a nt id i ab e tic a c tiv i ty of str ych n us p otat or ...jprcp.com/data/archives/2011/vol 1...

naJ ,ecitcarP lacinilC & hcraeseR lacituecamrahP fo lanruoJ - 81:)1(1 ;1102 hcraM - 62

1:)1(1 ;1102 PCRPJ ,la.te BS rakesardnahC 8-26 81

elcitrA hcraeseR

ditnA fo ytivitcA citebai murotatoP sunhcyrtS nniL llA tsniagA sdeeS decudnI naxoi sutilleM setebaiD staR n .

S uhgaR 1 nuhdiM , T1 oaR arawsetakneV , 1 , * BS rakesardnahC 2 , B rakayaJ 1 G amhsuS , 2

.1 fo tnemtrapeD Ph akayaniV ,ygolocamra M C s'noissi fo egello P .udanlimaT ,melaS ,ycamrah

.2 ,dtL .tvP seidemeR larutaN ,tnemeganaM ataD hcraeseR .erolagnaB

sdrowyeK :

,murotatop sonhcyrtS d sutillem setebai , a .naxoll

1 devieceR 6 beF 0102 mrof desiver ni devieceR 40 Ma hcr 1102

70 detpeccA hcraM 1102

:ecnednopserroC rof rohtuA* ,rakesardnahC .B.S

,reciffO hcraeseR roinuJ ,tnemeganaM ataD hcraeseR

dtL .tvP seidemer larutaN . , .erolagnaB :liamE moc.liamg@rakesardnahcbs

TCARTSBA

:dnuorgkcaB fo puorg a si sutillem setebaiD aimecylgrepyh yb deziretcarahc snoitaretla cilobatem ro noitca ,noiterces nilusni ni stcefed morf gnitluser eht yfitnedi ot saw yduts tneserp ehT .htob suoeuqa dna )PSEE( cilonahte fo ytivitca citebaiditna

o stcartxe )PSEA( f murotatop sonhcyrtS tsniaga sdees .star ni setebaid decudni naxolla :stluseR DL ehT 05 eht

o.p ,.w.b gk/gm 0002 eb ot dnuof erew stcartxe ehT ,. tnacifingis detibihxe stcartxe PSEA dna PSEE eht ni snoitcuder tnacifingis dna cimecylgopyh ,loretselohc latoT( sretemarap lacimehcoib saw niager thgiew ehT .)LDLV dna LDL ,sedirecylgirT llew sa PSEE eht htob ni tnacifingis eb ot dnuof osla

A eht sa dewohs yduts eht hguoht nevE .PSE dradnats eht htiw gnirapmoc ytivitca tnacifingis dnuof erew stcartxe eht fo ytivitca tub ,edimalcnebilg eht ot derapmoc sa desaerced ylthgils ro ralimis eb ot eht demrifnoc stluser ygolohtapotsih ehT .dradnats

esehT .sdnif lanicidem eht dewohs stluser .tnalp eht fo ecnacifingis :noisulcnoC tneserp ehT eht taht dedulcnoc yduts murotatop sonhcyrtS nnil

.setebaid fo tnemtaert eht ni lufesu devorp



NOITCUDORTNI eht si sutillem setebaiD nommoc tsom

ediwdlrow redrosid cilobatem ]1[ . tI a si deziretcarahc snoitaretla cilobatem fo puorg ni stcefed morf gnitluser aimecylgrepyh yb

.htob ro noitca ,noiterces nilusni sah tI cinorhc taht dehsilbatse neeb ydaerla

ossa si setebaid fo aimecylgrepyh htiw detaic dna noitcnufsyd ,egamad mret gnol yllaicepse ,snagro fo eruliaf eht yllautneve doolb dna traeh ,sevren ,syendik ,seye eht

slessev .]2[ nI htiw detalerroc si ti adevruyA lacinilc sa ,”ahemuhdaM“ dellac esaesid a

ralimis era htob fo serutaef 3[ .] ynaM era setebaid rof stnemtaert tnalp lanoitidart

dlrow eht tuohguorht desu [4- ]5 tsom tub si stceffe laicifeneb rieht rof ecnedive eht fo nilusni fo noitcudortni retfA .latodcena rof tnemtaert lanoitidart fo esu eht ypareht

