a perspective on minerals and metals in human health

8/3/2019 A Perspective on Minerals and Metals in Human Health

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A Perspective

onMinerals & Metals

inHuman Health

Bradford S. Weeks, M.D.

www.weeksmd.com

[email protected]


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Bradford S. Weeks, M.D. (c) 2009

Dedication:

Richard Kunin

&

Paracelsus

Alterius non sit qui suus esse potest~

Let no man that can belong to himself be of another


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Everything fails meevery thing

These instruments, do they not all

Mock me? Lathe, cylinder, and ring,

And cog and wheelin vain I call

On you for aid, ye keys of Science,

I stand before the guarded doorOf Nature; but it bids defiance

To latch or ward: in vain I prove

Your powers, the strong bolts will not move.

Faust, in his study, before the deal


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Mysterious, in the blaze of day,

Nature pursues her tranquil way:

The veil she wears, if hand profane

Should seek to raise, it seeks in vain,

Though from her spirit thine receives,

When hushed it listens and believes,Secretsrevealed, else vainly sought,

Her free gift when man questions not,__

Think not with levers or with screwsTo wring them out if she refuse.


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Definitions

Element - a type of atom that is distinguished by its

atomic number (the number of protons in its nucleus).The term is also used to refer to a pure chemicalsubstance composed of atoms with the same number ofprotons.

Mineral - a naturally occurring homogenous substancewith a crystalline structure and defined chemicalcomposition formed as a result of geological process.

Metala lattice of positive ions surrounded by a cloud of

delocalized electrons. They are one of the three groupsof elements as distinguished by their ionization andbonding properties, along with the metalloids andnonmetals. They rarely found in pure form in nature


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Lithium #3 in the periodic table = 3 protons

- lightest metal,- highest specific heat of any solid metal so

used in heat transfer technology

relieves hotheadedness mania


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Element A # Qualities

Lithium 3 Lightest metal, a dense as water, highest specific

heat, transfer use

Beryllium 4 Toxic, used in nuclear reactors, low thermal neutron

absorption

Boron 5 Natural fiber optic and transmits infrared light

Carbon 6 Hexagonal crystal, obtained from buring with

insufficient oxygen; Derives only from life forms

Nitrogen 7 78% of air, carrier of astrality, universes 5th most

abundant element; allergen yet inert as gas, cryo L

Oxygen 8 Oxy genes (GR acid forming), fire air 1/2 earth

crust, 2/3 of you 9/10th of water , 3rd in Universe;

Fluoride 9 Most electronegative and reactive of all elements; used

in producing uranium, waste to water supply


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Element A # Qualities

Hydrogen 1 Gr Hydro genes= water forming most

abundant element in universe; star fuel; saturates C

Lithium 3 Lightest metal, a dense as water, highest specific

heat, transfer use

Sodium 11 Med Latin sodanum headache remedy, ignites on

contact with water; burns yellow

Potassium 19 KCL fertilizer, KOH soap K nitrate, flash on matches

Rubidium 37 Byproduct of refining lithium, spectroscope deep red;

liquid at room temp, ignites H and O, blend w Hg Au

Cesium 55 Spectroscope blue (L caesius = blue sky), melting pt83 deg F in your hand, beer brewing, (watch K)

Francium 87 Last naturally occurring element discovered, 30 g on

earth at one time; radioactive; (Astatine is rarest)


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Irridium 77 - 2nd densest element, least corrosive,

siderophilic, meteorites, dinosaur extinction;

Platinum 78 - alchemical symbol joined Ag and Au

catalytic converters, missile cones, chemo Rx

Gold 79most malleable: 1 oz -> 5 meters sq; 400x

thinner than a human hair = 0.000127mm

Mercury 80 - one of 6 elements liquid at room temp and

the only metal,

Titanium 81 - 9th most common earth element, stronger

and lighter than steel, non-corrosive with salt water, human

tissue, only element than burns in pure nitrogen;


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Egyptian

signs

for theElements


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Alchemical and chemical

symbols in

Nicolas de Locques

Les rudimens de laphilosophie naturelle,

Paris 1655.


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Elements

1. Oxygen.

2. Hydrogen.

3. Nitrogen.4. Carbon.

5. Sulphur.

6. Phosphorus

7. Gold.

8. Platinum.9. Silver.

Chemical Symbols used by Dalton 19th century


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10. Mercury.

11. Copper.12. Iron.

13. Nickel.

14. Tin.

15. Lead.16. Zinc.

17. Bismuth.

18. Antimony.


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Compounds.

37. Water.

38. Hydrofluoric acid.

39. Hydrochloric acid.40. Chloric acid.

41. Nitric oxide.


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Alum


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Woodcut from William Cuningham

The cosmographical glasse, 1559

Frontpiece Woodcut of the celestial

sphere by Erhard Schn, 1515.


