abstract’s book chilean society for cell biology · 2019. 11. 21. · 2clínica indisa....

CHILEAN SOCIETY

FOR CELL BIOLOGY

October, 22 – 26, 2018

Puerto Varas, Chile

ABSTRACT’S BOOK

CHILEAN SOCIETY FOR CELL BIOLOGY XXXIII ANNUAL MEETING

November, 25 – 29, 2019

ABSTRACT’S BOOK

F

FINAL

Chilean Society for Cell Biology – XXXIII Annual Meeting – November 25-29, 2019

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CHILEAN SOCIETY FOR CELL BIOLOGY

XXXIII ANNUAL MEETING November, 25 – 29, 2019

Puerto Varas, Chile

SPONSORS FUNDACION CHILENA PARA BIOLOGIA CELULAR

FUNDACION CIENCIA & VIDA

GRUPOBIOS

EXHIBITORS ARQUIMED – FERMELO – GENEXPRESS GLOBALAB – GRUPO BIOS – LONCOTEC

MICROXCHILE – PERKIN ELMER – PRION LAB SPA


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CHILEAN SOCIETY FOR CELL BIOLOGY XXXIII ANNUAL MEETING

NOVEMBER 25-29, 2019 PUERTO VARAS

P R O G R A M


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MONDAY, NOVEMBER 25, 2019 09:00 – 13:30 Registration Convention Center Foyer 12:00 – 13:00 Technical Lectures Calbuco Room Qiagen – Grupo Bios Herramientas de Bioinformática para Análisis de NGS Rafael Filipelli, Qiagen 13:00 – 14:30 Lunch 14:30 – 16:00 Opening Remarks Volcanes Room Chair: Juan Pablo Henriquez, SBCCH President. PLENARY LECTURE “FEDERICO LEIGTHON PUGA” Fundacion Chilena para Biologia Celular Chair: Juan Pablo Henriquez, SBCCH President

CONNECTOMICS AT THE NANO- AND PETASCALE. Jeff Lichtman. Department of Molecular and Cellular Biology and The Center for Brain Science, Harvard University, Cambridge, MA, USA.

16:00 – 16:30 Coffee Break Convention Center Foyer 16:30 – 18:30 SCIENCE & FRIENDSHIP SYMPOSIUM “NOVEL MECHANISTIC INSIGHTS INTO

ANTI-TUMOR IMMUNITY” Fundación Ciencia & Vida; Millennium Institute on Immunology and Immunotherapy;

Fondecyt 1171703 y 1171213; Proyecto Basal AFB 170004. Calbuco Room Chair: Alvaro Lladser, Fundación Ciencia & Vida

GAP JUNCTIONS-MEDIATED INTERCELLULAR COMMUNICATIONS AT THE INTERFACE OF THE CYTOTOXIC SYNAPSE. Flavio Salazar-Onfray, Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile and Millennium Institute on Immunology and Immunotherapy, Santiago, Chile. TISSUE-RESIDENT MEMORY CD8+ T CELLS: NEW ORCHESTRATORS OF ANTI-TUMOR IMMUNITY. Alvaro Lladser, Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile. CLONALLY EXPANDED T CELLS REVEAL IMMUNOGENICITY OF RHABDOID TUMORS. Eliane Piaggio, Cancer Immunotherapy Center, Institute Curie, Paris, France. DETERMINANTS FOR SENSITIVITY AND RESISTANCE TO IMMUNE CHECKPOINT BLOCKERS IN CANCER: TUMOR ADAPTATIONS AND DOMINANT T-CELL REGULATORY PATHWAYS. Kurt A. Schalper, School of Medicine, Yale University, New Haven, CT, USA.


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SYMPOSIUM “LIPIDS HOMEOSTASIS AND CELL SIGNALING” Conicyt REDES 180084; Basal Center for Aging and Regeneration AFB 170005; FONDECYT 1190334 y 1161065.

Tronador Room Chair: Alejandra Alvarez, P. Universidad Católica de Chile

RECENT ADVANCES OF INTRACELLULAR CHOLESTEROL TRANSPORT AND HOMEOSTASIS. Carlos Enrich, Departament de Biomedicina, Unitat de Biologia Cellular. Centre de Recerca Biomèdica CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Spain. LIPIDS AND GLUTAMATERGIC SIGNALING. Francisco Muñoz, Laboratory of Molecular Physiology, Department of Health and Experimental Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain. CHOLESTEROL HOMEOSTASIS AND ABL1 SIGNALING AT THE CROSSROADS BETWEEN ALZHEIMER’S DISEASE AND NIEMANN-PICK C DISEASE. Alejandra Alvarez R. Departamento de Biología Celular y Molecular - CARE-UC, Facultad de Ciencias Biológicas, Chile. UNCOVERING NOVEL GENETIC REGULATORS OF LYSOSOMAL BIOLOGY. Andrés Klein, Center for Genetics and Genomics, Universidad del Desarrollo, Santiago, Chile.

18:45 – 20:00 Oral Presentations I Volcanes Room Chairs: Gloria Arriagada, Universidad Andrés Bello Angara Zambrano, Universidad Austral de Chile

18:45 Zebrafish retina as a model to understand glial cell metabolism within vertebrates. Andrea González-Aguilar1, Chetan Poudel2, Mark Charlton-Perkins3, Clemens Kaminski2, William Harris3, L. Felipe Barros4, Miguel L. Allende1. 1Facultad de Ciencias, Universidad de Chile. 2Department of Chemical Engineering and Biotechnology, Cambridge University. 3Department of Physiology, Development and Neuroscience, Cambridge University. 4CECs, Valdivia.

19:00 c-Abl kinase signaling from synapse-to-nucleus during early synaptic activation. Daniela

Gutiérrez1,2, Diego Guzmán1,2, Adrián Gonzalez1,2, Nancy Leal1,2, Pol Picón-Pagès3, Francisco Muñoz3, Alejandra Álvarez1,2. 1Cell Signaling Laboratory, Cellular & Molecular Biology Department, Faculty of Biological Sciences; 2CARE-Chile-UC, Pontificia Universidad Católica de Chile, Santiago, Chile; 3Molecular Physiology and Channelopaties Laboratory, Universitat Pompeu Fabra, PRBB, Barcelona, Spain. [email protected]

19:15 Cdk5 phosphorylates P2X2a subunit increasing P2X2/3R activity in mouse trigeminal

neurons. Rodrigo Sandoval1, Nicolás Pinto1, Patricio Castro2, Christian González-Billault1, Claudio Coddou2, Rodolfo Madrid3 and Elías Utreras1. 1Department of Biology, Faculty of Sciences, Universidad de Chile. 2Faculty of Medicine, Universidad Católica del Norte. 3Faculty of Chemistry and Biology, Universidad de Santiago de Chile.

19:30 Regeneration of the neuromuscular synapse: good or bad reminiscences? Francisca

Bermedo-García1, Diego Zelada1, Juan Ignacio Leal1, Lucia Tabares2, Juan Pablo Henríquez1. 1Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio, Facultad de Ciencias Biológicas,


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Universidad de Concepción, Concepción, Chile. 2Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Sevilla, Sevilla. Spain. [email protected]

19:45 Role VPS50 knock-out: establishing a new mice model of Autism Spectrum Disorder.

Fernando J Bustos. Instituto de Ciencias Biomédicas, Universidad Andres Bello, Santiago, Chile. [email protected]

20:00 – 21:00 YOUNG SCIENTIST AWARD - GRUPO BIOS AND SBCCH Grupo BIOS Volcanes Room

Chairs: Arturo Yudelevich, GrupoBIOS Juan Pablo Henriquez, SBCCH President

EPITRANSCRIPTOMIC REGULATION OF HIV-1 REPLICATION. Ricardo Soto-Rifo, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile.

21:00 Dinner


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TUESDAY, NOVEMBER 26, 2019 08:00 Poster Mounting Session I: N° 1 to N° 71 Convention Center Foyer 09:00 – 10:30 Oral Presentations II Volcanes Room Chairs: María Isabel Yuseff, P. Universidad Católica de Chile Vicente Torres, Universidad de Chile

09:00 Characterization of Ric-8A as a new cytoskeleton interacting protein. Andrea Beyer S.1, Pablo José Sáez2, Soraya Villaseca1, Ana María Lennon-Duménil2, Juan Pablo Henríquez1, Marcela Torrejón1. 1Faculty of Biological Sciences, University of Concepción, Chile. 2Immunity and Cancer U932, Institut Curie, France.

09:15 The proteasome regulator Ecm29 controls actin cytoskeleton dynamics at the immune

synapse of B cells. Felipe Del Valle*, Jorge Ibañez*, María-Isabel Yuseff. Department of Cellular and Molecular Biology, Faculty of Sciences, Pontificia Universidad Católica de Chile. *These authors contributed equally.

09:30 Galectin 9 enhances gastric cancer cell invasion and associates with an immune

suppressive microenvironment. Charlotte Hill1,3, Camille Cabrolier1, Maximiliano Arce1, Marcelo Garrido1, Gareth I. Owen1,2,3. 1Pontificia Universidad Católica de Chile. 2Advanced Center for Chronic Diseases. 3Millennium Institute on Immunology and Immunotherapy.

09:45 The TMBIM protein RECS1 induces cell death through lysosomal membrane

permeabilization. Philippe Pihán1, Fernanda Lisbona1, Janina Borgonovo11, Paula Nunes-Hasler2, Diego Rodríguez3, Amado Carreras-Sureda2, Hery Urra1, Daniela De Giorgies4, Amaury Pupo4, Giovanni Quarato3, Álvaro Glavic1, Karen Castillo4, Benjamin Dehay5, Anthony G. Letai, Miguel Concha1, Nicolas Demareux2, Douglas R. Green3 and Claudio Hetz1. 1University of Chile. 2University of Geneva. 3Saint Jude Children's Research Hospital. 4University of Valparaíso. 5University of Bordeaux.

10:00 ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in

tumor cells and overexpressed in cancer. Solange Rivas1, Patricio Silva1, Montserrat Reyes1, Hugo Sepúlveda2, Luis Solano1, Martín Montecino2,3 and Vicente A. Torres1,4#. 1Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile. 2Institute of Biomedical Sciences, Faculty of Medicine, Universidad Andrés Bello. 3FONDAP Center for Genome Regulation (CRG). 4Advanced Center for Chronic Diseases (ACCDiS).

10:15 Developing small molecules to study the functions of domains within long noncoding RNA.

Rodrigo Aguilar1,2, Kerrie Spencer3, Barry Kesner1,2, Noreen Rizvi3, Elliot Nickbarg3, Jeannie T. Lee1,2. 1Department of Genetics, Harvard Medical School; 2Department Molecular Biology, Massachusetts General Hospital; 3Merck Research Laboratories, Boston, MA, USA. [email protected]

10:30 – 12:00 Poster Viewing Session I: 1-71 Odd Numbers Convention Center Foyer

01. A novel approach for detecting similarities between gene expression profiles: assessing the effect of

ASncmtRNA knockdown in MDA-MB-231 breast cancer cells. Barbara Bernal1,2, Alejandro J Martinez1, Christopher Fitzpatrick3, Verónica Burzio2,3 and Tomas Perez-Acle1,4. 1Computational


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Biology Lab, Fundación Ciencia & Vida, Santiago, Chile. 2Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile. 3Andes Biotechnologies, Santiago, Chile. 4Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Universidad de Valparaíso, Valparaíso, Chile. [email protected], [email protected], [email protected]

03. Administration of secretome derived from mesenchymal stem cells reverts neuronal degeneration

in an animal model of diabetic neuropathy. Constanza Cárcamo1,2, Cristian De Gregorio1, David Contador1, Daniela Santapau1, Marcelo Ezquer1, Fernando Ezquer1. 1Centro de Medicina Regenerativa, Facultad de Medicina, Universidad del Desarrollo. 2Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.

05. Altered autophagy in Sjögren’s syndrome patients is associated with increased pro-inflammatory

markers expression. María-José Barrera1, Sergio Aguilera2, Soledad Matus3, Isabel Castro4, Patricia Carvajal4, Daniela Araya4, Sergio González5, Claudio Molina1, and María-Julieta González4. 1Facultad de Odontología, Universidad San Sebastián. 2Clínica INDISA. 3Fundación Ciencia & Vida. 4ICBM, Facultad de Medicina, Universidad de Chile.5Facultad de Ciencias, Universidad Mayor. [email protected]

07. Analysis of the cellular and molecular organization of the retinal lactate-shuttle. Calbiague,

V.M.1,2, Schmachtenberg, O.1. 1CINV, Ciencias, Universidad de Valparaíso, Valparaíso, Chile. 2Programa Doctorado en Ciencias, mención Neurociencias, Universidad de Valparaíso, Valparaíso, Chile.

09. Calcein release by PLA2 activity from DPPC liposomes: Effect of cholesterol and amphipathic

copolymers. Eduardo Cena1, Jaime Meléndez2 and Marco Soto-Arriaza1,3. 1Laboratorio de Biocoloides y Biointerfaces, Facultad de Química y de Farmacia, PUC 2Pharma Integral SpA y 3Centro de Investigación en Nanotecnología y Materiales Avanzados CIEN-UC, PUC. [email protected]

11. Characterization of a photoactivatable reporter of selective autophagy pathways in C.elegans for

in vivo screening of molecular regulators. Gallardo M.1,3, Minniti A.N.2, Alfaro I.3 and Aldunate R.1. 1Escuela de Biotecnología Universidad Santo Tomás. 2Facultad de Ciencias Biológicas, P. Universidad Católica de Chile. 3Fundación Ciencia & Vida. [email protected]

13. Characterization of Chaperon Mediated Autophagy (CMA) in POMC like neurons under fatty

acids exposure. Javiera Rios1,2, Fernando Ormeño1, Sergio Hernández2,4, Liliana Yantén3, Iván E. Alfaro3, Eugenia Morselli2,5, Patricia Burgos2,4, Alfredo Criollo1,2, Mauricio Budini1,2,6. 1Universidad de Chile. 2Autophagy Research Center. 3Fundación Ciencia & Vida. 4Universidad San Sebastián. 5Pontificia Universidad Católica de Chile. [email protected]

15. Characterization of epigenetic changes in a murine model of Alzheimer's disease. Matías I.

Cáceres1, Miguel V. Guerra1, Brigitte van Zundert1,2 and Lorena Varela-Nallar1. 1Institute of Biomedical Sciences Faculty of Medicine and Faculty of Life Science. Universidad Andrés Bello, Santiago, Chile. 2Centro de Envejecimiento y Regeneración (CARE-UC).

17. Characterization of intestinal dendritic cells behavior in tolerance and inflammation in zebrafish.

Katterine Astorga, Bastian Gonzalez, Luis Figueroa, Yalen del Rio and Carmen G. Feijoo. Fish Immunology Laboratory, Facultad Ciencias de la Vida, Universidad Andres Bello.

19. Characterization of mitochondrial morphology and function in in vitro differentiated Agpat2-/-

brown adipocytes. Ana María Figueroa1, Verónica Eisner2, Víctor Cortés1. 1Departments of Nutrition, Diabetes and Metabolism, and 2Cellular and Molecular Biology. Pontificia Universidad Católica de Chile. [email protected]


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21. Characterization of multivesicular bodies (MVBs) in chemoresistance ovarian cancer cells with reduced macroautophagy. Cerda-Troncoso C.1, Alvarez F.2, Gaete-Ramirez B.1, Varas-Godoy M.2 and Burgos PV.1,3. 1Organelle Phagy Lab, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Chile. 2Cancer Cell Biology Lab, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Chile. 3Centro CARE-UC, Chile.

