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A Team Science Approach to Nicotine Dependence Treatment Caryn Lerman, Ph.D. Center for Interdisciplinary Research on Nicotine Addiction

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Continuum of Research Teams Investigator works largely independently on research problem in own lab Each group member brings expertise to address research problems Group members work on separate parts of research problem which later become integrated Data sharing or brainstorming varies from limited to frequent Each team member brings expertise to address common research problem Teams meet regularly to discuss team goals, individuals objectives and next steps Team shares leadership responsibility, decision authority, data and credit Level of Interaction and Integration LowHigh IndividualCollaboration Team Science

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Team Science 1.Get the right people on the bus. 2.Develop a collective vision to address an important scientific, clinical, and or public health problem. 3.Identify a unifying theme that can/must be addressed from a multi-disciplinary perspective. 4.Generate a common conceptual model that links individual scientific projects to address the problem. 5.Develop a common vocabulary through cross-education of team members. 6.Meet often to facilitate synergy across projects and communicate goals and interests. 7.Support junior investigators in all aspects of career development.

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Who to get on the bus? Team Science Essentials (smart is not sufficient) Creative Open (cognitive flexibility) Dependable Accessible team science takes extra time

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Common vision: Elucidate the cellular, molecular and neural regulation of cognitive and affective responses that promote relapse, and translate findings to improve therapy for nicotine dependence (2009-2014) Julie Blendy multi-PI CIRNA Center for Interdisciplinary Research on Nicotine Addiction (1999- )

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Common Conceptual Model Cellular and genomic studies to identify potential targets Screening of novel compounds and repurposed meds Cognitive, neurobiological markers of medication effects A focus on the key clinical endpoint: relapse

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A Translational Research Example Opioid genetic mechanisms in nicotine reward and relapse Exon1 *

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Opioid Mechanisms in Nicotine Reward Nestler

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Mouse Model of Nicotine Reward Preconditioning Day A B DRUG SALINE C C C C S S S S ?? Day 1 Pairing Days 2-8 Test Day Blendy Lab

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Naloxone on Test Day Blocks Conditioned Rewarding Effects of Nicotine in 129/C57 B16 Mice Saline Nicotine (1.0mg/kg) Treatment on Test Day *p