DEAR COLLEAGUE,It is with great pleasure and enthusiasm that we invite you to attend the 9th Annual Perspectives in Colorectal Cancer.

We are certain you will value the unique approach of this meeting in its coverage of a broad range of topics dealing with colorectal cancer. From genetics to the management of advanced disease, from screening to surgery and supportive care, from the optimal use of standard therapies to expert perspectives on emerging agents, the full spectrum of clinical management will be addressed. Our ultimate goal is to provide you with the information needed to optimize care of your colorectal cancer patients and to direct your attention to those trends and evolutions that may affect your practice in the future.

Again this year we will be examining and discussing challenging cases submitted by clinical oncology fellows. We received many positive comments last year about the fresh approach and valuable information these presentations provide to attendees. We encourage fellows to submit their cases for consideration by the July 11th deadline.

We are sure you will fi nd this meeting to be informative and enjoyable. We look forward to welcoming you in Miami again this September!

Sincerely,

Richard M. Goldberg, MD

Mace L. Rothenberg, MD

September 19-20, 2008 Miami, FloridaInterContinental Miami

9th

September 19-20, 2008 Miami, FloridaInterContinental Miami

9th

Timothy J. Akhurst, MDMemorial Sloan-Kettering Cancer CenterNew York, New York

Nancy N. Baxter, MD, PhD, FRCSCUniversity of TorontoSt. Michael’s HospitalToronto, Ontario, Canada

Francis M. Giardiello, MDJohns Hopkins UniversityBaltimore, Maryland

Richard M. Goldberg, MDThe University of North Carolina at Chapel HillChapel Hill, North Carolina

Catherine Handy, PhD, RN, AOCNSt. Vincent’s Comprehensive Cancer CenterNew York, New York

Mario Lacouture, MDNorthwestern UniversityChicago, Illinois

Henry T. Lynch, MDCreighton University School of Medicine

Omaha, Nebraska

Timothy Maughan, MDUniversity of WalesCardiff, United Kingdom

Timothy Pawlik, MD, MPHJohns Hopkins University School of MedicineBaltimore, Maryland

Karen A. Roesser, RN, MS, AOCNThomas Johns Cancer CenterRichmond, Virginia

Mace L. Rothenberg, MDVanderbilt UniversityNashville, Tennessee

David P. Ryan, MDHarvard Medical SchoolMassachusetts General HospitalBoston, Massachusetts

Katherine S. Virgo, PhDSaint Louis University Saint Louis, Missouri

CONFIRMED FACULTY

IMPORTANT DATES

Discounted Registration Deadline ............July 24, 2008

Regular Registration Deadline ..................September 11, 2008

Presentation Dates .....................................September 19-20, 2008

*Visit www.imedex.com regularly to see the most updated faculty list and conference agenda

8:00 am Welcome and introduction

Session I: Biology and pathogenesis

8:10 am Cell signaling in colorectal cancer

8:30 am Topic to be determined

8:50 am Genetics of colorectal cancer: Hereditary aspects

9:10 am Panel discussion

Session II: Screening and prevention

9:30 am Optimal strategies for surveillance after initial treatment

9:50 am Applying translational research to the clinic: Concepts in colorectal cancer prevention

10:10 am Coffee break

10:30 am Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening?

10:50 am Molecular markers for colorectal cancer screening and validation

11:10 am Panel discussion

11:30 am Fellows clinical case studies and expert discussion: Determining screening recommendations based on family history

12:00 pm Lunch break

Session IIIa: Colorectal surgery and staging

1:15 pm PET scan vs. whole-body CT scan in the preoperative staging of colorectal cancer

1:35 pm Advances in colorectal surgery

1:55 pm Staging of rectal cancer: MRI versus ultrasound

2:15 pm Altering outcomes: Interventions for hepatic metastases

2:35 pm Panel discussion

2:55 pm Break

Session IIIb: Symptom management and supportive care

1:15 pm Diarrhea: Identifying who’s at increased risk and offering the appropriate management