,denilced yltaerg setebaid emos hguohtla rof deunitnoc era secitcarp lanoitidart ot stcnujda dna esoprup citcalyhporp

.ypareht lanoitnevnoc stnalp lanicidem ehT laro fo ecruos lufesu a edivorp eht rof sdnuopmoc cimecylgopyh sdael lacituecamrahp wen fo tnempoleved

rateid a sa llew sa gnitsixe ot tnemelppus yseipareht .]4[

rof desu gnieb era hcihw stnalp eht fo emoS deviecer evah setebaid fo tnemtaert eht eht neve dna yniturcs lanicidem ro cifitneics setebaid no eettimmoc trepxe OHW rehtruf tnarraw aera siht taht sdnemmocer

noitnetta .]6[ A labreh fo rebmun egraldetats sgurd ytivitca citebaiditna ssessop ot

fo enicidem fo metsys cidevruyA eht ni ,aidnI murotatop sonhcyrtS gnignoleb nniL

nwonk neeb sah eaecainagoL ylimaf eht otitna ssessop ot - desu osla tI .ytivitca citebaid

idnuaj ni ,amredocuel ,noitammalfni ,ec ,citerohpaid ,citeme sa desu aehrronog ,citeruid ,tnegnirtsa ,ssensuoilib ,ciretixela

setib ekans gnitaert rof desu ,citnimlehtna

7[ - ]9 . yevrus erutaretil fo kcal ehT , tneserp

citebaiditna eht yfitnedi ot saw yduts fo ytivitca murotatop sonhcyrtS sdees

.star ni setebaid decudni naxolla tsniaga SDOHTEM DNA SLAIRETAM

murotatop sunhcyrtS eht fo noitaraperPtcartxe nnil

dees deird ehT fo s murotatop sunhcyrtS melaS ,ittapirraK morf deviecer erew nnil

imaT( saw nemiceps rehcuov A .)udanl eht fo muirabreh eht ni detisoped akayaniV ,ysongocamrahp fo tnemtraped

aidnI ,melaS ,ycamrahp fo egelloc s'noissim .dees ehT ,deredwop ylesraoc erew s

noitalocrep toh suounitnoc V/V %59 htiw eht ,noitcartxe fo noitelpmoc retfA .lonahte kraD .noitallitsid yb devomer saw tnevlos ehT .deniatbo saw eudiser ruoloc neerg ehT .rotaccised ni derots neht saw eudiser deird saw noitcartxe lonahte retfa tfel cram

etaw htiw detcartxe neht dna mroforolhc r 7 rof ssecorp noitarecam dloc yb )1.0:01(

7 fo dne eht tA .syad ht deretlif saw ti ,yad saw etartlif eht dna htolc nilsum hguorht saw noitulos gniniamer ehT .detartnecnoc ehT .htab retaw a no gnitaeh yb detaropave

iatbo saw eudiser ruoloc nworb ehT .deni derots neht saw eudiser ehT .rotaccised n

eht fo dleiy tcartxe cilonahte sunhcyrtSmurotatop suoeuqa dna %7 saw )PSEE( nnil

fo tcartxe murotatop sunhcyrtS )PSEA( nnil.%56.7 saw

sutarappa dna slacimehC morf deniatbo saw etardyhonom naxollA

amgiS slacimehc rehto llA .ASU ,siuoL tS , edarg lacitylana erew desu stnegaer dna lacimehc devorppa morf derucorp dna cilobatem eht sa hcus sutarappA .sreilppus rezylanaotuaimes ,)ylatI ,tsalpinceT( segac

dloC ,)balorteM( ( egufirtnec imeRVU ,)stnemurtsnI - ceps uzdamihS( retemort

eht ni desu erew )stnemurtsni cifitneics



.yduts slaminA

nI tluda demrofrep stnemirepxe ehtyelwaD eugarpS 051( star - ssiwS dna )g 00202( ecim onibla - erew sexes htob fo )g 52

eht morf derucorp erew slamina ehT .desu arawsetakneV .irS fo esuoh lamina ni tpek erew yehT .erolagnaB ,sesirpretne

