a true revolution in the world of sport · 2 1 a true revolution in the world of sport combating...
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A TRUE REVOLUTION IN THE WORLD OF SPORTCombating fatigue has always been the goal sought after by generations of athletes.Trainers and sports medicine consider lactate threshold an excellent indicator of an athlete’s potential resistance. The ability to exercise intensely without building up lactic acid is highly advantageous.
Today, thanks to the agreement signed by SIXS and LVM Technologies, we are able to announce that the goal has fi nally been reached.
Results of medical tests which used the LVM technology testify to the effi ciency of the system, consultancy activities by the Universities of Pisa, Pavia and Ferrara underline it’s unique features, tests undertaken in Italy’s most important athletic training and sports research centre confi rm it, the textile experience of SIXS has given it form.
is born
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THE PRINCIPLE: The application possibilities are endless, going from energy to new materials. One of the main applications is in the health and sport fi eld. Although the benefi cial effects of manyactive ingredients have been known for a while, a practical system, free from any collateral effects, is not always knownwhich provides for the application of active ingredients in the right amount and at the right place in order to gain the best results.
THE MICROENCAPSULATION OF THE ACTIVE INGREDIENTS ADMINISTERED VIA TRANSDERMAL DELIVERY, MAXIMISES BIOAVAILABILITY AND THEREFORE OPTIMISES THE INGREDIENT’S EFFICIENCY.For example, in the medical fi eld, some skin conditions (diabetic foot infections, infl ammation of amputated areas etc.) have been cured by use of LVM technology. In these cases, the suitable active ingredient was known, but the right system of
application had not yet been found. The use of LVM technology guarantees the possibility to deliver the active ingredient at a constant rate and at the right place, and in the right amount.
LVM technology concerns the design of a molecular fi lmand of the necessary process to transform various active ingredients into microcapsules.
The LVM molecular fi lm is integrated into a specifi cally designed textile structure and is characterised by the fact that it can be recharged with microcapsules containing the active ingredient to be used. The release of the active ingredient occurs over a longer period and at a constant rate, beginning only when the textile structure is put on, and activated by the change in temperature together with the microfriction with the skin.
MICROTECHNOLOGY APPLICATION:
The transfer of this technology from the medical to the sporting fi eld opens up further interesting application possibilities.
The fi rst active ingredient considered in this fi eld is CARNOSINE, a natural antagonist to lactic acid . The problem with Carnosine is that when it is taken orally
(the only system currently in use) and is only absorbed by the organism at a maximum of 8-10%. Via transdermal OSMOSIS (thus the need to “wrap” the ingredient in a molecular fi lm containing microcapsules) it is absorbed by the deepest layers of the epidermis, in a markedly higher amount and already localised.
THE PRODUCT:Following the specifi cations of LVM, a range of different products have been conceived which are suitable for use in a variety of sporting situations such as cycling and motorcycling.
The areas of release are the muscle groups which are most used in the various situations.
Therefore stockings have been created with a release area in the sole of the foot (the most receptive area of the body), pads of different dimensions with release areas on the calves and vastus medialis thighs, and shirts with release areas on the forearm and biceps.
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USE:
Items are delivered ready for use and charged with amicrocapsules containing Carnosine. In the packaging, as well as instructions, three recharging doses will be included. As well as single packs, recharging doses will be available in bottles of around 20 and 40 measures.
The continued use of OSMOSIXS has a soothing effect andbuffers muscular fatigue caused by the build-up of lactic acid during sporting performance. It also improves recovery after activity.
Release is activated from the moment the item is put on (item should be worn at least one hour before the beginning of the sporting performance) and it lasts around 36 hours.
After every use it is necessary to recharge the OSMOSIXS itemwith the specifi c recharging measures of Carnosine molecular fi lm, with a simple charge operation which can be done at home. Dissolve the right recharging dose in water and leave the item soak for around 20 minutes.
MICROSYSTEMS WITH ACTIVE INGREDIENT CONTROLLED RELEASE THROUGH THE FABRIC
ITALIAN RESEARCH AND DEVELOPMENT COMPANYLVM has years of experience in the study of microtechnology and innovative transdermal release systems.
In collaboration with universities and international scientifi c authorities DIFOPREV has been created (PCT European patent): the fi rst bio-technical application which has revolutionised the treatment of diabetic foot infections.
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LVM - R&DMedicalDevices
Area: diabetic foot infection
Metabolic illnesses and Diabetes Dept.Endocrinology
University Clinic of Pisa University of Pisa
Professor A. Piaggesi
Hight FrequencyDiagnosticUltrasound
CambridgeUniversity (UK)
Dr. S. Young
University ofDermatology
H. S.Orsola of Bologna
Prof. A. TostiAmb. of Podology
University“La Sapienza”
Roma
Vascular Diagnostics Centre
H. Maggiore in Bologna
Dr. LeonardoAluigi
Pharmacology Faculty
University of Pavia
Endocrinology Department
UniversityClinicLjubljana, Slovenia
D.r VilmaUrbancic
Rehabilitation sciences Sports podology SIPU (It. Univ. Society
of Podology)Dr. LucaAvagninaResearch Center
Mapei SportCastellanza (VA)
Diabetology National Health
Service Naples 1 ANIAD (Italian
National Association of Diabetic Athletes)
Dr. Luca Avagnina
Centre for the prevention and treatment of diabetic foot infections
IRCCS MultimedicaSesto San Giovanni
Dr. G. Clerici
Research Centre Phlebology
University of Ferrara
Dr. V. Gasbarro
Centre for prothesisINAIL Budrio
Prof. T. A. Moscato
Centre of VulnologyIst. Zucchi MonzaDr. R. Brambilla
MAINCOLLABORATIONS TREATED FABRIC NON - TREATED FABRIC
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SOME EXAMPLES OF EFFICIENCYIN THE MEDICAL FIELD
MEDICAL DEVICES CLASS I AND CLASS IIA • WOUND CARE distributed by SMITH & NEPHEW • LARGE AMPUTATIONS distributed by SMITH & NEPHEW • PHLEBOLOGY distributed by PHARMENTIS
DIFOPREV GALARGE AMPUTATIONS
A new possible therapy for skin issues at the stump of an amputation.