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Definitions cont.It is far easier to define something

than it is to know it.

When we name something we demystify it

and have dominion over it.


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Which box are you thinking outside of?


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Knowing and Thinking

In medicine,

you need to know nothingbut you need to be able to think.

Otto Wolff, M.D.


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Engraving from Baro Urbigerus

Besondere chymische Schrifften, 1705.Frontispiece engraving from 1774

Drey curieuse chymische tracttlein


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Many have said of alchemy,

that it is for the making of

gold and silver.

For me such is not the aim,but to consider only what

virtue and power

may lie in medicines.

Paracelsus


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Year Date Alchemist Metal Place

1382 Apr 25 5pm N.Flamel Hg Paris

1586 Dec 19 NS Kelly Hg Bohemia

1602 Mar 13 4pm NS A.Seton Pb Amsterdam1648 Jan 15 Richthausen Hg Prague

1667 Jan 19 10am Helvetius Pb The Hague

1701 Oct 1 8pm Bttger Ag Germany

1709 Feb 16 eve Lascaris Hg Germany

1716 Dec 31 Pb Rhineland

1782 May 25 J. Price Hg Guildford

Golden Moments


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Metals are condensed vapors from the

various planets which were trappedwhen earth solidified from a gaseous

state to its solid state. When you hold a

metal in your hand, you are holding theforces of its planet also.

paraphrase Rudolf SteinerOccult Science


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Metallic Presence in Humans

Element Decimal Potency

Mg, Fe, Al, Zn D1-D2

Cu, Mn D2-D3

As, Ti, V, Cr, Ni, St, Li D3-D4

Ag, Co, Rb, Sn, Mo D4D5

Ag, U D5-D6

U in bones D6

Ra D11

D1 = 10 to the -1


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Sunday Dimanch Sun

Monday Lundi Moon

Tuesday Mardi Mars

Wednesday Mercredi Mercury

Thursday Jeudi Jupiter

Friday Vendredi Venus

Saturday Samedi Saturn

Weekdays (French) Planet


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Monday's child is fair of face.Tuesday's child is full of grace.

Wednesday's child is full of woe.

Thursday's child has far to go.Friday's child is loving and giving.

Saturday's child works hard for a living,

But the child who is born on the Sabbath DayIs bonny and blithe and good and gay.


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Sunday good and gay Sun

Monday fair of face Moon

Tuesday full of grace Mars

Wednesday full of woe Mercury

Thursday far to go Jupiter

Friday loving and giving Venus

Saturday hard for a living Saturn

Weekdays Child Planet

Fortune telling rhymes of this type circulating in England in the 1570s


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Electrical Conductivity of Metals

Iodine 8.0E-16 10 6th /cm

Sulfur 5.0E-24 10 6th /cm

Mercury 0.0104 10 6th /cm

Uranium 0.038 10 6th /cm

Lead 0.0481 10 6th /cm

Tin 0.0917 10 6th /cm

Iron 0.0993 10 6th /cm

Gold 0.452 10 6th

/cmCopper 0.596 10 6th /cm

Silver 0.63 10 6th /cm

Least

More

Most


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Upon this age that never speaks its mind,

This furtive age, this age endowed with power

To wake the moon with footsteps, fit an oar

Into the rowlocks of the wind, and find

What swims before his prow, what swirls behind---

Upon this gifted age in its dark hour,Rains from the sky a meteoric shower

Of facts . . . they lie unquestioned, uncombined.

Wisdom enough to leech us of our ill

Is daily spun; but there exists no loomTo weave it into fabric. . .

"Huntsman, What Quarry?" by Edna St. Vincent Millay


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The essence of a living

organism lies not in itssubstance, but in its action.

The organization is not asystem of substances, it is

activity.

Dr. Rudolf Steiner and Ita Wegman, M.D.

Fundamental of Therapy


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Lilly Kolisko

http://www.science.a

nth.org.uk/kolisko/

http://www.science.a

nth.org.uk/kolisko/K

olisko_211126.htm

http://www.science.anth.org.uk/kolisko/K

olisko_290627.htm


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Further Reading

1966 The Nature of Substance - Rudolf Hauschka, trans.

from German.

1973 The Secrets of Metals - Wilhelm Pelikan,

Anthroposophic Press, trans. from German.

1918 Fundamental of Therapy - Dr. Rudolf Steiner and Ita

Wegman, M.D.