62 ta esuoh lamina latnemtraped eht 2 C 44 ytidimuh evitaler dna – ni %65

erew slamina ehT .segac enelyporpylop dna ssenkrad fo h 21 etanretla ot desopxe htiw dedivorp erew slaminA .hcae thgil ,nahtsudniH( teid tellep tnedor dradnats

81 nwardhtiw saw doof eht dna )aidnI - h 42 saw retaw hguoht tnemirepxe eht erofeb

dewolla da mutibil stnemirepxe eht llA . gnidrocca gninrom eht ni demrofrep erew fo noitagitsevni rof senilediug tnerruc ot ehT .slamina suoicsnoc ni niap latnemirepxe

alunnac cirtsagoro dradnats rof desu saw ni sgurd fo noitartsinimda gurd laro latnemirepxe ehT .slamina latnemirepxe lanoitutitsni yb devorppa erew slocotorp /.loC.P .oN CEAI( eettimmoc scihte lamina

.)9002/ 44 seiduts yticixot etucA

detcudnoc saw seiduts yticixot laro etucAdrocca tseT .senilediug )324( DCEO ot gni

tset fo esod fo noitartsinimda sevlovni tluda gnuoy yhtlaeh retsaf ot secnatsbus 51 otpu rof noitavresbo ,egavag laro yb ecim ydob fo gnidrocer dna gnisod retfa syad .slamina eht lla fo ysporcen eht dna thgiew

em siht nI erp doht - fo sesod dexif deificepsi desu erew secnatsbus tset eht .e. ,gk/gm 5 ,

eht dna gk/gm 0002 ,gk/gm 003 ,gk/gm 05 erew sesod eseht ot eud ytilatrom siht rof desu erew slamina elamef ,devresbo

tsisnoc puorg esod hcae dna yduts s 3 foslamina 01[ - .]21

nI setebaid fo noitcud a htiw yllaenotirepartni detcejni erew staR

naxolla fo noitulos deraperp ylhserf 051 fo esod a ta enilas ni etardyhonom

thgiew ydob fo gk/gm .]31[ naxolla ecniS sa aimecylgopyh lataf ekovorp nac noitcejni

r evissam evitcaer fo tluser a fo esaele nevig osla erew star ,nilusni citaercnap

5 yllaro - retfa noitulos esoculg %02 fo lm 01 h 42 txen eht rof tpek neht erew staR .h 6 ot egareveb sa noitulos esoculg %5 a no

ereves tneverp aimecylgopyh .]41[ doolB retfa syad 3 derusaem erew slevel esoculg ot retemarap sa desu dna noitcejni naxolla setebaid htiw star fo sriap gnihctam niatbo htiw star ylnO .ytireves fo level ralimis fo naht retaerg slevel esoculg doolb gnitsaf

itebaid deredisnoc erew Ld/gm 002 dna c doolb naem ehT .yduts eht ni dedulcni neht cimecylgomron ni esoculg fo noitartnecnoc erew star citebaiD .Ld/gm 59 saw star spuorg tnereffid ruof ot dengissa ylmodnar

( n stnemtaert llA .)spuorg/lamina 6 = trats noitcejni naxolla retfa syad 3 ylno 1[ 5- .]61

ngised latnemirepxE :sehctab neves otni dedivid erew star ehT

puorg - nevig puorg lortnoc lamron saw I retaw dellitsid repyh fo noitcudni tuohtiw

acylg puorg ,aime - naxolla saw II - star citebaid citebaid saw III puorg ,retaw dellitsid nevig

detaert star gk/gm 5.0( edimalcnebilg htiww.b ,.o.p ,. ) , ]71[ star citebaid saw VI puorg

PSEE htiw detaert .w.b gk/gm 001( ,.o.p , ,) PSEE htiw detaert star citebaid saw V puorg