1:35 pm Optimizing the treatment strategies for chemotherapy- induced neurotoxicity

1:55 pm Caring for the patient with advanced colorectal cancer

2:15 pm Mechanisms and management of EGFR inhibitor associated dermatologic toxicities

2:35 pm Panel discussion

2:55 pm Coffee break

Session IV: Adjuvant treatment for rectal cancer

3:15 pm Optimizing standards in the surgical management of rectal cancer

3:35 pm Perioperative adjuvant chemotherapy for locally advanced rectal cancer

3:55 pm Adjuvant radiation therapy for rectal cancers: Evidence from randomized trials and applications to practice

4:15 pm Panel discussion

4:35 pm Closing remarks

4:40 pm Adjourn

FRIDAY, SEPTEMBER 19, 2008

SCIENTIFIC AGENDA

For the latest updates and to register, visit WWW.IMEDEX.COM

8:00 am Welcome and introduction

Session V: Adjuvant treatment for locally advanced colon cancer

8:10 am Currently available adjuvant treatment of stage II/III colon cancer

8:30 am Perspectives on the future of biologics in the adjuvant setting

8:50 am Clinical and molecular features guiding us in adjuvant therapy

9:10 am Panel discussion

9:30 am Fellows clinical case studies and expert discussion: Adjuvant therapy for locally advanced disease

10:00 am Coffee break

Session VI: Metastatic colorectal cancer I

10:20 am Frontline chemotherapy for metastatic colorectal cancer: Single agents versus combinations versus sequential therapy

European perspective and American perspective

11:00 am Systematic continuum of care: Second and third-line treatment for metastatic colorectal cancer

11:25 am Predicting survival in metastatic colorectal cancer

11:50 am Panel discussion

12:10 pm Lunch break

Session VII: Metastatic colorectal cancer II

1:15 pm Antiangiogenic therapy for colorectal cancer

1:40 pm Targeting EGFR: Implications in colorectal cancer management

2:05 pm Innovative and emerging agents for metastatic colorectal cancer

2:30 pm Fellows clinical case studies and expert discussion: Metastatic colorectal cancer

3:00 pm Break

3:20 pm Perspectives on key advances in colorectal cancer: Where we’ve been and where we’re going

3:45 pm Pharmacoeconomics of colorectal cancer management

4:10 pm Panel discussion

4:25 pm Closing remarks

4:30 pm Adjourn

SATURDAY SEPTEMBER 20, 2008

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COMMENTS FROM PREVIOUS ATTENDEES:

“I believe this is one of the best conferences in colorectal cancer!”

“Great review - covered many new points”

“Fellow presentations were excellent”

September 19-20, 2008 Miami, FloridaInterContinental Miami

9th

CONTINUING MEDICAL EDUCATIONImedex, LLC is accredited by the Accreditation Council for Continuing Medical Education

to provide continuing medical education for physicians.

Imedex, LLC designates this educational activity for a maximum 13.0 of AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

WHO SHOULD ATTENDThis educational activity is specifi cally designed for medical and radiation oncologists, gastroenterologists, colorectal surgeons and other healthcare professionals (gastroenterology and oncology nurses) in active clinical practice who wish to review and update their knowledge and management of colorectal cancer.

CORPORATE SUPPORTThe following companies have provided unrestricted educational grant in support of this conference:

GOLD

SILVER

Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) 751 7332, or by email at cme@imedex.com.