1921 Spiritual Science and Medicine - Rudolph Steiner

1537 The Book Concerning the Tincture of the

Philosophers - Paracelsus

1531 The Aurora of the Philosophers - Paracelsus


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Gold substance

Sun forces


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Gold for ArthritisJacques Forestier (1890 - 1978) was a French internist who

was a pioneer in the field of rheumatology. He studied and

practiced medicine in Paris, and was founder of the

National French Society of Rheumatology. Jacques

Forestier is remembered for his introduction of gold salts as

a remedy for rheumatoid arthritis. Today, injectable gold

salts such as gold sodium thiomalate and aurothioglucose

are considered by many to be the most effective treatment

for arthritic ailments.

(His son, 3rd generation rheumatologist, uses honey bee venomto treat arthritis)

Gold isotope 198 is a chemotherapy agent;


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Pro-apoptotic effect of aurothiomalate in prostate cancer cells.

Trani M , Sorrentino A , Busch C Landstrm M

Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.

It has been recently demonstrated that small gold compounds could have a

potential anti-tumoral activity.

Here, we report that aurothiomalate (ATM), a gold compound already used in

clinical therapy for the treatment of rheumatoid arthritis, has a pro-apoptotic

effect in aggressive prostate cancer (PC3U) cells.

Moreover we could link ATM treatment to activation of the mitochondrial or so

called intrinsic pathway, as we observed release of cytochrome c from

mitochondria to cytoplasm, suggesting that the mitochondrial pathway is

involved in the pro-apoptotic effect mediated by ATM.

Taken together our data suggest that ATM could be a new promising drug for

the treatment of advanced prostate cancer.

Cell Cycle. 2009 Jan 15;8(2):306-13. Epub 2009 Jan 10.


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Copper substance

Venus forces


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- Copper (Cu) shifts attitude between the cuprous

(Cu1+) and cupric (Cu2+) forms, (usually cupric in

vivo) in order to easily receive and donate electronsin perpetual oxidation-reduction (redox) reactions

and also in order to serve as the anti-oxidant

function of scavenging free radicals.

- Prevents the peroxidation of PUFA maintaining

cell membrane integrity.

- Maintains myelin sheath via synthesis of

phospholipids.


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Copper prepares the Bed for Iron

Rudolf Steiner

1) Two copper-containing enzymes,

ceruloplasmin (ferroxidase I and II) oxidize

ferrous iron (Fe2+) to ferric iron (Fe3+),

allowing protein transferrin for transport iron

to the site of red blood cell formation.

2) Iron mobilization from storage sites is

impaired in copper deficiency


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Anemia is a clinical sign not only of iron

deficiency but of too little copper also.

Ceruloplasmin is required for iron transportto the bone marrow for synthesis of RBC.

High levels of dietary zinc increases thesynthesis metallothionein, which binds certain

metals at the intestinal villi and prevents their

absorption.

Metallothionein binds copper stronger than

zinc, so high levels zinc cause a decrease in the

absorption and bioavailability of copper.


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Copper-dependent enzyme actions (cuproenzymes)

Cytochromec oxidase catalyzes the reduction of

molecular oxygen (O2) to water (H2O), thereby

creating an electrical gradient used by the

mitochondria to produce ATP.

Cytochrome c oxidase activity regulates generation

and resilience of myelin sheath

Lysyl oxidase, is required for the cross-linking ofcollagen and elastin (support for the integrity of

connective tissue in coronary artery system)


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Copper-dependent enzyme actions (cuproenzymes) cont.

Dopamine-b-mono-oxygenase catalyzing dopamine -> NE

Monoamine oxidase (MAO) regulate norepinephrine,

epinephrine, and dopamine.

MAO also functions in the degradation of theneurotransmitter serotonin

Tyrosinase (a cuproenzyme) regulates melanin synthesis

Highest concentration of copper in brain and liver.

Copper deficiency is quite rare in humans.

Copper dependent enzyme actions (cuproenzymes) cont


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Copper-dependent enzyme actions (cuproenzymes) cont.

Superoxide dismutase (SOD) serves as an antioxidant by

catalyzing superoxide radicals to hydrogen peroxide which is

easily reduced to water.1) Intracellular copper/zinc SOD is found within most cells of

the body (RBC)

2) extracellular SOD is a copper-containing enzyme (in lungs

and plasma).

Ceruloplasmin seves as an antioxidant by binding copper, and

via its ferroxidase activity facilitates iron joining it transport

protein, transferrin, thereby mopping up Fe2+

Copper levels alter the synthesis of gene proteins which

regulated by copper-dependent transcription factors

(copper/zinc superoxide dismutase (Cu/Zn SOD), catalase

(think HDVit C and cancer)


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Mercury substance

Mercury forces


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Chinese emperor Qin Shi Huang Di buried in tomb with a

model of the land he ruled complete with rivers of mercurydied from drinking mercury and jade designed to give him

eternal life;

Ancient Greeks used mercury ointments

Romans use mercury cosmetics

Indian word for alchemy translates as the way of

mercury

Paracelsus

Mercury is harmless in insoluble form (mercuric sulfide)

but toxic in mercuric chloride and methyl/ethyl mercury;


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Lewis and Clark expedition:

Penis syringe was used to inject mercury solutions directly into the

urethra to treat venereal disease symptoms

Also used was oral elemental mercury and mercury salves.

