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éê��X©8� ªd�1. Tsuda H, Morita D, Kimura M, Shinto E, Ohtsuka Y, Matsubara O, Inazawa J, Tamaki K,

Mochizuki H, Tamai S, Hiraide H. Correlation of KIT and EGFR overexpression with invasive ductal carcinoma of solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation in breast cancer. Cancer Sci. 96(1):48-53, 2005.

2. Shinto E, Tsuda H, Ueno H, Hashiguchi Y, Hase K, Tamai S, Mochizuki H, Inazawa J, Matsubara O. Prognostic significance of laminin-5 gamma 2 chain expression in the invasive fronts of pT3 colorectal carcinomas disclosed by immunohistochemical survey of site-specific multipoint tissue microarray. Lab. Invest , 85(2): 257-266, 2005.

3. Tanimoto T, Tsuda T, Imazeki N, Ohno Y, Imoto I, Inazawa J, Matsubara O. Nuclear expression of c-IAP1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas. Cancer Lett. 224(1): 141-151, 2005.

4. Morita D, Tsuda H, Ichikura T, Kimura M, Aida S, Inazawa J, Kosuda S, Mochizuki H, Matsubara O. Analysis of sentinel node involvement in gastric cancer. Clin. Gastroenterol. Hepatol,, 5(9):1046-1052, 2007.

5. Yamamoto S, Tsuda H, Kita T, Maekawa K, Fujii K, Kudoh K, Furuya K, Tamai S, Inazawa J, Matsubara O. Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma. Virchows Arch., 451(1): 27-35, 2007.

6. Yamamoto S, Tsuda H, Honda K, Kita T, Takano M, Tamai S, Inazawa J, Yamada T, Matsubara O, Actinin-4 expression in ovarian cancer: a novel prognostic predictor independent of clinical stage and histological type. Mod. Pathol., in press

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ÒÓÔÕ�1. Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai

Y, Kondo T, Imoto I, Inazawa J, Hirohashi S: Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res. 2005, 11, 6177-6185.

2. Peng WX, Shibata T, Katoh H, Kokubu A, Matsuno Y, Asamura H, Tsuchiya R, Kanai Y, Hosoda F, Sakiyama T, Ohki M, Imoto I, Inazawa J, Hirohashi S: Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung. Cancer Sci. 2005, 96, 661-667.

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3. Katoh H, Shibata T, Kokubu A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, Hosoda F, Ohki M, Imoto I, Inazawa J, Hirohashi S: Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome. J Hepatol. 2005, 43, 863-874.

4. Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S: Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Cancer Sci. 2007, 98, 392-400.

5. Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T. Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.Gastroenterology. 133:1475-86,� 2007 �

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Y, Kondo T, Imoto I, Inazawa J, Hirohashi S: Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res. 2005, 11, 6177-6185.

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8. Katoh H, Shibata T, Kokubu A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, Hosoda F, Ohki M, Imoto I, Inazawa J, Hirohashi S: Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome. J Hepatol. 2005, 43, 863-874.

9. Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S: Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Cancer Sci. 2007, 98, 392-400.

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Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines. Int J Exp Pathol. 86:231-40,2005�

2. Ban S, Ishikawa K, Kawai S, Koyama-Saegusa K, Ishikawa A, Shimada Y, Inazawa J, Imai T: Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression. J Radiat Res (Tokyo) 46:43-50, 2005��

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1. Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. Oncogene (in press)

2. Tanaka E, Hashimoto Y, Ito T, Kondo K, Higashiyama M, Tsunoda S, Ortiz C, Sakai Y, Inazawa J, Shimada Y: The suppression of Aurora-A/STK15/BTAK expression enhances chemosensitivity to Docetaxel in human esophageal squamous cell carcinoma. Clin Cancer Res. 13:1331-40, 2007

3. Tanaka E, Hashimoto Y, Ito T, Okumura T, Kan T, Watanabe G, Imamura M, Inazawa J, Shimada Y: The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res 11:1827-34, 2005

4. Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Gray JW, Hirohashi S, Inazawa J: Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous-cell carcinoma. Cancer Res. 64:3741-7,2004

5. Imoto I, Yuki Y, Sonoda I, Ito T, Shimada Y, Imamura M, Inazawa J: Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. Cancer Res.63:5691-6,2003

6. Shimada Y, Maeda M, Watanabe G, Yamasaki S, Komoto I, Kagonoi J, Kan T, Hashimoto Y, Imoto I, Inazawa J: Cell culture in esophageal squamous cell carcinoma and the association with molecular markers. Clin Cancer Res 9:243-9,2003

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silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas. Oncogene (in press)

2. Misawa A, Inoue J, Sugino Y, Hosoi H, Sugimoto T, Hosoda F, Ohki M, Imoto I, Inazawa J: Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification. Cancer Res. 65:10233-42, 2005

3. Kuroda H, Moritake H, Sawada K, Kuwahara Y, Imoto I, Inazawa J, Sugimoto T: Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16. Cancer Genet Cytogenet 158:172-9, 2005

4. Misawa A, Hosoi H, Imoto I, Iehara T, Sugimoto T, Inazawa J: Translocation (1;22)(p36;q11.2) with concurrent del(22)(q11.2) resulted in homozygous deletion of SNF5/INI1 in a newly established cell line derived from extrarenal rhabdoid tumor. J Hum Genet 49:586-9,2004

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�Ö Fujita Y, Sakakura C, Shimomura K, Nakanishi M, Yasuoka R, Aragane H, Hagiwara A, Abe T, Inazawa J, Yamagishi H: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Hepatogastroenterology 50:1857-63,2003 �

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�Ö Hirasawa A, Aoki D, Inoue J, Imoto I, Susumu N, Sugano K, Nozawa S, Inazawa J: Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer. Clin Cancer Res.15:5675-82,2003 �

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Medina MT, Takeuchi T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey JN, Ochoa

A, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K: Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet 36:842-9,2004

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2. Suzuki T, Delgado-Escueta AV, Alonso ME, Morita R, Okamura N, Sugimoto Y, Bai D, Medina MT, Bailey JN, Rasmussen A, Ramos Peek J, Cordova S, Rubio-Donnadieu F, Ochoa A, Jara-Prado A, Inazawa J, Yamakawa K: Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy. Neurosci Lett. 405:126-31, 2006 �

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of hepatocellular carcinomas. J Hum Genet. 48:609-13,2003 2. Sanada T, Yokoi S, Arii S, Yasui K, Imoto I, Inazawa J: Skp2 overexpression is a

p27Kip1-independent poor prognosticator in patients with biliary tract cancers. Cancer Sci. 95:969-76, 2004

3. Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J: PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Hepatology 38:1242-9,2003

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Inazawa J. PRTFDC1, a possible tumor suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene (in press) �

2. Kozaki K, Imoto I, Pimkhaokham A, Hasegawa S, Tsuda H, Omura K, Inazawa J: PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sci. 97:1351-8,2006�

3. Nakagawa T, Pimkhaokham, A, Suzuki E, Omura K, Inazawa J, Imoto I: Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell

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1. Zhao C, Inoue J, Imoto I, Otsuki T, Iidab S, Ueda R, Inazawa J. POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17. Oncogene (in press)

2. Suzuki E, Imoto I, Pimkhaokham P, Nakagawa T, Kamata N, Kozaki Ken-ichi, Amagasa T, Inazawa J. PRTFDC1, a possible tumor suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene (in press)

3. Okamoto N, Kubota T, Nakamura Y, Murakami R, Nishikubo T, Tanaka I, Takahashi Y, Hayashi S, Imoto I, Inazawa J, Hosokai N, Kohsaka S, Uchino S.22q13 microduplication

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in two patients with common clinical manifestations: A recognizable syndrome?� Am J Med Genet A. 2007 Nov 1; [Epub ahead of print]

4. Arai A, Yan W, Wakabayashi S, Hayashi S, Inazawa J,Miura O. Successful Imatinib Treatment of Cardiac Involvement of FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia Followed by Severe Hepatotoxicity. Int J Hematol. 86:233-7,2007.

5. Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T. Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.Gastroenterology. 133:1475-86,�2007

6. Udaka T,Imoto I,Aizu Y,Torii C,Izumi K,Kosaki R,Takahashi T,Hayashi S, Inazawa J,Kosaki K. Multiplex PCR/Liquid Chromatography Assay for Screening of Subtelomeric Rearrangements.Genet Test.11:241-8, 2007

7. Yamamoto S,Tsuda H,Honda K,Kita T,Takano M,Tamai S,Inazawa J,Yamada T,Matsubara O. Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Mod Pathol. 20:1278-85, 2007 Sep 14.

8. Mitsui F,Dobashi Y,Imoto I,Inazawa J,Kono K,Fujii H,Ooi A. Non-incidental coamplification of Myc and ERBB2,and Myc and EGFR,in gastric adenocarcinomas. Modern Pathology 20,622-631,2007

9. Morita D, Tsuda H, Ichikura T, Kimura M, Aida S, Kosuda S, Inazawa J, Mochizuki H, Matsubara O. Analysis of Sentinel Node Involvement in Gastric Cancer.Clinical Gastroenterology And Hepatology.5;1046-1052, 2007

10. Amino T, Ishikawa K, Toru S, Ishiguro T, Sato N, Tsunemi T, Murata M, Kobayashi K, Inazawa J, Toda T, Mizusawa H.� Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia.� J Hum Genet.52:643-9,2007

11. Yamamoto S, Tsuda H, Kita T, Maekawa K, Fujii K, Kudoh K, Furuya K, Tamai S, Inazawa J, Matsubara O. Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma. Virchows Arch. 451:27-35,2007

12. Kawanishi H, Takahashi T, Ito M, Matsui Y, Watanabe J, Ito N, Kamoto T, Kadowaki T, Tsujimoto G, Imoto I, Inazawa J, Nishiyama H, Ogawa O. Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation. Br J Cancer 97:260-6,2007

13. Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S: Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Cancer Sci. 2007, 98, 392-400.

14. Tanaka E, Hashimoto Y, Ito T, Kondo K, Higashiyama M, Tsunoda S, Ortiz C, Sakai Y, Inazawa J, Shimada Y: The suppression of Aurora-A/STK15/BTAK expression enhances chemosensitivity to Docetaxel in human esophageal squamous cell carcinoma. Clin Cancer Res. 13:1331-40, 2007

15. Chiyonobu T, Hayashi S, Kobayashi K, Morimoto M, Miyanomae Y, Nishimura A, Nishimoto A, Ito C, Imoto I, Sugimoto T, Jia Z, Inazawa J, Toda T. Partial tandem duplication of GRIA3 in a male with mental retardation. Am J Med Genet A. 143:1448-5,2007

16. Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I. Connective Tissue Growth Factor is a putative conditional tumor-suppressor gene frequently inactivated by promoter hypermethylation in ovarian cancer. Cancer Res.67:7095-105,2007

17. Sugino Y, Misawa A, Inoue J, Kitagawa M, Hosoi H, Sugimoto T, Imoto I, Inazawa J. Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas. Oncogene 26:7401-7413,2007

18. Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. Oncogene 26:6456-68,2007

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19. Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J. Association of KLK5-overexpression with invasiveness of urinary bladder carcinoma cells.Cancer Sci.98:1078-86,2007