CONFERENCE ORGANIZER

4325 Alexander DriveAlpharetta, Georgia30022-3740, USATel.: +1 (770) 751 7332Fax: +1 (770) 751 7334Email: meetings@imedex.comwww.imedex.com

EDUCATIONAL OBJECTIVESAfter successful completion of this continuing medical education activity, participants should be able to:

• Comment on the latest scientifi c developments in the understanding of colorectal tumor biology

• Identify contemporary methods related to screening, surveillance and prevention of colorectal cancer patients

• Discuss state-of-the-art surgical and staging procedures for colon and rectal cancer

• Select the most appropriate adjuvant regimens for patients with colon and rectal cancer

• Describe a systematic continuum of care for patients with advanced disease including selecting the most appropriate fi rst and second line chemotherapy regimens

• Discuss symptom management and supportive care issues in the management of colorectal cancer patients

• Identify promising emerging agents in the treatment of colorectal cancer

• Describe clinical and molecular features that guide physicians during the identifi cation and management of patients with colorectal cancer

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WILL THIS CONFERENCE BEOF VALUE TO ME?

From last year’s evaluationsQuality of scientifi c agenda (on a scale of 1-10) 9.04

Did you increase professional knowledge? 100% yes

Will you share this information with colleagues? 100% yes

HOTEL ACCOMMODATIONSInterContinental Miami100 Chopin PlazaMiami, Florida 33131Tel.: +1 (305) 577 1000Fax: +1 (305) 577 0384http://www.icmiamihotel.com/

The InterContinental Miami offers richly appointed accommodations and state of the art conference facilities. Discover this enchanting downtown Miami hotel, in a magical setting and enjoy the following:

• Overlooking Biscayne Bay, in the heart of Miami

• Minutes from South Beach, the Port of Miami, Coconut Grove, and Coral Gables

• Only 7.5 miles from Miami International Airport (MIA)

• Just 25 miles from Fort Lauderdale International Airport (FLL)

• Modern fi tness center

• Three stylish restaurants and cocktail lounges

For the convenience of attendees, a limited number of rooms have been reserved until August 27, 2008 at a discounted rate of $165 single/double occupancy, plus tax, currently at 13%. This rate is not guaranteed outside the conference dates or after August 27, 2008.

To reserve your room please contact the InterContinental Miami reservations department at (866) 396 7606. To receive the group rate, callers must identify themselves as being with the 9th Annual Perspectives in Colorectal Cancer group. Reservation requests received after August 27, 2008 may not be guaranteed the group rate.

CONFERENCE LOCATION AND REGISTRATIONInterContinental Miami100 Chopin PlazaMiami, Florida 33131Tel.: +1 (305) 577 1000Fax: +1 (305) 577 0384

The Registration and Information Desk will be staffed:

Friday, September 19, 2008 ...........7:00 am – 4:00 pmSaturday, September 20, 2008 ......7:00 am – 4:30 pm

DISCOUNTED AIRFARESContact conference travel agent, Williamsburg Travel, for assistance with your travel needs. Williamsburg Travel can also accommodate pre- and post-conference extensions.

Tel.: +1 (888) 232 9394 or +1 (770) 261 8613Email: judit@willtrav.com

Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda’s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualifi ed medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES’ RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED.

In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual’s own physician.

Neither Imedex nor any of its subsidiaries or affi liates is affi liated with or formally endorsed by a medical society.

Copyright 2008 Imedex, LLC. All rights reserved.

COMMENTS FROM PREVIOUS ATTENDEES:

“Amazing speakers and relevant experts. A good mix of oncologists, surgeons and gastrointestinal speakers.”

“Case presentation were very good, brings “reality” to the conference, clinically”

September 19-20, 2008 Miami, FloridaInterContinental Miami

9th

Check if you require special facilities or assistance and attach a note with specific details and requirements.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the

event of cancellation. The event program content is subject to change without notice.