.w.b gk/gm 002( ,.o.p , saw IV puorg ,) gk/gm 001( PSEA htiw detaert star citebaid

.w.b ,.o.p , star citebaid saw IIV puorg ,).w.b gk/gm 002( PSEA htiw detaert ,.o.p , .)

htiw deretsinimda erew sgurd slamina eht llA ehT .syad 21 rof ebut egavag laro fo pleh eht

derusaem esoculg doolb dna thgiew ydob no1 ts 3 , dr 6 , ht 9 , ht 21 , ht yad .puorg hcae htiw

eht rof detcelloc erew selpmas doolB morf level esoculg doolb fo tnemerusaem saw level esoculg doolB .sunis latibro orter



cinortcele na gnisu denimreted retemoculg .)nozirph hcuot eno( erew selpmas doolb ehT

gurd retfa h1 gninrom ni detcelloc1 no noitartsinimda ts 3 , dr 6 , ht 21 , ht rof yad

yad lanif eht no doolb ni noitamitse esoculg elpmas doolb erom eno tnemirepxe eht fo ehT .star puorg hcae morf detcelloc saw

oc erew seussit saercnap demrofrep detcell.yduts lacigolohtapotsih

sisylana mureS orter eht morf detcelloc saw doolb ehT -

dna noitidnoc citehtseana rednu sunis latibro ta noitagufirtnec yb detarapes saw mures rof dezylana dna nim 01 rof g 000,01

l ,)LGT( sedirecylgirt ,loretselohc ytisned wo nietorpopil ytisned hgih ,)LDL( nietorpopil nietorpopil ytisned wol yrev dna )LDH( napS morf desahcrup erew stik llA .)LDLV(

.aidnI ,.dtL scitsongaid sisylana lacigolotsiH

.ygolotsih rof desu saw erudecorp lacissalC

nivob ni noitaxif retfA fo seceip ,noitulos ,niffarap otni deddebme erew eussit dexif

eruoloc dna secils norcim 5 ni tuc htiw dnilyxotameh - nisoe .

sisylana lacitsitatS erpxe erew stluser ehT ± naem sa dessMES( naem rorre dradnats lacitsitats ehT .)

gnisu dessessa saw ecnacifingis yaw eno yb dewollof )AVONA( ecnairav fo sisylana daPhparG gnisu tset nosirapmoc s’ttennuD sa deredisnoc erew secnereffiD .60.3 tatsnI

nehw tnacifingis yllacitsitats 50.0 < p p dna .10.0 <

STLUSER yduts yticixot etucA

DL ehT 05 ot dnuof erew stcartxe eht htob fo oN .ecim ni ,.o.p .w.b gk/gm 0002 eb

a ni devresbo saw ytidibrom fo yn ecim eht .detset

slevel esoculg doolb dna thgiew ydoB

1 elbaT . no PSEA dna PSEE fo tceffE B ydo W ni thgie R sta .

oN

spuorG

dna syaD marg ni thgiew ydob laitinI 3 6 9 21

I lamroN ±39.981 51.1

±0.981 18.0

±65.881 03.2

±66.291 59.2

±03.491 92.1

II citebaiDlortnoc

±65.581 75.0

±61.571 60.1 **a

±33.661 75.1 **a

±33.351 18.0 **a

±61.241 93.1 **a

III edimalcnebilG

gk/gm 5.0

±35.781

46.1

±38.781

39.0 **b

±66.981

83.2 **b

±61.091

88.2 **b

±66.291

51.1

VI 001 PSEEgk/gm

±34.981 93.1

±38.271 39.0 **a

±66.571 13.1 **b **a

±00.771 69.1 **b **a

±.76.871 80.2 **b **a

V 002 PSEE

gk/gm

±66.881

92.1

±61.771

69.1 **a

±08.671

37.1 **b **a

±21.871

02.2 **b **a

±0.081

88.2 **b **a



IV 001 PSEA

gk/gm

±86.881

37.1

±61.071

88.2 **a

±38.171

75.1 **a

±50.471

51.1 **b **a

±38.771

20.2 **b **a

IIV 002 PSEA

gk/gm

±67.981

85.2

±61.571

93.1 **a

±5.071

93.1 **a

±3.271

61.1 **b **a

±61.281

48.0 **b **a

naem sa desserpxe era seulaV + yrev = 10.0<p ** dna tnacifingis = 50.0<p* ,6=n ,MES ,tnacifingis a ,lortnoc lamron htiw edam era nosirapmoc b citebaid htiw edam era nosirapmoc

