a close look at bion anotechnology mccb october 21 2011 thomas l. deits, ph.d
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A close look at Bion anotechnology MCCB October 21 2011 Thomas L. Deits, Ph.D . What is nanotechnology?. Any process or product that involves analysis or manipulation of materials at the nanometer scale. A thumbnail introduction to nanotechnology. Your fingernail is about as thick as. - PowerPoint PPT PresentationTRANSCRIPT
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A close look atBionanotechnology
MCCBOctober 21 2011
Thomas L. Deits, Ph.D.
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What is nanotechnology?
Any process or product that involves analysis or manipulation of materials at the nanometer scale
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A thumbnail introduction to nanotechnology
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Your fingernail is about as thick as 500 E. coli,
each of which is as thick as
500 1- nanometer slices
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E. coli with Pili and FlagellaAng L National University of Singapore
http://www.icmm.csic.es/spmage07/spmageview.php?id=50
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Why is the nanometerscale important?
Virtually every property of matter that we care aboutarises at the nanometer scale:
ColorOdorStrengthFlexibilityConductivityDurabilityBiological activity
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Bionanotechnology
Biology happens at the nanoscale:
DNAenzymesmusclesnervessenses
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Biology is a Big Idea in Nanotechnology• Size and Scale• Structure of Matter• Forces and Interactions• Quantum Effects• Size-Dependent Properties• Self Assembly • Tools and Instrumentation• Models and Simulations• Science, Technology and Society
The Big Ideas of Nanoscale Science and EngineeringS.Y. Stevens et al. NSTA Press 209
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Capillary net of alveolae showing erythrocytes within the blood vessels.Oliver Meckes
http://www.flickr.com/photos/fei_company/5679999618/in/set-2157626382741945
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Human beta-amyloid fibrils and oligomers"Prof. Francesco MantegazzaUniversita' degli studi di Milano-Bicocca
http://www.icmm.csic.es/spmage07/spmageview09.php?id=165
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Human malaria Infected red blood cellsDr. Li Ang Li
http://www.icmm.csic.es/spmage07/spmageview09.php?id=30
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BionanotechnologyTools and Instrumentation
How do we work at the nanometer scale?
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BionanotechnologyTools and Instrumentation
How do we work at the nanometer scale?TheAtomic Force Microscope
A workhorse of nanotech
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Really…
TheAtomic Force Microscope
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How does it work?
Prettymuchlikethis….
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How does it work?
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Mss. Elizaveta Drozd. A.V. Luikov Heat and Mass Transfer Institute (Belarus)
http://www.icmm.csic.es/spmage07/spmageview09.php?id=62
What can it do?
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Pre-metastasis cell aggregateINASMET-Tecnalia
http://www.icmm.csic.es/spmage07/spmageview09.php?id=25
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Pyrococcus furiosus(archaea)
http://www.sciencephoto.com/media/13219/enlarge
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www.nanosurf.com
And it’s not so hard to do these days….
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BionanotechnologyForces and Interactions
Examples from Physiology and Biotechnology
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Kodera et. al Nature 468 72-76 (2010)
Myosinwalkingvisualizedby AFM
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Yves F. Dufrêne Journal of Bacteriology, October 2002, p. 5205-5213, Vol. 184, No. 19
Yeast bud scar
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High speed AFMCellulase enzymes – traffic jams on the cellulose fiber
Kiyohiko Igarashi, et al. Science 333, 1279 (2011)
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High speed AFMCooperation between two types of cellulases
Kiyohiko Igarashi, et al. Science 333, 1279 (2011)
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BionanotechnologyTools and Instrumentation
Manipulation at the nanoscale
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Nanotweezers
http://www.amir.uni-oldenburg.de/en/37099.html
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Optical tweezers – nanoscale tools for biology
P. Gross, et al. Nature Physics PUBLISHED ONLINE: 22 MAY 2011 |
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P. Gross, et al. Nature Physics PUBLISHED ONLINE: 22 MAY 2011 |
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Optical tweezers- There’s an app for that…
R. W. Bowman, et al. J. Opt. 13 (2011)
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BionanotechnologySelf Assembly
DNA Origami
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Toroidally supercoiled DNADr Jozef Adamcik Ecole Polytechnique Federale de Lausanne
http://www.icmm.csic.es/spmage07/spmageview.php?id=153
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DNA Origami
Depending onthe sequenceof DNA, the double helix can be bent or straight
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Using the simple rules of DNA pairing, bends can be introduced by design into a DNA molecule…
DNA Origami
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…making it possible to design a shape that will assemble when the right pieces of DNA are mixed.
DNA Origami
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DNA Origami
DNA Origami in 3 dimensions!
Han, et al. Science 332, 342 (2011)
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ES Andersen et al. Nature 459, 73-76 (2009)
DNA Origamiboxes (with lids)
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BionanotechnologyStructure and Function
The Lotus Leaf
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Abaxial side of a tomato leaf with trichomes.Adriaan van Aelst
http://www.flickr.com/photos/fei_company/5636849589/in/photostream
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http://www.gereports.com/nanotech-breakthrough-keeps-computers-fast-by-tackling-heat/
GE announces a thermal cooling system with twice the thermal conductivity of copper and a quarter of the weight usingsuperhydrophobicity
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Forepart of a miteMargit WallnerAngelika Reichmann
http://www.flickr.com/photos/fei_company/5886650891/in/set-72157626985240386
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RadiolarianLinnea Rundgren
http://www.flickr.com/photos/fei_company/5730242836/in/set-72157626382741945
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Sponge spiculesMiranda Waldron
http://www.flickr.com/photos/fei_company/5889773523/in/set-72157626985240386
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http://www.nanotechproject.org/inventories/consumer/analysis_draft
There are over 1,000 products incorporating nanotechnology on the market today
What are they? There’s an app
for that.....
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http://nnin.org
Projected job opportunities in nanotechnology by 2015 are estimated at 2 million worldwide and 1 million of those will be in the United States….
If we educate ourselves and our children to be ‘nano-savvy’
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But where are the nanobots?
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The nano cargo truck
Laboratory for Nanobioelectronics P.I.: Dr. Joseph Wang Department of NanoEngineering University of California, San Diego 2009
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ηanoDay
Saturday in March/April 2012 (date TBD)10 AM – 4 PM
Impression 5 Science CenterLansing, MI
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Nanoday 2010, Impression 5 Science Center, Lansing Michigan. Lotus leaf investigation.
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Thank [email protected]