86. jahrestagung der deutschen gesellschaft für ... · 5th german pharm-tox summit 2–5 march...

5th German Pharm-Tox SummiT

2–5 marchLeiPziG l 2020

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86. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT) in Zusammenarbeit mit der AGAH

ProgrAMME

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Table of conTenTs

Organisation and imprint ................................................................................................................ 4

Welcome note ................................................................................................................................ 5

Programme overview Monday, 2 March ..................................................................................................................... 6 Tuesday, 3 March ..................................................................................................................... 7 Wednesday, 4 March ............................................................................................................... 8 Thursday, 5 March .................................................................................................................... 9

Special meetings ............................................................................................................................. 10

Scientific programme Monday, 2 March ..................................................................................................................... 11 Tuesday, 3 March ..................................................................................................................... 14 Wednesday, 4 March ............................................................................................................... 22 Thursday, 5 March .................................................................................................................... 32

Poster presentations Poster session I • Tuesday, 3 March ........................................................................................ 39 Poster session II • Wednesday, 4 March ................................................................................. 55

Social programme ........................................................................................................................... 71

General Information ....................................................................................................................... 72

General hints for authors and presenters ...................................................................................... 74

Index of authors and chairs ............................................................................................................ 75

Media cooperations ........................................................................................................................ 88

Industrial programme ..................................................................................................................... 88

Sponsors and exhibitors ................................................................................................................. 90

Plan of venue and exhibition area .................................................................................................. 91

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oRGanIsaTIon anD IMPRInT

Hosting societiesDeutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e. V. (DGPT) www.dgpt-online.de

Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH)www.agah.eu

Conference chairsProf. Dr. Michael SchaeferUniversität Leipzig, Medizinische FakultätRudolf-Boehm-Institut für Pharmakologie und Toxikologie

Vice-chairsProf. Dr. Achim AignerUniversität Leipzig, Medizinische FakultätSelbständige Abteilung für Klinische Pharmakologie am Rudolf-Boehm-Institut für Pharmakologie und Toxikologie

Prof. Dr. Angelika RichterUniversität Leipzig, Veterinärmedizinische FakultätInstitut für Pharmakologie, Pharmazie und Toxikologie

Professional congress organiserConventus Congressmanagement & Marketing GmbHKatharina Szulc/Jenny GotzmannPhone +49 3641 31 16-314/[email protected] • www.conventus.de

Design/layoutLayout krea.tif-studio UG (haftungsbeschränkt)Print siblog – Gesellschaft für Dialogmarketing, Fulfillment & Lettershop mbHCirculation 1.000Editorial deadline 18 February 2020

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WelcoMe noTe

Dear colleagues and friends,

On behalf of the scientific committee, we warmly welcome all participants of the 5th German Pharm-Tox-Summit which will be held from March 2–5, 2020 in Leipzig. As in the last years, the Pharm-Tox-Summit is organized as a joint conference of the member societies of the Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT), the Arbeitsgemeinschaft für Angewandte Humanpharmakologie (AGAH), and also features an integrated Symposium of the Paul-Martini-Stiftung. Bridging between clinical pharmacology, experimental pharmacology, and toxicology will be a central goal of this conference and implemented by joint symposia.

Overcoming borders in science, culture and politics is a key feature of Leipzig. The New Augusteum - venue of the conference - is positioned in midst of the center of this quickly growing and open-minded city. Leipzig ranks among the most liveable university cities in Germany. We hope you will enjoy the inspiring atmosphere of Leipzig and make the 5th German Pharm-Tox Summit an exciting event to foster existing and build up new scientific interactions, collaborations and friendships.

