advanced micro- and nanofluidics revolutionizing the point
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The Growth Pipeline™ Company Powering clients towards a future shaped by growth
A p r i l 2 0 2 1
Advanced Micro- and Nanofluidics Revolutionizing the Point-of-Care Diagnostics Industry
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D i s r u p t i ve m i c ro f l u i d i c t e c h n o l o g i e s e n a b l i n g d e c e nt ra l i zat i o n o f d i a g n o s t i c t e s t s
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1.1 The Strategic Imperative 8™ Factors creating Pressure on Growth in the Microfluidics- and Nanofluidics-based Point of Care Diagnostics Industry
Source: Frost & Sullivan
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1.1 The Strategic Imperative 8™ (Continued)
Customer Value Chain
Compression
Innovative Business
Models
Transformative Mega
Trends
Customer value chain compression as a result of advanced technologies, Internet platforms, and other direct-to-consumer models that enables reduction in friction and the number of steps in customer journeys
A new revenue model that defines how a company creates and capitalizes economic value, typically impacting its value proposition, product offering, operational strategies, and brand positioning
Global forces that define the future world with their far-reaching impact on business, societies, economies, cultures, and personal lives
The internal organizational behaviors that prevent a company from making required changes
Internal Challenges
Geopolitical Chaos Competitive Intensity Disruptive Technologies
Chaos and disorder arising from political discord, natural calamities, pandemics, and social unrest that impact global trade, collaboration, and business security
A new wave of competition from start-ups and digital business models that challenge the standing conventions of the past, compelling established industries to re-think their competitive stance
New, disruptive technologies that are displacing the old, and significantly altering the way consumers, industries, or businesses operate
Collaboration between previously disparate industries to deliver on whitespace cross-industry growth opportunities
Industry Convergence
Source: Frost & Sullivan
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1.2 The Impact of the Top Three Strategic Imperatives on the Microfluidics- and Nanofluidics-based Point of Care Diagnostics Industry
DISRUPTIVE TECHNOLOGIES GEOPOLITICAL CHAOS INDUSTRY CONVERGENCE
• New materials and fabrication technologies are already being explored for low cost mass production of devices.
• Point of care (POC) diagnosis can be expected to be more autonomous enabling at-home tests in 3 to 5 years.
• Participants in the microfluidic POC diagnosis industry have made use of the opportunity and adapted their platforms for detection and management of COVID-19. Some platforms developed by diagnostic companies such as LightDeck Diagnostics, when approved for diagnostic use, will ease the entry of the company into the industry.
• The trend of decentralized medical testing of diseases will continue in the years to come.
• POC diagnostic platforms are increasingly being connected to the Internet to enable rapid assessment of health and updated health records.
• Epidermal microfluidic devices enabling real-time monitoring of health can be expected to thrive in the market in the next 5 years.
SI8
The high cost of the current microfluidic cartridge readers and difficulty in fabricating complex microfluidic devices demand adoption of disruptive sensor and fabrication technologies to develop more autonomous and cost-effective devices.
• A huge demand for accurate POC diagnostics and decentralized healthcare was witnessed during COVID-19, for effective management of the disease.
• As laboratories are overloaded with COVID-19 tests, POC tests for other infectious diseases and chronic diseases are required.
• Healthcare is shifting toward a more value-based care and personalized patient care.
• Integrating POC diagnosis devices with information technologies will enable physicians to track their patient’s progress and improve clinical outcome.
Wh
y W
he
n
Source: Frost & Sullivan
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1.3 About the Growth Pipeline Engine ™
Frost & Sullivan’s Growth Pipeline Engine™ supports clients through all 5 phases of growth from developing, evaluating, and prioritizing opportunities to building and implementing go-to-market strategies and optimizing opportunities. The objective of this study is to be a client’s first step on a growth journey.
