adolescent brain development: risk and resilience€¦ · 2/11/2017 · adolescent brain...
TRANSCRIPT
Beatriz Luna, PhD
Staunton Professor of Psychiatry and Pediatrics
Laboratory of Neurocognitive Development
University of Pittsburgh Medical Center
Adolescent Brain Development:
Risk and Resilience
Paus et al., 2008
Age of Onset of Psychiatric Disorders
• Major psychopathology emerges and
intensifies during adolescence
Adolescence: Vulnerabilities
• There is a peak in sensation seeking that can
lead to risk-taking undermining survival • Despite peak physical health there is a twofold increase
in mortality (Dahl 2004) -Substance abuse, unprotected
sex, extreme sports, suicide
• Present across societies and species – Biological
Adaptive Stage
SAMHSA
Age of Substance Use Initiation Age of Fatal Car Crashes
15
to
20
15-20
NCCP Farrell et al, 2015
Robbery Arrests
18
Adult
Adolescence Child
Giedd lab
Brain Maturation
Kid
s
Adults
Ghetti Lab
Gray Matter
MRI
Age
Sowell Lab
Striatum Hippocampus
Adult
Adolescence Child
Giedd lab
Brain Maturation
Luna lab K
ids
Adults
Ghetti Lab
Gray Matter Connectivity
White M
att
er
Tra
cts
UF
GM
inputs
CG
10 15 20 25 Age
DTI FA
MRI
Age
Sowell Lab
Striatum Hippocampus
Adult
Adolescence Child
Giedd lab
Brain Maturation
Luna lab
Lewis Lab
Kid
s
Adults
Ghetti Lab
Gray Matter Connectivity
Neurochemistry
White M
att
er
Tra
cts
UF
GM
inputs
CG
10 15 20 25 Age
DTI FA
MRI
Age
Sowell Lab
Striatum Hippocampus
Response Inhibition Working Memory
Age
Ordaz et al.,2013
Simmonds et al.,2017
Behavior
Age
10 15 20 25 Age
0
10
20
30
Bra
in F
un
ctio
n
10 15 20 25
DLPFC
Age
Cognition and Brain Function
Response Inhibition Working Memory
Age
Teens Adults
% C
orr
ect
$ $
Bra
in F
un
ctio
n
Geier et al, 2009
Ordaz et al.,2013
Simmonds et al.,2017
Behavior
Age
VS Teens
Adults
0
0.2
0.4
10 15 20 25 Age
FEF
0 6 12 18
0
0.1
0.2
Brain Activation Timecourse (sec)
0 6 12 18
0
10
20
30
Bra
in F
un
ctio
n
10 15 20 25
DLPFC
Age
Cognition and Brain Function
Encoding
Maintenance
Retrieval
Response Inhibition Working Memory Variability
Age
Teens Adults
% C
orr
ect
$ $
Bra
in F
un
ctio
n
Geier et al, 2009
Ordaz et al.,2013
Simmonds et al.,2017
Montez et al.,2017
Behavior
Age
Age
10 15 20 25 30
Brain State
Expression
10 15 20 25 30
Age
VS Teens
Adults
0
0.2
0.4
10 15 20 25 Age
FEF
0 6 12 18
0
0.1
0.2
Brain Activation Timecourse (sec)
0 6 12 18
0
10
20
30
Bra
in F
un
ctio
n
10 15 20 25
DLPFC
Age
Cognition and Brain Function
Larsen et al., (in press)
Brain Connectivity
Frontolimbic Frontoamygdala
Jalbrzikowski et al., 2017
10 15 20 25 Age
10 15 20 25 Age
Str
uctu
ral
Co
nn
ectivity
Amy/rACC Amy/vmPFC
Anxiety/Depression (YSR/ASR) Affect
Cog
Age
Larsen et al., 2017
Functional Con
Structural Con
Affect
Cognitive
Affect
Larsen et al., (in press)
Brain Connectivity
Frontolimbic Frontoamygdala Frontohippocampal
Jalbrzikowski et al., 2017 Calabro et al., (under review)
10 15 20 25 Age
10 15 20 25 Age
Str
uctu
ral
Co
nn
ectivity
Amy/rACC Amy/vmPFC
Anxiety/Depression (YSR/ASR)
p=0.002 * Age
10 15 20 25 30
Affect
Cog
Age
HPC/PFC Connectivity
0.2 0.4 0.6 0.8
SO
C C
og
nitiv
e P
lann
ing
10
9.5
9
Larsen et al., 2017
Functional Con
Structural Con
Affect
Cognitive
Affect Experience
Adolescent CP of Association Cortices
Genes
Environment
Adolescent
Brain Maturation
Adult Trajectories
Genes
Environment
Adolescent
Brain Maturation
Adult Trajectories
Genes
Environment
Adolescent
Brain Maturation
Adult Modes of
Operation
Genes
Environment
Adolescent
Brain Maturation
Adult Modes of
Operation
Age
Neu
roco
gnitiv
e M
atu
rity
•Finn Calabro PhD - Faculty
•Maria Jalbrzikowski PhD – Faculty
•Vishnu Murty PhD - Faculty
•Bart Larsen – PhD Student
•Scott Marek – PhD Student
•David Montez – PhD Student
•Brenden Tervo-Clemmens – PhD Student
•Sarah Ordaz PhD
•Dani Simmonds MD PhD
•Will Foran- MS
•Julia Lekht -Res Assistant
•Jen Fedor-Res Assistant
Laboratory of Neurocognitive Development
MH067924
MH080243
K23 NS 052234
K01 MH081191
K01 MH082123
PSYCHOLOGY
Thank you!