20. Kawasaki T, Yokoi S, Tsuda H, Izumi H, Kozaki K, Aida S, Ozeki Y, Yoshizawa Y, Imoto I, Inazawa J. BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line. Cancer Sci.98:1070-7,2007

21. Hayashi S, Ono M, Makita Y, Imoto I, Mizutani S, Inazawa J.Fortuitous Detection of a Submicroscopic Deletion at 1q25 in a Girl With Cornelia-de Lange Syndrome Carrying t(5;13)(p13.1;q12.1) by Array-based Comparative Genomic Hybridization. Am J Med Genet.143:1191-7,2007

22. Hayashi S, Honda S, Minaguchi M, Makita Y, Okamoto N, Kosaki R, Okuyama T, Imoto I, Mizutani S, Inazawa J. Construction of a High-density and High-resolution Human Chromosome X Array for Comparative Genomic Hybridization Analysis. J Hum Genet 52:397-405,2007

23. Tokutomi T, Hayashi S, Imai K, Chida A, Ishiwata T, Asano Y, Inazawa J, Nonoyama S. Dup(8p)/del(8q)Recombinant Chromosome in a Girl with Hepatic Focal Nodular Hyperplasia. Am J Med Gene.143:1334-7,2007

24. Honda S, Hayashi S, Kato M, Niida Y, Hayasaka K, Okuyama T, Imoto I, Mizutani S, Inazawa J. Clinical and molecular cytogenetic characterization od two patients with non-mutational aberrations of the FMR2 gene. Am J Med Genet 143: 687-93,2007

25. Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J. RGC32, a Novel p53-inducible Gene, is Located on Centrosomes during Mitosis and Result in G2/M Arrest. Oncogene 26: 1110-21, 2007

26. Kozaki K, Imoto I, Pimkhaokham A, Hasegawa S, Tsuda H, Omura K, Inazawa J. PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sci. 97:1351-8,2006

27. Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene 26:1178-87,2006

28. Takada H, Imoto I, Tsuda H, Nakanishi Y, Sakakura C, Mitsufuji S, Hirohashi S, Inazawa J. Genomic loss and epigenetic silencing of very low density lipoprotein receptor involved in gastric carcinogenesis. Oncogene 25:6554-62,2006

29. Suzuki T, Delgado-Escueta AV, Alonso ME, Morita R, Okamura N, Sugimoto Y, Bai D, Medina MT, Bailey JN, Rasmussen A, Ramos Peek J, Cordova S, Rubio-Donnadieu F, Ochoa A, Jara-Prado A, Inazawa J, Yamakawa K: Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy. Neurosci Lett. 405:126-31, 2006

30. Nakagawa T, Pimkhaokham, A, Suzuki E, Omura K, Inazawa J, Imoto I: Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma. Cancer Sci. 97:1070-4, 2006

31. Imoto I, Izumi H, Yokoi S, Hosoda H, Shibata T, Hosoda F, Ohki M, Hirohashi S, Inazawa J: Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers. Cancer Res. 66:4617-26, 2006

32. Kumada K, Yao R, Kawaguchi T, Karasawa M, Hoshikawa Y, Ichikawa K, Sugitani Y, Imoto I, Inazawa J, Sugawara M, Yanagida M, Noda T: The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol. 172:835-46, 2006

33. Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N: Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann Neurol. 59:298-309, 2006

34. Nakada S, Katsuki Y, Imoto I, Yokoyama T, Nagasawa M, Inazawa J, Mizutani S: Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations. J Clin Invest. 116:80-9, 2006

35. Takada H, Imoto I, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Mitsufuji S, Hosoda F, Hirohashi S, Ohki M, Inazawa J: ADAM23, a possible tumor suppressor gene, is frequently

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silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. Oncogene 24:8051-60, 2005

36. Misawa A, Inoue J, Sugino Y, Hosoi H, Sugimoto T, Hosoda F, Ohki M, Imoto I, Inazawa J: Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification. Cancer Res. 65:10233-42, 2005

37. Saigusa K. Hashimoto N, Tsuda H, Yokoi S, Maruno M, Yoshimine T, Aoyagi M, Ohno K, Imoto I, Inazawa J: Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas. Cancer Sci. 96:676-83,2005

38. Hayashi S, Kurosawa K, Imoto I, Mizutani S, Inazawa J: Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9)(p34.2;p24) by array-based comparative genomic hybridization. Am J Med Genet A. 139:32-6, 2005

39. Tanami H, Tsuda H, Okabe S, Iwai T, Sugihara K, Imoto I, Inazawa J: Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis. Lab Invest. 85:1118-29,2005

40. Tanaka E, Hashimoto Y, Ito T, Okumura T, Kan T, Watanabe G, Imamura M, Inazawa J, Shimada Y: The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res 11:1827-34, 2005

41. Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hirohashi S, Inazawa J, Imoto I. Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Hum Molec Genet 14:997-1007, 2005

42. Takada H, Imoto I, Tsuda H, Sonoda I, Ichikura T, Mochizuki H, Okanoue T, Inazawa J. Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization. Cancer Sci 96:100-10, 2005

43. Peng WX, Shibata T, Katoh H, Kokubu A, Matsuno Y, Asamura H, Tsuchiya R, Kanai Y, Hosoda F, Sakiyama T, Ohki M, Imoto I, Inazawa J, Hirohashi S. Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung. Cancer Sci.96:661-7,2005

44. Katoh H, Shibata T, Kokubo A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, Hosoda F, Ohki M, Imoto I, Inazawa J, Hirohashi S. Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: Identification of genetic indicators to predict patient outcome. J Hepatol. 43:863-74, 2005

45. Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai Y, Kondo T, Imoto I, Inazawa J, Hirohashi S: Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res. 11:6177-85,2005

