1500 2000 2500 3000
EAM2201
AB-PINACA
BB-22
PB-22
Raman Shift ∆cm-1
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TruNarc Type-H kit
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French Customs
• Charles de Gaulle
airport
• Customs
demonstration at
FedEx
• Numerous packages
tested
• Chemicals
manufactured in China
identified as synthetic
drugs
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VFestival - UK
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February 2014 – “Gravel” in Massachusetts
• Feb 21 – Quincy Police, TruNarc
users, receive request from
neighboring town on unknown
sample – drugs suspected
• TruNarc immediately identifies
Alpha-PVP (“Gravel”) a synthetic
cathinone
• First seizure in Massachusetts
• 1 day later: received official alert
warning that new drug be
trafficked to Massachusetts
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Meth Lab/Drug Bust, Quincy, MA, USA
• Quincy Drug Unit called to support a “disorder
in progress”
• Drugs & Unknowns in plain view
• Assessed as meth lab (one-pot)
• Hazmat Team used AhuraFD to safely &
accurately identify liquids in mason jars
• Acetone, methyl ethyl ketone, camping fuel &
ammonium nitrate
• Used TruNarc to safely & accurately ID
multiple narcotics, pre-cursors & cutting
agents
• Cocaine, Methamphetamine, Ketamine, Heroin, MDMA,
Methylone, MDPV, pseudoephedrine, benzocaine, inositol,
creatine, baking soda, sugar, ethanol, etc.
• And Saved $$ by using far less NIK kits
• Proved “intent to distribute”
• Locked up 5; seized cash; condemned house
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South America
http://www.youtube.com/watch?v=q_8GxuKib_E&feature=youtu.be&a
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Other Narcotics Application Examples
New Zealand
The Netherlands
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Thermo Scientific Gemini Analyzer
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Gemini Components
Touch Screen
Display
Motorized
Anvil
Vial
Compartment
Laser
Indicator
Lights Raman
Probe
Keypad
FTIR
Sampling
Surface
SD Card
Slot
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XX
Gemini Development
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Final Configuration Rapid Prototypes Layout Concepts
• Evaluated several design approaches
• Leveraged expertise
• Ground up design – every aspect was scrutinized
• Pushed the technology envelope
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• Raman Optical Engine is the
same as the RMX Optical Engine
with a smaller probe
• 30% smaller Raman probe
• FTIR Optical Engine is a smaller
version of the FTX Optical
Engine with a replaceable IR
source
• 44% smaller FTIR engine
Technology Enablers
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Enhanced User Interface
Touch Screen Profiles Trusted Results
• Brighter, larger
screen (4.3”/11cm)
• Full Control:
rugged buttons and
resistive touch
screen (designed
for gloves)
• Quick Setup: using
response profiles
• Pre-loaded with:
Chemical, Clan
Lab, Explosives,
Hazmat, &
Narcotics profiles
• 5 customizable
configurations
available
• Clear results, no
subjective
interpretation
• Automatic mixture
analysis
• Hazard warnings
and chemical
information
• Scan assist guides
efficient and safe use
• Most beneficial for
new or infrequent
users
Scan Assist
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Easy to Understand, Actionable Information
Raman Shift ∆cm-1
0 500 1000 1500 2000 2500 3000
What is it?
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Simplified GUI
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FTIR Measurement
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Raman Measurement
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Easy to Understand, Actionable Information
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Summary
• Instrument Trends • Smaller, rugged, field instruments
• Instruments at point-of-need
• Implications for End-Users • Answers where they’re needed
• Enables faster decision making
• Real-time support when it’s needed
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Mike Hargreaves Global Applied R&D Manager
Thermo Scientific Portable Analytical Instruments
[email protected] | +1.978.495.0859