23. Circadian control of synaptic connectivity and neuropeptide release during Drosophila

metamorphosis. Javier Cavieres, John Ewer. Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Gran Bretaña 1111, Valparaíso, Chile.

25. Circadian control of the daily rhythm of adult emergence in Drosophila melanogaster. L. Bustos-

González1,2 and J. Ewer1. 1Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso. 2Doctorado en Neurociencia, Universidad de Valparaíso.

27. CRISPR editing of GOLGB1 gene reproduced the altered localization of Giantin observed in

labial salivary glands of patients with Sjögren’s syndrome. Isabel Castro1, Matilde Nuñez2, Sergio Aguilera3, María José Barrera4, Patricia Carvajal2, Daniela Jara2, Benjamín Heathcote2, Sergio González5, Claudio Molina4 and María Julieta González2. 1Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile. 2Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile. 3Clínica Indisa. 4Facultad de Odontología, Universidad San Sebastián. 5Facultad de Ciencias, Universidad Mayor.

29. D-Propranolol counteracts p53-driven tumoral aggressiveness and EGFR recycling involving PKA

substrates. Jonathan Barra-Carrasco1,2, Javier Cerda-Infante3, Lisette Sandoval1, Mariana Labarca1, Jennifer Henriquez3, Claudia Metz1, Jaime Venegas1, Claudio Retamal1, Jorge Cancino1, Juan Carlos Roa4, Stephanie Miserey-Lenkei5, Viviana Montecinos3, and Alfonso González1,2. 1Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián. 2Fundación Ciencia y Vida. 3Departamento de Hematología y Oncología and 4Departamento de Patología, Facultad de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile. 5Molecular Mechanisms of Intracellular Transport Laboratory, Institut Curie, Paris, France.

31. Decreased caveolae in Agpat2-/- adipocytes associates with intracellular cholesterol accumulation

and altered localization of caveolin-1 and cavin-1. Lila González-Hódar1, Jay Horton2, Víctor Cortés1. 1Department of Nutrition, Pontificia Universidad Católica de Chile. 2Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas.

33. Defining the role of KDM5A as epigenetic regulator of gene expression during the differentiation

of human induced pluripotent cells to neural progenitors. Estefanía Cardona1,2, Benjamín Gaete1,2, Francisca Cañulef1,2, Gino Nardoci1,2, Hugo Sepúlveda1,2, Brigitte van Zundert1,3, Martin Montecino1,2. 1Institute of Biomedical Sciences, Universidad Andrés Bello. 2FONDAP Center for Genome Regulation. 3Care-UC.

35. Differential distribution and activity profile of acylpeptide hydrolase in rat spermatogenesis.

Alejandra Antonia Covarrubias, Erwin De la Fuente-Ortega, Gabriela Rossi, Floria Pancetti. Laboratory of Environmental Neurotoxicology. Department of Biomedical Sciences. Faculty of Medicine. Universidad Católica del Norte, Chile.

37. Dynamics of nicotinic acetylcholine receptor subpopulations at the normal and injured

neuromuscular synapse in vivo. Diego Zelada, Francisca Bermedo-García and Juan Pablo Henríquez. Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile. [email protected], [email protected]


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39. Dynlrb2 role in nuclear localization and cytoplasmic traffic of murine leukemia virus preintegration complex. Gianfranco Pietrantoni1, Aracelly Gaete2, Diego Herrera-Rojo1, Fernando Valiente-Echeverria2 and Gloria Arriagada1. 1Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad Andrés Bello. 2Programa de Virología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile.

41. Effect of commercial sweeteners on glucose uptake in an in vitro neuronal model. Joel Gutiérrez1,

Javier Fernandez1, Pedro Cisternas1 and Nibaldo Inestrosa1,2. 1Centro de Envejecimiento y Regeneración (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile.

43. Effect of IPN virus in vivo challenge on autophagy related pathwaysin skeletal muscle of rainbow

trout (Oncorhynchus mykiss). Jeffrey Barbosa1,2,3, Marcia Fuentes1,2,3, Alfredo Molina1,2,3, Juan Antonio Valdés1,2,3. 1Laboratorio de Bioquímica Celular, Universidad Andrés Bello, Santiago, Chile. 2Laboratorio de Biotecnología Molecular, Universidad Andrés Bello, Santiago, Chile. 3Interdiciplinary Center for Aquaculture Research (INCAR), Concepción, Chile.

45. Effect of the canonical Wnt pathway on the regulation of AMPK. Camila Gherardelli1, Roberto

Vera1, Pedro Cisternas1 and Nibaldo C. Inestrosa1,2. 1Centro de Envejecimiento y Regeneración (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile.

47. Effect of transcranial light emitting diode therapy on hippocampal synaptic plasticity in a murine

model of the Alzheimer disease. Débora Buendía1,3,5, Macarena Oyanedel1, Tatiana Guncay3,4, Makarena Lemus1, Álvaro Ardiles2,3, Alejandro Weinstein1, Renato Zângaro5, Pablo Muñoz2,3,4. 1School of Biomedical Engineering, Universidad de Valparaíso; 2Department of Pathology and Physiology, Faculty of Medicine, Universidad de Valparaíso; 3Center of Translational Neurology, Universidad de Valparaíso; 4Center of Biomedical Research, Universidad de Valparaíso; 5Universidade Anhembi Morumbi, São Paulo, Brasil. [email protected]

49. Effects of anti-ribosomal P protein antibodies from systemic lupus erythematosus in renal cell

lines. Javiera Álvarez-Indo1, Patricia Gajardo-Meneses1, Marcela Bravo-Zehnder1,2, Loreto Massardo1, Alfonso González1,2. 1Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián. 2Centro de Envejecimiento y Regeneración (CARE-UC), Pontificia Universidad Católica de Chile.

51. Effects of nitrosative stress triggered by hyperglycemic glucose levels on retinal explants. Bárbara

Cádiz, Alex Vielma, Oliver Schmachtenberg. Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso.

53. Epigenetic control during differentiation of human iPSCs to neural progenitors. Francisca

Cañulef1, Hugo Sepúlveda1, Gino Nardocci1,2, Elvis Acevedo1,2, Brigitte van Zundert1,3, Martín Montecino1,2. 1Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andrés Bello. 2FONDAP Center for Genome Regulation. 3CARE-UC.

55. ERYM3, a novel putative mitochondrial protein potentially involved in mitophagy. Gabriela

Gómez-Lillo, Paola Tiozzo-Lyon, Juan Pablo Soffia y Álvaro Elorza. Laboratory of Mitochondrial Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Andres Bello University.


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57. Establishment of a Viral Core Facility to provide high titer viral particles to the Chilean community. Henny Haensgen, Brigitte van Zundert, Martín Montecino, Fernando J Bustos. Instituto de Ciencias Biomédicas, Universidad Andres Bello, Santiago, Chile. [email protected]

59. Evaluation of the antitumoral activity of organic extracts of Leptocarpha rivularis on gastric

cancer cells. Nicolás Carrasco1, Christian Palavecino1; Esteban Palacios1, Maritza Garrido2; Joan Villena3; Manuel Valenzuela1. 1Laboratorio de Microbiología Celular, Facultad de Ciencias de la Salud, Universidad Central de Chile. 2Laboratorio de Endocrinología y Biología de la Reproducción, Hospital Clínico Universidad de Chile. 3Centro de Investigaciones Biomédicas, Universidad de Valparaíso, Chile.

61. Expression and function of the novel Alzheimer-linked gene def-8 in zebrafish. Benitez J.M.;

Vicencio, E.; Santis, O.; Cortes, B.; Nassif, M. and Valdivia, L.E. CIB, Universidad Mayor. 63. Galectin-8 increases AMPAR at the cell surface contributing to synaptic plasticity and memory.

Francisca Barake1,2,3, Sofía Espinoza1,2,3, Francisco Carvajal2, Evelin Pardo3, Claudio Retamal1, Nancy Leal2,3, Adely de la Peña1,2, Claudia Oyanadel1, Waldo Cerpa2,3, Alejandra Álvarez2,3, Andrea Soza1,3, Alfonso González1,3. 1Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián. 2Departamento de Biología Celular y Molecular and 3Centro de Envejecimiento y Regeneración (CARE), Facultad Ciencias Biológicas, Pontificia Universidad Católica de Chile.

65. Glioblastoma cells promote angiogenesis trough the activation of the unfolded protein response in

endothelial cells. Aravena R.1,2, Moraga P.1,2, Fernandez R.1,3, Hetz C.1,2,4, and Urra H.1,2. 1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. 2Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile. 3Neurosurgery Institute, Santiago, Chile. 4Buck Institute for Research on Aging, Novato, USA.

67. Herpes Simplex Virus type 1 (HSV-1) infection impairs the ERAD Machinery function in host

cells. Bustamante H.A.1, Salamín M.1, Leyton L.1, Salazar P. J.1, Burgos P.V.2,3, Otth C.1,4. 1Department of Clinical Microbiology, Universidad Austral de Chile, Valdivia, Chile; 2Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile; 3Center for Aging and Regeneration (CARE), Pontificia Universidad Católica de Chile, Santiago, Chile; 4Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.

69. High quality reconstruction of chicken transcriptome with hybrid sequencing approaches reveals

genomic organization and expression of SSPO gene. Carlos Farkas1,2, Estefanía Tarifeño2, Teresa Caprile1. 1Department of Cellular Biology, 2Department of Biochemistry and Molecular Biology, University of Concepcion, Chile.

71. HMGN5/CTCF regulating the nuclear-lamina dependent chromatin organization. Ingrid Araya1,2,

Miriam Barros3, Gisselle Poblete1,2, Julia Wimmer4, Gernot Längst4, Martín Montecino1,2. 1Institute of Biomedical Sciences, Universidad Andrés Bello. 2FONDAP Center for Genome Regulation. 3Confocal Microscopy Facility UNAB. 4Biochemistry Center Regensburg (BCR), Universität Regensburg, Germany.

12:00 – 13:00 Plenary Lecture

Fundación Ciencia y Vida; Programa Cáncer, Fac. de Medicina, P. Universidad Católica de Chile; Proyecto Basal AFB 170004.

Volcanes Room Chair: Alvaro Lladser, Fundación Ciencia & Vida


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TARGETING IMMUNE REGULATION WITHIN TUMOURS: FROM MECHANISMS TO NEW THERAPIES. Sergio A. Quezada, Cancer Immunology Unit, University College London Cancer Institute, London, UK.

13:00 – 15:00 Lunch 15:00 – 17:00 SCIENCE & FRIENDSHIP SYMPOSIUM “THE mTOR NETWORK IN HEALTH &

DISEASE”. Fundación Ciencia y Vida; BNI – Universidad de Chile; Center for Geroscience; Proyecto

Basal AFB 170004; Fondecyt 1161284. Calbuco Room Chair: Soledad Matus, Fundación Ciencia & Vida

mTOR SIGNALING IN GROWTH AND METABOLISM. Michael Hall, University of Basel, Basel, Switzerland. (This thalk is part of a EMBO Global Lecture). TRANSLATIONAL CONTROL OF CANCER AND AUTISM BY eIF4E VIA mTOR. Nahum Sonenberg. Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. mTOR COMPLEXES IN NEUROLOGICAL DISORDERS. Mauro Costa-Mattioli. Memory and Brain Research Center, Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. RAPAMYCIN ANALOGS AND ITS IMPACT IN NEURODEGENERATION AND GLUCOSE METABOLISM. René Vidal. María José Hormazábal1,2,3,4, Richard Marshak5, Claudio Hetz2,3,4, René Vidal1,3,4. 1Center for Integrative Biology, Universidad Mayor, Santiago, Chile. 2Biomedical Neuroscience Institute, University of Chile. 3Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 4Faculty of Medical Sciences, University of Santiago de Chile, Santiago, Chile. 5Mount Tam Biotechnologies, Burlington, MA, USA

SYMPOSIUM “OUTSIDE-IN CUES CONTROLLING CELL MIGRATION” Conicyt Redes 170212; Fondecyt Regular 1180926.

Tronador Room Chair: Marcela Torrejon, Universidad de Concepción

WISDOM OF THE CROWDS: COLLECTIVE CELL MIGRATION CONTROLLED BY CHEMICAL AND MECHANICAL CUES. Roberto Mayor, Department of Cell and Developmental Biology, University College London, London, UK. IMPACT OF MECHANICAL STRESS ON THE IMMUNE-SURVEILLANCE FUNCTION OF DENDRITIC CELLS. Ana-Maria Lennon-Duménil. INSERM U932, Institut Curie, France. IN VIVO GUIDANCE OF CELL MIGRATION BY ENVIRONMENTAL MECHANICAL CUES. Miguel Concha, ICBM, Facultad de Medicina, Universidad de Chile. Biomedical Neuroscience Institute, Santiago, Chile. Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.


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THE LORD OF THE G: A MASTER REGULATOR DRIVING COLLECTIVE CELL MOVEMENT. Marcela Torrejón, Department of Biochemistry and Molecular Biology. Faculty of Biological Sciences. University of Concepción.

17:30 – 19:00 Poster Viewing Session I: 1-71 Even Numbers Convention Center Foyer

02. hsa-miR-424-5p levels regulate ATF6α expression in salivary glands of primary Sjögren’s

syndrome patients. Patricia Carvajal1, Sergio Aguilera2, Daniela Jara1, Isabel Castro3, María José Barrera4, Maracaja-Coutinho V5, Aliaga-Tobar V5, Sergio González6, Claudio Molina4, Benjamín Heathcote1and María Julieta González1. 1Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile. 2Clinica Indisa. 3Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile. 4Facultad de Odontología, Universidad San Sebastián. 5Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 6Facultad de Ciencias, Universidad Mayor.

04. Human induced pluripotent stem cells and cerebral cortex assembly. Jorge Ojeda1, Markus Uhrig2,

Fernando Ezquer2, Ariel Ávila1. 1Biomedical Science Research Laboratory, Department of Basic Sciences and Morphology, Faculty of Medicine, Universidad Católica de la Santísima Concepción (UCSC), Chile. 2Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Chile.

06. IIIG9 (PPP1R32) subcellular dynamics in cell-cell adhesion during ependymal cell specification

and maturation from radial glia progenitors. Victor Baeza1, Maria Jose Oviedo1, Roberto Gajardo1, Manuel Cifuentes2, Francisco Nualart1, Katterine Salazar1. 1Laboratory of Neurobiology and Stem Cells, Neuro CellT, Center for Advanced Microscopy CMA BIOBIO, Concepcion University, Chile. 2Department of Cell Biology, Genetics and Physiology, IBIMA, BIONAND, Andalusian Center for Nanomedicine and Biotechnology, University of Malaga, Malaga, Spain.

08. IL-8/CXCR1 activation induces cancer stem-like cells properties in ovarian cancer cells. Albano

Cáceres-Verschae1,2, Manuel Varas-Godoy1. 1Cancer Cell Biology Lab, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile. 2Doctorado en Biomedicina, Centro de Investigación e Innovación Biomédica (CIIB), Universidad de los Andes, Santiago, Chile.

