A. LOOK AT THE MANY NlEW ~ACIES Of THEBENZODIAZIEPINES(contd)

Lorazepam

PharmacologyAmnesic action of three benzodiazepines. diazepam. l1unitrazepam and

lorazepam. George, K.A. et al. British Journal of Clinical Pharmacology3: 357 (1976)

Respiratoryeffects of lorazepam. Dodson. M:E . et al . British Journal of. Anaesthesia 48: 611 (1976)

Respiration and amnesia after lorazepam or morphine premedication.

Cormack, R.S . et al. British Journal of Anaesthesia 48: 813 (I 976)

An evaluation of memory under regional anesthesia with IV lorazepam as a

premedicant. Taub, H.A. et al. Anesthesia and Analgesia 55 : 368 (1976)

Metabolism of lorazepam. Elliott . H .W. British Journal of Anaestbesia 48 :1017(1976)

Clin ical pharmacokinetics oflorazepam. I. Absorption and disposition of oral

I·C-!orazepam. Greenblatt. D.J . et al . Clinical Pharmacology and

Therapeutics 20: 329 (1976)

Clin ical evaluation of injectable lorazepam as a premedicant: the effect on

recall . Blitt, Petty et al. Anesthesia and Analgesia 55 : 522 (1976)

Residual effects and skills related to driving after a single ora l administration

of diazepam. medazepam or lorazepam: Seppala . T . et al. British Journal

ofOinical Pharmacology 3: 831 (1976)

Biotransformation and excretion of lorazepam in pat ients with chronic renal

failure. Verbeeck, R. et al . British Journal of Clinical Pharmacology 3:1033 (1976)

Further studies of the anti-recall effect of lorazepam: A dose-time-effect

relationship. Pandit, S.K. et al. Anesthesiology 45 : 495 (1976)

Visual tracking following lorazepam or pentobarbital. Stoller, K.P. et al.

Anesthesiology 45: 565 (1976)

Effects of combined treatment with nortriptiline and lorazepam on conl1ict

behaviour and motility of rats. Babbini, M. et al. Psychopharmacology 48:

25 I (1976)

The amnesic action of diazepam, l1unitrazepam and lorazepam in man .

.. Dundee, J.W: et a1. Acta Anaesthesiologica Belgica 27: 3 (1976)

Relative amnesic actions of diazepam. l1unitrazepam and lorazepam in man.

George. K.A . et al. British Journal of Clinical Pharmacology 4: 45 (1977)

Effects of certain benzodiazepine derivatives on disorganization of thought asmanifested in speech. Gottschalk, L.A . Current Therapeutic Research 21:192 (977)

Clinical useLorazepam as a sedative amnesic in an intensive care unit. Dundee. 1.W. et al.

Current Medical Research and Opinion 4: 290 (1976)

Lorazepampremedication: lack of recall and relief of anxiety. Fragen, R.J . et

al , Anesthesia and Analgesia 55 : 792 (1976)

Intramuscular premedication withlorazepam. Mundeleer, P. Acta

Anaesthesiologica Belgica 27: 12(1976)

Lorazepam (Temestalversus bromazepam (Lexotanil), A controlled crossover

trial . Modestin. J. et al. Muenchener Medizinische Wochenschrifl 118 :

1335 (1976)

Lorazepam in the treatment of neurosis. Delgado Lameiras, J.c. Current

Medical Research and Opinion 4: 411 (1976)

Evaluation of anxiolytic and amnesic effects of intramuscular lorazepam as a

pre-operative medication. Paymaster. Nalin 1. Current Medical Research

and Opinion I: 288 (( 976)

A test of the concept of 'underlying depressive illness' in the treatment of

anxiety states . Walsh, M.R. et at. Current Medical Research and Opinion4: 340 (1976)

Clinical evaluation of injectable lorazepam as a premedicant. the effect on

recall . Blitt, Petty et al. Anesthesia and Analgesia 55 : 522 (1976)

Preliminary report: parenterallorazepam in induced epileptic states in man.

Waltregny, A . et al. Acta Neurologica Belglca 76: 173 (J 976)

Demand method evaluation of hypnotics. Sechzer, P.H. Current TherapeuticResearch 19: 637 (1976)

Anxiety therapy in the neoplastic patient. Batelli, T. et al . Current Med ical

Research and Opinion 4: 185 (1976)

Lorazepam in the treatment of neurosis - an uncontrolled clinical study.

Ananth, J .V . et al. Psychopharmacology Bulletin 12: 19 (( 976)

Lorazepam in gastrointestinal disorders with anxiety overlay. Furtado, J.D.