Source: Frost & Sullivan
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1.4 Growth Opportunities Fuel the Growth Pipeline Engine™
The Growth Pipeline EngineTM The Innovation Generator™
An
alytical P
ersp
ective
s
Source: Frost & Sullivan Prev
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2.1 Scope of the Research
This research service (RS) explores the emerging microfluidic and nanofluidic technologies employed for point-of-care diagnosis of health status and diseases. Microfluidic-based point-of-care diagnostic devices can improve accessibility, affordability and accuracy of diagnostic tests, thus enabling rapid clinical decisions and better disease management leading to enhanced clinical outcomes.
Microfluidics which manipulate small volumes of fluid in microchannels enable gentle manipulation of cells and molecules and precise control of experimental conditions. It allows miniaturization of bulk assays in small devices requiring small volumes of samples and reagents and integration of several components for multiplexing analysis and achieving higher throughput.
This RS explores the advantages and challenges of traditional as well as emerging materials and fabrication technologies for the point-of-care applications. Various nanofluidic phenomena being investigated for point-of-care diagnosis is also reported. The report also covers some of the remarkable innovations in different segments of the industry, and also lists OEM manufacturing companies supporting innovations in the field.
The drivers and challenges of the microfluidics and nanofluidics-based point-of-care diagnostics industry are explored in detail. Notable funding and acquisition activities in the last three years are also investigated. The growth opportunities offered by autonomous microfluidic devices, 3D printing, flexible microfluidics and integration with information technologies are discussed. Strategic recommendations to succeed in the space are also put forth.
In addition to the above, this research service also offers insights on the IP landscape and the key patents in the last six years.
Source: Frost & Sullivan
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3.1 Microfluidics and Nanofluidics Scale down a Laboratory onto a Chip
Length scale
Nanofluidics
Microneedles
Microanalysis systems
Microfilters or microreactors
Micropumps/valves/flow sensors
“1Microfluidics is the science and technology of systems that process or manipulate small (10-9 to 10-18 litres) amounts of fluids, using
channels with dimensions of tens to hundreds of micrometres”. At least one critical dimension, width, depth or radius, of the
microfluidic device is in the micro scale. The microfluidic channels confine, guide, mix and manipulate fluids within them.
Microfluidics allows precise control of fluids of small volumes involving low energy consumption.
“2Nanofluidics is the study of fluids confined in structures of nanometric dimensions (typically 1−100 nm)”. As molecules become
similar in size to the channels in nanofluidics, the technology deals with a large spectrum of characteristic lengths that induce coupled
phenomena and complex fluid behaviors. Though it has existed for several years, the name ‘nanofluidics’ evolved only recently on
account of recent technological progress in nanoscience and technology.
Applications in Life Sciences
Note: 1G.M. Whitesides., 2006 Nature (442) 368-373. 2Simon Gravelle. Nanofluidics: a pedagogical introduction. 2016. hal-02375018. 3Nam-Trung Nguyen; Steven Wereley; Seyed Ali Mousavi Shaegh, Fundamentals and Applications of Microfluidics, Third Edition , Artech, 2019. Source: Frost & Sullivan
Microfluidics and Nanofluidics-based Point of Care Diagnostics Industry: Length and Volume Scale of Microfluidic and Nanofluidic Devices3
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6.2 Growth Opportunity 1: Self-contained Microfluidic Devices to Enable Expanded Scope of POC Diagnostics
Frost & Sullivan has identified 10 Growth Processes that serve as levers for determining and evaluating new Growth Opportunities.
Growth Processes
Customer and Branding Distribution
Channel Optimization
Geographic Expansion
Competitive Strategy
New Product Development
New Product Launch
Vertical Market Expansion
Strategic Partnering
Mergers & Acquisitions
Technology and IP
Relevant Industries for this Growth Opportunity Applicable Regions
Industrial Automation
Environmental
Oil & Gas
Building Technologies
Consumer Electronics
Consumer Mobility
Commercial Mobility
Chemicals & Materials
Ag., Food & Nutrition
Test & Measurement
Aerospace
Defense
Security
Communications Tech
Information Tech
Pharma & Biotech
Advanced Medtech
Fintech
North America
Latin America
Cent/East Europe
Asia-Pacific
Africa
China
South Asia
Middle East
European Union
UK
Japan
Oceania
2 Years Timeline for Action Base Year 2020 Source: Frost & Sullivan
Disruptive Technologies
R&D Investment
Technology Convergence
R&D Partnerships
R&D Outsourcing
New Product Development
Technology Sourcing
IP Monetization Preview
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6.3 Growth Opportunity 2: 3D Printing to Enable Low-cost Disposable Point of Care Devices
Frost & Sullivan has identified 10 Growth Processes that serve as levers for determining and evaluating new Growth Opportunities.