10. Impact of culture conditions and genogroup (A and B) on the citotoxicity capacity of Piscirickettsia

salmonis in skeletal muscle cells of rainbow trout (Oncorhynchus mykiss). Camila Aros1,2, Claudia Altamirano3, Alfredo Molina1,2, Juan Antonio Valdés1,2. 1Laboratorio de Biotecnología Molecular, Universidad Andrés Bello, Santiago, Chile. 2Interdiciplinary Center for Aquaculture Research (INCAR), Concepción, Chile. 3Laboratorio de cultivos celulares, Escuela Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso.

12. Impaired exocytosis in myoblasts derived from patients with dysferlinopathy. Hugo Almarza-

Salazar1,2, María José Guerra-Fernandez1, Jacqueline Vasquez-Navarrete1, María Constanza Maldifassi1, Ximena Baez-Matus1, Arlek González-Jamett1, John Ewer1, Ana María Cárdenas1. 1Centro Interdisciplinario de Neurociencias de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso, Chile. 2Magister en Ciencias Biológicas, mención Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Chile.

14. Impaired neuro-angiogenic crosstalk in Schizophrenia: an hiPSC-derived neurodevelopmental

study. Bárbara Casas1, Tomás Monteverde1, Sofía Puvogel1, Joaquín Cerda1, Gabriela Vitória2,


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Marcelo Costa2, Stevens Rehen2 and Verónica Palma1. 1Laboratory of Stem Cells and Development, Universidad de Chile, Chile. 2Instituto D’Or de Pesquisa e Ensino, Rio de Janeiro, Brasil. [email protected]

16. Increased Cdk5 kinase activity in spinal trigeminal nucleus from TNF-α conditional transgenic

mice. Camila Durán, Rodrigo Sandoval, Nicolás Pinto, Elías Utreras. Department of Biology, Faculty of Sciences, Universidad de Chile.

18. IRE1-XBP1s pathway mediates cognitive and motor function during aging. Felipe Cabral-

Miranda1,2,3,4, Giovani Tamburini1,2,3, Gabriela Martinez1,2,3, Danilo B. Medinas1,2,3, Yannis Gerakis1,2,3, Claudia Duran-Aniotz1,2,3, Adrian Palacios5, Alvaro Ardiles5, Cristobal Gonzalez5, Lars Plate 6, Claudio Hetz1,2,3,7. 1BNI, University of Chile, Santiago, Chile. 2Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 3Biomedical Neuroscience Institute, Santiago, Chile. 4Instituto de Ciências Biomédicas, Universidade do Rio de Janeiro, Brazil. 5Centro Interdisciplinario de Neurociencia de Valparaiso, Universidad de Valparaiso, Chile. 6Department of Chemistry, Vanderbilt, TN, USA. 7Buck Institute for Research on Aging, Novato, CA, USA.

20. Knockout of the Golgi apparatus oncoprotein GOLPH3 increases degradation of the autophagy

receptors P62/SQSTM1 and NBR1 in MDA-MB-231 breast cancer cell. Viviana Cavieres1,2, Patricia Burgos3, Gonzalo Mardones1,2. 1Department of Physiology. 2CISNe Center, Universidad Austral Chile, Valdivia. 3CEBICEM Center, Universidad San Sebastián, Santiago, Chile.

22. Laminin as the main constituent of the tubular wall in vasculogenic mimicry in ovarian and breast

cancer. Varina Aldana1, Gabriel Mingo1,5, Andres Valdivia1,5, Pamela Gonzalez1, Francisco Nualart3, Gareth Owen1,2,4,5. 1Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. 2Facultad de Medicina, Pontificia Universidad Católica de Chile. 3Facultad de Ciencias Biológicas, Universidad de Concepción. 4Millennium Institute on Immunology and Immunotherapy. 5Advanced Center for Chronic Disease (ACCDIS), Universidad de Chile.

24. Low protein diet activates the integrated stress response and protects against aging. Marcela

Escandón, Paulina Falcon, Soledad Matus. Fundación Ciencia & Vida. Biomedical Neuroscience Institute (BNI), University of Chile. Geroscience Center for Brain Health and Metabolism (GERO).

26. Mutation in PDIA3 links altered proteostasis to intellectual disability. Danilo B. Medinas1,2,3, and

Claudio Hetz1,2,3,4. 1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. 2Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 3Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. 4Buck Institute for Research on Aging, Novato, CA, USA.

28. Neuroprotector effect of IGF2 in survival of dopaminergic neurons, through exosomal alpha-

synuclein secretion in Parkinson’s disease. Javiera Arcos1,2,3, Paulina Troncoso1,2,3,4, Sirley Leal1,2,3, Felipe Grunenwald1,2,3, Denisse Sepulveda1,2,3, Rodrigo Diaz5, René Vidal1,2,3. 1Center for Integrative Biology, Universidad Mayor, Santiago, Chile, 2Biomedical Neuroscience Institute, University of Chile, 3Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, 4Faculty of Medical, University of Chile, Santiago, Chile, 5Faculty of Sciences, University of Chile, Santiago, Chile.

30. P2X7 receptor in chromaffin cells controlls exocytosis through a positive feed-back loop

mechanism. M. Constanza Maldifassi1, M. José Guerra1, Ximena Báez-Matus1, Daniela Ponce1, Claudio Acuña-Castillo2, Agustín D. Martínez1, Ana María Cárdenas1. 1Centro Interdisciplinario de Neurociencias de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso. 2Centro de Biotecnología Acuícola (CBA), Facultad de Química y Biología, Universidad de Santiago de Chile.


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32. p62-macroautophagy independent mechanism contributes to eliminate damaged lysosomes.

Cereceda K.1,2,3, Hernandez S.1,2,3, Albornoz N.1,2,3, and Burgos P.V.1,2,3. 1Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián; 2Autophagy Research Center; 3Centro CARE-Chile UC.

34. Production and characterization of an Agarophyton chilensis oily extract possessing selective

PPAR modulator (SPPARM)-like activity, insulin sensitizing and anti-oxidant properties in vivo. Pinto, C.1, Ibañez M.R.1, Loyola, G.1,3, Barraza, V.1,3, León L.1,3, Contreras. L.3, Aldunate, R.2, Fuenzalida, K*1,3, Bronfman FC*1,3. 1P. Universidad Católica de Chile, 2Universidad Santo Tomas and 3Instituto de Ciencias Biomédicas. Universidad Andres Bello. [email protected]

36. Proteostaser-1®, a gene therapy-based strategy to modulate the unfolded protein response and

target alterations in C9ALS/FTD. José Ignacio Astorga1,2, Daniela Becerra1,2, Irene van Dijken3, Paulina Torres1,2, Pablo Sardi4, Vicente Valenzuela1,2 and Claudio Hetz1,2. 1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; 2Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, Santiago, Chile; 3European Research Institute for the Biology of Ageing, University of Groningen, Groningen, The Netherlands. 4Sanofi Genzyme Corp., Framingham MA, USA. [email protected]

38. PTPRD null mice have impairments in cortical development and show autistic-like behaviors.

Francisca Cornejo1, Bastián Cortés1, Jessica Molina1, Hideaki Tomita2, Constanza C. Rioseco2, David R. Kaplan2,3, Freda D. Miller2,3, Gonzalo I. Cancino1,2. 1Center for Integrative Biology, Universidad Mayor, 2Hospital for Sick Children, 3University of Toronto.

40. Reassessment of anti-ribosomal P autoantibodies showing no association with lupus nephritis and

no cross-reactivity with dsDNA. Marcela Bravo-Zehnder1,2, Patricia Gajardo-Meneses1, Tomás Toledo1, Gonzalo Méndez3, Milena Mimica1, María Rosa Bono4, Gabriela Tejón4, Loreto Massardo1 and Alfonso González1,2. 1Centro de Biología Celular y Biomedicina (CEBICEM). Facultad de Ciencias Biológicas y Medicina, Universidad San Sebastián. Santiago, Chile. 2Centro de Envejecimiento y Regeneración (CARE). Santiago, Chile. 3Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. 4Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile. [email protected]

42. Receptors expression in an animal model for Hantavirus pulmonary disease. Amelina Albornoz1,

Rebecca Brocato2, Carola Otth3, Jay W. Hooper2, Nicole D. Tischler1. 1Fundación Ciencia & Vida, Laboratorio de Virología Molecular, Santiago, Chile. 2United States Army Medical Research Institute for Infectious Diseases, Virology Division, Fort Detrick, USA. 3Universidad Austral de Chile, Facultad de Medicina, Instituto de Microbiología Clínica, Valdivia, Chile.

44. Role of HDAC1 on the downregulation of proliferative genes induced by genotoxic stress in Ramos

cells. Hugo Faurand, Yennyfer Arancibia, Marcos Castro-Guarda, Angara Zambrano. Instituto de Bioquímica y Microbiología, Universidad Austral de Chile, Valdivia.

46. Role of Herpes Simplex Virus Type 1 (HSV-1) on the function of regulatory members of the

ubiquitin-conjugation system and autophagic machinery in host cells. Aguilar R.A.1, Bustamante H.A.1, Salazar P.J.1, Burgos P.V.2,3, Otth C.1,4. 1Department of Clinical Microbiology, Universidad Austral de Chile, Valdivia, Chile; 2Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile; 3Center for Aging and Regeneration (CARE), Pontificia Universidad Católica de Chile, Santiago, Chile; 4Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.


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48. Role of mTOR in the modulation of metabolic routes during genotoxic damage in Ramos cells of the germinal center Marcos Castro-Guarda1, Yennyfer Arancibia1, Mónica Salas1, Francisco J. Morera2, Angara Zambrano1. 1Instituto de Bioquímica y Microbiología, Universidad Austral de Chile. Valdivia. 2Instituto de Farmacología, Universidad Austral de Chile. Valdivia.

50. Role of αv integrins in the fibrotic response to LPA in skeletal muscle derived fibro/adipogenic

progenitors. Meilyn Cruz-Soca, Adriana Córdova-Casanova, Enrique Brandan. Laboratorio de Diferenciación Celular y Patología. Pontificia Universidad Católica de Chile. Santiago, Chile.

52. Schwann cell activation and neuro-immune responses to dental caries. Eduardo Couve1, Oliver

Schmachtenberg2. 1Instituto de Biología, Facultad de Ciencias, Universidad de Valparaíso. 2CINV, Facultad de Ciencias, Universidad de Valparaíso.

54. SNAP23 regulates lysosome exocytosis at the immune synapse and facilitates B cell spreading.

Martina Alamo, María Isabel Yuseff. Department of Cellular and Molecular Biology, Faculty of Science, Pontificia Universidad Católica de Chile.

56. Starvation increases the expression of a mitochondrial protein at the cell surface. Catalán Jorge1,

Negrete Ayline1, Vásquez Beatriz1,2, Retamal Claudio1, González Alfonso1,2 and Oyanadel Claudia1. 1CEBICEM, Facultad de Medicina y Ciencia Universidad San Sebastián. 2Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. [email protected]

58. The devil is in the detail: How electrostatics shape structure/function relationships in connexin

hemichannels. Jorge Carrasco Alarcón1, Joaquín Jensen1, Felipe Villanelo1, Tomás Perez-Acle1,2. 1Computational Biology Lab (Dlab), Fundacion Ciencia & Vida. 2Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaíso. [email protected]

60. The nutrient stress sensor GCN2 is important for myelin structure in the central nervous system

in mouse (CNS). Alvaro Brito1,2,3, Paulina Falcón1,2,3, Marcela Escandón1,2,3, Carolina Jerez1,2,3, Soledad Matus1,2,3. 1Laboratorio de Biología de la Neurodegeneración. Fundación Ciencia & Vida. 2Biomedical Neuroscience Institute (BNI), University of Chile. 3Geroscience Center for Brain Health and Metabolism.

62. The opening of connexin 43 hemichannels alters astroglial function in the hippocampus of

prenatally LPS-exposed adult offspring. Carla A. Inostroza, Carolina E. Chávez, Juan E. Oyarzún, Beatriz C. Avendaño, Luis A. Mellado, Tanhia F. Alvear and Juan A. Orellana. Departamento de Neurología; Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

64. Ubiquitinome siRNA High-Content Screening (HCS) reveals a role of PSMD14 deubiquitinating

enzyme as a crucial regulator of Golgi-ER retrograde transport with impact in macroautophagy. Bustamante H.A.1,2, Cereceda K.3, González A.E.1,4, Valenzuela G.E.5,6, Cheuquemilla Y.6, Hernández S.3, Arias-Muñoz E.3, Cerda-Troncoso C.3, Soza A.3, Kausel G.5, Kerr B.3, Mardones G.A.1, Cancino J.3, Hay R.T.7, Rojas-Fernandez A.6,7, Burgos P.V.3,8. 1Department of Clinical Microbiology, UACh, Chile. 2Department of Physiology, UACh, Chile. 3CEBICEM, USS, Chile. 4Institute of Biochemistry II, Goethe-Universität, Germany. 5Department of Biochemistry & Microbiology, UACh, Chile. 6CISNe, UACh, Chile. 7Centre for Gene Regulation and Expression, University of Dundee, UK. 8CARE, UC, Chile.

66. Vitamin D receptor polymorphisms regulate mRNA levels of β-amiloide transporters LRP1 and P-

gp in lymphocytes from mild cognitive impairment patients. Nohela Arévalo1,2, Daniela Castillo1, Nicole Rogers3, Isabel Behrens3,4, Luisa Herrera6, Rene Vidal1 y Carol San Martín1,5. 1Biology


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Integrative Center, Science Faculty, Universidad Mayor. 2Programa de Magíster en Genética, Escuela de Postgrado, Facultad de Medicina. 3Departamento de Neurociencias, Facultad de Medicina. 4Centro de Investigación Clínica Avanzada. 5Departamento de Neurología y Neurocirugía Hospital Clínico Universidad de Chile. 6Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile.

68. Wnt5a promotes neurogenesis in the adult mouse hippocampus by non-canonical Wnt signaling.

Sebastian B. Arredondo1, Fernanda G. Guerrero1, Andrea Herrera-Soto1, Joaquin Jensen-Flores1, Daniel B. Bustamante1, Alejandro Oñate-Ponce2, Pablo Henny2, Manuel Varas-Godoy3, Nibaldo C. Inestrosa4 and Lorena Varela-Nallar1. 1Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andres Bello; 2Laboratorio de Neuroanatomía, P.Universidad Católica de Chile; 3Cancer Cell Biology Lab, Universidad San Sebastián; 4Centro de Envejecimiento y Regeneración (CARE), P. Universidad Católica de Chile. [email protected]

70. α-synuclein increases the activity of pannexin channels and alters intracellular Ca2+ dynamics

evoked by glutamate in cultured neurons. Tanhia F. Alvear and Juan A. Orellana. Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

19:00 – 20:00 PLENARY LECTURE “LUIS IZQUIERDO FERNANDEZ” SOCIEDAD DE BIOLOGIA CELULAR DE CHILE Volcanes Room Chairs: Juan Pablo Henriquez, SBCCH President. Andres Klein, Universidad del Desarrollo, Chile

THE LYSOSOME BEYOND A RECYCLING CENTER: A BIOMEDICAL PERSPECTIVE OF CELL SUSTAINABILITY. Silvana Zanlungo, Facultad de Medicina, P. Universidad Catolica de Chile.