.lortnoc

( elbaT 1) star citebaid eht taht stciped )PSEA dna PSEE( stcartxe eht htiw detaert )10.0 < p( tnacifingis dewohs sesod htob

thgiew ydob fo ssol eht ni dellortnoc retteb.lortnoc eht ot derapmoc sa

2 elbaT . doolB no PSEA dna PSEE fo tceffE leveL esoculG A ni naxoll I decudn R citebaiD sta .

ON tnemtaerT

d/gm dna syaD l

0 3 6 9 21

I lamroN 86.67 ± 60.1

68.77 ± 93.1

33.87 ± 02.2

68.87 ± 96.2

61.97 ± 20.3

II

citebaiDlortnoC

53.77 ±

08.1

67.052 ± 58.01 **a

41.742 ± 51.5 **a

26.842 ±

03.3 **a

37.152 ±

14.3 **a

III

imalcnebilG

5.0( ed

)gk/gm

54.87 ±

93.1

48.542 ± 23.5 **a

48.291 ± 10.3 **b **a

62.231 ± 88.2 **b **a

33.131 ± 12.4 **b **a

VI

001 PSEE

gk/gm

34.67 ± 0. 15

33.642 ± 54.3 **a

61.212 ± 10.3 **b **a

24.591 ± 88.2 **b **a

65.581 ± 11.3 **b **a

V

002 PSEE

gk/gm

83.77 ± 75.0

23.042 ± 88.2 **a

61.891 ± 03.3 **b **a

61.281 ± 36.2 **b **a

61.081 ± 18.2 **b **a



IV

001 PSEA

gk/gm 63.87 ± 18.0

63.842 ± 76.2 **a

54.612 ± 02.3 **b **a

67.391 ± 96.2 **b **a

78.981 ± 19.2 **b **a

IIV 002 PSEA

gk/gm 38.97 ± 91.1

34.932 ± 74.3 **a

78.991 ± 56.2 **a

52.581 ± 88.2 **b **a

61.971 ± 21.3 **b **a

naem sa desserpxe era seulaV + yrev = 10.0<p ** dna tnacifingis = 50.0<p* ,6=n ,MES ,tnacifingis a ,lortnoc lamron htiw edam era nosirapmoc b citebaid htiw edam era nosirapmoc

.lortnoc

( elbaT 2) tnemtaert fo tceffe eht sebircsed esoculg doolb gnitsaf no stcartxe eht fo

esod tnacifingiS .slevel noitcuder tnedneped .star detaert tcartxe eht ni devresbo saw

s saw ,.o.p w.b gk/gm 002 PSEE yrev dewoh0.0 < p( tnacifingis htiw derapmoc nehw )1

uorg rehto .sp

eliforp dipil mureS

.3 elbaT lacimehcoiB P sretemara L i PSEA dna PSEE fo leve n A naxoll I decudn R citebaiD sta A 21 retf D fo sya T tnemtaer