Prof. Dr. Michael SchaeferConference chair

Prof. Dr. Angelika Richter & Prof. Dr. Achim AignerVice-chairs

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PRoGRaMMe oveRvIeW • MonDay, 2 MaRch

HS 15 HS 10 HS 16

10:00–17:00

13:00–17:00

14:00–17:00

p. 12 p. 11 p. 13

Advanced course in Pharmacology

Advanced course in Toxicology Risikokommunikation

Advanced course in Clinical Pharmacology Advanced course on drug transporter models

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PRoGRaMMe oveRvIeW • TuesDay, 3 MaRch

HS 9 HS 2 HS 4 HS 10 HS 1508:30–09:30

09:00–10:30 09:00–10:30 09:00–10:30

p. 1409:30–10:30

p. 15 p. 16 p. 16

10:45–11:00

Welcome note

11:00–11:45

12:00–13:30 12:00–13:30 12:00–13:30 12:00–13:30 12:00–13:30

p. 71

14:30–16:00p. 39

15:15–16:00

Meet the company

16:15–17:45 16:15–17:45 16:15–17:45 16:15–17:45

18:00–19:30 18:00–19:30 18:00–19:00

p. 21p. 21 p. 21

14:15–15:15Poster Session Iin the foyer

Forum Young Scientists – Social evening Beyerhaus Leipzig

19:30–20:15

Symposium 6Stratified pharmacotherapies in oncology

Symposium 7Existence and rele‐vance of thresholds of genotoxic carcinogens

Symposium 8Structural dynamics of G protein‐coupled receptors

p. 71

Get‐together in the foyer

Symposium 1New therapeutic trends

Forum Young Scientist Photopharmacology and Optogenetics – switching on the light in therapy

Symposium 4Microbiota and toxicology – links and questions

13:30–14:15

Short talks Food Toxicology

Symposium 9Antiobesic drugs‐ new hopes or riding a dead horse?

General meetingGT

General meetingDGP

General meetingDGKliPha

Symposium 2Adenine nucleotides in immunity and inflammation

Symposium 3Air pollution related chronic inflammatory diseases – from molecularmechanism to disease control

Short talks Genetic Toxicology

Symposium 5Mechanisms of chemosensation – SFB‐TRR 152

Plenary lecture IPharmacology

Short talks Cancer pharmacology and treatment

Short talks G protein‐coupled receptors

Short talks Ion channels and membrane transporters

p. 14

p. 17

p. 17

p. 18

p. 88 p. 19

p. 20 p. 20 p. 20 p. 21

p. 18 p. 18 p. 19 p. 19

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PRoGRaMMe oveRvIeW • WeDnesDay, 4 MaRch

HS 9 HS 2 HS 4 HS 10 HS 1508:30–09:30

09:00–10:30 09:00–10:30 09:00–10:30 09:00–10:30

p. 2209:30–10:30

p. 23 p. 24 p. 24 p. 25

11:00–12:30

12:40–14:10 12:40–17:40

p. 55

14:45–16:15 14:45–16:15 14:45–16:15 14:45–16:15

p. 27 p. 28 p. 28 p. 28

16:30–17:15

17:30–18:30 17:30–18:30 17:30–18:30 17:30–18:30 p. 26

p. 2918:30–19:30Award ceremony

p. 31

p. 71

Short talksin vitro Toxicology I

Social evening Ratskeller Leipzig

AGAH Workshop Part II

Introduction to physiologically‐based pharmacokinetic (PBPK) modeling and the Open Systems Pharmacology (OSP Suite) (PK‐Sim® & MoBi®)

Young Scientists Award selection talks

Symposium 11Nanomedicine and Theranostics

Symposium 12ADME research and PGx

Symposium 13Joint symposium SFET/GT

Short talksToxins

Short talksCNS / endocrine pharmacology and treatment

20:00–23:15

Short talksCardiac pharmacology and treatment II

Short talksToxic Compounds

Short talksDisease models and drug development I

Short talksNuclear receptors, enzymes and other targets

12:45–14:45

Plenary lecture II Clinical Pharmacology

WorkshopWas bedeutet der NKLM2 für die Pharmakologie/ Toxikologie?