20:15 Dinner


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WEDNESDAY, NOVEMBER 27, 2019 08:00 Poster Mounting Session II: N° 72 to N° 142 Convention Center Foyer 09:00 – 10:30 Oral Presentations III Volcanes Room Chairs: Patricia Burgos, Universidad San Sebastián Nelson Osses, P. Universidad Católica de Valparaiso

09:00 Functional role for vitamin c during parenchymal glioblastoma development and progression. Eder Ramírez1, Luciano Ferrada1, Nery Jara2, Fernando Martínez1, Katterine Salazar1, Arabel Vollmann-Zwerenz3, Peter Hau3 and Francisco Nualart1. 1Laboratory of Neurobiology and Stem Cells, NeuroCellT, Center for Advanced Microscopy, CMA Bio-Bio, University of Concepción, Chile. 2Department of Pharmacology, University of Concepción, Chile. 3Department of Neurology and Wilhelm Sander – NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany.

09:15 Characterization of E3 ubiquitin ligases in adult neural progenitor cells. Muriel D.

Mardones, Daniela L. Valenzuela, Andrea Herrera-Soto and Lorena Varela-Nallar. Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andrés Bello.

09:30 ABL1 kinase in Niemann-Pick type A disease: its implication in the pathogenic

mechanisms leading to autophagic flux alterations and neurodegeneration. Marín T.1; De la Fuente C.2; Campos F.1; Acuña M.1; Castro J.1; Cortéz C.3; Marugan J.4; Dulcey A.4; Gorshkov K.4; Zheng W.4; Fonseca M.C.5; Alvarez A.R.2; Zanlungo S.1. 1Medicine Faculty, 2Biological Sciences Faculty, CARE-CHILE UC, Pontificia Universidad Católica de Chile. Santiago, Chile. 3Bioinformatic and Genomic Center, Universidad Mayor, Santiago, Chile. 4NCATS-NIH, Rockville, MD, USA. 5Molecular Medicine Institute, Universidad de Lisboa, Portugal. [email protected]

09:45 Role of chaperone mediated autophagy in excitatory synaptic development. Felipe Perez de

Arce, Liliana Yanten, Juan Hormazábal, Javiera De la Cruz, Iván E. Alfaro. Laboratory of Lysosome Biology and Autophagy, Fundación Ciencia y Vida, Santiago, Chile.

10:00 Tanycyte-AMPKa1/a2 ablation modulates hypothalamic leptin transport. Monica

Imbernon1, Florent Sauvé F1, Daniela Fernandois D1, Eleanora Deligia1, Emilie Caron1, ValerienVingtdeux2, Vincent Prevot V1. 1Development and Plasticity of the Neuroendocrine Brain, Inserm, University of Lille, School of Medicine, Lille-59037, France. 2University of Lille, Inserm, Jean-Pierre Aubert Research Centre, 59045, Lille, France.

10:15 Mechano-molecular mechanisms regulating cell adhesion nanomachines. Cristina,

Bertocchi. Physiology Department, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile.

10:30 – 12:00 Poster Viewing Session II: 72-142 Odd Numbers Convention Center Foyer

73. XBP1s and ATF6f modulates the misfolded proteins and neurodegeneration process. Constanza

Gonzalez1,3,4, Paulina Troncoso1,2,3,4, Valentina Castillo1,2,3, José Canovas1, Carolina Jerez1,3, Pablo Sardi5, René L. Vidal1,2,3, and Claudio Hetz1,3,4,6. 1Biomedical Neuroscience Institute, Faculty of


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Medicine, University of Chile, Santiago, Chile. 2Center for Integrative Biology, Universidad Mayor, Santiago, Chile. 3Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 4Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. 5Department of Molecular Biology, Genzyme Co.

75. Wnt3a overexpression in muscle cells alters pre and postsynaptic organization and acetylcholine

receptor stability at the neuromuscular junction. Jessica Mella1, Juan Ignacio Leal1, Isabel Martinez-Peña y Valenzuela2, Mohammed Akaaboune2, Juan Pablo Henríquez1. 1Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile. 2Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. [email protected]

77. Vitamin C recycling regulates neurite growth through an oxidative effect in neurospheres in vitro.

Francisca Espinoza1, Rocío Magdalena1, Fernando Martínez1, Katterine Salazar1, Felipe Ávila2, Rodrigo Lerchundi3, Christine R. Rose3, Francisco Nualart1. 1Laboratory of Neurobiology and Stem Cells, Center for Advanced Microscopy, CMA BIO BIO, Faculty of Biologycal Sciences, University of Concepcion, Chile. 2School of Nutrition and Dietetics, Faculty of Health Sciences, University of Talca, Chile. 3Institute of Neurobiology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Duesseldorf, Germany. [email protected]

79. Visualization of mitochondrial nucleoids dynamics in live cell. Josefa Macuada, Benjamín Cartes-

Saavedra, Verónica Eisner. Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

81. Uncovering the significance of the Unfolded Protein Response (UPR) in brain physiology under

environmental stress. Mei-Li Díaz1,2,3, Gabriela Martínez1,2,3, Giovanni Tamburini1,2,3, Laia Morato4, Carmen Sandi4, Claudio Hetz1,2,3,5. 1Biomedical Neuroscience Institute. 2Center for Molecular Studies of the Cell, ICBM, University of Chile. 3Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 4Brain Mind Institute. EPFL – Switzerland. 5Buck Institute for Research on Aging, USA. [email protected]; [email protected]

83. Tumour-associated neutrophils promotes motile and invasive properties in breast cancer by the

activation of NF-kB pathway. Violeta Kallens1,2, Daniela Sauma2, Jonas Chnaiderman3, Miguel Allende1. 1Center for Genome Regulation, Universidad de Chile. 2Laboratorio de Inmunología, Facultad de Ciencias, Universidad de Chile. 3Programa de Virología, ICBM, Facultad de Medicina, Universidad de Chile.

85. The unfolding protein response is activated in an idiopathic model of Parkinson’s disease in vivo.

Alexis Martínez1, María Jesús Cerna1, Romina Gozalvo1, Nélida Lopez1, Hilal Lashuel2 and Claudio Hetz1. 1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile; FONDAP Center for Brain Health and Metabolism, Chile. 2LMNN, EPFL, Switzerland.

87. The BMP receptor type II is required for vertebrate neuromuscular junction maintenance.

Patricia Hanna1, Angelymar Medina1, Diego Zelada1, Nelson Osses2 and Juan Pablo Henríquez1. 1Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile. 2Instituto de Química, PUCV, Valparaiso, Chile.

89. T lymphocytes escape death by engaging in mitochondrial transfer via a caspase-dependent

mechanism. Eliseo Parra1, Angela Court1,2, Fernando Figueroa1 and Maroun Khoury1,2. 1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile. 2Regenero, Chilean Consortium for Regenerative Medicine, Cells for Cells, Santiago, Chile.


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91. Structural comparison of the pallial eyes in two pectinid species endemic to Chile. Alejandra Díaz-Valdivia1,2, Eduardo Couve1, Oliver Schmachtenberg1,2. 1Facultad de Ciencias, Universidad de Valparaíso. 2Centro Interdisciplinario de Neurociencia de Valparaíso. [email protected]

93. Structural aspects of Threonyl-carbamoyl transferase complex (TCTC) assembly in Drosophila

melanogaster. Emiliano Molina and Álvaro Glavic. Developmental Genetics laboratory, Faculty of Sciences, Universidad de Chile. [email protected]

95. Simvastatin modify uptake and endocytic properties of microvesicles/exosomes generated by

HEYA8 ovarian cancer cells. Paula Mancilla1, María Francisca Liberona1, Sumie Kato1, Jonathan Barra3,4, Alfonso González2,3, and Mauricio Cuello1. 1Department of Gynecology, School of Medicine, Pontificia Universidad Católica de Chile. 2Centro de Envejecimiento y Regeneración (CARE-UC), Pontificia Universidad Católica de Chile. 3Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile. 4Fundación Ciencia y Vida, Santiago, Chile.

97. Saturated fatty acids impairs the autophagic and endo-lysosomal system in hypothalamic neurons.

María Paz Hernández-Cáceres1, Karina Cereceda2, Yenniffer Ávalos1, Sergio Hernández2, Paulina Burgos1, Ying Li3, Li Yu3, Patricia Burgos2, Eugenia Morselli1. 1Physiology Department, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Centro de Biología Celular y Biomedicina, Universidad San Sebastián, Santiago, Chile. 3School of Life Sciences, Tsinghua University, Beijing, China.

99. Role of the LPA/LPARs axis in the expression of the pro-fibrotic factor CTGF/CCN2 in skeletal

muscle. Adriana Córdova-Casanova1,2, Meilyn Cruz-Soca1,2, Daniela Rebolledo1,2,3, Carlos Céspedes2, Carlos Vío2, Enrique Brandan1,2. 1Laboratorio de Diferenciación Celular y Patología, Facultad de Ciencias Biológicas. Pontificia Universidad Católica de Chile. Santiago, Chile. 2CARE Chile UC, Pontificia Universidad Católica de Chile. Santiago, Chile. 3Escuela de Obstetricia y Puericultura, Facultad de Salud. Universidad Bernardo O’Higgins, Santiago, Chile.

101. Role of PrP in axonal tract formation during zebrafish neural development. Fabrizio Cuevas1,2,

Ignacio Gutierrez1,2, Carmen G. Lemus1,2, Miguel L. Concha1,2,3. 1Anatomy and Developmental Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile. 2Biomedical Neuroscience Institute, Santiago, Chile. 3Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. [email protected], [email protected]

103. Release of extracellular vesicles from gastric cells is enhanced by infection with Helicobacter pylori.

Maria Fernanda González C., Andrew Quest. Laboratorio de Comunicaciones Celulares. Centro de estudios en Ejercicio, Metabolismo y Cáncer (CEMC), Advanced Center for Chronic Diseases (ACCDiS), Facultad de Medicina, Universidad de Chile.

105. Palatable foods decrease the anorexigenic effect of exendin 4 in paraventricular nucleus of

hypothalamus. Pamela Mattar, Claudio Perez-Leighton. Pontificia Universidad Católica de Chile, facultad de Ciencias Biológicas, departamento de Fisiología. (Sponsor: E. Morselli).

107. Patient-derived xenografts: a useful model for the study immune landscape in an intact human

tumor microenvironment. Henríquez F. Jenny1, Cerda-Infante Javier1, Muriel Nuñez1, Diego Figueroa2, Álvaro Lladser2, Sergio Quezada3, Montecinos Viviana P1. 1Departamento Hematología-Oncología, Pontificia Universidad Católica de Chile. 2Fundación Ciencia y Vida, 3University College London.


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109. Pacer controls RIPK1-dependent apoptosis induced by TNF in mesenchymal stem cells. Diego Rojas-Rivera1,2,3,5,6, Sebastián Beltrán1, Cristian Bergmann1, Patricia V Jorquera1, Daniela Böhme1,2, Paulina Oliva1,2, Peter Vandenabeele5,6, Patricio Manque1,4, Ute Woehlbier1, Mathieu JM Bertrand*5,6. 1Center for Integrative Biology, Faculty of Science, Universidad Mayor. 2Escuela de Tecnología Médica, Facultad de Ciencias, Universidad Mayor. 3Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor. 4Center for Genomics and Bioinformatics, Faculty of Science, Universidad Mayor. 5VIB Center for Inflammation Research. 6Department of Biomedical Molecular Biology, Ghent University.

111. Overexpression of hsa-miR-513c-3p contributes to IFN-γ-mediated IRE1α/XBP1 pathway

inhibition by targeting XBP1 in salivary glands from patients with Sjögren’s Syndrome. Benjamin Heathcote1, Patricia Carvajal1, Sergio Aguilera2, Daniela Jara1, Isabel Castro3, María-José Barrera4, Sergio González5, Claudio Molina4, Matilde Núñez1 and María Julieta González1. 1Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile. 2Clínica Indisa. 3Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile. 4Facultad de Odontología, Universidad San Sebastián. 5Facultad de Ciencias, Universidad Mayor. [email protected]

113. OCRL1 mutations on Reelin signaling: a neurological perspective for Lowe Syndrome. Luz María

Fuentealba, Mario Caracci, Vania Macías, Anibal Pacheco, María-Paz Marzolo. Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad Católica de Chile.

115. NSPA protein, target of anti-P antibodies, is involved in adult neurogenesis, PTPN4-controlled

postsynaptic NMDAR levels and memory. Sofía Espinoza*1,3, Sebastian Arredondo2, Francisca Barake1,3, Francisco Carvajal3,4, Waldo Cerpa3,4, Ursula Wyneken5, Alejandro Rojas-Fernandez6, Loreto Massardo1, Lorena Varela-Nallar2, Alfonso González1,3. 1Centro de Biología Celular y Biomedicina, Universidad San Sebastián. 2Insituto de Ciencias Biomedicas, Universidad Andrés Bello. 3Centro de Envejecimiento y Regeneración (CARE), Universidad Católica de Chile. 4CEBIMA, Universidad de Magallanes. 5Facultad de Medicina, U de los Andes. 6CISNe, Universidad Austral de Chile.

117. Neuroprotective effect of rapalogs in a pharmacological model of Parkinson´s disease. María José

Hormazábal1,2, Claudio Hetz1,2,3, René Vidal2,3. 1Facultad de Medicina, Universidad de Chile. 2Centro de Biología Integrativa, Universidad Mayor, Chile. 3Instituto Neurociencia Biomédica-BNI.

119. Neuronal activity modulates pro-regenerative Schwann cell exosomes microRNAs through

activation of an ATP-P2Y axis. Cristian Saquel1,2, Romina Catalán1,2, Rodrigo Lopez-Leal1, Ursula Wyneken3 and Felipe A. Court1, 2. 1Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile. 2Fondap Geroscience Center for Brain Health and Metabolism, Santiago, Chile. 3Universidad de los Andes, Santiago, Chile.

121. Multi-parametric cell migration profiling in a microenvironmentally tunable gelatin

methacrylamide-based device for predictive evaluation of stem cells potency. Enrique Ros, Matias Encina, Fabian Gonzalez, Rafael Contreras, Patricia Luz-Crawford, Maroun Khoury, and Juan Pablo Acevedo. Cells for Cells; Consorcio Regenero, Chilean Consortium for Regenerative Medicine. Laboratorio de Inmunología Celular y Molecular, Centro de Investigación Biomédica, Factulad de Medicina, Universidad de los Andes. Laboratory of Nano-Regenerative Medicine, Faculty of Medicine.

123. Palmitic acid inhibits autophagic flux and ciliogenesis impairing insulin signaling in hypothalamic

neurons. Yenniffer Ávalos1,2, Pablo Lagos2, María Paz Hernández-Cáceres2, Lilian Toledo2, Flavia Cifuentes2, Paulina Burgos2, Eugenia Morselli2. 1Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile. 2Departamento de Fisiología, Facultad Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.


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125. miR-145-5p modulates MUC1 and TLR4 overexpression in salivary glands from primary Sjögren’s syndrome patients. Jara D.1, Carvajal P.1, Aguilera S.2, Barrera M.J.3, Castro I.4, Nuñez M.1, Heathcote B.1, González S.5, Molina C.3 and González M.J.1. 1Laboratorio de biología celular, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile. 2Clínica Indisa. 3Facultad de Odontología, Universidad San Sebastian. 4Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile. 5Facultad de Ciencias, Universidad Mayor.

127. Migratory properties of keratinocytes on extracellular matrices secreted by fibroblasts maintained

in high glucose. Christine Kreindl1, Omar Porras1,2, Ana Luisa Riveros3, Marcelo Kogan3, Jorge Martínez1. 1Molecular and Cellular Biology Laboratory, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile. 2ABCVital. Universidad de Chile. 3Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.

