adulteration and evaluation of crude drugs -...
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Adulteration and Evaluation of
Crude drugs
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Recap
In the last class, we have discussed about
• Alphabetical classification
• Taxonomical Classification
• Morphological classification
• Chemical classification
• Pharmacological classification of Crude Drugs
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Objectives
On completion of this lesson, you would be able to
know:
• Methods of adulteration of Crude Drugs
• Commonly used substitutes in adulteration
• Evaluation for determining adulterants
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Adulteration and Evaluation
• Adulteration involves incorporation of impurities.
• Includes spoilage deterioration admixture.
• Genuine drugs are intentionally substituted.
• With spurious, inferior, defective or harmful substances.
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Adulteration of Crude Drugs
• Adulteration is the debasement of Genuine materials
• Adulteration is done when
There is scarcity of crude drugs or
Cost of the drug is high even though there is no
scarcity
• The drug is either partially or completely substituted
• The adulterant used must be having same morphological
characters as that of genuine drug
• In case of powdered drugs colour, texture and density
taken into consideration
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Methods of Adulteration
1. Manufacture of Substitutes:
Adulterants are artificially manufactured so as to
resemble the genuine drug morphologically.
Ex. Pieces of Basswood into correct size & shape of
Nutmeg and sprayed with volatile oil
Flour dough moulded into correct size & shape
and dipped into red ink and writing ink so as to
resemble Ergot
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Methods of Adulteration
2. Substitution of superficially similar but cheaper
natural materials obtained from same species
Ex. Addition of Clove stalks to genuine Cloves
Substitution of Digitalis purpurea with leaves of
Digitalis thapsi
3. Substitution of inferior commercial varieties
Ex. Substitution of Alexandrian Senna with Indian Senna
Substitution of Capsicum annum fruits with
Capsicum minimum
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Methods of Adulteration
4. Substitution with exhausted materials
Ex. Exhausted Cloves substituted to genuine Cloves
Exhausted Ginger to genuine Ginger
Exhausted Benzoin to genuine Benzoin
5. The presence of extraneous matter if in excess
forms adulteration
Ex. Presence of clove stalks and fruits in Cloves
Presence of stems and other parts in Belladonna
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Methods of Adulteration
6. Addition of synthetic principles to fortify inferior
varieties
Ex. Addition of synthetic Citral to oil of Lemon
Addition of synthetic balsamic acids to Tolu Balsam
7. Powdered drugs
Ex. In case of powdered drugs colour, texture and
density of the powder taken into consideration
irrespective of its origin.
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Faulty collection
• In some cases the quantity of medicinal
constituents reaches the maximum at a
particular season.
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Drug Season age stage of maximum activity
Solanaceous drugs - Summer flowering stage of Plant
Rauwolfia - Autumn 3 to 4 years old plant
Coriander - When fully grown and ripe
Linseed - When fully ripe
Colchicum corm - Early summer
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Pyrethrum flower - Half or 2/3rd open flower
Wild cherry bark - Autumn bark of young stem
Male fern - Late autumn
Belladonna root - Root of 3 to 4 years old plant
Rasna - 4 to 10 years of age
Opium -Collected in afternoon when
sky is clear
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Drug Official drug Substituent_____
Aconite - Aconitum -Aconitum
napellus deinorhizum
Guggul - Commiphora - Commpihora
mukul roxburghii
Myrrh - Commiphora - Commpihora
molmol erythaea
Pale catechu - Uncaria gambier - Acacia deinorhizum
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Belladonna - Atropa Scopola
belladonna carniolica
Phytolacca
decandra
Digitalis - Digitalis purpurea Verbascum
(Species) - Adulterants thapsus
Symphtum Officinale
Primula Vulgaris
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Cascara bark Rhamnus Rhamnus californica
purshiana
Tragacanth Astragalus Sterculia urens
Cinnamon Cinnamonum Cinnamonum
zeylanicum cassia
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Improper Preparation
- Before marketing several drugs are to be prepared inert
or undesirable part is discarded if not done lead to
adulteration.
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Drug Officially used part Unwanted part
• Ginger - Rhizome freed from - Cork
cork
• Male Fern - Rhizome and leaf bases - Roots
• Orange - Dried out part - Spongy inner
• Lemon peel pericarp part of pericarp
• Quillaia bark - Inner part of - Rhytidoma
bark
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• Tamarind - Fruits free from - Outer part of
brittle outer part pericarp
• Clove - Freed from stalks - Excess stalk
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• Neglect of proper conditions for drying
• Leads to adulteration in some drugs
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Drug Faulty Treatment
• Cochicum corm - Drying at temperature 650
which accelerate the rate
of hydrolysis of
colchicines
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• Digitalis - Leaves in wet condition for
period which provide suitable
atmosphere for hydrolysis of
glycosides by enzyme or drying
above 600C also leads to
hydrolysis of glycosides
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• Gentian - Allowing excessive fermentation
before drying in which sugars are
converted into alcohol and carbon
dioxide which leads to reduction in
water soluble extractive value.