Short talksCardiac pharmacology and treatment I

Short talksSignal transduction and second messengers

AGAH Workshop Part I

Symposium 10Paul‐Martini‐ Symposium

Poster Session II in the foyer

p. 22

p. 29

p. 29 p. 30 p. 31

p. 26

p 25

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PRoGRaMMe oveRvIeW • ThuRsDay, 5 MaRch

HS 9 HS 2 HS 4 HS 1008:30–09:30

09:00–10:30 09:00–10:30 09:00–10:30

p. 32 09:30–10:30

p. 33 p. 34 p. 34

10:45–11:30

11:45–13:15 11:45–13:15 11:45–13:15 11:45–13:15

p. 36 p. 36

13:30–15:00 13:30–15:00 13:30–15:00 13:30–15:00

p. 37 p. 37 p. 3815:00–15:30Closing Ceremony

Short talksin vitro toxicology II

Short talksDisease models, drug development II

Short talksImmunopharmacology / inflammation / antiinfectives

Symposium 16Joint Symposium SPS/DGPT

Symposium 19Medicine informatics and education

AGAH‐Symposium Clinical and economic aspects of medical application of biologics

Short talksin vitro toxicology III

Plenary lecture III Toxicology

Symposium 15RNAs as pharmacological drugs or targets

Symposium 14Uncertainty of toxicological assessments

Symposium 18Bomben, Minen, weißer Phosphor – ökologische u. gesundheitl. Risiken durch Kriegsaltlasten im Meer

Short talksDrug transport, pharmacokinetics and PK/PD modeling

Symposium 17Cannabis and cannabinoids

Symposium 20Pharmakologie‐historisches Forum

p. 32

p. 35

p. 35 p. 36

p. 37

p. 38

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sPecIal MeeTInGs

Monday, 2 March

10:00–17:00 Prüfungen der ToxikologieSR 205

18:00–21:00 Treffen der AG Planmäßige Professoren der Experimentellen und Klinischen Pharmakologie und ToxikologieLocation Rittersaal – Eingang von Innenhof Härtelstraße 16-18 l 04107 Leipzig

Tuesday, 3 March

15:30–16:00 AK „Biogene Toxine“ HS 15

Wednesday, 4 March

09:30–10:30 Fachgruppe Pharmakologie der DPHGSR 205

10:40–11:40 Editorial Board Meeting in Naunyn-Schmiedebergs Archive’s of PharmacologySR 205

14:00–14:30 AK „Respirationstoxikologie/Inhalationstoxikologie“HS 2

14:00–14:30 AK „Kanzerogenese“HS 4

13:00–14:00 Präsidiumssitzung und Mitgliederversammlung der Deutschen GesellschaftSR 205 für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT) e. V.

16:30–17:30 AK „Computational Toxicology“ & AK „3R Praxis/Alternativmethoden“SR 205

Please note, that SR 205 is located in the “Seminargebäude” just next to the “Hörsaalgebäude”.

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scIenTIfIc PRoGRaMMe • MonDay, 2 MaRch

10:00–17:00 Advanced course in Toxicology – RisikokommunikationHS 10

Chair S. Fiack (Berlin/DE)

10:00 Begrüßung – Einführung/Überblick zum Thema Risikokommunikation S. Fiack (Berlin/DE), M. Werner (Hofheim a. T./DE)

10:15 Risikokommunikation – Herausforderungen für die Toxikologie W. Lilienblum (Hannover/DE)

11:00 Fragebogen Risikoquiz/Risikokompetenz

11:45 Risikokommunikation aus Sicht der Behörde – giftig, riskant oder unbedenklich? Kriterien zielgruppengerechter Risikokommunikation G.-F. Böl (Berlin/DE)

12:45 Mittagspause/Mitgliederversammlung des AK Regulatorische Toxikologie & Braune-Tüte-Lunch

13:45 Risikokommunikation aus Sicht der Öffentlichkeitsarbeit/Presse – zwischen zwei Welten: Erfahrungen im Wissenschaftsjournalismus H. Wewetzer (Berlin/DE)

14:45 Risikokommunikation aus Sicht der Industrie: Risikokommunikation im Kosmetik-Sektor – endokrin aktive Stoffe als besondere Herausforderung W. Schuh (Frankfurt a. M./DE)

15:45 Kaffeepause

16:15 Podiumsdiskussion – Risikokommunikation vor dem Hintergrund der Transparenz und Glaubwürdigkeit gegenüber der Öffentlichkeit

10:00–17:00 ExaminationsSR 205

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13:00–17:00 Advanced course in PharmacologyHS 15

Chair R. Seifert (Hannover/DE)

