abp testing essentials - world anti-doping agency › sites › default › files › 39... · •...
TRANSCRIPT
ABP Testing EssentialsWADA ABP Symposium 2018
Matthew Fedoruk, PhD
www.usada.org
Educate - Where do I find information?
Guidelines
• ABP Guidelines 6.1
• Implementing an Effective Testing Program 1.0
Standards & Technical Documents
• International Standard for Testing & Investigations (ISTI) 2017
• ISTI Annex K - Collection, Storage and Transport of Blood ABP Samples
• Annex L – Results Management Requirements and Procedures for the Athlete Biological Passport
• Technical Document for Sport Specific Analysis (TDSSA) 3.1
• TDSSA FAQs – Supporting Document B
www.usada.org2
Testing Guides APMUs, Labs & ADOs
• Erythropoietic Stimulating Agents (ESAs)
• Growth Hormone (GH) & Growth Hormone Releasing Factors (GHRFs)
• Scientific, Technical & Practical Experience
• APMU reports
• Previous cases
• Peer-reviewed literature
Why the ABP?
www.usada.org3
The Passport can lead to an Anti-Doping Rule Violation by:
• Adverse Analytical Finding (AAF), Code Article 2.1: Improved target testing and flagging samples for analytical drug tests (e.g. EPO), leading to direct detection of prohibited substances
• Adverse Passport Finding (APF), Code Article 2.2: Identifying profiles requiring expert review. Experts must assess atypical profiles and determine if they are the result of normal physiological variation, a pathology, or a doping scenario
ToxicologicalForensic
Who to Test?
www.usada.org4
Sottas, 2018, Moving from Testing to Strategic Testing: The Athlete Biological Passport
Plan - Who to Test?
www.usada.org5
New Athlete
No Data
Established Athlete
Normal ABP
New or Established Athlete
Atypical ABP
ABP Program Inclusion - Risk Assessment
www.usada.org6
ABP Program Inclusion
Focus on Maximizing Detection & Deterrence
Intel
Performance
TDSSA
Testing - How many tests in enough?
www.usada.org7
Guiding Principles
• Gather meaningful data – right athlete, right test, right time– Dynamic risk assessment
– Test planning & ADO collaboration
• Use data gathered through the ABP effectively – interpretation & follow-up action– APMU & Expert reports
– Communication with intel & legal teams
– Communication between ADOs
– Action!
When and Where to Test? Athlete-Focused ABP
www.usada.org8
Example ABP Distribution – Annual Testing Strategy
Preparation
Competition
Recovery
www.usada.org9
1 1 1
• 3 tests per athlete per year; adjust based on APMU reports
Interpret - How many tests is enough? Testing Scenarios
www.usada.org10
Sottas, 2018, Moving from Testing to Strategic Testing: The Athlete Biological Passport
Holistic Approach Gathering Data - Sources of Information
In-house Information
• Biological (ABP) data & APMU guidance
• Testing histories & Frequency
• Doping Control Form data
• Doping Control Officer After Action Reports
• Whereabouts information & Updates
• Play Clean Tips
• Sanctioned athletes
• Competition results & rankings
• WADA investigations
• WADA-accredited Laboratories
• Prior cases
Information to Seek-Out
• Government investigations
• Government databases
• Relationships with law enforcement
• Civil cases
• Media reports
• Reporters
• Blogs/Websites
• Twitter and other social media
• Fellow competitors
• Coaches
• Event organizers
• Other trusted sources
11
Leverging Existing Data
www.usada.org12
1 2 3 4 5 6 7 8 9 1 0 1 1 1 2
0
5
1 0
1 5
2 0
% N
on
-Ne
ga
tiv
e o
f T
ota
l T
es
ts
IC
O O C
Cycling
months
Q: When should we test
target Cyclist A?
New Analytics-based Testing Strategies
www.usada.org13
1 2 3 4 5 6 7 8 9 1 0 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 2 1 2 2 2 3 2 4
0
5 0
1 0 0
Nu
mb
er o
f A
thle
tes A th le te s w ith T e s ts #
P o s itiv e o n T e s t #
Theory to Practice = Effective ABP
www.usada.org14
Plan
Test
Interpret
React
Educate
Thank you! [email protected]
www.usada.org