Psychosomatics 17: 32 (J 976)

Lorazepam and diazepam in the treatment of neurotic anxiety: a double-blind

trial . Valarino, F. et at. Diseases of the Nervous System 37: 58 ((976)

Intravenous lorazepam in the treatment of acute anxiety states in neurotic

patients. Comparison of two dosages in a placebo-controlled trial. Bacellar,B.B. Pharmatherapeutica I: 8 (I 976)

Intravenous lorazepam in acute anxiety crisis : a preliminary report on 60

cases. Gomez-Lozano, P. Current Therapeutic Research 19: 469 (1976)

Hypnotic efficacy of lorazepam and flurazepam. Wang. R.I.H . et al. Clinical

Pharmacology and Therapeutics 19: 19\ (I 976)

Lorazepam in the management of anx iety associated with chronic gastro­

intestinal disease . Kasich , A.M. et al, Current The~peutic Research 19:292 (J976)

Evaluation oflorazepam and pentobarbital as surgical premedicants. Conner,

T.J. et aI. Clin ical Pharmacology and Therapeutics 19: 24 (1976)

Lorazepam as a premedication. Gale. G . et al . Canadian Anaesthetists' Society

Journal 23: 22 (1976)

A double-blind crossover controlled study of lorazepam (Wy 4036) and

diazepam. Corni, L. et aI. Current Medical Research and Opinion 3: 668(1976)

Paradoxical reaction to a new minor tranquillizer. Goldney, R.D. Medical

Journal of Australia I: 139 (1977)

A comparison of high- and low-dose lorazepam with amylobarbitone in

patients with anxiety states. Schapira, K. et al. American Journal ofPsychiatry 134: 25 (( 977)

MedalspamThe effect of medazepam and alcohol on cognitive and motor skills used in car

driving. Landauer. A.A. et al. Psychopharmacologia 37: 159 (1974)

The treatment of anxious/depressive states : A double-blind comparison of

medazepam with fluphenazine/nortriptyline, Freeman. H.L. et al. J~urnalof ln tem ational Medical Research 2: 197 (1974)

Medazepam-clidinium in the ambulatorial treatrnent of neurotic patients.

Garcia, J .A . Revista Brasileira de Medicina 31 : 57 (J 974)

Bromazepam, medazepam, chlordiazepoxide in treatment of neurotic anxiety.

Kerry. R.J . et al. British Journal of Psych iatry 124 :'48 5 (l974)

Medazepam. oxazepam and placebo - clinical and experimental study .

Boleloucky, Z. et al, Activitas Nervosa Superior 17: 277 (1975)

A double-blind controlled therapeutic trial of lorazepam vs medazepam in

psychosomatic conditions in general prac tice. Sim , M. et al, British Journalof Clinical Practice 29: 304(1975)

Studies o f drugs given before anaesthesia XXV: medazepam. a new

benzodiazepine. Assaf. R.A .E . et al. British Journal of Anaesthesia 47 :464 (1975)

Management of some functional digestive disorders: comparative clinical trial

of a medazepam-metoclopramide combination with a medazepam­anticholinergic agent combination. Natale , L La ClinicaTerapeutica 72:141 (1975)

EEG changes in the treatment with medazepam and oxazepam. A cross over

study. Misurec , J. et at. Activitas Nervosa Superior 17: 276 (1975)

Residual effects and skills related to driving after a single oral administration

of diazepam. medazepam or lorazepam. Seppala. T. er at. British Journalof Clinical Pharmacology 3: 831 (1976)

Changes in excitability of amygdaloid and septal nuclei induced by

medazepam hydrochloride. Stock, G: et al . Psychopharmacologia 46: 197(1976)

INPHARMA 30th April, 1977 p19

Plasmaconcentrationsofbenzodiazepines. Bond, Alyson J . et al. BritishJournal of Clinical Pharmacology 4: 5I (1977)

PrazepamThedetection·ofprazepam,a·new.benzodiazepine:tranquillizer. Maier, R.D. et

al. Archivesof Toxicology,Archiv Fuer Toxikologie 32: 341 (I 974)Clinical.studies with demetrine in surgicalpatients. Pyszko,J. Die

Medizinische Welt 25: 1004(974)Therapeutical experiences with the new benzodiazepinederivate 'Demetrin ' .

