a rare dinorditerpene from jatropha curcas

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Biochemical Systematics and Ecology 31 (2003) 431–432 www.elsevier.com/locate/biochemsyseco A rare dinorditerpene from Jatropha curcas N. Ravindranath, C. Ramesh, Biswanath Das Organic Chemistry Division, I, Indian Institute of Chemical Technology, Hyderabad, 500 007, India Received 14 March 2002; accepted 6 June 2002 Keywords: Jatropha; Euphorbiaceae; Aerial parts; Heudolotinone; Dinorditerpene 1. Subject and source Jatropha curcas Linn. is a small shrub that grows widely in India. Aerial parts were collected from Dhanasri, Andhra Pradesh in September, 2000. A voucher speci- men (NBRI-202102) is preserved in the herbarium of National Botanical Institute, Lucknow, India. 2. Previous work Several flavones (Subramanian et al., 1971), phorbol derivatives (Adolf et al., 1984), diterpenes (Naengchomnong et al., 1986; Chen et al., 1988) and a coumarino- lignan (Chen et al., 1988) have previously been reported. 3. Present study Corresponding author: Tel.: +91 40 7170512; fax: +91 40 7173387. E-mail address: [email protected] (B. Das). Studies on phytochemicals: Part 36 0305-1978/03/$ - see front matter 2003 Elsevier Science Ltd. All rights reserved. doi:10.1016/S0305-1978(02)00166-7

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Page 1: A rare dinorditerpene from Jatropha curcas

Biochemical Systematics and Ecology 31 (2003) 431–432www.elsevier.com/locate/biochemsyseco

A rare dinorditerpene fromJatropha curcas�

N. Ravindranath, C. Ramesh, Biswanath Das∗

Organic Chemistry Division, I, Indian Institute of Chemical Technology, Hyderabad, 500 007, India

Received 14 March 2002; accepted 6 June 2002

Keywords: Jatropha; Euphorbiaceae; Aerial parts;Heudolotinone; Dinorditerpene

1. Subject and source

Jatropha curcas Linn. is a small shrub that grows widely in India. Aerial partswere collected from Dhanasri, Andhra Pradesh in September, 2000. A voucher speci-men (NBRI-202102) is preserved in the herbarium of National Botanical Institute,Lucknow, India.

2. Previous work

Several flavones (Subramanian et al., 1971), phorbol derivatives (Adolf et al.,1984), diterpenes (Naengchomnong et al., 1986; Chen et al., 1988) and a coumarino-lignan (Chen et al., 1988) have previously been reported.

3. Present study

∗ Corresponding author: Tel.:+91 40 7170512; fax:+91 40 7173387.E-mail address: [email protected] (B. Das).

� Studies on phytochemicals: Part 36

0305-1978/03/$ - see front matter 2003 Elsevier Science Ltd. All rights reserved.doi:10.1016/S0305-1978(02)00166-7

Page 2: A rare dinorditerpene from Jatropha curcas

432 N. Ravindranath et al. / Biochemical Systematics and Ecology 31 (2003) 431–432

The air-dried aerial parts of J. curcas (1 kg) were powdered and extracted withCH2CI2-MeOH (1:1) at room temperature for 120 h. The concentrated extract wassubjected to column chromatography over silica gel to afford heudolotinone (1) (45mg, yield 0.045%). The physical (m.p., [a]D) and spectral (IR,1H and 13C NMR andMS) properties of the compound were found to be identical to those reported earlier.(Kimbu et al., 1991).

4. Chemotaxonomic significance

Heudolotinone and related dinorditerpenes have previously been isolated(Dominguez et al., 1990, 1992; Kimbu et al., 1991) from other Euphorbiaceae spec-ies.

Acknowledgements

The authors thank UGC, New Delhi for financial assistance.

References

Adolf, W., Opferkuch, H.J., Hecker, E., 1984. Phytochemistry 23, 129.Chen, M., Hou, L., Zhang, G. 1988. Zhiwu X., 30, 308 (1989 Chem. Abstr. 110, 21068h).Dominguez, X.A., Sanchez, V.H., Espinosa, B.G., Villarreal, A.M., Guerra, N.E., 1990. Rev Quim. Latin

Amer 21, 26.Dominguez, X.A., Sanchez, V.H., Garcia, G., Espinosa, B.G., Williams, H.J., Ortiz, C., Scott, A.I., Reib-

enspies, J.H., 1992. J. Nat. Prod. 55, 221.Kimbu, S.F., Xeumedjio, F., Sondengam, B., Connolly, J.D., 1991. Phytochemistry 30, 619.Naengchomnong, W., Thebtaranonth, Y., Wiriyachitra, P., Okamoto, K.T., Clardy, J., 1986. Tetrahedron

Lett. 27, 2439, 5675.Subramanian, S.S., Nagarajan, S., Sulochana, N., 1971. Phytochemistry 10, 2548.