129. Mice exposed to urban air pollution display behavioral and epigenetic alterations. Nur Jury1,2,

Mario Sanchez1,2,3, Gino Nardocci1,3, Elvis Acevedo1,3, Martin Montecino1,3, Lorena Varela-Nallar1, Brigitte van Zundert 1,2. 1Instituto de Ciencias Biomédicas, UNAB. 2Centro de Envejecimiento y Regeneración (CARE-UC). 3Centro de Regulación del Genoma (FONDAP).

131. Metabolic analysis of human aqueous humor concentrations of growth factors and cytokines in

relation to high myopia. Enrique García Gen1,2, Francisco Bosch Morell1, Salvador Mérida Donoso1, Oliver Schmachtenberg2. 1CEU-Cardenal Herrera. 2Centro Interdisplinario de Neurociencia de Valparaíso.

133. Mesenchymal stem cell secretome protects hepatic cells from drug-induced mitochondria

dysfunction. Ya-Lin Huang1, Lorena Lobos1, Fernando Ezquer1, Ivan Alfaro1,2 and Marcelo Ezquer1. 1Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo. 2Laboratorio de Biología Lisosomal y Autofagia, Fundación Ciencia & Vida.

135. Ligand-independent EGFR endocytosis through clathrin-dependent and -independent routes

involving p38 and ERK1/2 downstream of a phosphatidic acid/PDE4/PKA pathway. Claudia Metz1, Juan Jung2,3, Claudia Oyanadel1, Claudio Retamal1, Jorge Cancino1, Andrea Soza1,2 and Alfonso González1,2. 1Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián. 2Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. 3European Molecular Biology Laboratory, Heidelberg, Germany.

137. Intrahippocampal injection of α-synuclein increases the opening of connexin 43 hemichannels and

pannexin-1 channels in hippocampal astrocytes. Valeria C. Labra1, Luis A. Mellado1, Tanhia F. Alvear1, Carla A. Inostroza1, Waldo Cerpa2 and Juan A. Orellana1. 1Departamento de Neurología; Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

139. Insights on the oligomerization mechanisms of GPCR heteromers involved in the migration of

CD4+ T-cells towards the intestinal mucosa. Sebastian E. Gutierrez-Maldonado1,2, Rodrigo Pacheco1,2, Tomas Perez-Acle1,3. 1Computational Biology Lab, Fundación Ciencia & Vida, Santiago, Chile. 2Neuroimmunology Lab, Fundación Ciencia & Vida, Santiago, Chile. 3Centro Interdisciplinario de Neurociencia de Valparaíso, Valparaíso, Chile. [email protected]


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141. In vitro tubulogenesis model of gastric epithelial cells. Robert Cancino, Alicia Meneses, Sebastián Ramírez, Tomás Soto-Rifo and Pablo Nelson. Laboratorio de Biología Celular, Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomás, Sede Santiago.

12:00 -13:00 PLENARY LECTURE

Centro de Envejecimiento y Regeneración (CARE) de la P. Universidad Católica de Chile (Proyecto Basal AFB 170005).

Volcanes Room Chair: Nibaldo C. Inestrosa, P. Universidad Católica de Chile

A NOVEL MIOKINE PROTECTS THE BRAIN IN ALZHEIMER MODELS. Sergio T. Ferreira. Institute of Biophysics Carlos Chagas Filho & Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Brazil.

13:00 – 14:30 Lunch 14:30 – 16:30 SYMPOSIUM “MECHANISMS OF AUTOPHAGY IN HEALTH AND DISEASE”

Proyecto Anillo PIA 172066; Proyecto Conicyt PCI 170147; Fondecyt 1160820. Calbuco Room Chair: Eugenia Morselli, P. Universidad Católica de Chile

CROSS-TALK BETWEEN AUTOPHAGY AND PRIMARY CILIUM IN THE REGULATION OF HYPOTHALAMIC NEURONAL FUNCTION. Eugenia Morselli, Departamento de Fisiología, Facultad de Ciencias Biologícas, Pontificia Universidad Católica de Chile, Chile. NEGATIVE REGULATION OF AUTOPHAGY BY UBA6-BIRC6–MEDIATED UBIQUITINATION OF LC3. Juan S. Bonifacino, Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. INTERFACE BETWEEN ER STRESS AND AUTOPHAGY IN THE HEART. Zhao V. Wang, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AUTOPHAGY INDUCTION ENHANCES MEMORY FORMATION AND MEDIATES THE EFFECTS OF YOUTHFUL SYSTEMIC FACTORS IN AGED BRAIN. Franck Oury, Institut National de la Santé et de la Recherche Médicale (INSERM) U1151, Institut Necker Enfants-Malades (INEM), Université Paris Descartes-Sorbonne–Paris Cité, 75014 Paris, France.

SYMPOSIUM “UNREVEALING THE CORRELATION BETWEEN THE ADIPOSE TISSUE AND THE BRAIN FUNCTION, AN INTEGRAL VIEW AGAINST OBESITY” Redes Internacionales para Investigadores en Etapa Inicial, REDI 170324; Centro de Envejecimiento y Regeneración (CARE) de la P. Universidad Católica de Chile (Proyecto Basal AFB 170005); Proyecto Fondecyt de Iniciación 11160651. Tronador Room

Chair: Pedro Cisternas, P. Universidad Católica de Chile


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SHAPING BIOENERGETICS AND CELL FATE FROM MITOCHONDRIAL CRISTAE. Rubén Quintana-Cabrera. University of Salamanca, CSIC, Institute of Functional Biology and Genomics, 37007 Salamanca, Spain. Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, 37007 Salamanca, Spain. CIBERFES, Institute of Health Carlos III, Madrid, Spain. Department of Biochemistry and Molecular Biology, University of Salamanca, Spain. METHYL CpG BINDING PROTEIN-2: AN EPIGENETIC BRIDGE CONNECTING THE HYPOTHALAMUS-ADIPOSE TISSUE CROSS-TALK REQUIRED FOR THE MAINTENANCE OF ENERGY HOMEOSTASIS. Bredford Kerr. Centro de Estudios Científicos, Valdivia, Chile. Centro de Biología Celular y Biomedicina-CEBICEM, Universidad San Sebastián, Santiago. EFFECTS OF ADIPOKINES OVER THE BRAIN DYSFUNCTION INDUCED BY OBESITY, A NEW LINK TO UNDERSTAND THE OBESITY-ALZHEIMER DISEASE RELATIONSHIP. Pedro Cisternas. Centro de Envejecimiento y Regeneración (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. REGULATION OF FOOD INTAKE AND MOUSE BEHAVIORS BY A NOVEL NEUROKINE, FAM19A1. G. William Wong. Department of Physiology, Johns Hopkins University, Maryland, USA.

16:45 – 17:30 PLENARY LECTURE Volcanes Room Chair: Juan Pablo Henriquez, President SBCCH.

PUBLISHING ARTICLES: TOOLS FOR RESEARCHERS. Gonzalo Cordova. Associate Editor, Springer Nature, Dordrecht, The Netherlands.

17:30 – 19:00 Poster Viewing Session II: 72-142 Even Numbers Convention Center Foyer

72. In vitro aging of mesenchymal precursor cells correlates with impaired function and changes in

BMP receptor levels. Cristian Mejías, Karina Carvajal, Valentina De Améstica, Juan Carlos Forero and Nelson Osses. Instituto de Química, Pontificia Universidad Católica de Valparaíso, Chile. [email protected], [email protected]

74. Impact of caffeic acid and quercetin on the antioxidant machinery expression on Caco-2 cells is

consistent with changes in the cytoplasmic disulfide transmission capacity. Miltha Hidalgo1, Violeta Kallens1, Nicolás Tobar1, Omar Porras1,2. 1Instituto de Nutrición y Tecnología de Alimentos. 2ABCVital, Universidad de Chile.

76. Human glioblastoma cells are sensitized to ferroptosis by co-treatment with dehydroascorbic acid

and Erastin. Luciano Ferrada1,2, Eder Ramírez1 & Francisco Nualart1,2. 1Laboratorio de Neurobiología y Células Madres, Neuro-CellT, Facultad de Ciencias Biológicas. 2Centro de Microscopía Avanzada, CMA BIOBIO, Universidad de Concepción, Concepción, Chile. [email protected]

78. Heterologous expression of the histone lysine methyltransferases SUV39H1 and SUV39H2 in

astrocytes of amyotrophic lateral sclerosis. Guillermo Diaz1,2,3, Sebastian Abarzúa1,2,3, Ivan Diaz1,2, Nur Jury1,2, Macarena Vargas1,2, Martin Montecino1,3, Brigitte van Zundert1,2. 1Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andrés Bello,


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Santiago. 2Centro de Envejecimiento y Regeneración (CARE-UC). 3FONDAP Center for Genome Regulation.

80. GOLPH3 promotes chemoresistance in T98G cells of glioblastoma multiforme through regulation

of the multidrug resistance transporter MRP1. Charlotte Luchsinger, Marcelo Aguilar, Alejandra Pérez, Gonzalo A. Mardones. Department of Physiology and CISNe Center, Universidad Austral de Chile, Valdivia.

82. Gold nanoparticles enhance the fluorescence of CRANAD dye for the detection of β-amyloid

aggregates in vivo. Pablo Cabrera1, María Paz Oyarzún1, Monica Soler3, Pedro Jara-Guajardo1, Marcelo J. Kogan1, Rebeca Aldunate2. 1Advanced Center for Chronic Diseases (ACCDiS), University of Chile. 2School of Biotechnology, Faculty of Sciences, Santo Tomás University. 3Faculty of Physical Sciences and Mathematics, University of Chile.

84. Giantin forms complexes with Gal3-O-sulfotransferase enzymes of the Golgi apparatus in salivary

gland epithelial cells. Matilde Nuñez1, Isabel Castro2, Soledad Matus3, Sergio Aguilera4, María José Barrera5, Patricia Carvajal1, Daniela Jara1, Benjamín Heathcote1, Sergio González6, Claudio Molina5 and María Julieta González2. 1Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile. 2Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile. 3Fundación Ciencia & Vida. 4Clínica Indisa. 5Facultad de Odontología, Universidad San Sebastián. 6Facultad de Ciencias, Universidad Mayor.

86. GFRA3 expression as a putative marker for parasympathetic neurons during development.

Franco-Campos FA, Osorio M, Torres F, Maureira A, Carrasco M, Tapia JC. Stem Cells and Neuroscience Research Center, University of Talca, Talca, Chile. [email protected]

88. Generation of a transgenic tools to visualize neural crest formation and migration in vivo in

Xenopus tropicalis. Carlos Pérez-Yáñez1, Felipe Aguilera2, Marcela Torrejón1. 1Laboratory of Signaling and Development, Department of Biochemistry and Molecular Biology, University of Concepcion, Concepcion, Chile. 2Laboratory of Marine Genomics, Development and Evolution, Department of Biochemistry and Molecular Biology, University of Concepcion, Concepcion, Chile.

90. GCN2-induced eIF2α phosphorylation is necessary for remyelination. Falcón P., Brito A.,

Escandón M., Matus S. Laboratorio de Biología de la Neurodegeneración. Fundación Ciencia & Vida. Biomedical Neuroscience Institute (BNI), University of Chile. Geroscience Center for Brain Health and Metabolism. [email protected]

92. Exo70 distribution alterations following traumatic brain injury. Matías Lira1, Pedro Zamorano2 and

Waldo Cerpa1. 1Laboratorio de Función y Patología Neuronal, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. 2Laboratorio de Neurobiología, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Chile. [email protected]

94. Evaluation of lactadherin presence in mouse ortotopic breast tumors and determination of its role

in breast cancer cell-secreted exosomes. Eduardo Durán-Jara*, Valentina Gutiérrez*, Matías del Campo, Marcelo Ezquer, Lorena Lobos-González. Center for Regenerative Medicine, Institute of Sciences and Innovation in Medicine (ICIM), Faculty of Medicine, Universidad del Desarrollo.

96. Epigenetic repression through histone post-translational modifications during adult neurogenesis.

Miguel V. Guerra1, Brigitte van Zundert1,2 and Lorena Varela-Nallar1. 1Instituto de Ciencias Biomedicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile. 2Centro de Envejecimiento y Regeneración (CARE-UC). [email protected]


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98. Effects of cannabidiol on the regeneration of caudal fin of zebrafish (Danio rerio). Piedad Maldonado1, Mai Neguyen2, George Lutfalla2, Miguel Allende1. 1Center for Genome Regulation, Facultad de Ciencias, Univesidad de Chile. 2Laboratory of Pathogenes Hosts Interactions, Université de Montpellier.

100. Effect of thermal stress on larval and juvenile stages of red sea urchin (Loxechinus albus). Joaquin

González1,2, Phillip Dettleff1,2, Rodrigo Zuloaga1,2, Marcia Fuentes1,2, Pamela González1,2, Juan Manuel Estrada3, Alfredo Molina1,2,3, Juan Antonio Valdés1,2,3. 1Laboratorio de Bioquímica Celular, Universidad Andrés Bello, Santiago, Chile. 2Interdiciplinary Center for Aquaculture Research (INCAR), Concepción, Chile. 3Centro de Investigación Marina Quintay (CIMARQ), Quintay, Chile.

102. Effect of Spinal Cord Stimulation (SCS) in the nigrostriatal dopaminergic system of a α-synuclein

model of Parkinson’s disease. Alejandra V. Parra1,2,3,4, Rómulo Fuentes1,2, Pablo Henny3 & René Vidal2,4. 1Laboratorio de Neuromodulación y Control Motor. Departamento de Neurociencias, Facultad de Medicina. Universidad de Chile. 2Instituto de Neurociencia Biomédica-BNI. 3Laboratorio de Neuroanatomía. Departamento de Anatomía, Facultad de Medicina. Pontificia Universidad Católica de Chile. 4Laboratorio de Neurobiología Traslacional. Centro de Biología Iintegrativa (CIB). Universidad Mayor.

104. Effect of cortisol on growth-related genes of rainbow trout (Oncorhynchus mykiss) myotubes

challenged with Piscirickettsia salmonis. Luciano Frez-Muñoz1,2, Rodrigo Zuloaga1,2, Phillip Dettleff1, Claudia Altamirano3, Camila Aros1,2,3, Marcia Fuentes1,2, Macarena Bastías-Molina4, Claudio Meneses4, Juan Antonio Valdés1,2 and Alfredo Molina1,2. 1Laboratorio de Bioquímica Celular, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile. 2Interdiciplinary Center for Aquaculture Research (INCAR), Universidad de Concepción, Concepción, Chile. 3Laboratorio de Bioprocesos, Universidad Católica de Valparaíso, Valparaíso, Chile. 4Centro de Biotecnología Vegetal, Universidad Andrés Bello, Santiago, Chile.