Paracelsus: first documented use of a metal as medicine, mercury.


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Silver substance

Moon forces


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Palolo WormThis worm dances to thelight of the moon.

Spawning follows the lunar

cycle, around the seventhnight after the full moon

that follows the autumnal

equinox.

If it's a weak showing, then

a second rising can be

expected in November.


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Clinicial Indications for Silver

- regeneration,

- anti-biotic,- tissue detoxification

- see Gary Gordons FACT website:http://promed.gordonresearch.com/factfor

um/welcome.html topic silver


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IV Silver

250 cc bag colloidal silver 10ppm3cc of methylcobalamine and 50cc of

D50 glucose (to aid absorption)

Run at slow drip over 2 hrs

NOTE: IV silver for humans is not FDAapproved in USA despite the fact that silver

was Americas first IV antibiotic: 1860!


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December 20, 2007 the world press

published re Paul Karason, a California

man whose entire skin gradually turned

blue after consuming homemade

colloidal silver containing salt, waterand silver.

(Note: only silver chloride is toxic)


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Argyria: blue skin, eyes, nails.

Not dangerous, just unsightly


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Silicate

(with Oxygen)

substance

Earth forces


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Testosterone Estrogen


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Iron substance

Mars forces


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Oxygen transport and storage: Hemoglobin and

myoglobin are heme-containing proteins that store and

transport oxygen. Hemoglobin = 2/3 of total body iron

Electron transport and energy metabolism: Cytochromes

are heme-containing compounds involved in

mitochondrial electron transport and ATP production

Antioxidant and beneficial pro-oxidant functions:

Heme-containing enzymes catalase and peroxidase protect

cells against the accumulation of hydrogen peroxide,

Oxygen sensing (esp high altitudes or COPD):

compensate with RBC formation and angiogenesis


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Lead substance

Jupiter forces


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Lead and Light

Great refraction

Great dispersion

Radioactivity

Protection against diagnostic radiation

Lead has more more naturally occuring

isotopes than any other metal


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Lead

- Melts by candle flame 327 deg C.

- Vaporizes at temperature most metals

require to melt 1555 deg C.

- Expands and contracts faster and more

powerfully than other metals


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Just consider where the strongest forces of

decomposition are found in the earth, where

radium occurs;In lead the cosmos prepares a substance for

itself in which to concentrate the most

powerful splitting forces.By bringing lead into the human body you

place the body directly amid the process of

world degeneration; in lead we have aneffective means of evoking the forces of

decomposition. (Rudolf Steiner)


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Uranium and thorium, substances of the

highest density are starting points for

decomposition into other elements withthe accompanying transmutation of

matter into radiation, an imponderable,

leaving behind finally non-radioactivelead.

L d A th hi d


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Lead as an Anthroposophic remedy

(after Rudolf Steiner)

Lead mixed with honey and sugar for

arteriosclerosis

Lead subdues the hypertrophic forces of the

astral body that express themselves in craving. It

strengthens the forces of the ego organization and

produces an antipathy to alcohol.

Silver is an antidote to lead.


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Lead Toxicity

Neurological Symptoms

- Behavioral problems (erratic)

- Visual/Auditory dysfunction- Motor deficits (tremor)

- Cognitive deficits (dementia, depression),

Osteoporosis Int. 9 (1999)


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- Pb neurotoxicity typically manifests as a

disruption of Ca metabolism

- Lead keeps Ca channels open about 5X

longer than Ca and pollutes cells in that

manner.

Lead is a calcium antagonist

M h i f L d N t i it


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Mechanism of Lead Neurotoxicity

- Activates phosphokinase c (out competes calcium

binding creating erratic neuronalresponsiveness: impulsivity and restlessness

- Inhibits NMDA receptor function

- Disrupts synthesis of dopaminergic, cholinergic,and glutamatergic neurotransmitters

- Disrupts calcium homeostasis,

- Increases erratic and spontaneous NT release

- Disrupts microtubule metabolism

Ann Rev Pharmacol Toxicol(1995)35:391


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Tin substance

Saturn forces


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Cellular Attributes, Functions & Interactions:

Tin Synergists: Nickel, iodine, Vitamin B1, Vitamin C,

Tin Antagonists / Inhibitors: Iron, calcium, copper,

chloride, Vitamin B2, Vitamin E, [bismuth, zinc],

Low Levels / Deficiency - Symptoms and/or Risk Factors:Fatigue, depression, low cardiac output (left), low

adrenals, shortness of breath, asthma, headaches,

insomnia. - In animals, low tin results in poor growth,

alopecia / bilateral hair loss, hearing loss, andreduced feeding efficiency

source http://www.acu-cell.com/tin.html


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Tin in the human organism

- Highest in the thymus.