_______________________________________________________________________________________FIRST NAME LAST NAME

DEGREE: MD PhD PharmD RN Other Degree _________________\____________________

SPECIALTY: Gastroenterology Medical Oncology Nursing Radiation Oncology

Surgery Other ______________________________________________________________________

_______________________________________________________________________________________EMAIL ADDRESS

_______________________________________________________________________________________TELEPHONE FAX

_______________________________________________________________________________________INSTITUTE DEPARTMENT

_______________________________________________________________________________________ADDRESS

_______________________________________________________________________________________CITY STATE / PROVINCE

_______________________________________________________________________________________ZIP / POSTAL CODE COUNTRY

A035.01C O N F E R E N C E R E G I S T R AT I O N

R E G I S T R AT I O N F E E S

$195 Discounted Physician If payment received by July 24, 2008

$295 Regular Physician If payment received by September 11, 2008

$395 Full/Onsite Physician If payment received after September 11, 2008

-$50 Group discount (physicians only)* *cannot be combined with any other discounts

$75 Nurses/Residents/Students* *proof of eligibility must accompany registration

Credit card transactions will appear under the name Imedex Inc. on your next statement.

To pre-register, registration and payment must be received no later than September 11, 2008. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure that the program is being held as scheduled and to confirm that the meeting is not full.

For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than September 11, 2008. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after September 11, 2008.

American Express Discover MasterCard Visa Check in the amount of $______________________________

Card No. _________________________________________________________ Exp. Date: _______________ /______________

Cardholder’s Name: __________________________________________ Signature: ____________________________________

PAY M E N T M E T H O D

4 EASY ways to register:

ONLINE. . .

www.imedex.com FA X US. . .+1 (678) 242 0920

C ALL US. . .+1 (678) 242 0906

MAIL US. . .Imedex®

4325 Alexander Dr., Alpharetta, GA30022-3740, USA

REGISTRATIONTo Register: You may register online by September 11, 2008 at www.imedex.com, by calling Imedex at +1 (678) 242 0906 or by returning the registration form in this program by mail or fax. If you mail the form, please keep a copy for your records. Registration confi rmations will be issued before the meeting.

To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specifi ed.

Group Discounts: Each one of multiple registrants from the same institute or practice each receive a $50 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Discounts are not available for Nurses/Residents/Students rate.

Payment: To pre-register, registration and payment must be received no later than September 11, 2008. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure the course is being held as scheduled and to confi rm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Include the full name of the attendee and the name of the conference: A035.01 – 9th Annual Perspectives in Colorectal Cancer. An attendee is not registered until full payment is received.

Registration Fee Inclusions: Registration fees include admittance to all scientifi c sessions, conference materials, processing of certifi cates of attendance or continuing medical education, and all event functions as specifi ed in the agenda.

Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than September 11, 2008. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notifi cation. No refunds will be made if notice is received after September 11, 2008.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice.

TRAVEL/EDUCATION GRANTSApplications are now available for a limited number of travel/education grants for fellows or residents to the 9th Annual Perspectives in Colorectal Cancer. The grant will provide each fellow or resident with complimentary conference registration, up to 2 nights (September 18-19, 2008) single or double occupancy at the Intercontinental Miami and round-trip travel to Miami, Florida (up to $400).

Applicants are required to submit at least one clinical case for possible presentation at the meeting in one or more of the following areas:

1) determining screening recommendations based on family history

2) adjuvant therapy for locally advanced colon cancer

3) metastatic colorectal cancer

Applications are available online at www.imedex.com/A035.01application.pdf or may be requested by email to meetings@imedex.com. Grant applications must be received at Imedex by July 11, 2008. Notifi cation of acceptance will be sent by July 25, 2008.

ONLINE products are produced by Imedex in 6 user-friendly formats

LIVE meetings are produced by Imedex in 15 countries

3 WAYS TO LEARN: www.imedex.com

PRINT materials are produced by Imedex for your reference needs

REGISTRATION FEESDiscounted Physician $195If payment received by July 27, 2007

Regular Physician $295If payment received by August 30, 2007

Full/Onsite Physician $395If payment received after August 30, 2007

Group discount (physicians only)* -$50 *cannot be combined with any other discounts

Nurses/Residents/Students* $75*proof of eligibility must accompany registration

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