46. Ban S, Michikawa Y, Ishikawa K, Sagara M, Watanabe K, Shimada Y, Inazawa J, Imai T: Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines. Int J Exp Pathol. 86:231-40,2005

47. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology 128:1851-67,2005

48. Tanimoto T, Tsuda H, Imazeki N, Ohno Y, Imoto I, Inazawa J, Matsubara O: Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas. Cancer Lett 224:141-51, 2005

49. Ban S, Ishikawa K, Kawai S, Koyama-Saegusa K, Ishikawa A, Shimada Y, Inazawa J, Imai T: Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression. J Radiat Res (Tokyo) 46:43-50, 2005

50. Kuroda H, Moritake H, Sawada K, Kuwahara Y, Imoto I, Inazawa J, Sugimoto T: Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16. Cancer Genet Cytogenet 158:172-9, 2005

51. Susumu N, Aoki D, Noda T, Nagashima Y, Hirao T, Tamada Y, Banno K, Suzuki A, Tsuda H, Inazawa J, Nozawa S: Diagnostic clinical application of two-color fluorescence in situ

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hybridization that detects chromosome 1 and 17 alterations to direct touch smear and liquid-based thin-layer cytologic preparations of endometrial cancers. Int J Gynecol Cancer 15:70-80,2005

52. Tsuda H, Morita D, Kimura M, Shinto E, Ohtsuka Y, Matsubara O, Inazawa J, Takami K, Mochizuki H, Tamai S, Hiraide H: Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation. Cancer Sci 96:48-53,2005

53. Shinto E, Tsuda H, Ueno H, Hashiguchi Y, Hase K, Tamai S, Mochizuki H, Inazawa J, Matsubara O: Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays. Laboratory Invest 85:257-66,2005

54. Sanada T, Yokoi S, Arii S, Yasui K, Imoto I, Inazawa J: Skp2 overexpression is a p27Kip1-independent poor prognosticator in patients with biliary tract cancers. Cancer Sci. 95:969-76, 2004

55. Tanami H, Imoto I, Hirasawa A, Yuki Y, Sonoda I, Inoue J, Yasui K, Misawa-Furihata A, Kawakami Y, Inazawa J: Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene 23:8796-804,2004

56. Misawa A, Hosoi H, Imoto I, Iehara T, Sugimoto T, Inazawa J: Translocation (1;22)(p36;q11.2) with concurrent del(22)(q11.2) resulted in homozygous deletion of SNF5/INI1 in a newly established cell line derived from extrarenal rhabdoid tumor. J Hum Genet 49:586-9,2004

57. Inazawa J, Inoue J, Imoto I: Comparative genomic hybridization (CGH) arrays pave the way for identification of novel cancer-related genes. Cancer Sci. 95:559-63, 2004

58. Yokoi S, Yasui K, Mori M, Iizasa T, Fujisawa T, Inazawa J: Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes. Am J Pathol. 165:175-80, 2004

59. Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J: Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma. Am J Pathol. 165:71-81,2004

60. Yuki Y, Imoto I, Imaizumi M, Hibi S, Kaneko Y, Amagasa T, Inazawa J: Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).Cancer Sci. 95:503-7,2004

61. Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Gray JW, Hirohashi S, Inazawa J: Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous-cell carcinoma. Cancer Res. 64:3741-7,2004

62. Yasui K, Mihara S, Zhao C, Okamoto H, Saito-Ohara F, Tomida A, Funato T, Yokomizo A, Naito S, Imoto I, Tsuruo T, Inazawa J: Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 64:1403-10,2004

63. Suzuki T, Delgado-Escueta AV, Aguan K, Alonso ME, Shi J, Hara Y, Nishida M, Numata T, Medina MT, Takeuchi

T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey JN, Ochoa

A, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K: Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet 36:842-9,2004

64. Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M: The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet. 74:1255-61,2004

65. Sato H, Saito-Ohara F, Inazawa J, Kudo A: Pax-5 is essential for kappa sterile transcription during Ig kappa chain gene rearrangement. J Immunol. 172:4858-65,2004

66. Hirasawa A, Aoki D, Inoue J, Imoto I, Susumu N, Sugano K, Nozawa S, Inazawa J: Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer. Clin Cancer Res.15:5675-82,2003

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67. Yokoi S, Yasui K, Iizasa T, Imoto I, Fujisawa T, Inazawa J: TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers. Clin Cancer Res.15:4705-13,2003

68. Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J: PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas. Hepatology 38:1242-9,2003

69. Imoto I, Yuki Y, Sonoda I, Ito T, Shimada Y, Imamura M, Inazawa J: Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. Cancer Res.63:5691-6,2003

70. Zhao C, Yasui K, Lee CJ, Kurioka H, Hosokawa Y, Oka T, Inazawa J: Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Cancer 98:18-23,2003

71. Yokoi S, Yasui K, Iizasa T, Takahashi T, Fujisawa T, Inazawa J: Down-regulation of SKP2 induces apoptosis in lung-cancer cells. Cancer Sci.94:344-9,2003

72. Hirasawa A, Saito-Ohara F, Inoue J, Aoki D, Susumu N, Yokoyama T, Nozawa S, Inazawa J, Imoto I: Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets. Clin Cancer Res 9:1995-2004,2003

73. Yu W, Inoue J, Imoto I, Matsuo Y, Karpas A, Inazawa J: GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. J Hum Genet 48:331-5,2003

74. Yasui K, Okamoto H, Arii S, Inazawa J: Association of over-expressed TFDP1 with progression of hepatocellular carcinomas. J Hum Genet. 48:609-13,2003