Growth Processes
Customer and Branding Distribution
Channel Optimization
Geographic Expansion
Competitive Strategy
New Product Development
New Product Launch
Vertical Market Expansion
Strategic Partnering
Mergers & Acquisitions
Technology and IP
Relevant Industries for this Growth Opportunity Applicable Regions
Industrial Automation
Environmental
Oil & Gas
Building Technologies
Consumer Electronics
Consumer Mobility
Commercial Mobility
Chemicals & Materials
Ag., Food & Nutrition
Test & Measurement
Aerospace
Defense
Security
Communications Tech
Information Tech
Pharma & Biotech
Advanced Medtech
Fintech
North America
Latin America
Cent/East Europe
Asia-Pacific
Africa
China
South Asia
Middle East
European Union
UK
Japan
Oceania
Source: Frost & Sullivan
Disruptive Technologies
R&D Investment
Technology Convergence
R&D Partnerships
R&D Outsourcing
New Product Development
Technology Sourcing
IP Monetization 3 Years Timeline for Action Base Year 2020
Preview
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6.4 Growth Opportunity 3: Flexible Microfluidics to Enable Real-time Assessment of Health
Frost & Sullivan has identified 10 Growth Processes that serve as levers for determining and evaluating new Growth Opportunities.
Growth Processes
Customer and Branding Distribution
Channel Optimization
Geographic Expansion
Competitive Strategy
New Product Development
New Product Launch
Vertical Market Expansion
Strategic Partnering
Mergers & Acquisitions
Technology and IP
Relevant Industries for this Growth Opportunity Applicable Regions
Industrial Automation
Environmental
Oil & Gas
Building Technologies
Consumer Electronics
Consumer Mobility
Commercial Mobility
Chemicals & Materials
Ag., Food & Nutrition
Test & Measurement
Aerospace
Defense
Security
Communications Tech
Information Tech
Pharma & Biotech
Advanced Medtech
Fintech
North America
Latin America
Cent/East Europe
Asia-Pacific
Africa
China
South Asia
Middle East
European Union
UK
Japan
Oceania
Source: Frost & Sullivan 3 Years Timeline for Action Base Year 2020
Disruptive Technologies
R&D Investment
Technology Convergence
R&D Partnerships
R&D Outsourcing
New Product Development
Technology Sourcing
IP Monetization Preview
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6.5 Growth Opportunity 4: Integration with Communication Technologies to Enable eHealth Diagnostics
Frost & Sullivan has identified 10 Growth Processes that serve as levers for determining and evaluating new Growth Opportunities.
Growth Processes
Customer and Branding Distribution
Channel Optimization
Geographic Expansion
Competitive Strategy
New Product Development
New Product Launch
Vertical Market Expansion
Strategic Partnering
Mergers & Acquisitions
Technology and IP
Relevant Industries for this Growth Opportunity Applicable Regions
Industrial Automation
Environmental
Oil & Gas
Building Technologies
Consumer Electronics
Consumer Mobility
Commercial Mobility
Chemicals & Materials
Ag., Food & Nutrition
Test & Measurement
Aerospace
Defense
Security
Communications Tech
Information Tech
Pharma & Biotech
Advanced Medtech
Fintech
North America
Latin America
Cent/East Europe
Asia-Pacific
Africa
China
South Asia
Middle East
European Union
UK
Japan
Oceania
Source: Frost & Sullivan
Disruptive Technologies
R&D Investment
Technology Convergence
R&D Partnerships
R&D Outsourcing
New Product Development
Technology Sourcing
IP Monetization
Defense Fintech
2 Years Timeline for Action Base Year 2020 Prev
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Client Impact
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