- Next in the tongue and salivary mucosa

- Then skin

- Then liver

- Then spleen

- Then brain

- Then heart

Tin concentration in the thymus glands of rats and mice and


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its relation to the involution of the gland.

Sherman LR, Masters J, Peterson R, Levine S

Tin is an ubiquitous element and thus enters mammals through the food

chain. It has never been found to be dysfunctional in either plants or

animal tissue and has been regarded as an innocuous background

material. Of the many organs and glands that have been analyzed for tin,

only the thymus gland exhibits an above average value.

The tin analysis of the muscle, spleen, and thymus indicated constant

values for the muscle and spleen tissue, but an increase in the thymic tin

concentration (ppm) with age. The increase indicates that the tin was

probably located in the medulla of the thymus, which may be theactive biochemical site for tin in rodents.

J Anal Toxicol1986 Jan-Feb;10(1):6-9


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Tin as a Remedy

to bring form to a disordered structure RS

regulates opposing fields of force RS

- Hydrocephalus- Tuberculosis and Pleurisy

- Liver congestion

- Eczema- Joint effusions - the tin cry when it is bent

- Immune function

Ti d th th l d i


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Tin and the thymus gland: a review.

Cardarelli N

Engineering and Science Technology U of Akron, OH 44325.

Experimental studies over the last decade have suggested an

association between thymus immune and homeostatic

function and exogenous tin. It has been hypothesized that

the thymus gland synthesizes and secretes one or more tin

bearing factors that enhance immune defenses against

malignancy and retard the gradual loss of immunecapacity with senescence.

Thymus 1990 Jun;15(4):223-31


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Tin Sources:

Tinned / canned foods,

cereal grains, dairy, meat,

vegetables, seaweed, licorice,

some toothpastes

Paracelsus Oath:


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Paracelsus Oath:

This is my Vow:

To perfect my medical art and never to swerve

from it so long as God grants me my office, and to

oppose all false medicines and teachings. Then to love

the sick, each and all of them, more than if my ownbody were at stake. Not to judge superficially, but by

symptoms, nor to administer any medicine without

understanding, nor to collect any money without

earning it. Not to trust any apothecary, nor to do anyviolence to any child. Not to guess, but to know.

Paracelsus 1493 - 1541


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Other Elements

(non-planetary)relevant to health


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Calcium

99% of our Calcium ~ 1 kg ~ is in bones

- Osteoporosis is initially a magnesium

disorder -> disrupted calcium deposition

(magnesium hardens teeth, not calcium)

- Take Cal and Mag @ 1:1 c D3 5000u/daysome say to not take together: antagonists

- See www.notmilk.com


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Zinc

- Clinical zinc deficiency humans first described in 1961,

"adolescent nutritional dwarfism" Middle East

- Zinc regulates growth and development, buttresses the

immune response, supports neurological function, andreproduction.

- > 100 different catalytic enzymes depend on zinc

- Zinc supports protein and cell membrane structure

- Zinc regulates gene expression functioning as transcription

factors as they bind to DNA

- Zinc is instrumental in cell signaling esp. re hormone

release and nerve impulse transmission and apoptosis


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Clinical Indications

- Skin

- Immune function

- Nerve sense

- Eyes

- Hearing- Regeneration of tissues

N


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Bradford S. Weeks, M.D. (c) 2009The worlds best deodorant~ think zinc!

New

From

Dr. Kunin


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Magnesium

Light bearer

Ignite a disc the size of sunhold up to thesun and magnesium burns as brightly

Stepping stone for light to become sugar

Where the imponderable gathers substance

Respiration for plantschlorophyll

Magnesium: Clinical Indications


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g

Rhymes with spasm (use it thusly)

Constipation

Headache

Uterine cramps

PreeclampsiaAngina

Claudication

Mitral ValveProlapse

Seizure

Prevention

Twitching (Chovsteks sign)

Fibromyalgia

Pre-chiropractic visit

AlcoholismInsomnia (relax muscles)

Anxiety (soma & psyche)

GERD, gastritisDental health (enamel)

High Cholesterol

Diabetes (metabolizes glucose)


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Iodine/Iodide

Clinical IndicationsRussian wisdom:

If the problem is internal, drink iodine,

If the problem is external, paint iodine.

Thyroid disorders

Cancer (enhances apoptosis)

ASCVDImmune function

Cystic processes

-Fibroids (labial swab with Lugols)

-Fibrocystic breast disease

Iodine Deficiency


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Iodine Deficiency- Most commonly preventable cause of mental retardation- Most common cause of endocrinopathy (goiter and primary

hypothyroidism).