75. Saito-Ohara F, Imoto I, Inoue J, Hosoi H, Nakagawara A, Sugimoto T, Inazawa J: PPM1D is a potential target for 17q gain in neuroblastoma. Cancer Res 63:1876-83,2003

76. Fujita Y, Sakakura C, Shimomura K, Nakanishi M, Yasuoka R, Aragane H, Hagiwara A, Abe T, Inazawa J, Yamagishi H: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Hepatogastroenterology 50:1857-63,2003

77. Hashimoto N, Murakami M, Takahashi Y, Fujimoto M, Inazawa J, Mineura K: Correlation between genetic alteration and long-term clinical outcome of patients with oligodendroglial tumors, with identification of a consistent region of deletion on chromosome arm 1p.Cancer 97:2254-61,2003

78. Murakami M, Hashimoto N, Takahashi Y, Hosokawa Y, Inazawa J, Minneura K: A consistent region of deletion on 1p36 in meningiomas: identification and relation to malignant progression. Cancer Genet Cytogenet 140:99-106,2003

79. Li M, Ishikawa K, Toru S, Tomimitsu H, Takashima M, Goto J, Takiyama Y, Sasaki H, Imoto I, Inazawa J, Toda T, Kanazawa I, Mizusawa H: Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan. J Hum Genet 48:111-8,2003

80. Shimada Y, Maeda M, Watanabe G, Yamasaki S, Komoto I, Kagonoi J, Kan T, Hashimoto Y, Imoto I, Inazawa J: Cell culture in esophageal squamous cell carcinoma and the association with molecular markers. Clin Cancer Res 9:243-9,2003

81. Watanabe T, Imoto I, Katahira T, Hirasawa A, Ishiwata I, Emi M, Takayama M, Sato A, Inazawa J: Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers. Jpn J Cancer Res 93:1114-22,2002

82. Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S, Inazawa J: Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res 62:4860-6,2002

83. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M: Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med 8:1011-7,2002

84. Saito-Ohara F, Fukuda Y, Ito M, Agarwala KL, Hayashi M, Matsuo M, Imoto I, Yamakawa K, Nakamura Y, Inazawa J: The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase

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gene in a patient with Duchenne muscular dystrophy and profound mental retardation. Am J Hum Genet 71:637-45,2002

85. Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J: A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Am J Pathol 161:207-16,2002

86. Yasui K, Arii S, Zhao C, Imoto I, Ueda M, Nagai H, Emi M, Inazawa J: TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology 35:1476-84,2002

87. Nakakuki K, Imoto I, Pimkhaokham A, Fukuda Y, Shimada Y, Imamura M, Amagasa T, Inazawa J: Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas. Carcinogenesis 23:19-24,2002

88. Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T: cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope. Gene 296:29-36,2002

89. Suzuki T, Morita R, Sugimoto Y, Sugawara T, Bai DS, Alonso ME, Medina MT, Bailey JN, Rasmuseen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Ochoa A, Jara-Prado A, Inazawa J, Delgado-Escuta AV, Yamakawa K: Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5.Epilepsy Res 50:265-75,2002

90. Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T: Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene. J Biochem Mol Biol Biophys 6:113-7,2002

91. Janssen JW, Imoto I, Inoue J, Shimada Y, Ueda M, Imamura M, Bartram CR, Inazawa J: MYEOV, a gene, at 11q13, is coamplified with CCND1, but epigenetically inactivatated in subset of esophageal squamous cell carcinomas. J Hum Genet 47:460-4,2002

92. Chano T, Ikegawa S, Saito-Ohara F, Inazawa J, Mabuchi A, Saeki Y, Okabe H: Isolation, characterization and mapping of the mouse and human RB1CC1 genes.Gene291:29-34,2002

93. Hashimoto Y, Zhang C, Kawauchi J, Imoto I, Adachi MT, Inazawa J, Amagasa T, Hai T, Kitajima S: An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res30:2398-406,2002

94. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y: Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109:113-24,2002

Ë�Ö Yamamoto S, Oka S, Saito-Ohara F, Inazawa J, Kawasaki T: Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitope. J Biochem (Tokyo) 131:337-47,2002�

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3. Imoto I, Hayashi S, Honda S, Inazawa J: Array-CGH detecting Human Genome Variation in Japan. The 8th International Meeting on Human Genome Variation and Complex Genome Analysis(Hong Kong, China) 15/September/2006(14-16/September/2006)

4. Imoto I, Inazawa J: Identification of novel gastrointestinal cancer-related genes through bacterial artificial chromosome (BAC)-array based analyses of cancer genome. The 10th Japan-Korea Cancer Research Workshop(Tokyo)17/December/2005

5. Inazawa J: Exploring of cancer-specific genome alterations by using high-density CGH-microarray and identification of novel cancer-related genes. The 13th Takeda Science Foundation Symposium on Bioscience Genome Analysis and Medicine (Tokyo, Japan) 6/December/2004

6. Inazawa J: Exploring of cancer-specific genome alterations by using high-density CGH-microarray and identification of novel cancer-related genes. The 7th Cardiovascular Genomics Symposium (Seoul, Korea) 12/November/2004

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8. Inazawa J: Exploring cancer related genes using array-based comparative genomic hybridization (CGH). Departmental Seminar of Oncology Research Institute of Singapore National University (Singapore) 3/March/2004

9. Inazawa J: Exploring cancer-related genes in neoplastic tumors using a comparative genomic hybridization array. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association (Hawaii, USA) 25-29/January/2004

10. Inazawa J: Exploring cancer-related genes by molecular cytogenetic approach. An International Symposium to Celebrate the 30 Anniversary of Medical Research Institute of Tokyo Medical and Dental University and Establishment of School of Biomedical Science (Tokyo, Japan) 29/November/2003