PRE POST
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MAJOR COLLABORATIONS
2005 L. Aluigi, G. Pirotta – Prevention of “DIABETIC FOOT” prelimina-ryresults of a new delivery system with cosmetic microcapsules - Po-dium presentation - IFSCC World Wide Wellness - Proceedings Cosme-tics 2005 International conference - Firenze, 19-21 Settembre 2005.
2005 E. Banchellini, L. Ambrosini, A. Civitelli, S. Macchiarini, E. Lepo-rati, V. Sciré, I. Teobaldi, A. Piaggesi - Valutazione del nuovo sistema DIFOPREV nella prevenzione e nel trattamento delle condizioni Pre-ulcerative nei pazienti con piede diabetico neuropatico: uno Studio prospettico randomizzato - Podium presentation - Congresso PiedeDiabetico 2005 - Firenze 5-7 Dicembre 2005.
2006 E. Banchellini, L. Ambrosini, A. Civitelli, S. Macchiarini, E. Le-porati, V. Sciré, I. Teobaldi, A. Piaggesi - Applicazione delle nanotec-nologie Alla gestione delle condizioni pre-ulcerative nel piedediabe-tico Neuropatico - Poster session – 21° Congresso Nazionale SID - Milano, 17-20 Maggio 2006.
2006 R.Piro, F.De Bernardinis, G.Grossi,S.Carnevale - Trattamento di Prevenzione e Ripristino della cute nel piede diabetico con siste-
ma Difoprev - podium presentation - Piede diabetico la realtà cen-tro-Meridionale - 19-21 Ottobre 2006 - Paola (CS)
2006 L. Aluigi – Educazione e prevenzione piede diabetico - PodiumPresentation – Giornate Nazionali di angiologia XXVIII Congresso Nazionale SIAPAV – Roma Novembre 2006
2007 Banchellini, L. Ambrosini, V. Dini, L. Rizzo, M. Romanel-li, A. Piaggesi - Nano technologies for the treatment of preul-cerative Condition of the diabetic foot - a prospective randomi-zed trial - Podium presentation - V International Symposium on the diabetic foot -9-12 May 2007, Noordwijkerout – Netherands
2007 A. Piaggesi - Facing the challenge of prevention in the diabeticFoot - Podium presentation - 13° National Congress of Internal Me-dicine 8-13 Ottobre 2007 - Athens - Greece
2008 Pirotta - Skin delivery of active ingredient from fabric - Publication“Cosmetic & Toiletries” Allured Publishing Corporation USA, Aprile 2008
2008 E. Banchellini, S. Macchiarini, V. Dini, L. Rizzo, A. Tede-schi, A. Scatena, C. Goretti, F. Campi, M. Romanelli, A. Piagge-si - Use of nanotechnology- Designed footsock in the mana-gement of preulcerative conditions in the Diabetic foot: results of a single, blind randomized study - Publication The Inter-national Journal of Extremity Wounds - USA - Giugno 2008
2008 E. Banchellini, S. Macchiarini, V. Dini, L. Rizzo, L. Abruzzese, A. Tedeschi A. Scatena, C. Goretti, M. Romanelli, A. Piaggesi – Na-notechnologies for The management of preulcerative conditions in the diabetic foot - Poster session - Seven meeting of DFSG - 11-14 Settembre 2008 Il Ciocco Castelvecchio Pascoli Italy
2008 Douglas H. Richie jr., DPM - Therapeutic hosiery: An Essential Component Of Footwear for the Pathologic Foot – Publication Footwear & Podiatry - Podiatry Management - East Islip - NY USA - Ottobre 2008
2008 H. Hosalcar, MBMS, FCPS, DNB, J. Hsu, N.K.Pandya and M. A. Keenan - What’s news in Orthopaedic Rehabilitation - Publication The Journal of Bone And Joint Surgery - USA Ottobre 2008
2009 A.Piaggesi, L.Rizzo, A.Tedeschi, A.Scatena, C.Goretti,S.Del Prato -Measurements in Diabetic Foot - Publication Journal Of Wound Technology – Edition MF – Paris - France Gennaio 2009
2010 A.Piaggesi - DF care in Italy - Publication Wounds Internatio-nal-London Febbraio 2010
2010 S.Manfredelli, I.Martire, F.Passafi ume, N.Di Tullio, A.Forte, A. Lo-renzotti, V.Malagnino, A. Chiaravalloti, M. Bezzi, F. Vietri, P.G.Pastore - Trattamento della neuropatia autonomica nella prevenzione delle ulcere del piede diabetico - Acta Vulnologica Roma Giugno 2010
2011 E.Banchellini, L.Abruzzese, L.Ambrosini Nobili, E.Leporati, S.Macchiarini, I.Teobaldi, A.Piaggesi - Nanotechnologies for the pre-vention and treatment of pre-ulcerative lesions of the ischemic foot-Podium presentation - VI° International Symposium on the diabetic foot – 11-14 May 2011, Noordwijkerhout, Netherlands
2012 Lan-Anh Lem Ross J Hunterm Victor R Preedy-Nanotechno-logy and Nanomedicine in Diabetes Pubblicazione Taylor & Francis Inc Science Publishers U.S.- Marzo 2012.
