a2e agenda:
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A2E Agenda:. Enzyme Function Worksheet/Activity (In IB 3406) Brief Aquaporin Structure and Function Overview Lab Presentations Group Discussion of Aquaporin Readings Aquaporin Revisited. - PowerPoint PPT PresentationTRANSCRIPT
A2E Agenda:A2E Agenda:• Enzyme Function Worksheet/Activity (In IB 3406)• Brief Aquaporin Structure and Function Overview• Lab Presentations• Group Discussion of Aquaporin Readings• Aquaporin Revisited
Reminder: Bring a food sample tomorrow (soy, papaya, or corn are best) if you’d like
to test it tomorrow!
Comparing Your ModelsComparing Your Models
Comparing Comparing Your ModelsYour Models
Biological Functions of Biological Functions of Aquaporins:Aquaporins:
What do your
kidneys do?!?
Some Biological Functions Some Biological Functions of Aquaporinsof Aquaporins
Mammals have two Mammals have two kidneys, each supplied kidneys, each supplied
with LOTS of blood with LOTS of blood flow; as a result, all flow; as a result, all
blood is filtered blood is filtered ~every 30 minutes~every 30 minutes
Our kidneys can excrete Our kidneys can excrete urine 4X as urine 4X as
concentrated (1,200 concentrated (1,200 mosm/L) as our blood!mosm/L) as our blood! Image: The Biology Project
Functional Unit = the Functional Unit = the Nephron (single Nephron (single
long tubule with a long tubule with a ball of capillariesball of capillaries
Kidneys are Kidneys are compacted bundles compacted bundles of nephrons (~1.3 of nephrons (~1.3
million) all draining, million) all draining, eventually, into the eventually, into the
ureterureterImage: The Biology Project
Some Biological Functions Some Biological Functions of Aquaporinsof Aquaporins
What does Antidiuretic What does Antidiuretic Hormone (ADH) do?Hormone (ADH) do?
Note that Antidiuretic Hormone (ADH) is also known as vasopressin.
So should the cells lining the collecting ducts in your kidneys become more or less
permeable to water in response to ADH? How might they control this
permeability?
Revisiting Revisiting Aquaporin:Aquaporin: Use your understanding of protein Use your understanding of protein structure to construct a model structure to construct a model (drawing) of what a water channel in a (drawing) of what a water channel in a cell membrane would look like, and cell membrane would look like, and how it would orient itself in a plasma how it would orient itself in a plasma membrane. membrane.
Structure Structure of of
PhenylalaPhenylalanine and nine and
TryptophaTryptophann
GlycerolGlycerol