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> â�7Q� � � X~)6^� 112 �a~´6^� 29 �d [~´7QtÇT/\ 1. Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I:

TSOVC2 is a putative conditional tumor-suppressor gene frequently inactivated by promoter hypermethylation in ovarian cancer. 98th annual meeting of American Association for Cancer Research 2007. (LosAngeles,USA)15/April/2007 (14-18/April/ 2007)

2. Imoto I, Saigusa K, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J: RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA)16/April/2007(14-18/April/2007)

3. Nakamura E,Suzuki E, Nakagawa T, Tsuda H,Yamamoto G, Kozaki K, Irie T, Tachikawa T, Amagasa T, Imoto I, Inazawa J: Epigenetic silencing of TSOC25 by hypermethylation of the CpG island in oral cancer. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA)16/April/2007(14-18/April/2007)

4. Kozaki K, Imoto I, Inazawa J: MicoroRNA expression profiles in oral squamous cell carcinoma cell lines. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA) 17/ April/ 2007(14-18/April/2007)

5. Ishihara T, Yu W, Inoue J, Onda M, Emi M, Imoto I, Inazawa J: A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA)18/April/2007(14-18/April2007)

6. Hayashi S, Honda S, Imoto I, Inazawa J: Exploring cryptic genomic aberrations responsible for multiple congenital anomaly with mental retardation using in-house CGH-arrays. 56th Annual Meeting of the American Society of Human Genetics (New Orleans, Louisiana) 10/October/2006 (9-13/October/2006)

7. Chiyonobu T, Hayashi S, Morimoto M, Miyanomae Y, Nishimura A, Nishimoto A, Ito C, Imoto I, Sugimoto T, Jia Z, Inazawa J, Toda T: Partial tandem duplication of GRIA3 in a male with mental retardation. 56th Annual Meeting of the American Society of Human Genetics (New Orleans, Louisiana) 12/October/2006 (9-13/October/2006)

8. Nakagawa T, Yokoi S, Inoue J, Atiphan Pimkhaokham, Suzuki E, Kamata N, Omura K, Imoto I, Inazawa J: Detection of altered DNA methylation patterns in oral cancer. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

9. Inoue J, Misawa A, Sugino Y, Hosoi H, Sugimoto T, Hosoda F, Ohki M, Imoto I, Inazawa J: Methylation-associated silencing of NR1I2 in advanced-type neuroblastomas, identified by BAC array-based methylated CpG island amplification (BAMCA). 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

10. Imoto I, Izumi H, Takada H, Tanaka K, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hosoda F, Ohki M, Hirohashi S, Inazawa J: Frequent Silencing of the Candidate

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Tumor-suppressor PCDH20 by Epigenetic Mechanism in Non-Small Cell Lung Cancers. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

11. Sugino Y, Inoue J, Misawa A, Hosoi H, Sugimoto T, Imoto I, Inazawa J: Methylation-associated gene silencing of prostaglandin D2 receptor (PTGDR) and prostaglandin E receptor 2 (PTGER2) in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA). 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

12. Yokoi S, Inoue J, Imoto I, Inazawa J: Identification of novel E2F1 target genes detected on a BAC-array platform. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

13. Tanaka K, Imoto I, Inoue J, Tsuda H, Suzuki E, Shimada Y, Kawano T, Iwai T, Inazawa J: Methylation-associated silencing of a candidate tumor suppression gene, TSEC1, in esophageal squamous-cell carcinoma, identified by bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA). 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

14. Kozaki K, Suzuki E, Pimkhaokham A, Imoto I, Inazawa J: PIK3CA mutations in oral squamous cell carcinoma. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 4/April/2006 (1-5/April/2006)

15. Takada T, Tanaka K, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hosoda F, Ohki M, Hirohashi S, Inazawa J: Frequent silencing of the candidate tumor-suppressor PCDH20 by epigenetic mechanism in non-small cell lung cancers. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 4/April/2006 (1-5/April/2006)

16. Shibata T, Kokubu A, Hosoda F, Matsuno Y, Tsuchiya R, Kanai Y, Inazawa J, Hirohashi S: Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 4/April/2006 (1-5/April/2006)

17. Imoto I, Takada H, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Hosoda F, Hirohashi S, Ohki M, Inazawa J: ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. The American Society of Human Genetics 55th Annual Meeting (Salt Lake City, Utah) 28/October/2005 (25-29/October/2005)

18. Hayahi S, Imoto I, Inazawa J: Result of exploring pathogenesis of congenital disorders using array-CGH. The American Society of Human Genetics 55th Annual Meeting (Salt Lake City, Utah) 28/October/2005 (25-29/October/2005)

19. Inoue J, Misawa-Furihata A, Hosoi H, Sugimoto T, Imoto I, Inazawa J: High-throughput screening of methylated DNA sequences at 1p35-p36 in neuroblastoma by using BAC array-based MCA method(BAMCA). 95th American Association for Cancer Research (Anaheim, CA) 19/April/2005

20. Yokoi S, Inoue J, Imoto I, Inazawa J: Establishment of “ChIP on chip” exploring of novel E2F1 target genes on a BAC-array platform. 95th American Association for Cancer Research (Anaheim, CA) 19/April/2005

21. Imoto I, Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hirohashi S, Inazawa J: Frequent Silencing of DBC1 is by Genetic or Epigenetic Mechanisms in Non-Small Cell Lung Cancers. 95th American Association for Cancer Research (Anaheim, CA) 18/April/2005

22. Takada H, Imoto I, Tsuda H, Shibata T, Okanoue T, Hosoda F, Hirohashi S, Ohki M, Inazawa J: Epigenetic silencing of MCG22 by hypermethylation of the CpG island in gastric cancer. 95th American Association for Cancer Research (Anaheim, CA) 17/April/2005