106. Cytosolic and mitochondrial Ca2+ transients in mitochondrial fission proteins MiD49 and MiD51-

defficient cells. Erik Lopez, Daniel Lagos, Benjamín Cartes-Saavedra, Verónica Eisner. Laboratorio de Función y Comunicación Mitocondrial, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

108. Curcumin and MitoQ treatment modify synaptic structure and mitochondrial function,

attenuating age-associated memory loss by different mechanisms. Claudia Jara1, Margrethe Olesen1, Angie K. Torres1, Michael P. Murphy2 and Cheril Tapia-Rojas1. 1Laboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Chile. 2Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

110. Cryopreserved mesenchymal stem cells: are they safe and effective for treatment of acute

respiratory distress syndrome? Nicol Parada1, Johnatas Silva2, Rocío Corrales1, Luisa Andrade2, Fernanda Cruz2, Christina Schuh1, Francisca Alcayaga1, Francisco Espinoza1, Alejandro Bruhn3, Patricia Rocco2, Maroun Khoury1, Jimena Cuenca1. 1Laboratory of Nano-Regenerative Medicine, Universidad de Los Andes, Chile. 2Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Brazil. 3Departamento de Medicina Intensiva, Pontificia Universidad Católica, Chile. [email protected]

112. Connexin 43 hemichannel activity disturbs dendritic arborization and neuronal survival in the

hippocampus of prenatally LPS-exposed adult offspring. Luis A. Mellado, Carolina E. Chávez, Juan E. Oyarzún, Beatriz C. Avendaño, Carla A. Inostroza, Tanhia F. Alvear and Juan A. Orellana. Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.


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114. Charcot Marie Tooth 2A-causing Mfn2 mutants alter mitochondrial fusion and motility but not ER-mitochondria communication. Daniel Lagos, Sergio Henríquez, Diego Troncoso, Pamela Rojas, Benjamín Cartes-Saavedra and Verónica Eisner. Laboratorio de comunicación y función mitocondrial, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

116. Characterization zebrafish intestinal macrophages during tolerance and inflammation. Yalén Del

Río, Carmen G. Feijóo. Universidad Andrés Bello, Facultad Ciencias de la Vida, Laboratorio Inmunología en Peces.

118. Characterization of the neuromuscular system of the cephalochordate amphioxus. Esperanza

Martínez-Campos1, Teresa Caprile2, Stephanie Bertrand3, Hector Escrivá3, Juan Pablo Henríquez1. 1Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio. 2Axonal Guidance Laboratory, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile. 3Sorbonne Université, CNRS, Biologie Intégrative des Organismes Marins, Observatoire Océanologique, Banyuls-sur-Mer, France. [email protected]

120. Characterization of Slit exocytic/endocytic pathway in the development of the visual system in

Drosophila. Mª Constanza González and Carlos Oliva. Departamento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile.

122. Characterization of an extract enriched in free-fatty acids derived from Agarophyton chilensis

with selective PPAR modulator (SPPARM)-like activity and with a neuroprotective effect in cortical neurons. Ibanez M.R.1,2, Fuenzalida, K.1,2, Loyola, G.1,2, Contreras L.2, and Bronfman FC1,2. 1Pontificia Universidad Católica de Chile, 2Instituto de Ciencias Biomédicas. Universidad Andrés Bello. [email protected]

124. Cellular senescence and senescence-associated secretion phenotype (SASP) involvement in the

inverse association between Alzheimer disease and cancer. Jorge Concha1,4, Daniela Ponce1, Patricia Ayala1, Carol San Martín3, Felipe Salech1,2, Andrea Paula-Lima2,4 and María Isabel Behrens1,2,3. 1Centro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile y Facultad de Medicina, Universidad de Chile. 2Departamento de Neurociencias Facultad de Medicina, Universidad de Chile. 3Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile. 4Instituto de Ciencias Odontológicas Facultad de Odontología. Universidad de Chile.

126. Cellular proliferation in neurogenic niches involved in the regulation of food intake. López S.,

Recabal A. and García M.A. Laboratorio de Biología Celular, Universidad de Concepción, Concepción, Chile.

128. BDNF/TrkB signaling activates CREB in muscle cells: a possible role in neuromuscular junction

maintenance. Viviana Pérez1,2, Francisca C. Bronfman2, Juan Pablo Henríquez1. 1Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile. 2CARE-UC, Institute of Biomedical Sciences, Faculty of Medicine and Faculty of Life Sciences, Universidad Andrés Bello, Santiago, Chile. [email protected], [email protected]

130. Axonal signaling endosomes mediate BDNF long-distance signaling regulating plastic changes in

cell bodies of cortical neurons. Moya-Alvarado, G.1, Ramirez-Alvarez, C.1,2, Stuardo, N. and Bronfman, F.C.1,2. 1Pontificia Universidad Católica de Chile, 2Instituto de Ciencias Biomédicas. Universidad Andrés Bello. [email protected]


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132. Atypical cadherins FAT1 and FAT4 act as tumor suppressors in ovarian cancer. E. Flores1, M. González-Quiroz2, F. Sandoval3, J. Díaz-Mijares2, P. Fuenzalida1, A. Godoy1, A. Rojas4 & J. Meléndez5. 1Laboratorio Endocrinología y Metabolismo Celular, Fac. Cs. Biológicas, PUC. 2Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, U. of Chile. 3Laboratorio de Bioquímica y Biología Molecular, Depto. Farmacia, Fac. Química y de Farmacia, PUC. 4Espacio Cisne, Facultad Medicina, U. Austral de Chile. 5Pharma Integral SpA. [email protected]

134. Alzheimer’s disease-like features triggered by oral Porphyromonas gingivalis infection depends on

the bacterial serotype. Díaz-Zúñiga J.1, More J.2, Melgar-Rodríguez S.1, Jiménez M.1, Villalobos F.1, Monasterio G.1, Valdés J.L.2,3, Vernal R.1, Paula-Lima A.2,4. 1Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile. 2Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile. 3Department of Neuroscience, Faculty of Medicine, Universidad de Chile. 4Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile.

136. Altered epigenetic control of chromatin organization and transcription in ALS glial cells. Sebastian

Abarzua1,2,3, Gino Nardocci1,2, Elvis Acevedo1,2, Brigitte van Zundert1,3 and Martín Montecino1,2. 1Institute of Biomedical Sciences, Faculty of Medicine & Faculty of Life Sciences, Universidad Andres Bello. 2FONDAP Center for Genome Regulation. 3Basal Center for Aging and Regeneration (CARE-PUC).

138. Age-related alterations in accumbal GlyRs: A molecular and functional study. Macarena Konar,

Scarlet Gallegos, Lorena Armijo, Luis Aguayo. Laboratorio de Neurofisiología, Departamento de Fisiología, Universidad de Concepción, Concepción, Chile.

140. Administration of secretome derived from mesenchymal stem cells enhances wound healing in an

animal model of diabetic foot ulceration. Diego Díaz1,2, Cristian De Gregorio1, David Contador1, Daniela Santapau1, Marcelo Ezquer1, Fernando Ezquer1. 1Centro de Medicina Regenerativa, Facultad de Medicina, Universidad del Desarrollo. 2Instituto de Química, Pontificia Universidad Católica de Valparaíso.

142. Adenosine receptor antagonism prevents diabetes-induced podocyte retraction by regulating

cytoskeletal remodelling. Pablo Mendoza, Angelo Torres, Analia Tellez and Rody San Martín. Instituto de Bioquímica, Universidad Austral de Chile.

19:00 – 20:00 BEST THESES AWARDS “FUNDACION CHILENA PARA BIOLOGIA CELULAR” Fundación Chilena para Biología Celular. Volcanes Room

Chairs: Arturo Yudelevich, Fundacion Chilena para Biologia Celular Juan Pablo Henriquez, SBCCH President

Undergraduate Martina Alamo Rollandi Bioquímica, P. Universidad Católica de Chile

“SNAP23 regula la secreción de lisosomas hacia la sinapsis inmune promoviendo la extracción y presentación de antígeno”

Director Tesis: María Isabel Yussef, P. Universidad Católica de Chile Graduate Denisse Sepúlveda Alvarado Doctor en Ciencias Biomédicas, Universidad de Chile

“El papel de la chaperona de colágeno Hsp47 en la activación del sensor de estrés de retículo endoplasmático IRE1α”

Director Tesis: Claudio Hetz, Universidad de Chile


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20:00 Society Members Meeting 21:00 Dinner


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THURSDAY, NOVEMBER 28, 2019 08:00 Poster Mounting Session III: N° 143 to N° 217 Convention Center Foyer 09:00 – 10:15 Oral Presentations IV Calbuco Room Chairs: María de los Angeles García, Universidad de Concepción René Vidal, Universidad Mayor

09:00 Vitamin C is required for collagen release by human hepatic stellate cells. Natalia Smith-Cortinez1, Valentina Gomez Mellado2, Dirk R. de Waart2, Raphael Fagundes1, Svenja Sydor3, Coen C. Paulusma2, Klaas Nico Faber1. 1Hepatology and Gastroenterology, University Medical Center Groningen. 2Tytgat Institute for Liver and Intestinal Research, Amsterdam Umc, University of Amsterdam. 3Otto von Guericke University Magdeburg. [email protected]

09:15 Hypothalamic alpha-tanycytes: A novel appetite regulators. Barahona MJ1, Langlet F2,

Croizier S2, Labouèbe G2, Picard A2, Thorens B2, García-Robles MA1. 1Laboratorio de biología celular. Facultad de Ciencias Biológicas, Universidad of Concepción, Concepción, Chile. 2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

09:30 Modulation of the Integrated Stress Response in a murine model of amyotrophic lateral

sclerosis. Luis Osorio1,2,3, Carolina Jerez1,2,3, Giovanna Mallucci4, Claudio Hetz2,3, Soledad Matus1,2,3. 1Fundación Ciencia & Vida. 2Biomedical Neuroscience Institute (BNI), University of Chile. 3Geroscience Center for Brain Health and Metabolism. 4University of Cambridge, UK.

09:45 Insulin-like Estradiol receptor alpha in tanycytes participates in the control of metabolism

and reproduction. Daniela Fernandois1, Mégane Piet1, Emilie Caron1, Françoise Lenfant2, Bénédicte Dehouck1, Vincent Prévot1. 1Team Development and Plasticity of the Neuroendocrine Brain, Centre JPARC, Inserm UMR-S1172 – Université de Lille – CHRU, 59000, Lille, France. 2INSERM U1048-I2MC- Equipe 9, CHU Rangueil, 31432, Toulouse, France.

10:00 Preeclampsia associates with increased RECK expression in trophoblast and reduced

migration, invasion, and endothelial-like differentiation of first trimester human trophoblast cells. R. Escalona, J. Maldonado and J. Gutiérrez. Cellular Signaling and Differentiation Laboratory (CSDL), Faculty of Health Sciences, Universidad San Sebastián, Chile. [email protected]

10:15 – 11:45 Poster Viewing Session III: 143-217 Odd Numbers Convention Center Foyer

143. A continuous neural-immune interface questions the peripheral and central olfactory sensory system divide. KE Whitlock1, Maria Fernanda Palominos1, Danissa Candia1, Eugene Mbar Tine1, Jorge Torres2. 1Centro Interdisciplinario de Neurociencia de Valparaíso (CINV) Universidad de Valparaíso, Valparaíso, Chile 2Paris-Saclay Institute of Neuroscience, Universite ́ Paris Sud, CNRS UMR9197, Universite ́Paris-Saclay, Gif-sur-Yvette, France.

145. A method for analysis of domain-domain interactions from molecular dynamics simulations.

Joaquín Jensen1, Felipe Villanelo1, Alejandro Martínez1, Tomás Perez-Acle1,2. 1Computational Biology Lab, Fundación Ciencia & Vida. 2Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso.


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147. ABL1 kinase signaling mediates RIP3 phosphorylation in Gaucher Disease models. Yáñez M.J.1, Klein A.D.4, Alvarez A.R.2,3 and Zanlungo S.1. 1Facultad de Medicina, 2Facultad de Ciencias Biológicas, 3CARE-CHILE-UC, Pontificia Universidad Católica de Chile, 4Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile.

149. Activation of the Golgi-localized KDEL Receptor increases mitochondrial function in HT22

hippocampal cells. Diego Tapia1,2, Cheril Tapia-Rojas2 y Jorge Cancino1. 1Laboratory of Cell Biology of Inter-Organelle Signaling (CeBIOS). 2Laboratory of Neurobiology of Aging. Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.

151. Augmented cilia formation leads to activation of FAK, Rac1 and cell migration. Patricio Silva,

Catalina Kretschmar, Alfredo Criollo and Vicente A. Torres. Institute for Research in Dental Science, Faculty of Dentistry, Universidad de Chile and Advanced Center for Chronic Diseases (ACCDIS).

153. Brain IRE1/XBP1 axis modified gut physiology. F. Guerrero1,2,3, A. Espinoza4, C. Gonzalez4, C.

Poblete5, G. Tamburini1,2,3, C. Hetz1,2,3,6 and Gabriela Martínez1,2,3. 1Biomedical Neuroscience Institute. 2Center for Molecular Studies of the Cell, ICBM, University of Chile. 3Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 4Esc. de Med. Veterinaria, Fac. de Ciencias de la Vida, UNAB. 5Esc. de Tec. Médica, Fac. de Ciencias, U. Mayor. 6Buck Institute for Research on Aging, USA. [email protected]

155. c-Abl activation by Aβ fibrils promotes axon initial segment disassembly and tau missorting in

hippocampal neurons. Nicolás Stuardo, Álvaro Cáceres, Nancy Leal, Alejandra Álvarez. Cell Signaling Laboratory, Department of Cellular and Molecular Biology, CARE-UC, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. [email protected]

157. Ca2+ induced blockage in connexin hemichannels: a simple model to test electrostatic and

conformational mechanisms. Felipe Villanelo1, Joaquín Jensen1, Jorge Carrasco1, Tomás Perez-Acle1,2. 1Computationl Biology Lab, Fundación Ciencia & Vida. 2Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso.

159. Cell adhesion protein analysis in polarized kidney and ependymal cells. María José Oviedo1, Victor

Baeza1, Roberto Gajardo1, Manuel Cifuentes2, Francisco Nualart1, Kattterine Salazar1. 1Laboratory of Neurobiology and Stem Cells Neuro-CellT. Center for Advanced Microscopy, CMA BIO-BIO, Concepción, Chile. 2Department of Cell Biology, Genetics and Physiology, IBIMA, BIONAND, Andalusian Center for Nanomedicine and Biotechnology, University of Malaga, Malaga, Spain.

161. Characterization of putative molecular markers to identify subsets of parasympathetic neurons.

Osorio M., Franco-Campos F.A., Maureira A., Carrasco M., Tapia J.C. Stem Cells and Neuroscience Research Center, University of Talca.

163. Characterization of the expression of the preprohormone phoenixin in zebrafish. Eugene M. Tine,

Ricardo Ceriani, Kathleen E. Whitlock. Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Universidad de Valparaíso, Valparaíso, Chile.

165. Conditional deletion of c-Abl in neural precursor cells induce aberrant neurogenesis during

cortical brain development. Fernando Soto1, Beatriz Gárate1, Begoña Aranda-Pino1, Ma. Agustina Roccatagliata1, Jessica Molina1, Alejandra R. Alvarez2, Gonzalo I. Cancino1. 1Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor 2Pontificia Universidad Católica de Chile. [email protected]


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167. Contribution of reactive astrocytes to myelin repair. Raúl Pulgar-Sepúlveda1,*; María-Angeles Carrillo-de Sauvage2,,*; Sebastián Vejar1; Julien Flament2,3; Carole Escartin2; Fernando C. Ortiz1. 1Instituto de Ciencias Biomédicas, Fac. Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile. 2CEA, MIRCen, 92260, CNRS, Université Paris-Sud, UMR 9199, 92260Fontenay-aux-Roses, France. *co-first authors (Sponsor: R.A. Quintanilla).