- Neurological damage during fetal development as well as

during lactation.- The safety of therapeutic doses of iodine above the established

safe upper limit of 1 mg is evident in the lack of toxicity in

the Japanese population that consumes 25 times the median

intake of iodine consumption in the United States. (Japan'spopulation suffers no demonstrable increased incidence of

autoimmune thyroiditis or hypothyroidism)

- Klein-Levy Syndrome - myxedema coma (case report)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=18645607&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract


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Iodine alters gene expression in the MCF7 breast cancer cell

line: evidence for an anti-estrogen effect of iodine.

Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ.

Department of Surgery, Drexel University College of Medicine, Philadelphia, PA

The protective effects of iodine on breast cancer have been postulated from

epidemiologic evidence . suggests that iodine may inhibit cancer promotionthrough modulation of the estrogen pathway. Quantitative RT-PCR confirmed the

array data demonstrating that iodine/iodide treatment increased the mRNA levels of

several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1)

while decreasing the levels of the estrogen responsive genes TFF1 and WISP2. This

report presents the results of the first gene array profiling of the response of a breast

cancer cell line to iodine treatment. In addition to elucidating our understanding ofthe effects of iodine/iodide on breast cancer, this work suggests that iodine/iodide may

be useful as an adjuvant therapy in the pharmacologic manipulation of the estrogen

pathway in women with breast cancer.

Int J Med Sci. 2008 Jul 8;5(4):189-96.


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Iodine and Breast CancerIodine: deficiency and therapeutic considerations.

Patrick L. Southwest College of Naturopathic Medicine, [email protected]

Studies using 3.0- to 6.0-mg doses to effectively treatfibrocystic breast disease may reveal an important role foriodine in maintaining normal breast tissue architecture andfunction. Iodine may also have important antioxidantfunctions in breast tissue and other tissues that concentrate

iodine via the sodium iodide symporter.

Altern Med Rev. 2008 Jun;13(2):116-27


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Find

a cure

before I

grow

boobs!


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David Derry, M.D. & David Brownstein, M.D.


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Tin (Sn) is associated with Iodine (I) the same

way as calcium is associated with magnesium.

Tin supports the adrenals, iodine supports the

thyroid, both then affect cardiac output:

Tin + adrenals control the left side,

Iodine + thyroid control the right side.

http://www.acu-cell.com/sni.html

Food Serving Iodine (mcg)Salt (iodized) 1 gram 77


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( ) g

Cod 3 ounces* 99

Shrimp 3 ounces 35

Fish sticks 2 fish sticks 35Tuna, canned in oil 3 ounces (1/2 can) 17

Milk (cow's) 1 cup (8 fluid oz) 56

Egg, boiled 1 large 12

Navy beans, 1/2 cup 32Potato w peel 1 medium 60

Turkey breast, 3 ounces 34

Seaweed1/4 oz Variable; 4,500 mcg

A three-ounce serving of meat is about the size of a deck

of cards.

Turkey and potato were baked, navy beans cooked

Only Mae West believes


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Association of High Iodine Intake withthe T1799A BRAF Mutation in Papillary

Thyroid Cancer.

Guan H, Ji M, Bao R, Yu H, Wang Y, Hou P, Zhang Y,Shan Z, Teng W, Xing M.

J Clin Endocrinol Metab. 2009 Feb 3

y

Too much of a good thing is wonderful!

Be careful with excess iodine.

Iodine Drug interactions


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Amiodarone contains high levels of iodine and may

affect thyroid function.

Lithium in combination with SSKI ->

hypothyroidism.

SSKI -> less anticoagulant effect of warfarin

Acute Iodine ToxicityThis is rare (requires gram dosing)

Symptoms: burning of the mouth, throat, and stomach; fever;

nausea; vomiting; diarrhea; a weak pulse; and coma


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Selenium

glutathione peroxidase (anti-oxidant)

cytochrome P450 detoxification of xenobiotics;

Clinical indications:

cancer

viral infection

infertilityheavy metal detoxification

macular degeneration

Selenium


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Birth control for virus / viriE.W. Taylors theory that viruses encode for the selenoenzyme

glutathione peroxidase because they have a practicallyidentical enzyme - the net result being selenium deficiency forhumans and subsequent immunocompromised status.

See

Selenium and cellular immunity. Evidence that selenoproteins may beencoded in the +1 reading frame overlapping the human CD4, CD8, andHLA-DR genes. Taylor EW. Biol Trace Elem Res. 1995 Aug-Sep;49(2-3):85-95.

Functional studies of an HIV-1 encoded glutathione peroxidase Zhao L,Olubajo B, Taylor EW Biofactors. 2006;27(1-4):93-107

http://www.hdfoster.com/WhatReallyCausesAIDS.pdf By Harold Foster


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Lithium for Learning

Lithium: The Misunderstood Mineral Part 1

By Jonathan V. Wright, M.D.