23. Saigusa K, Imoto I, Inoue J, Aoyagi M, Ohno O, Inazawa J: Characterization of TSGL1, a candidate tumor suppressor gene for glioma frequently silenced by CpG island methylation, identified from 13q deletion lesion detected CGH-array analysis. 95th American Association for Cancer Research (Anaheim, CA) 17/April/2005

24. Imoto I, Yuki Y, Sonoda I, Ito T, Shimada Y, Imamura M, Inazawa J: Identification of ZASC1 Encoding a Krüppel-like Zinc Finger Protein as a Novel Target for 3q26 Amplification in Esophageal Squamous-Cell Carcinomas. 6th Joint Conference of the American Association for

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Cancer Research and the Japanese Cancer Association (Waikoloa, Hawaii) 25-29/January/2004 25. Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J:

Amplification and Consequent Overexpression of PDZK1 within the 1q12-q22 Amplicon is Associated with Drug-resistance Phenotype in Multiple Myeloma. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association (Waikoloa, Hawaii) 25-29/January/2004

26. Imoto I, Tanami H, Harasawa A, Yuki Y, Sonoda I, Inoue J, Yasui K, Misawa-Furihata A, Kawakami Y, Inazawa J: Possible Involvement of Overexpressed Wild-type BRAF in the Growth of Malignant Melanoma Cell Lines. 95th American Association for Cancer Research (Orlando, Florida) 27-31/March/2004

27. Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Joe W Grey, Hirohashi S, Inazawa J: Identification of Homozygous Deletion and Candidate Tumor-Suppressor Gene in Esophageal Cancer Cell using CGH-array. 95th American Association for Cancer Research (Orlando, Florida) 27-31/March/2004

28. Tanami H, Imoto I, Sonoda I, Sugihara K, Inazawa J: Genome-wide copy number analysis for genetic alterations involved in liver metastasis of the colon. 95th American Association for Cancer Research (Orlando, Florida) 27-31/March/2004

29. Yokoi S, Yasui K, Mori M, Iizasa T, Fujisawa T, Inazawa J: Gene amplification and over-expression of SKP2 are associated with lymph node metastasis in non-small cell lung cancers. 95th American Association for Cancer Research (Orlando, Florida) 29/March/2004

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1. Hayashi S, Honda S, Imoto I, Inazawa I. Exploring cryptic genomic aberrations related to multiple congenital anomaly with mental retardation using in-house CGH-arrays. The American Society of Human Genetics 57th annual meeting (San Diego, CA) 25/October /2007 (23-27/October/2007).

2. Honda S, Hayashi S, Imoto I, Nakagawa E, Goto Y, Inazawa J:Exploration of genes related to X-linked mental retardation (XLMR) by MCGX-tiling array.57th Annual Meeting of the American Society of Human Genetics (San Diego, CA) 24/October/2007 (23-27/October/ 2007)

3. Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I: TSOVC2 is a putative conditional tumor-suppressor gene frequently inactivated by promoter hypermethylation in ovarian cancer. 98th annual meeting of American Association for Cancer Research 2007. (LosAngeles,USA)15/April/2007 (14-18/April/ 2007)

4. Nakamura E,Suzuki E, Nakagawa T, Tsuda H,Yamamoto G, Kozaki K, Irie T, Tachikawa T, Amagasa T, Imoto I, Inazawa J: Epigenetic silencing of TSOC25 by hypermethylation of the CpG island in oral cancer. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA)16/April/2007(14-18/April/2007)

5. Kozaki K, Imoto I, Inazawa J: MicoroRNA expression profiles in oral squamous cell carcinoma cell lines. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA) 17/ April/ 2007(14-18/April/2007)

6. Ishihara T, Yu W, Inoue J, Onda M, Emi M, Imoto I, Inazawa J: A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. 98th annual meeting of American Association for Cancer Research 2007( LosAngeles, USA)18/April/2007(14-18/April2007)

7. Hayashi S, Honda S, Imoto I, Inazawa J: Exploring cryptic genomic aberrations responsible for multiple congenital anomaly with mental retardation using in-house CGH-arrays. 56th Annual Meeting of the American Society of Human Genetics (New Orleans, Louisiana) 10/October/2006 (9-13/October/2006)

8. Chiyonobu T, Hayashi S, Morimoto M, Miyanomae Y, Nishimura A, Nishimoto A, Ito C, Imoto I, Sugimoto T, Jia Z, Inazawa J, Toda T: Partial tandem duplication of GRIA3 in a male with mental retardation. 56th Annual Meeting of the American Society of Human Genetics (New Orleans, Louisiana) 12/October/2006 (9-13/October/2006)

9. Nakagawa T, Yokoi S, Inoue J, Atiphan Pimkhaokham, Suzuki E, Kamata N, Omura K, Imoto I, Inazawa J: Detection of altered DNA methylation patterns in oral cancer. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

10. Inoue J, Misawa A, Sugino Y, Hosoi H, Sugimoto T, Hosoda F, Ohki M, Imoto I, Inazawa J: Methylation-associated silencing of NR1I2 in advanced-type neuroblastomas, identified by BAC array-based methylated CpG island amplification (BAMCA). 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

11. Imoto I, Izumi H, Takada H, Tanaka K, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hosoda F, Ohki M, Hirohashi S, Inazawa J: Frequent Silencing of the Candidate Tumor-suppressor PCDH20 by Epigenetic Mechanism in Non-Small Cell Lung Cancers. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C.

