Kurt Zatloukal M.D. Institute of Pathology

Medical University of Graz Austria

Addis Ababa, June 27th, 2013

A 50 Year Roadmap for the Future of Medicine

Diseases associated with ageing societies

(re)emerging infectious diseases and pandemics

Increased health care costs

New models for collaboration

across sectors and continents

Ageing populations result in major health challenges

Marked increase in chronic diseases Cancer, metabolic diseases, Alzheimer‘s disease .....

Pandemics and (re)emerging infectious diseases still not under control

There are no solutions on the horizon to finance health care systems in the future

Innovative solutions have to be based on top level

research

Fundamental changes are required

From a reductionistic view to understanding the complexity of biological systems and diseases

Environment

Lifestyle

Microbiome Genome

Individual‘s Health / Disease

From therapy to prevention

Define a common goal

Develop a process to achieve this goal

From small scale to large scale interdisciplinary and multinational collaborative research

CERN LHC

Driver: Cold war

One goal: definde by JF Kennedy 1961

Structured process aligning 400000 people to collaborate to achieve this goal

Driver: Medical need

One goal: definde by R. Nixon 1971

No structued process established; Individual scientists and companies wanted to win this war

Commitment to a process enabling ground breaking innovation

Balanced integration of a top-down and bottom-up strategy

Collaboration across scientific fields and continents

Highly complex regulatory framework

Protectionism of established fields

Evidence-based medicine

Changes are costly

Implementation of research and innovation processes independent of current health care and research systems

How to use current solutions and current way of thinking to build the future?

Networks Networks Networks

Resources, Technologies

Services

Individual research groups

pan-European Research Infrastructures

Access

Competition

Bottom-up

Collaboration

Integration

Harmonization

Sustainability

Collaboration

Capacity building

Competition

Individual cancer: >100 mutations altered DNA methylation CNV struct. chrom. alterations In addition Individual genetic make up ~ 300 loss of function variants ~10000 non syn. SNPs

1

4

10 PFlops

1 PFlops

100 TFlops

10 TFlops

1 TFlops

100 GFlops

10 GFlops

1 GFlops

100 PFlops

10 EFlops

1 EFlops

100 EFlops

1993 2017 1999 2005 2011 2023

1 ZFlops

2029

Weather forecast

Astrophysics

Personalized Medicine

Forecast 100 MFlops

Personalized Medicine a key driver for Exascale ICT

from Intel 2012

Patient

The garbage in – garbage out problem

Basic

research

Biomarker

Targets for

therapy

Data

Samples

Pre-analytics

Knowledge

Biobanks

•Scientific excellence

•One type of infrastructure for Europe

•Access to high quality human biological samples and associated data

•Ethical and legal compliance

•Long-term sustainability

•International integration

Driver: Medical and economical needs

One goal: definde by global think tank

Structured process: elaborated in the 50 year roadmap ◦ STI policy

◦ Research agenda with emphasis on collaborative research

◦ Funding instruments

Feasibility: building blocks exist

Thank you