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• Cod-liver oil - Excessive heat used in separating
the oil from liver tissues effect
the vitamin content as well as
odour and colour.
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• Improper Storage:
• The quality value and medicinal potency
• Impaired or destroyed by action of
• Moisture
- Temperature
- Microorganisms
- Drug becomes unfit for human consumption
- To be considered adulterated
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• Cascara bark - To be stored at least for one year
before being medicinally utilized
• Ergot - Should be kept entire after
removal of fat and stored in cool
place to prevent attack by insects
moulds and bacteria
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• Colophony - Should be stored only in lump
form
• Male Fern - To be used after the internal
• green colour is lost.
• Digitalis -To be stored in air tight
Belladona -containers protected from sunlight
Hyoscyamus
Stramonium
• Cord-liver oil - Air tight amber coloured bottles
away from sunlight in cool place.
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• Deliberate Adulteration:
Gross Substitution by entirely different Plant Material
Some times in place of genuine drug substitute
Product similar in appearance to the genuine
Due to scarcity or purely for making profit.
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Due to their morphological resemblance
• They are marketed as adulterant
Drug Substitutional Drug
• Ashoka:
• Saraca indica Tremna orientalis
• Kurchi:
• Holarrhena antidysentrica Wrightia tinctoria
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• Rauwolfia - Rauwolfia canescens
(Rauwolfia serpentina)
• Senna (Cassia aungustifolia) - Cassia auriculata
• Nux vomica - S. nuxblanda
(Strychnos nux-vomica) - S. potatorum
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• Substitution by spent or exhausted material
• Many costly crude drugs are extracted
• For one or more active constituents or
• Essential oil partially or completely
• Same drug is admixed with the genuine drug
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Drug Component extracted
• Fennel - Volatile oil
• Clove
• Coriander
• Liquorice - Glycyrrhizin and other
water soluble components
• Jalap - Resin
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• Capsicum - Capsaicin
Pungent Principle
• Ginger - Gingerol
Resin
Volatile oil
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• Tolu balsam - Benzoic and
Benzoin Cinnamic acid
Storax
• Tea and Coffee - Caffeine
• Cannabis - Tetra hydro
Cannobinol
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Adulteration with non-Plant Material
- Some times foreign / fictitious material mixed
- With the authentic drug.
• Artificially manufactured similar looking
• Material is sued as substitute
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Drug Component Extracted
• Myrrh - Quartz and other mineral
substances
• Resins - Colophony
• Clove and - Imitation material
Caraway made of clay
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• Balsam of - Admixture of synthetic
Peru Benzyl benzoate
storax
Benzoin and Balsam of
Tolu
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• Nutmeg - Broken kernels moulded with
clay or similarly shaped pieces of
wood
• Oil of lemon - Mixture of terpenes and Citral
• Opium - Lead shots
• Asafoetida - Lime stones
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• Substitution or Adulteration due to confusion
in Vernacular name:
- Several plants in India known by different vernacular
- More confusion exists between common vernacular
causes of this type of adulteration
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Common Name Biologically different plants
• Punarnava - Boerhavia diffusa
- Trianthema species
- Portulacastrum species
• Brahmi - Hydrocotyl asiatica
Herpestris monniera
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• Shankhpushpi -Evolvulus alsinoides
Concolvulus pluricaulis
and Clitoria ternatea
• Rasna - Acorus calamus
Alpinia officinarum
Anacyclus pyrethrum
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Adulteration in Powdered Drugs
• Besides the entire drugs the powdered drugs
• Also found to be adulterated.
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Drug Adulterant
Ipecacuanha - Dextrin
Colocynth Ginger - Exhausted ginger powder
Barks - Brick powder
Olive stone - Liquorice
Gentian powder
Capsicum - Red sanders wood
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Evaluation Detection of Adulteration:
• Evaluation of crude drug involves
• Confirmation of its Identity
• Determination of its Quality and Purity.
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• If adulterated requires detection of nature of
adulteration in the identified drug
• Before use of any plant drug
• Its identity should be thoroughly confirmed
comparing morphological and microscopic
characters
• Listed in Pharmacopoeial monograph comparing
characters with authentic drug from herbarium.
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• Considering the wide variations in source
• Crude drugs their chemical nature
• Biological activity
• Standard by different techniques
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Summary
In this class we learnt about
• Types of adulterations
• Commonly used substitutes in adulteration
• Evaluation for determining adulterants
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Quiz
1. Volatile oil is not extracted from one of the
following
a. Fennel
b. Coriander
c. Jalap
d. Clove
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1.Total balsamic acids are
a. Benzoic and Cinnamic acid
b. Cinnamic and salicylic acids
c. Benzoic and salicylic acids
d. All correct
Quiz
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Frequently Asked Questions
1. What are different types of adulterations
2. What are the common substituants used for
adulteration in crude drugs.