169. Cytosolic phosphoenolpyruvate carboxykinase is expressed in α‐cells from human and murine

pancreas. Fernando Martínez1, Francisco Westermeier2, Rodrigo Gatica3, Marianne Negrón1, Consuelo Soto1, Francisco Nualart1, Romina Bertinat1. 1Centro de Microscopía Avanzada, CMA‐BIOBIO, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile. 2FH JOANNEUM Gesellschaft mbH University of Applied Sciences, Institute of Biomedical Science, Department of Health Studies, Graz, Austria. 3Escuela de Veterinaria, Facultad de Ciencias, Universidad Mayor, Santiago, Chile. [email protected]

171. Damage induced neutrophil migration to the olfactory epithelium depends on calcium transients.

M. Fernanda Palominos, Kathleen E. Whitlock. Centro Interdisciplinario de Neurociencia de Valparaiso, Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaiso.

173. Dibenzoylmethane restores memory impairment in C9FTD/ALS. Paulina Torres, Vicente

Valenzuela, Jose Astorga and Claudio Hetz. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile and Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile. [email protected]

175. Dopamine receptor D3 signalling reduces suppressive activity and limits migration of regulatory T

cells into the gut mucosa. Valentina Ugalde1, Francisco Contreras1, Alexandra Espinoza1, Rodrigo Pacheco1,2. 1Laboratorio de Neuroinmunología, Fundación Ciencia & Vida. 2Facultad de Ciencias de la Vida, Universidad Andres Bello.

177. Dopamine signaling and the retinal pigment epithelium: Calcium dynamics, growth factor

production and implications for myopia. Felipe Tapia1,2, Andrés Chavez1, Alex Vielma1, Oliver Schmachtenberg1. 1Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso. 2PhD Program in Neuroscience, Universidad de Valparaíso.

179. Eclosion Hormone function during ecdysis behavior in D. melanogaster. Valeria Silva Moeller1,2,

Catalina Berrios1,2, Rubén Herzog1,3, Robert Scott4, Benjamin White4 and John Ewer1. 1Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso. 2Doctorado en Ciencias mención Neurociencia, Universidad de Valparaíso. 3Doctorado en Ciencias mención Biofísica y Biología Computacional, Universidad de Valparaíso. 4Section on Neural Function, NIH, Bethesda, MD, USA.

181. Elucidating the regulatory mechanism of PPARγ transcription factor by BDNF in primary culture

of cortical neurons. Possible role of CREB transcription factor. Zavala-A D. and Bronfman F.C. Pontificia Universidad Católica de Chile and Instituto de Ciencias Biomédicas. Universidad Andres Bello. [email protected]

183. Enzalutamide inhibits androgen-independent IL6-induced AR activation and prostate cancer cell

migration through downregulation of JAK2/STAT3 signaling. Liliana Yantén2, Luz Delgado1, Claudia Acuña1, Sebastián Bernales1, Iván Alfaro1,2. 1Translational Research Laboratory y 2Lysosome Biology and Autophagy Research Laboratory, Fundación Ciencia y Vida, Santiago, Chile.

185. Evaluation of the effect of cortisol mediated by cell surface receptors on the focal adhesion

pathway in RT-GUT cells. Carla Soto, Marcia Fuentes, Alfredo Molina, Juan Antonio Valdés.


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Laboratorio de Bioquímica Celular, Universidad Andrés Bello, Santiago, Chile and Interdiciplinary Center for Aquaculture Research (INCAR), Concepción, Chile.

187. Fasciola hepatica co-infection is associated with morphological changes in Echinococcal Cyst of

naturally infected cattle. Caroll Stoore1, Christian Hidalgo1,2, Rodolfo Paredes1. 1Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile. 2Instituto de Ciencias Agronómicas y Veterinarias, Universidad de O'Higgins, Rancagua, Chile.

189. FGF2 from embryonic cerebrospinal fluid binds to SCO spondin to regulate the early

neurogenesis. Vania Sepúlveda, Jaime Aguayo, Carlos Farkas, Hernan Montecinos, Teresa Caprile. Laboratorio Guía Axonal, Departamento de Biología Celular, Universidad de Concepción. [email protected]

191. Functionalization of DPPC/Dox liposome with cell penetrating peptide for drug delivery. Diego

Salas1, Jaime Melendez2, Marco Soto-Arriaza1,3. 1Laboratorio de Biocoloides y Biointerfaces, Facultad de Química y de Farmacia, PUC. 2Pharma Integral SpA. 3Centro de Investigación en Nanotecnología y Materiales Avanzados CIEN-UC, PUC.

193. Generation of specific nanobodies in Chile. Yorka Cheuquemilla1, Johanna Himelreichs2, Guillermo

Valenzuela2, Alejandro Rojas-Fernandez2, Anne Berking1. 1Berking Biotechnology, Valdivia, Chile. 2Institute of Medicine & Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.

195. Helicobacter pylori outer membrane vesicles induce astrocyte reactivity which prevents neurite

outgrowth. Esteban Palacios1,2, Andrew F.G. Quest1, Manuel Valenzuela2*, Lisette Leyton1*. 1Cellular Communication Laboratory, Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Advanced Center for Chronic Diseases (ACCDiS), Facultad de Medicina, Universidad de Chile, Santiago, Chile. 2Laboratorio de Microbiología Celular, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, Chile.

197. High fat diet consumption alters the morphology of neuronal primary cilia in the hypothalamus of

male mice. Sandoval-Caballero C., Cifuentes F., Ávalos Y.1, Morselli E. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile. [email protected]

199. Impact of membrane-initiated cortisol action over the expression of corticosteroid receptors in

rainbow trout hepatocytes (Oncorhynchus mykiss). Carolina Ramírez Riffo1,3, Alfredo Molina2,3, Juan Antonio Valdés1,3. 1Laboratorio de Bioquímica Celular, Universidad Andrés Bello, Santiago, Chile. 2Laboratorio de Biotecnología Molecular, Universidad Andrés Bello, Santiago, Chile. 3Interdiciplinary Center for Aquaculture Research (INCAR), Concepción, Chile.

201. In vivo gain/loss of GKRP expression in hypothalamic tanycytes produces alterations in

neuropeptides expression and an abnormal feeding behavior. Salgado M.1, Barahona M.J.1, Elizondo-Vega R.1, Uribe E.2, García-Robles M.A.1. 1Laboratorio de Biología Celular, Universidad de Concepción. 2Laboratorio de Enzimología, Universidad de Concepción.

203. Induction of the ecto 5’-nucleotidase by profibrotic TGF-β signaling during diabetic nephropathy.

Analia Téllez, Claudio Cappelli, Claudia Jara, Pablo Mendoza, Carlos Oyarzún, Rody San Martín. Instituto de Bioquimica, Universidad Austral de Chile.

205. Inhibition of the ryanodine receptor blocks long-term presynaptic plasticity induced by low

frequency stimulation. Tatiana Guncay1,2,3, Genaro Barrientos4, Italo Espinoza5, Tatiana Adasme5, Álvaro Ardiles1,2, Cecilia Hidalgo4 and Pablo Muñoz1,2,3. 1Department of Pathology and Physiology,


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Universidad de Valparaíso; 2Center of Translational Neurology, Universidad de Valparaíso; 3Center of Biomedical Sciences, Universidad de Valparaíso; 4Institute of Biomedical Sciences, Biomedical Neuroscience Institute, Universidad de Chile; 5Integrative Center of Biology and Applied Chemistry, Universidad Bernardo O'Higgins. [email protected]

207. Intracellular amyloid-beta oligomers decrease AMPA-mediated currents and excitability of

medium spiny neurons in nucleus accumbens. Nicolás Riffo1, Francisca Cayumán1, Eduardo Javier Fernandez1, Pedro Cisternas2, Nibaldo Inestrosa2, Luis Gerardo Aguayo1. 1Laboratory of Neurophysiology, Department of Physiology, University of Concepción. 2Biomedical Research Center (CARE), Department of Cell Biology, Pontificia Universidad Católica de Chile.

209. IRE1α regulates Filamin A phosphorylation and promotes migration and invasion in mouse

glioblastoma cells. Moraga-Schaaf P1,2, Pihan P1,2, Fernández R1,3, Aravena R1,2, Limia C.M1,2, Urra H1,2, and Hetz C1,2,4. 1Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. 2Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile. 3Neurosurgery Institute, Santiago, Chile. 4Buck Institute for Research on Aging, Novato, USA.

211. KDEL receptor retrograde transport requires Rab11-Binding-Protein (Rab11BP) that also binds

Rab1 and Rab6. Beatriz Vásquez1,2, Bernardita Medel2,3, Stephanie Miserey-Lenkei4, Jorge Cancino2, Claudio Retamal1,2 and Alfonso González1,2. 1Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Facultad de Ciencia and Facultad de Medicina, Universidad San Sebastián, Santiago, Chile. 3Facultad de Ciencias Biológicas, Universidad Andrés Bello, Santiago, Chile. 4Institut Curie, Paris, France.

213. Lack of the ubiquitin-like domain of HERPUD1 causes the formation of crystalloid ER having a

positive impact in the protein quality control machinery. Vargas G.1,4, Cortés O.1,4, Cavieres V.1,2,4,

Bustamante H.A.3, Hernández S.1,4, Varas-Godoy M.1, Cancino J.1, Mardones G.A.2, Tapia-Rojas C.1 and Burgos P.V.1,4. 1Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile. 2Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. 3Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. 4CARE, UC, Chile.

215. Loss of the JAK/STAT pathway in fat body reverts insulin resistance induced by the Drosophila

melanogaster type 2 diabetes model. Lourido Fernanda, Quenti Daniela and Tobar Nicolás. Cellular Biology Laboratory, INTA-Universidad de Chile.

217. Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface. Eduardo

A. Bignon1, Amelina Albornoz1, Pablo Guardado-Calvo2, Félix A. Rey2, Nicole D. Tischler1. 1Laboratorio de Virología Molecular, Fundación Ciencia & Vida, Santiago, Chile; 2Structural Virology Unit, Virology Department, Institut Pasteur, CNRS UMR 3569, Paris, France.

12:00 – 13:00 PLENARY LECTURE Centro de Biología Integrativa, Universidad Mayor; Conicyt/PCI Redes 180113. Volcanes Room Chair: Gonzalo Cancino, Universidad Mayor

FROM STEM TO STERN: EXPLORING PROTEIN KINASE SIGNALLING IN PLURIPOTENT CELLS. Greg M. Findlay, Programme Leader & Wellcome Trust/Royal Society, Sir Henry Dale Fellow MRC, Protein Phosphorylation & Ubiquitylation Unit, University of Dundee, Scotland.

13:00 – 14:30 Lunch


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14:30 – 16:30 SYMPOSIUM “ORGANELLE CELL BIOLOGY FOR LATINOAMERICAN CONNECTIONS”

Centro de Envejecimiento y Regeneración (CARE) de la P. Universidad Católica de Chile (Proyecto Basal AFB 170005); Fondecyt 1180936, 1171649 y 1190928; Centro de Biología Celular y Medicina, Universidad San Sebastián

Calbuco Room Chairs: Patricia Burgos and Manuel Varas-Godoy, Universidad San Sebastián

EXPOSING SECRET COLLABORATIONS: GOLGI-BASED MODULATION OF INTERORGANELLE COMMUNICATIONS. Jorge Cancino, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Chile. HIJACKING THE GOLGI: INSIGHTS INTO THE MECHANISM OF ORTHOBUNYAVIRUS ASSEMBLY IN MAMMALIAN CELLS. Luis da Silva, Departamento de Biologia Celular e Molecular, Universidad de Sao Paulo, Sao Paulo, Brazil. MANIPULATION OF THE ENDOSOMAL SYSTEM BY HIV-1. Matias Ostrowski, Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, Universidad de Buenos Aires, Buenos Aires, Argentina. THE ENDOCYTIC MATRIX AS AN ACHILLES’ HEEL IN CANCER. Alfonso González de la Rosa, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Chile.

SYMPOSIUM “GLIA INVOLVEMENT ON HYPOTHALAMIC REGULATION OF ENERGY BALANCE” Redes Internacionales para Investigadores en Etapa Inicial (REDI 170306); Fondecyt Regular 1180871. Tronador Room

Chair: Maria de los Ángeles García TANYCYTES AND THEIR ROLE IN GLUCOSENSING AND FOOD INTAKE REGULATION. Maria de los Angeles Garcia, Laboratorio de Biología Celular, Universidad de Concepción, Chile. TANYCYTES: THE HYPOTHALAMIC HYPERDRIVE FOR METABOLIC HORMONES. Vincent Prevot, Laboratory of Development and Plasticity of the Neuroendocrine Brain, INSERM, University of Lille, Lille, France. SEX STEROIDS IN DIET-INDUCED GLIOSIS AND OBESITY. Mauricio D. Dorfman, University of Washington, Diabetes Institute, Seattle WA, USA. THE METABOLIC IMPACT OF MICROGLIAL ACTIVATION. Joshua Thaler, Division of Metabolism, Endocrinology & Nutrition, University of Washington, USA.

16:30 – 18:00 Power Hour “COMUNICACIÓN CIENTIFICA EN LA ERA DE LAS FAKE NEWS” Volcanes Room Chair: Francisco Aravena, Subdirector de Radios, Grupo Copesa Juan Pablo Henriquez, SBCCH President


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18:00 – 19:30 Poster Viewing Session III: 143-217 Even Numbers Convention Center Foyer

144. Lactate modulates the activity of POMC neurons of the arcuate nucleus through a receptor.

Órdenes P.1, Hu R.2, Villar P.2, Salgado M.1, Elizondo-Vega R.1, Araneda R.C.2 and García-Robles M.A.1. 1Laboratorio de Biologia Celular, Universidad de Concepción, Chile. 2Department of Biology, University of Maryland, United States.

146. Matrix stiffness as determinants of metabolic reprogramming in human mammary cells. Ponce I.,

Garrido N., Tobar N. and Martínez J. Cell Biology Lab. INTA, University of Chile. 148. Mesenchymal stem cell transferred mitochondria elicit an immune function reprogramming that

entails T regulatory cell commitment and clinical improvement of graft vs host disease. Angela C. Court1, Alice Le-Gatt1, Patricia Luz-Crawford2, Victor Aliaga-Tobar3, Luis Federico Bátiz2, Eliseo Parra-Crisóstomo4, Rafael A. Contreras2, María Ignacia Ortúzar1, Mónica Kurte2, Roberto Elizondo-Vega2, Vinicius Maracaja-Coutinho3,5, Karina Pino-Lagos2, Franchesca Velarde2, Maroun Khoury1,2,4 and Fernando E. Figueroa2,4. 1Cells for Cells, Santiago, Chile. 2Centro de Investigación Biomédica, Faculty of Medicine, Universidad de los Andes, Santiago, Chile. 3Programa de doctorado en genómica integrativa, Vicerrectoría de Investigación, Universidad Mayor, Santiago, Chile. 4Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile. 5Advanced Center for Chronic Disease.

150. Metabolic and cognitive dysfunction characterization at different stages of Alzheimer's disease

transgenic model. Paulina Salazar1, Felipe Serrano, Roberto Vera, Patricio Fuentes3, Pedro Cisternas1, Camila Gherardelli1, Nibaldo C. Inestrosa1,2. 1Centro de Envejecimiento y Regeneración (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile. 3Sección Geriatría, Departamento de Medicina, Hospital Clínico Universidad de Chile.