Unter Federführung der Deutschen Gesellschaft für Pharmakologie ist in den letzten 12 Monaten die neue Arzneistoffliste für den Gegenstandskatalog GK2 des Instituts für Medizinische und Pharmazeutische Prüfungsfragen (IMPP) entwickelt worden. Diese Liste wird ab dem Jahr 2021 examensrelevant sein und festigt die zentrale Bedeutung der Pharmakologie und Pharmakotherapie als Querschnittsfächer in der Medizinerausbildung. Die neue Arzneistoffliste standardisiert die Medizinerausbildung in Deutschland und wird einen wesentlichen Beitrag zur Qualität der Arzneitherapie, Patientensicherheit sowie zur verbesserten interprofessionellen Kommunikation leisten. Der Advanced Course richtet sich an Pharmakologiedozenten aller Erfahrungsstufen und stellt die neue Arzneistoffliste in allen Aspekten ausführlich dar. Außerdem wird an Hand eines konkreten pharmakologischen Themas (Psychopharmaka) dargestellt, wie die Arzneistoffliste leicht und sinnvoll in den Pharmakologieunterricht sowie die Erstellung von Prüfungsfragen integriert werden kann. Jeder Teilnehmer erhält zu Kursbeginn ausführliche Kursunterlagen.

13:00 Begrüßung, Einführung, Kursablauf R. Seifert (Hannover/DE)

13:10 Vorstellung der Arzneistoffliste des IMPP H. Bachmann (Witten-Herdecke/DE)

13:50 Die Arzneistoffliste aus Sicht des IMPPs K. Höcherl (Mainz/DE)

14:20 Pharmakologie und Pharmakotherapie im NKLM R. Maas (Erlangen/DE)

14:50 Kaffeepause

15:10 Umsetzung der Arzneistoffliste und des NKLM in der Pharmakologie – Unterricht am Beispiel des Themas „Arzneistoffe für die Behandlung neuropsychiatrischer Erkrankungen” R. Seifert (Hannover/DE)

16:40 Abschlussdiskussion und Ausgabe der Teilnahmebestätigungen

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14:00–17:00 Advanced course in Clinical Pharmacology – Advanced course on drug HS 16 transporter models

14:00 In vitro transport models J. König (Erlangen/DE)

15:00 Quantification of drug transporter activity in vivo U. Fuhr (Cologne/DE)

16:00 Transporter quantification S. Oswald (Greifswald/DE)

18:00–19:00 Treffen AG Planmäßige Professoren der Experimentellen und Klinischen Pharmakologie und ToxikologieLocation Härtelstraße 16–18 | Rittersaal

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scIenTIfIc PRoGRaMMe • TuesDay, 3 MaRch

08:30–09:30 Short talks HS 9 Food Toxicology

08:30 The MDCKII-bABCG2 cell line – assessment of pesticide accumulation in1 dairy milk L. Kuhnert, S. Halwachs, W. Honscha (Leipzig/DE)

08:45 Abrogation of heme oxygenase 1 (HO-1) in human colonic epithelial cells 2 potentiates heme iron-triggered ROS formation, DNA damage and cell death induction N. Seiwert (Kaiserslautern/DE), S. Wecklein, S. Hasselwander (Mainz/DE) T. Marschall, T. Schwerdtle (Nuthetal/DE), J. Shay (Dallas/US) T. Brunner (Konstanz/DE), J. Döhring, P. Steinberg (Hannover/DE) J. Fahrer (Kaiserslautern, Mainz/DE)

09:00 Detection of DNA adducts of cis- and trans-anethole in primary rat 3 hepatocytes and HepG2 cells J. A. Fuhlbrueck, C. Rech, E. Richling, A. T. Cartus (Kaiserslautern/DE)

09:15 Pyrrolizidine alkaloid-induced changes in transcription patterns in rat liver4 and lung J. Buchmüller, J. Ebmeyer (Berlin/DE), J. Daniel Rasinger (Bergen/NO) S. Hessel-Pras, A. Braeuning, A. Lampen (Berlin/DE)

09:30–10:30 Short talks HS 9 Genetic Toxicology

09:30 PARP1 catalytic variants reveal branching and chain length-specific 5 functions of poly(ADP-ribose) in cellular physiology and genotoxic stress response L. Rank, A. Krüger, J. Reber, M. Hufnagel, M. Schmalz I. R. E. A. Trussina, T. Zubel, K. Schütz (Konstanz/DE) A. Hartwig (Konstanz, Karlsruhe/DE), A. Marx, E. Ferrando-May A. Bürkle, A. Mangerich (Konstanz/DE)