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USA) 2/April/2006 (1-5/April/2006) 12. Sugino Y, Inoue J, Misawa A, Hosoi H, Sugimoto T, Imoto I, Inazawa J:

Methylation-associated gene silencing of prostaglandin D2 receptor (PTGDR) and prostaglandin E receptor 2 (PTGER2) in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA). 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

13. Yokoi S, Inoue J, Imoto I, Inazawa J: Identification of novel E2F1 target genes detected on a BAC-array platform. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

14. Tanaka K, Imoto I, Inoue J, Tsuda H, Suzuki E, Shimada Y, Kawano T, Iwai T, Inazawa J: Methylation-associated silencing of a candidate tumor suppression gene, TSEC1, in esophageal squamous-cell carcinoma, identified by bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA). 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 2/April/2006 (1-5/April/2006)

15. Kozaki K, Suzuki E, Pimkhaokham A, Imoto I, Inazawa J: PIK3CA mutations in oral squamous cell carcinoma. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 4/April/2006 (1-5/April/2006)

16. Takada T, Tanaka K, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hosoda F, Ohki M, Hirohashi S, Inazawa J: Frequent silencing of the candidate tumor-suppressor PCDH20 by epigenetic mechanism in non-small cell lung cancers. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 4/April/2006 (1-5/April/2006)

17. Shibata T, Kokubu A, Hosoda F, Matsuno Y, Tsuchiya R, Kanai Y, Inazawa J, Hirohashi S: Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis. 97th annual meeting of American Association for Cancer Research 2006 (Washington D.C. USA) 4/April/2006 (1-5/April/2006)

18. Imoto I, Takada H, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Hosoda F, Hirohashi S, Ohki M, Inazawa J: ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. The American Society of Human Genetics 55th Annual Meeting (Salt Lake City, Utah) 28/October/2005 (25-29/October/2005)

19. Hayashi S, Imoto I, Inazawa J: Result of exploring pathogenesis of congenital disorders using array-CGH. The American Society of Human Genetics 55th Annual Meeting (Salt Lake City, Utah) 28/October/2005 (25-29/October/2005)

20. Inoue J, Misawa-Furihata A, Hosoi H, Sugimoto T, Imoto I, Inazawa J: High-throughput screening of methylated DNA sequences at 1p35-p36 in neuroblastoma by using BAC array-based MCA method(BAMCA). 95th American Association for Cancer Research (Anaheim, CA) 19/April/2005

21. Yokoi S, Inoue J, Imoto I, Inazawa J: Establishment of “ChIP on chip” exploring of novel E2F1 target genes on a BAC-array platform. 95th American Association for Cancer Research (Anaheim, CA) 19/April/2005

22. Imoto I, Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hirohashi S, Inazawa J: Frequent Silencing of DBC1 is by Genetic or Epigenetic Mechanisms in Non-Small Cell Lung Cancers. 95th American Association for Cancer Research (Anaheim, CA) 18/April/2005

23. Takada H, Imoto I, Tsuda H, Shibata T, Okanoue T, Hosoda F, Hirohashi S, Ohki M, Inazawa J: Epigenetic silencing of MCG22 by hypermethylation of the CpG island in gastric cancer. 95th American Association for Cancer Research (Anaheim, CA) 17/April/2005

24. Saigusa K, Imoto I, Inoue J, Aoyagi M, Ohno O, Inazawa J: Characterization of TSGL1, a candidate tumor suppressor gene for glioma frequently silenced by CpG island methylation,

Page 67: @A&BC - JST · ˇ$(ef“fi 012"#$34ˇ5+,678 ˘ˇˆ˙˝{J›!9:;?xlÙ{–å8 fl˛6º çł34ˇ+,{|r B A " B Ž A 7'îD+,56 7˛6º ˘ ›4 ˛(•! 3g 34ˇ+,567˛6º

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identified from 13q deletion lesion detected CGH-array analysis. 95th American Association for Cancer Research (Anaheim, CA) 17/April/2005

25. Imoto I, Yuki Y, Sonoda I, Ito T, Shimada Y, Imamura M, Inazawa J: Identification of ZASC1 Encoding a Krüppel-like Zinc Finger Protein as a Novel Target for 3q26 Amplification in Esophageal Squamous-Cell Carcinomas. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association (Waikoloa, Hawaii) 25-29/January/2004

26. Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J: Amplification and Consequent Overexpression of PDZK1 within the 1q12-q22 Amplicon is Associated with Drug-resistance Phenotype in Multiple Myeloma. 6th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association (Waikoloa, Hawaii) 25-29/January/2004

27. Imoto I, Tanami H, Harasawa A, Yuki Y, Sonoda I, Inoue J, Yasui K, Misawa-Furihata A, Kawakami Y, Inazawa J: Possible Involvement of Overexpressed Wild-type BRAF in the Growth of Malignant Melanoma Cell Lines. 95th American Association for Cancer Research (Orlando, Florida) 27-31/March/2004

28. Sonoda I, Imoto I, Inoue J, Shibata T, Shimada Y, Chin K, Imamura M, Amagasa T, Joe W Grey, Hirohashi S, Inazawa J: Identification of Homozygous Deletion and Candidate Tumor-Suppressor Gene in Esophageal Cancer Cell using CGH-array. 95th American Association for Cancer Research (Orlando, Florida) 27-31/March/2004

29. Tanami H, Imoto I, Sonoda I, Sugihara K, Inazawa J: Genome-wide copy number analysis for genetic alterations involved in liver metastasis of the colon. 95th American Association for Cancer Research (Orlando, Florida) 27-31/March/2004

30. Yokoi S, Yasui K, Mori M, Iizasa T, Fujisawa T, Inazawa J: Gene amplification and over-expression of SKP2 are associated with lymph node metastasis in non-small cell lung cancers. 95th American Association for Cancer Research (Orlando, Florida) 29/March/2004

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