oN spuorG loretselohC )ld/gm( )ld/gm(LGT )ld/gm(LDH )ld/gm(LDL )ld/gm(LDLV

I lamroN ±66.211

93.1 ±6.221

96.2 ±66.53

05.1 ±5.38

96.2 ±39.52

89.0 II

citebaiD lortnoc

±62.651 10.3 **a

±39.881 55.2 **a

±4.62 37.1 **a

±89.17 44.1 **a

±67.14 60.1 **a

III

edimalcnebilG)gk/gm 5.0(

±62.111 49.2 **b

±87.421 03.2 **b

±26.73 22.1 **b

±39.37 05.1 **b **a

±49.42 51.1 **b

VI

001 PSEEgk/gm

±331 96.2 **b **a

±61.141 95.2 **b **a

±39.33 39.0 **b

±39.47 51.1 **b *a

±90.82 03.2 **b

V

002 PSEEgk/gm

±66.521 88.2 **b **a

±34.231 36.2 **b

±66.92 51.1 *a

±46.07 88.1 **b **a

±65.52 44.1 **b

IV 001 PSEAgk/gm

±32.641 10.3 **a

±67.551 88.2 **b **a

±33.23 22.1 **b

±3.67 37.1 **b

±89.62 37.1 **b

IIV 002 PSEAgk/gm

±61.421 87.2 **b *a

±2.041 10.3 **b **a

±38.03 93.1

±38.27 93.1 **b **a

±5.52 3.1 **b

naem sa desserpxe era seulaV + <p* ,6=n ,MES yrev = 10.0<p ** dna tnacifingis = 50.0 ,tnacifingis a ,lortnoc lamron htiw edam era nosirapmoc b citebaid htiw edam era nosirapmoc

.lortnoc



( elbaT 3) no stcartxe fo tceffe eht sebircsed lortnoc citebaid eht nI .eliforp dipil mures

citebaid tub detaertnu( puorg - latot )decudni slevel LDLV dna LDL ,edirecylgirt ,loretselohc

i erew 0.0 < p( yltnacifingis desaercn nehw )1 LDH tuB .lortnoc lamron ot derapmoc level

nehw )100.0 < p( yltnacifingis desaerced saw dna 001( PSEE .lortnoc lamron ot derapmoc 002 dna 001( PSEA dna ).o.p .w.b gk/gm 002 latot decuder yltnacifingis ).o.p .w.b gk/gm

,edirecylgirt ,loretselohc dna LDL dna ,. LDLVeht desaercni yltnacifingis nehw level LDH

esod lortnoc citebaid ot derapmoc.yltnedneped

snoitavresbo lacigolotsiH taht dewohs sgnidnif lacigolohtapotsih ehT

saercnap eht erew n htiw .erutcetihcra lamroew stelsi ehT .inica lamron fo desopmoc er

inica ehT ew lavo ot dnuor yb denil er sllec dnuor llams dna msalpotyc etaredom htiw detaert edimalcnebilg eht ni ielcun lavo ot htob fo sesod rewol eht fo noitceS .lamina slamina detaert stcartxe PSEA dna PSEE stelsi ehT .sisorcen yhctap dewohs saercnap

sopmoc era inica ehT .inica lamron fo de erew htiw sllec lavo ot dnuor yb denil

ams dna msalpotyc etaredom lavo ot dnuor llsaw erehT .ielcun fo etartlifni na

nihtiw sllec amsalp wef a dna setycohpmyl fo esod rehgih fo noitces ehT .amorts eht slamina detaert stcartxe PSEA dna PSEE

saercnap dewohs n htiw .erutcetihcra lamroew stelsi ehT .inica lamron fo desopmoc er

inica ehT ew sllec lavo ot dnuor yb denil er dnuor llams dna msalpotyc etaredom htiw

.ielcun lavo ot

1 giF . iH ygolohtapots P ygolohta S fo ydutP taR saercna

lortnoc lamroN .A

o.p thgiew ydob gk/gm 001 PSEE .B .

lortnoc citebaiD .C

.o.p thgiew ydob gk/gm 002 PSEE .D



thgiew ydob gk/gm 5.0 edimalcnebilG .E.o.p

.F .o.p thgiew ydob gk/gm 001 PSEA

.o.p thgiew ydob gk/gm 002 PSEA .G

NOISSUCSID

,yduts tneserp eht nI saw niager thgiew dna PSEE htob ni tnacifingis eb ot dnuof

fo stcartxe PSEA murotatop sonhcyrtS nnil . tnacifingis dewohs yduts eht hguoht nevE dradnats eht htiw gnirapmoc ytivitca tcartxe eht fo ytivitca tub ,edimalcnebilg ylthgils ro ralimis eb ot dnuof saw