(Reprinted From "Nutrition and Healing")

Think young into your 90s with this anti-aging

secret for your brain

Chronic lithium treatment magnifies learning in rats.


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Nocjar C, Hammonds MD, Shim SS. Dept Psychiatry, Louis Stokes Cleveland VA

Medical Center, Cleveland, OH 44141, USA. [email protected]

Recent electrophysiological work shows that chronic lithium

treatment increases long-term potentiation (LTP) in neurons

of the hippocampus, and LTP is thought to be the major

neurophysiological basis for the development of learning andmemory. This suggests that lithium might enhance learning

and memory. Thus chronic lithium treatment may improve

learning and memory in Alzheimer's disease, and do so not

only by blocking the formation of beta-amyloid and

neurofibrillary tangles as suggested by previous research, butalso by enhancing mechanisms involved in basal learning and

memory formation, such as hippocampal synaptic plasticity.

Neuroscience. 2007 Dec 19;150(4):774-88.

Lithium and cognitive enhancement: leave it or take it?


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Tsaltas E, Kontis D, Boulougouris V, Papadimitriou GN.

Experimental Psychology Laboratory, Department of

Psychiatry, Eginition Hospital, Athens, Greece,

[email protected].

Lithium is established as an effective treatment of acutemania, bipolar and unipolar depression and as prophylaxis

against bipolar disorder. Accumulating evidence is

also delineating a neuroprotective and

neurotrophic role for lithium.

Psychopharmacology 2009 Jan;202(1-3):457-76.

N-methyl-D-aspartate receptors are involved in lithium-induced

state dependent learning in mice


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state-dependent learning in mice.

Rezayat M, Niasari H, Ahmadi S, Parsaei L, Zarrindast M.

Department of Pharmacology, School of Medicine, Tehran, Iran.

We have previously shown lithium-induced state-

dependent learning in a step-down inhibitory avoidance

task. The results suggest that NMDA receptors may be

involved, at least partly, in the lithium-induced state-

dependent learning.

J Psychopharmacol. 2009 Jan 22. [Epub ahead of print]

Lithium reduces ischemia-induced hippocampal

CA1 damage and behavioral deficits in gerbils
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19164491&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19164491&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract


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CA1 damage and behavioral deficits in gerbils.

Bian Q, Shi T, Chuang DM, Qian Y.

Dept Anesthesiology, Nanjing Medical U, Nanjing, PR China.

This is believed to be the first report of lithium-induced

protection against hyperactivity in a novel open field andmemory impairment in a gerbil model of global ischemia.

These results underscore theability of lithium to improve

functional behavioral outcome in gerbil and rodent cerebral

ischemic models andfurther indicate the potential therapeutic

use of lithium in certain human stroke conditions.

Brain Res. 2007 Dec 12;1184:270-6

Cobalt Rx Vitamin B IM shots


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Cobalt Rx Vitamin B IM shots

Start with Folic Acid cc (precipitates)

then draw up Vitamin B12 ( or methylcobalamine) 1 cc

then draw up Vitamin B complex 1 cc,

and lastly Vitamin B6 (pyridoxine HCL) cc (= 3 cc total)

Take one shot as instructed with sterile procedure in upper outer buttock

(alternate sides) aim CHEEK to CHEEK.

Do this every AM for 30 days then we will reassess to determine any changes in

dosage and frequency.

Dispense: #4 vials, #30 3 cc syringes, 30 gauge needles, betadine Cansubstitute Folic acid with ACE 0.5 cc or Procaine 0.5 cc

or Glutathione 0.5 cc or Liver Extract 0.5 cc

Methylcobalamin used in peripheral neuropathy diabetic


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Methylcobalamin used in peripheral neuropathy, diabetic

neuropathy and disruptions of sleep-wake rhythms.

Cobalamins with folic acid enable DNA synthesis in cells

(in bone marrow and myeloid cells) and are essential co-

factors for two cellular reactions:

(1) the mitochondrial methylmalonyl coenzyme A mutase

conversion of methylmalonic acid (MMA) to succinate,

which links lipid and carbohydrate metabolism, and

(2) activation of methionine synthase, which is the rate

limiting step in the synthesis of methionine from

homocysteine and tetrahydrofolate


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Chromium

- metabolism of cholesterol and

glucose;

- assists with ASCVD, hypoglycemia,diabetes,

- GTF (niacin, glycine glutamic acid,

cysteine, and trivalent chromium)- hexavalent chromium is very toxic


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Manganese

Manganese is an essential mineral element

that is potentially toxic. The derivation of its

name from the Greek word for magicmagikos

remains appropriate because it plays an

important role in transmutation as a

constituent and an activator of many enzymes.

