8636 bp 18s tg (10 nm) 0 1 3 6 12 24 tg (100 nm) 0 1 3 6 12 24 (hr) supplemental fig. 1 supplemental...
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8636 bp
18s
TG (10 nM)
0 1 3 6 12 24
TG (100 nM)
0 1 3 6 12 24 (hr)
Supplemental Fig. 1
Supplemental Fig. 2
CHOP
GRP78
GRP94
CHOP
GRP78
GRP94
homocysteine (mM) palmitate (mM)
0 0.1 1 0 0.1 0.2 0.5
homocysteine (mM) 0 0.1 1 palmitate (mM) 0 0.1 0.2 0.5
Supplemental Fig. 3
0 5 50 500
TM (ng/ml)
CHOP
GRP78
GRP94
TM (ng/ml) 0 5 50 500
18s
8636 bp
18s
8636 bp
*
mtD
NA
/nD
NA
(a
rbit
rary
un
it)
mtD
NA
/nD
NA
(a
rbit
rary
un
it)
*
18s
8636 bp
mtD
NA
/nD
NA
(a
rbit
rary
un
it)
*
HepG2 cell
NRF-1
TFAM
18s
HO-1
PGC1α
CHOP
GRP78
XBP-1
TG (10nM ) 0 3 6 12 18 24
A
B
18s
TG (10nM ) 0 3 6 12 18 24
NRF-1
TFAM
18s
HO-1
PGC1α
TG ( nM) - 10 100
XBP-1
18s
TG ( nM) - 10 100
U937 cells
Supplemental Fig. 4
CHOP
GRP78
- 10 100
WT
TG (nM) - 10 100
8636 bp
18s
PERK-/-
B8636 bp
18s
TG (100 nM) - + + + + ZnPP (mM) - - 5 10 20
A
Supplemental Fig. 5
TG (100 nM) - + + + + -
Hb (mg) - - 5 10 20 20
A 8636 bp
18s
Supplemental Fig. 6