.ti ot derapmoc sa desaerced doolb ehT PSEE eht taht etacidni ylraelc slevel esoculg

fo PSEA dna decudorp stcartxe eht htob cimecylgrepyhitna tnetsisnoc dna tnacifingis .star citebaid decudni naxolla ni tceffe eerf ecudni ot dnuof neeb sah naxollA

yrujni eussit esuac dna noitareneg lacidar .]81[ eb yam stcartxe PSEA dna PSEE ehT

f fo level eht decuder noitareneg lacidar eer eht no tcartxe eht fo noitcnuf eht dna eht gnidulcni seussit lativ noitcetorp

.eussit saercnap yllausu era sdipil mures fo slevel ehT na hcus dna sutillem setebaid ni detavele rof rotcaf ksir a stneserper noitavele

sid traeh yranoroc hgih lamronba sihT .esae eht ot eud ylniam si sdipil fo level no senomroh citylopil fo snoitca detibihninu fo noitca eht ot eud ylniam stoped taf eht nilusni ,secnatsmucric lamron rednU .nilusni ,esapil nietorpopil emyzne eht setavitca

irt sesylordyh hcihw ni ,revewoH .sedirecylg ton si esapil nietorpopil ,etats citebaid a gnitluser ycneicifed nilusni ot eud detavitca

aimedirecylgirtrepyh ni .]91[ nI nilussi ycneicifed osla htiw detaicossa

ycneicifed nilusnI .aimeloretselohcrepyhilsyd rof elbisnopser eb yam ,aimedip

no noitca yrotibihni na sah nilusni esuacebGMH - etar yek a ,esatcuder AoC - gnitimil

fo msilobatem eht rof elbisnopser emyzne ehT .selcitrap LDL hcir loretselohc eht rof elbisnopser msinahcem dna aimedirecylgirtrepyh fo tnempoleved

eloretselohcrepyh dellortnocnu ni aim fo rebmun a ot eud era snamuh ni setebaid rucco taht seitilamronba cilobatem

yllaitneuqes .]02[

dewohs star citebaid eht ,yduts ruo nIaimeloretselohcrepyh dna

aimedirecylgirtrepyh tnemtaert eht dna desaerced yltnacifingis tcudorp eht htiw LDLV dna LDL ,edirecylgirt dna loretselohc nac tcudorp eht taht seilpmi sihT .slevel eht gnicuder ni lufpleh eb ro tneverp



emos ni nees eliforp dipil fo snoitacilpmocepyh mohw ni tneitap setebaid aimecylgr

oc aimeloretselohcrepyh dna - etiuq tsixe.netfo ygolohtapotsih ehT yduts demrifnoc

eht dewohs stluser esehT .stluser eht.tnalp eht fo ecnacifingis lanicidem

NOISULCNOC evah seiduts yticixot etuca yranimilerp ehT

sngis elbisiv on delaever ro fo smotpmysA dna PSEE eht fo yticixot .star lamron ni PSE

ehT yduts tneserp taht dedulcnoc sonhcyrtS murotatop eht ni lufesu devorp nnil

erom ,revewoH .setebaid fo tnemtaertlacimehcotyhp deliated era seiduts

selpicnirp evitca eht yfitnedi ot yrassecen reporP .noitca fo smsinahcem tcaxe dna deirrac eb osla dluohs noitagitsevni lacinilc namuh ni ytivitca eht mrifnoc ot tuo

.esaesid

SECNEREFER .1 A ,AS mootO l- .A ihafoklA ,KZ mereK ,AS ifas ehT

nainadroj citebaid yb sbreh lanicidem fo esu.stneitap J rehtocamrahP breH ;3002 13:6 - .14

.2 QG iL ,PB atoK ,G gneP ,WHT gnauH . ,J arahamaYitnA .Y iL ,DB silagofuoR - fo noitca citebaid acinuP

mutanarg RAPP fo noitavitca :tcartxe rewolf - c noitacifitnedi dna .tnenopmoc evitca na fo

locamrahP lppA locixoT ;5002 061:702 - .961 .3 .ayroosantaR ,areeviridE sbreh eht no weiver A

yb sutillem setebaid fo tnemtaert eht ni desu ,snaicisyhP lanoitidarT dna cidevruyA naknalirS

UYA . ;9002 :)4(03 373 - .193 .4 .C yaD ,JC yeliaB rof stnemtaert lanoitidarT

.eraC tebaiD .setebaid ;9891 355:21 - 455 .5 RN htrowsnraF ,JF selraM . stnalp citebaiditnA

etadpu na :stneutitsnoc evitca rieht dna .locotorp deM taN J retniW ;6991 58 - 111 .