152. Methotrexate-induced mucine secretion in HT29 cells provides an in vitro model to evaluate the

biological impact of digested food. Yarella Pizarro1, Miltha Hidalgo1, Nicolás Tobar1, Ailynne Sepulveda1, Igor Pacheco1, Omar Porras1,2. 1Instituto de Nutrición y Tecnología de Alimentos, Universidad de Chile. 2ABCvital, Universidad de Chile.

154. Migration and distribution patterns of cancers cells in extracellular matrix derived from benign

and carcinoma-associated fibroblasts. Muriel Núñez, Javier Cerda, Francisco Nualart, Gustavo Cerda, María Isabel Yuseff, Viviana Montecinos. Department of Hematology-Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile. Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción.

156. Mitochondrial dysfunction at the synapse during aging correlates with the accumulation of PHF-1

(Ser396/404) phosphorylated tau in this organelle. Angie K. Torres, Margrethe A. Olesen, Claudia Jara, and Cheril Tapia-Rojas. Laboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Chile.

158. Modulation of IRE1a reduce aggregation of toxic dipeptide repeats on a cellular model of

amyotrophic lateral sclerosis. Alexis Rivas and Claudio Hetz. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.


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160. Multiple haplotypes of Echinococcus granulosus sensu stricto in single naturally infected intermediate hosts. Christian Hidalgo1, 2, Caroll Stoore1, Ismael Pereira1, Cristian Álvarez-Rojas3, Rodolfo Paredes1. 1Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile. 2Instituto de Ciencias Agronómicas y Veterinarias, Universidad de O'Higgins, Rancagua, Chile. 3Institute of Parasitology, University of Zürich, Zürich, Switzerland.

162. NBCe1 knockout in astrocytes perturbs brain energy homeostasis and behavior. 1Iván Ruminot,

3Patrick S. Hosford, 3Shefeeq M. Theparambil, , 1Pamela Y. Sandoval, 1,2Héctor Oyarzún, 1,2Pablo Castro, 1Bredford Kerr, 1L. Felipe Barros and 3Alexander V. Gourine. 1Centro de Estudios Científicos (CECs), Valdivia, Chile; 2Escuela de Tecnología Médica, Facultad de Medicina, Universidad Austral de Chile and 3Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. [email protected]

164. Neuroprotective effect of red algae extract, against the toxicity of oxidative stress and amyloid

fibers in cortical neurons. Claudia Vásquez1,2, Brenda Riquelme1,2, Sofía Fajardo1, Milka Martínez1 and Nibaldo C. Inestrosa1,2. 1Centro de Envejecimiento y Regeneración (CARE-UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile.

166. Novel inositol 1,4,5-trisphosphate receptor inhibitor antagonizes hepatic stellate cell activation: a

potential drug to treat liver fibrosis. Natalia Smith-Cortinez1, Masa Podunavac2, Armen Zakarian2, César Cardenas2,3,4, Klaas Nico Faber1. 1Department of Gastroenterology and Hepatology, UMCG, University of Groningen. 2Department of Chemistry and Biochemistry, University of California. 3Center for Integrative Biology, Universidad Mayor, and Geroscience. 4Buck Institute for Research on Aging.

168. Phospholipase-D derived phosphatidic acid enhances Notch signaling by reducing sorting of Spdo

towards late endosomes and by increasing Notch trafficking towards the plasma membrane during development of the sensory organs of Drosophila. Patricio Olguín1,2, Gonzalo H. Olivares1,2, Franco Vega-Macaya3, Ignacio Medina-Yáñez1,2. 1Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile. 2Biomedical Neuroscience Institute, Departmento de Neurociencia, Facultad de Medicina, Universidad de Chile. 3Millennium Institute for Integrative Biology (iBio) Universidad de Santiago de Chile, Facultad de Química y Biología, Departamento de Biología, Santiago, Chile.

170. Prostaglandin E2 activates Rab5, leading E-cadherin endocytosis. Sebastián Venegas, Vicente A.

Torres. Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile and Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.

172. Protein Kinase A (PKA) regulates Rab11FIP1C (RCP) function on EGFR endocytic recycling and

invasive migration. Jaime Venegas1, Jonathan Barra1,2, Claudio Retamal1 and Alfonso González1. 1Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián. 2Fundación Ciencia y Vida.

174. Proteomic analysis in the cerebellum in chronic schizophrenia. América Vera-Montecinos1, Ricard

Rodriguez-Mias2, Belén Arranz3, Isidre Ferrer5, Judit Villen2, Belén Ramos1,3,4. 1Psiquiatria Molecular, Institut de Recerca Sant Joan de Déu, 08950, Spain. 2Genome Sciences Department, School of Medicine. University of Washington, 98195, USA. 3Parc Sanitari Sant Joan de Déu, 08830, Spain. 4Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Ministry of Economy, Industry and Competitiveness Institute of Health Carlos III, Spain. 5Neuropathology, Bellvitge Unive.


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176. Reelin signaling changes lysosome distribution to the periphery in a dopaminergic neuronal model. Aníbal Pacheco, Vania Macías, Mario Caracci, Luz Fuentealba, María Paz Marzolo. Laboratorio de Tráfico Intracelular y Señalización. Facultad de Ciencias Biológicas. Pontificia Universidad Católica de Chile.

178. Ric-8A/Galphaq signaling regulates neural crest induction and mesoderm formation in Xenopus

tropicalis. Maria Jose Ruiz-Norambuena, Marion Rodriguez, Marcela Torrejón. Laboratory of Signaling and Development, Department of Biochemistry and Molecular Biology, University of Concepcion, Concepción, Chile.

180. Ric-8A/Gαq signaling controls Ca2+ transients in cranial neural crest cell during migration in

Xenopus tropicalis. Gabriel Romero, Soraya Villaseca, Marcela Torrejón. Laboratory of Signaling and Development, Department of Biochemistry and Molecular Biology, University of Concepcion, Chile.

182. Role of GAG-NRP-1 in the induction and maintenance of activated phenotype in carcinoma

associated fibroblasts. Victoria Velásquez1, Javier Cerda-Infante1,2, Marianela Sánchez1, Enrique Brandan2 and Viviana P. Montecinos1. Departments of 1Hematology-Oncology and 2Celullar Biology, Pontificia Universidad Católica de Chile.

184. Role of IRE1α in amyotrophic lateral sclerosis. Vicente Valenzuela1,2,3, José Vicente González-

Teuber1,2,3, Rodrigo Salinas1,2,3, Danilo B. Medinas1,2,3, and Claudio Hetz1,2,3,4. 1Biomedical Neuroscience Institute, 2Center for Molecular Studies of the Cell, ICBM, Faculty of Medicine, University of Chile. 3Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile. 4Buck Institute for Research on Aging, Novato, CA, USA.

186. Role of mitochondrial permeability transition pore on bioenergetics failure and synaptic

impairment caused by tau protein cleaved by caspase 3. Carola Tapia-Monsalves and Rodrigo A. Quintanilla. Laboratory of Neurodegenerative Diseases, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.

188. RSPO signaling in adult neural progenitor cells. Daniela L. Valenzuela, Muriel D. Mardones and

Lorena Varela-Nallar. Institute of Biomedical Sciences Faculty of Medicine and Faculty of Life Sciences Universidad Andrés Bello, Santiago, Chile. [email protected]

190. Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma. L.

Rosenberger1, M. Ezquer2, F. Lillo-Vera3,4, A.I. Figueroa-Valdés1,4, A. Romero-Trujillo4, H. Lenden-Hasse4, J. Cuenca1,3,4, M. Khoury1,3,4 & F. Alcayaga-Miranda3,4. 1Consorcio Regenero, Santiago, Chile. 2Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile. 3Cells for Cells, Santiago, Chile. 4Laboratory of Nano-Regenerative Medicine, Facultad de Medicina, Universidad de los Andes, Chile.

192. Study of protein aggregation in Superoxide Dismutase 1 (SOD1) and DNA binding protein TAR

43 (TDP-43) in motor neurons derived from patients with ALS. Torres FC, Cáceres DE, Maureira A, Franco-Campos FA, Osorio M, Valdebenito B, Tapia JC & Carrasco MA. Stem Cells and Neuroscience Research Center, University of Talca.

194. SUMOylation determines the protein cargo of astrocyte-derived small extracellular vesicles. Maxs

Méndez-Ruette, Anllely Fernández, Karina Cordero, Roberto Henzi, Federico Batiz, Alejandro Rojas-Fernández, Ursula Wyneken. Laboratorio de Neurociencias, Universidad de los Andes. [email protected]


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196. The changes in systemic monocytes in humans undergoing surgical decompression for degenerative cervical myelopathy may influence clinical neurological recovery. Vidal PM1,2, Ulndreaj A1,3, Tetreault L4, Hong J1,3, Fehlings MG1,3,5. 1Division of Genetics & Development, Krembil Neuroscience Center and Spine Program, University Health Network, Toronto, Ontario, Canada. 2Department of Basic Science, Biomedical Science Research lab, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción, Chile. 3Institute of Medical Science, University of Toronto, Ontario, Canada. 4Graduate Entry Medicine, University College Cork, Cork, Ireland. 5Department of Surgery, Division of Neurosurgery and Spine Program, University of Toronto, Toronto, Ontario, Canada.

198. The process of cancer vasculogenic mimicry requires coordination between the extracellular

matrix and integrin pathway signaling. Gabriel Mingo1,4, Andres Valdivia14, Varina Aldana1, Pamela Gonzalez1, Lisette Leyton4,5, Gareth Owen1,2,3,4. 1Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. 2Facultad de Medicina, Pontificia Universidad Católica de Chile. 3Millennium Institute on Immunology and Immunotherapy. 4Advanced Center for Chronic Disease (ACCDiS), Universidad de Chile. 5Laboratory of Cellular Communication, ICBM, Faculty of Medicine, Universidad de Chile.

200. The role of abl tyrosine kinase in the activation of B-cells induced by antigen recognition. Cristian

Valls, Maria Isabel Yuseff, Alejandra Alvarez. Laboratorio de señalizacion Célular, Laboratorio de Biologia de linfocitos B. Pontificia Universidad Católica de Chile. [email protected]

202. The role of microscopy facilities in local science: opportunities and challenges. Nicole Salgado C.

Unidad de Microscopía Avanzada, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. (Sponsor: M.I. Yuseff).

204. The role of the UPR stress sensor IRE1α in the DNA damage response. Sagredo Alfredo1, Dufey

Estefanie1, Bravo-San Pedro José M3, Eggers Cristian4, Urra Hery1, González-Quiroz Matías Eduardo1,2, Pihán Philipe1, Glavic Alvaro4, Álvarez Alejandra5, Acosta-Alvear Diego6, Walter Peter6, Kroemer Guido3, Eric Chevet 2, Rémy Pedeux2 and Hetz Claudio 1,7. 1BNI and GERO, University of Chile, Santiago, Chile. 2Universite de Rennes-1, CLCC Eugene Marquis, Rennes, France. 3Gustave Roussy Cancer Campus, Paris, France. 4Center for Genome Regulation, Faculty of Sciences, University of Chile., Santiago, Chile. 5Department of Cell & Molecular Biology, PUC, Santiago, Chile 6UCSF, San Francisco, USA. 7The Buck Institute, Novato, California, USA. [email protected]

206. The use of CRISPR-CAS9 to explore the role of atypical cadherins (FATs) in pancreatic cancer

cells. F. Sandoval1, M. González-Quiroz2, J. Díaz-Mijares2, E. Flores3, K. Rodríguez1, A Rojas4 & J. Meléndez5. 1Laboratorio de Bioquímica y Biología Molecular, Depto. Farmacia, Fac. Química y de Farmacia, PUC. 2Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, U. of Chile. 3Laboratorio Endocrinología y Metabolismo Celular, Fac. Cs. Biológicas, PUC. 4Espacio Cisne, Facultad Medicina, U. Austral de Chile. 5Pharma Integral SpA. [email protected]

208. Translational regulation of the antiapoptotic protein Survivin by control elements in the 5’

untranslated region (5’UTR). Nicolás Carrasco-Véliz1, Christian E. Palavecino1, Maritza Garrido2, Andrew Quest3 and Manuel Valenzuela-Valderrama1,3. 1Laboratorio de Microbiología Celular. Facultad de Ciencias de la Salud, Universidad Central de Chile. 2Laboratorio de Endocrinología y Biología de la Reproducción, Hospital Clínico Universidad de Chile. 3Advanced Center for Chronic Diseases (AccDIS).

210. Tumor microbiome defines outcomes on pancreatic cancer. Erick Riquelme1,6, Yu Zhang1,

Liangliang Zhang1, Montiel Maria1, Zoltan Michelle1, Wenli Dong1, Pompeyo Quesada1, Ismet Sahin2, Vidhi Chandra1, Anthony San Lucas1, Paul Scheet1, Hanwen Xu1, Samir M Hanash1, Lei Feng1, Nadim


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Ajami3, Joseph Petrosino3, Christine B. Peterson1, Michael P. Kim1, Cynthia L. Sears4, James Robert White5, Laura D.Wood4, Anirban Maitra1, Matthew Katz1, Robert Jenq1, Jennifer Wargo1, Florencia McAllister1. 1The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 2Texas Southern University, Houston, TX, 3Baylor College of Medicine, USA, 4Johns Hopkins University School of Medicine, Baltimore, MD, USA, 5Resphera Biosciences, Baltimore, MD USA, 6Center for Integrative Biology, Faculty of Science, Universidad Mayor, Santiago, Chile.

212. β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal

differentiation. Cristina Pinto1, Danilo B. Medinas2, Francisco Fuentes-Villalobos3, Jaime Maripillán4, Ariel F. Castro3, Agustín D. Martínez4, Nelson Osses5, Claudio Hetz2, Juan Pablo Henríquez1. 1Neuromuscular Studies Laboratory (NeSt Lab), CMA-BioBio, Faculty of Biological Sciences, Universidad de Concepción, Concepción; 2Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago; 3Department of Biochemistry and Molecular Biology, Universidad de Concepción, Concepción; 4CINV, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso; 5Instituto de Química, P. Universidad Católica de Valparaíso, Valparaíso; Chile. [email protected]

214. Neurobiological basis of the changes in the ecdysis behavior. Catalina Berrios1,2, John Ewer2.

1Doctorado en Ciencias Mención Neurociencia, Universidad de Valparaíso, Chile. 2Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaíso, Chile.

216. Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts. Patricio C.

Smith1, Claudia Metz2, Adely de la Peña2, Claudia Oyanadel2, Patricio Avila1, Rodrigo Arancibia1, Lucas Vicuña3, Claudio Retamal2, Alfonso González2 and Andrea Soza2. 1School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile. 2Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile. 3Departament of Statistics, Faculty of Mathematics, Pontificia Universidad Católica de Chile.

19:30 – 20:30 CLOSING PLENARY LECTURE “SOCIEDAD DE BIOLOGÍA CELULAR DE CHILE” Volcanes Room Chair: Juan Pablo Henriquez, SBCCH President

CIRCULAR URBAN METABOLISM: THE CITY AS LIVING ORGANISM. Claudia Pabón Pereira, Facultad de Ingenieria y Ciencias, EcoParque-Peñalolen, Universidad Adolfo Ibañez.

20:30 – 21:15 AWARDS CEREMONY Volcanes Room Nikon - Loncotec: Best Images in Cell Biology Genexpress: Best Presentations in Oral and Poster Communications 21:15 Dinner

abstract’s book chilean society for cell biology · 2019. 11. 21. · 2clínica indisa....

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