a

b Cell Cycle

c Proliferation

KINASE A ANCHOR PROTEINCASPASE 3, APOPTOSIS-RELATED CYSTEINE PROTEASENUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 1BRUTON’S TYROSINE KINASE-ASSOCIATED PROTEIN-135 MRNARAG A PROTEINSP3 TRANSCRIPTION FACTORRAP1ACYCLIN HCASEIN KINASE 1, ALPHA 1SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION-ALPHA/BETARET PROTO-ONCOGENECYCLIN-DEPENDENT KINASE 7cAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT TYPE IARF-ACTIVATED PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE D 1ATGIF PROTEINCDC7-RELATED KINASEESTS, WEAKLY SIMILAR TO NITROPHENYL PHOSPHATASE INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE MRNADEOXYGUANOSINE KINASEGUANINE NUCLEOTIDE BINDING PROTEIN, BETA POLYPEPTIDE 1DUTP PYROPHOSPHATASERHO-ASSOCIATED, COILED-COIL CONTAINING PROTEIN KINASE P16 ROCK MRNAACID PHOSPHATASE 1, SOLUBLE68KDA TYPE I PHOSPHATIDYL INOSITOL-4-PHOSPHATE 5-KINASE ALPHA MRNAESTS, HIGHLY SIMILAR TO INORGANIC PYROPHOSPHATASEHS1 BINDING PROTEIN HAX-1 MRNA, NUCLEAR GENE ENCODING MITOCHONDRIAL PROTEINPROSTAGLANDIN E RECEPTOR 2

TRANSCRIPTION INITIATION FACTOR IIF, BETA SUBUNITESTS, HIGHLY SIMILAR TO PUTATIVE GTP-BINDING PROTEIN MOV10PHOSPHATIDYLINOSITOL(4,5)BISPHOSPHATE 5-PHOSPHATASE HOMOLOG MRNASUPEROXIDE DISMUTASE 1, SOLUBLEPROTEIN PHOSPHATASE 2A (BETA-TYPE)CLATHRIN, LIGHT POLYPEPTIDEPROTEIN PHOSPHATASE 2, CATALYTIC SUBUNIT, ALPHA ISOFORMALPHA-FETO PROTEIN ENHANCER BINDING PROTEINPROTEIN TYROSINE PHOSPHATASE MRNACLATHRIN COAT ASSEMBLY PROTEIN-LIKEPROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1ESTS, HIGHLY SIMILAR TO POSSIBLE GLOBAL TRANSCRIPTION ACTIVATOR SNF2L1PROTEIN-TYROSINE PHOSPHATASE MRNA, PARTIAL SEQUENCEDUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1TATA BOX BINDING PROTEIN-ASSOCIATED FACTOR, RNA POLYMERASE II, J, 20KDPROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2VASCULAR ENDOTHELIAL GROWTH FACTORCHIMERIN 1SMAD ANCHOR FOR RECEPTOR ACTIVATIONCCAAT/ENHANCER BINDING PROTEIN, DELTANADH-UBIQUINONE DEHYDROGENASE 1 BETA SUBCOMPLEX 7 18 KDA SUBUNITFLOTILLIN 1ALPHA GLOBINCLONE 23840 MRNA, PARTIALINTERFERON (ALPHA, BETA AND OMEGA) RECEPTOR 1RETINOBLASTOMA-LIKE 1MEGAKARYOCYTE-ASSOCIATED TYROSINE KINASEDOWN SYNDROME CANDIDATE REGION 1 LIKE-1EMS1 SEQUENCEENOLASE 1 ALPHADUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5FMS-RELATED TYROSINE KINASE 3MHC CLASS II DQ-ALPHA ASSOCIATED WITH DRW6, DQW1 PROTEINCYCLIN G-ASSOCIATED KINASECOMPLEMENT COMPONENT 5 RECEPTOR 1

GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN 12.3PROTEIN PHOSPHATASE 2A, REGULATORY SUBUNIT B ALPHA-1FK506-BINDING PROTEIN 3UBIQUITIN-CONJUGATING ENZYME E2BEUKARYOTIC TRANSLATION INITIATION FACTOR 4EGLUTATHIONE S-TRANSFERASE M3CD28CYCLIN-SELECTIVE UBIQUITIN CARRIER PROTEIN MRNANOVEL CENTROSOMAL PROTEIN RAN BPMFIBRILLARINPUTATIVE PROTEIN KINASE C INHIBITOR MRNABASIC TRANSCRIPTION FACTOR 3HISTONE (H2A, Z)ZINC FINGER PROTEIN 6PHOSPHOFRUCTOKINASE, PLATELETHUMAN GAP SH3 BINDING PROTEIN MRNACHEMOKINE (C-C MOTIF) RECEPTOR 1ESTS, HIGHLY SIMILAR TO INORGANIC PYROPHOSPHATASESUPEROXIDE DISMUTASE 1, SOLUBLESUPPRESSION OF TUMORIGENICITY 13ANTI-OXIDANT PROTEIN 2V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOGINSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1ESTS, HIGHLY SIMILAR TO INORGANIC PYROPHOSPHATASESMALL INDUCIBLE CYTOKINE A4NEUROBLASTOMA RAS VIRAL (V-RAS) ONCOGENE HOMOLOGINTERFERON STIMULATED GENEINTERLEUKIN 1, BETAFIBROBLAST GROWTH FACTOR RECEPTOR 2RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1TYROSINE-PROTEIN KINASE RECEPTOR TIE-1NERVE GROWTH FACTOR RECEPTORLEUKEMIA INHIBITORY FACTOR RECEPTORCYCLIN-DEPENDENT KINASE INHIBITOR 1CG PROTEIN-COUPLED RECEPTOR 9X-RAY REPAIR COMPLEMENTING DEFECTIVE REPAIR IN CHINESE HAMSTER CELLS 4GRO3 ONCOGENECORTICOTROPIN RELEASING HORMONE RECEPTOR 1PROTEIN TYROSINE PHOSPHATASE 1E MRNAALDEHYDE DEHYDROGENASE-3DIACYLGLYCEROL KINASE, GAMMA (90KD)MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DO ALPHACYCLIN KMITOCHONDRIAL CYTOCHROME P450 XIA1 PRECURSORANNEXIN VDEOXYTHYMIDYLATE KINASESYNAPTOBREVIN-3 MRNAPROTEIN KINASE MRNA

HCT15 MCF7 MDAMB231C

1 2CRE3 4

C5 6

CRE7 8

C9 10

CRE11 12