.6 eettimmoc trepxe OHW ,seires stroper lacinhceT ,noitazinagrO htlaeH dlroW ,sutillem setebaid no

.0891.aveneG .7 C erahK D weN stnalp lanicidem naidnI .P ihle ,

regnirpS p ;7002 ; .036 .8 KA inrakdaN . ralupoP ,acideM airetaM naidnI

yabmoB ,dtL tvP nahsakarP . 8991 ; p . .2132 .9 waR ,aidnI fo htlaeW ehT 1002 .lairetam ; .101.p

.01 oC cimonocE rof noitasonagrO[ DCEO - noitarepoD[ dna laro etucA :324 enilediuG ]tnempoleve

.2991 .DCEO :siraP ,yticixot .11 .NM hsohG latnemirepxE fo slatnemadnuF

dna notliH ,atakloK ;ygolocamrahPynapmoc 991. ;6 091.p - .791

.21 J ydnahcnuK ,KA atheM ,KS inrakluK . itnA - enicafnaug ,enidinolc fo snoitca yrotammalfni

B dna - negommalfni suoirav tsniaga 029 TH

star ni wap etuca decudni crA tnI hnydocamrahP :972;6891 423 - .433

.31 PM atpuG .zehcnaS ,S otisopsE ,GN siloS , fo ytivitca cimecylgopyH atabol anealorueN ).L(

locamrahponhtE J .rB .R . ;4891 323:01 . .41 edrukahT .A.P ,appagaN .N.A ,oaR takneV .N ,ias

.hgniS nawiJ fo ytivitca citebaiditnA ailanimreT appatac nniL locamrahponhtE J stiurf . ;3002 :88

54 - .05 .51 rawsemagnaS an ,RB nanhsirklaB ,R hgniS ,B

B rakayaJ . epyhitnA itna dna cimecylgr - simrofiner aeomopI fo stceffe cimedipilrepyh

tar citebaid decudni naxolla no siohC seR J .s deM naidnI cudE ;7002 72 - .03

.61 N hgniS ,V nagumurA ,D layuJ ,V layuJ , .VR idavas tcartxe cilonahte fo ytivitca cimecylg repyh itnA

fo krab fo ailofignoL aihtlayloP ollA ni nax sgurd naidnI .staR citebaiD ;5002 795:24 - .995

.71 G .T ,ubaB .V a .A ,ivedagn ,mainomarbuS fo tcartxE lonahtE fo ytivitcA citebaiditnA aissaC

iinielk ni fael nicotozotpertS - citebaiD decudnI dna noitcarF evitca na fo noitalosI dna staR

I ;tcartxE eht fo noitaulavE yticixoT naidn JP locamrah ;3002 092 :53 - .692

.81 .MJ egdirettuG .B llewillaH ni slacidar eerF.enicidem dna ygoloib 5891 ; .p 512 - .712

.91 H woL ,NP jaraphsuP ,KB naT ,J nadnakinaM ,K .HC naT fo stceffe citebaiditnA subytni muirohciC

nicotozotpets ni - itebaid decudni J .star clocamrahponhtE . ;7002 034:111 - .434

.02 M .KR layoG ,MU ayayhdapU ,B ilaru fo tceffE htiw tnemtaert cinorhc elarottil ammetsocinE ni

non - citebaid tnedneped nilusni J .star )MDDIN(locamrahponhtE . ;2002 991:18 - .402

a nt id i ab e tic a c tiv i ty of str ych n us p otat or ...jprcp.com/data/archives/2011/vol 1...

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