Food Serving Mn


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Pineapple, raw 1/2 cup, diced 0.91g

Pineapple juice

1/2 cup (4

ounces) 0.63

Pecans 1 ounce 1.28

Almonds 1 ounce 0.72

Peanuts 1 ounce 0.55Instant oatmeal (prepared with

water)1 packet 1.68

Raisin bran cereal 1 cup 1.88

Brown rice, cooked 1/2 cup 0.88Whole wheat bread 1 slice 0.60

In mg


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Manganese-activated enzymes

- critical in metabolism COH, bone, amino acids

Example of manganese containing enzymes:

1) Pyruvate carboxylase - gluconeogenesis

2) Phosphoenolpyruvate carboxykinase - gluconeogenesis

3) Arginase required by the liver for the urea cycle

(helps detoxifies ammonia)

4) Glycosyltransferases - synthesis of proteoglycans

(bone and cartilage)

5) Prolidase, prepares proline, for collagen formation6) Glycosaminoglycan synthesis

(manganese-activated glycosyltranserases) wound healing

Manganese and Wound


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Manganese and Wound

HealingShetlar MR, Shetlar CL. The role of

manganese in wound healing. In: Klimis-

Tavantzis DL, ed. Manganese in healthand disease. Boca Raton: CRC Press,

Inc.; 1994:145-157.


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Manganese superoxide dismutase

(MnSOD) is the principalantioxidant enzyme in the

mitochondria.

MnSOD catalyzes the conversion of

superoxide radicals to hydrogenperoxide, (itself reduced to water)

Manganese Deficiency


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g y

- impaired glucose tolerance - increased diabetes

- altered carbohydrate metabolism

- altered lipid metabolism

- bone demineralization and impaired growth

(note: blood calcium, phosphorus, and alkalinephosphatase levels were also elevated

suggesting increased bone remodeling

women with OP have lower serum MN levels

- decreased serum cholesterol levels- transient skin rash

- lowered seizure threshold


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Manganese - Clinical indications

- diabetes

- asthma

- fatigue

- allergies- osteoarthritis

- tendonitis

- manages metabolism of COH, proteins and fats- vital to thiamine metabolism, vitamin E utilization

and mucopolysacharide formation

Manganism Mn Toxicity: ~Parkinsons


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- Phase I

Psychiatric Abnormalities:

Hyperirritability, violence, compulsiveness, forced laughter,

apathy, sleep disturbance

- Phase II

Neurological Disorder of Extrapyramidal Motor System:Tremor, loss of speech/motion coherence, high-stepping gait

(velcro feet), mask-like face

- Phase III

Bradykinesia, rigidity

Slide from D. Quig, DD

Ref. Environ Health Perspective (2000)108;429-32

Carl GF, Gallagher BB.


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Manganese and epilepsy.

In: Klimis-Tavantzis DL, ed.

Manganese in health and disease.

Boca Raton: CRC Press, Inc;

1994:133-157.


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discovery of manganese as a cure fordrug-induced dyskinesia was the first

orthomolecular research to verify the

efficacy of mineral therapy for a disease(other than simple deficiency).

http://orthomolecular.org/hof/2008/kunin.html


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Sir Richard KuninOrthomolecular

Hall of Fame

Founder & Leader OMS

Closet Alchemist

Walker of the Talk

NOTE:

he hasnt aged a bit


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Title Page:Joseph ben

Abraham Gikatilla,

Portae lucis, 1516.


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SUMMARY

andRECOMMENDATIONS

Mineral Digestion A Chelation Process


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Mineral Digestion A Chelation Process

Foods Minerals as protein complexes

Unless bone is consumed to get hydroxyapatite salts

Stomach

Acid causes neutralization of carboxylic acids

Minerals become free ions with chloride and phosphate ascounter-ions

Duodenum

Alkaline pancreatic juice neutralizes chyme

Carboxylic acids take on negative charge again

New chelates and complexes formSmall intestine

Selective uptake of ionic forms under tight control ofregulatory proteins

Your best mineral supplement?


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1) Avoid milk (antacid)

2) Betaine HCL and pepsin

with each meal

layer it in with foodBetaine HCL (COH, protein, fats) + Pepsin (splits proteins)

Dropping Acid

see http://weeksmd com/?p=96

ee cummings


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ee cummings

"Oh, sweet spontaneous earth, how oftenhave the doting fingers of prurientphilosophers pinched and poked thee, hasthe naughty thumb of Science prodded thy

beauty. How often have Religions taken theeupon their scraggy knees squeezing andbuffeting thee that thou mightest conceiveGods (but true to the incomparable couch of

death, thy rhythmic lover, thou answerestthem only with spring)"


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a perspective on minerals and metals in human health

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