Recke, A. Fortsehritte der Medizin92: 871 {I 974)Expe*nces with Demetrin in general practice. Loos, K.H. et al, Die

Medizinische Welt 25: 1726(1974)Oxazepam. prazepam, and agression in mice. Fox, K.A. et al. Pharmacological

ResearchCommunications 6: 301 (1974)Effects of Demetrinon circulation. Kirchhoff, H.W. International Journal of

ClinicalPharmacologyand Biopharmacy 12: 152 (I 975)The effectof minor tranquilizerson psychomotor performance. Wittenborn,

J.R. et aI. Psychopharmacology47: 281 (1976)

TemazepamTemazepamin anxiety state. Sardesai, H.Y. et aI. BombayHospital Journal

16: 58 (1974)Anxietyand EEG alpha activity in neurotic patients. Baselinecorrelations and

changesduring a double-blind trial with temazepam Siciliani,O. et aI.Acta l'sychiatrica ScandinavicaSa .-l-l6(191-5)

A I ,4·benzodiazepine.temazepam(K 3917), its effect on some psychologicalparametersof sleepand behaviour. Hindmarch, I. Arzneimittel-Forschung25: 1836 (I 975)

A sub-chronic study of the subjectivequality of sleep and psychologicalmeasuresof performance on the morning followingnight-time medicationwith temazepam. Hindmarch, I. Arzneirnittel-Forschung26: 2113 (1976)

Comparison of the effectsof diazepam and 3·hydroxydiazepam(ternazepam)on sleepin man.Nicholson, A.N. et al, BritishJournal ofCIinicalPharmacology 3: 95 I {I 976)

Effectof a metaboliteof diazepam, 3-hydroxydiazepam(temazeparn) on sleepin man. Nicholson, A.N. et al. BritishJournal of Clinical Pharmacology 3:543 (976)

Nitrazepam and temazepam: a comparative trial of two hypnotics. Priest, R.G.et al, Journal of International MedicalResearch 4: 145 (I976)

A clinicaltrial of ternazepam, a sleep inducer, in hospital patients. Pines, A. etat, Journal of International MedicalResearch 4: 132(1976)

TriazolamComparison of triazolarn, l1urazepam and placeboas hypnotic.agents,inpre;

surgical patients. Matta, B. et al, Current Therapeutic Research 10:958(t 974)

Triazolam: a sleep laboratory study of a new benzodiazepinehypnotic. Roth,T. et-al-Current.Therapeutic.Research 16: .117 (t 974)

Triazolam: a new benzodiazepinehypnotic and its effecton mood. Schwanz,J .L. et aI. Current Therapeutic Research 16: 964 (\ 974)

The effeci df1iiaioIil~ on the sleep of insomniacs. Vogel,G. et al,

Psychopharmacologia41:6 5 (t 975)Comparison of the hypnotic activity of triazolam, flurazepam hydrochloride,

and placebo. Sunshine. A. Clinical Pharmacology and Therapeutics 17:573 (\ 975)

Triazolam in insomniac family practice patients. Rickels,K. et al. ClinicalPharmacology and Therapeutics 18: 315 (J 975)

A comparison of three benzodiazepinehypnotics as oral pre-anaestheticmedication. Hare, S.A. South African MedicalJournal 4 9: 1883(1975)

Hypnotic efficacyof triazolam and methylprylon in insomniac in-patients.Lornen, P. et aI.Journal oflnternational MedicalResearch4: 55 (1976)

Comparison of triazolam and flurazepam in repetitivedosing: themeasurement of sustained efficacy. Weintaub, M.et aI. ClinicalPharmacology and Therapeutics 19: 118 (J 976)

A comparison of the effects of l1urazepam30mg and triazolam O.Smgon the'sleepof insomniacs, Vogel, G.W. et al, Psychopharmacology47: 81(J 976)

Preferencestudiesof triazolam with standard hypnotics in out-patients withinsomnia. Fabre. L.F. et aI. Journal of International MedicalResearch 4:2470n6)

Hypnotic efficacyoftriazoJam: sleep laboratory evaluation of intermediate­term effectiveness. Kales,A. et aI. Journal of ClinicalPharmacology 16:399 (\ 976)

Intermediate use of triazolam: a sleep laboratory study. Roth, T. et al. Journaloflnternational MedicalResearch 4: 59 (1976)

The morning after: residual EEG effectsof triazolam and l1urazepam, aloneand in combination with alcohol. Mendelson, W.B. et aI. CurrentTherapeutic Research 19: 155 (J 976)

Effectsof certain benzodiazepinederivatives on disorganizationof thought asmanifested in speech. Gottschalk L.A. Current Therapeutic Research 21:192(1977)

Triazolam: An effectivehypnotic in general practice. Chatwin, 1.C. et al.Current Therapeutics Research 21: 207 (1977)

Comparative effectivenssof nine hypnotic drugs: sleep laboratory studies.Kales, A. et aI.Journal of Clinical Pharmacology 17: 207 (\ 977)