09:45 B[a]P induced repression of MMR and HR is associated with altered 6 E2F1/E2F4 signaling and represents an early event during DNA damage-induced senescence S. Allmann, C. Schwarzenbach, B. Rasenberger, M. Tomicic M. Christmann (Mainz/DE)

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10:00 Automated screening for oxidative or methylation-induced DNA damage in61 human cells M. Mack, K. Schweinlin, N. Mirsberger, A. Bürkle (Konstanz/DE)

10:15 CPI-613 targets mitochondria and synergizes with genotoxic anticancer 8 drugs in colorectal cancer therapy C. Neitzel, N. Seiwert (Kaiserslautern/DE), S. Stroh, G. Nagel (Mainz/DE) K. Boengler (Giessen/DE), D. Vogel, M. Huber (Marburg/DE) A. Moritz (Giessen/DE), M. Linnebacher (Rostock/DE) J. Fahrer (Kaiserslautern/DE)

09:00–10:30 Short talks HS 2 Cancer pharmacology and treatmentChair T. Büch (Leipzig/DE)

09:00 Analysis of clonal evolution to identify potential mechanisms of tyrosine 10 kinase inhibitor resistance in chronic myeloid leukemia cells M. Kaehler, D. Esser, I. Vater, P. Osteresch, S. Vieth, B. Unger, F. Wiebel R. Boehm, C. Kaleta (Kiel/DE), O. Ammerpohl (Ulm/DE), I. Cascorbi I. Nagel (Kiel/DE)

09:15 Functional role of SHP2 in the spontaneous development of resistance to 9 imatinib P. Osteresch, M. Kaehler, Daniela Esser, I. Vater, F. Wiebel, S. Vieth, C. Kaleta I. Cascorbi, I. Nagel (Kiel/DE)

09:30 Activation of phospholipase C-γ2 mutants mediating ibrutinib resistance in11 human chronic lymphocytic leukemia cells by non-catalytic functions of Bruton´s tyrosine kinase M. Wist, J. Haas, L. Meier (Ulm/DE), O. Gutman (Tel Aviv/IL), S. Endres, R. Rösler S. Wiese (Ulm/DE), Y. I. Henis (Tel Aviv/IL), P. Gierschik, C. Walliser (Ulm/DE)

09:45 Identification of novel key targets and candidate drugs in oral squamous 12 cell carcinoma Z. Shi, J. Fu, Y. Tang (Chengdu/CN)

10:00 The E3 ligase TRIM25 negatively interferes with the translation of 13 caspase-2 – therapeutic implications for sensitizing colon carcinoma cells to intrinsic apoptosis? U. Nasrullah, K. Haeussler, A.Biyanee, I. Wittig, J. Pfeilschifter W. Eberhardt (Frankfurt a. M./DE)

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10:15 OCTN2-mediated uptake of L-carnitine – a potential target for treatment of 14 glioblastoma? M. A. Fink, H.Paland, M. Schnell, S. Herzog, P. Meisel, M. Grube S. Vogelgesang, K. Weitmann, A. Bialke, S. Marx, W. Hoffmann, B. Rauch H. Schroeder, M. V. Tzvetkov, S. Bien-Möller (Greifswald/DE)

09:00–10:30 Short talks HS 4 G protein-coupled receptorsChair B. Moepps (Ulm/DE), A. Breit (Munich/DE)

09:00 BiasDB – a comprehensive overview on biased GPCR ligands15 M. Bermudez, C. Omieczynski, T. Ngoc Nguyen, D.Sribar, L. Deng, D. Stepanov D. Schaller, G. Wolber (Berlin/DE)

09:15 Interaction of the β2-adrenergic receptor with arrestin 316 N. Mösslein, M. Bünemann, C. Krasel (Marburg/DE)

09:30 Role of Gαi2 in neutrophil-platelet complex (PNC) migration during cardiac 17 reperfusion injury in mice L. Beichert, S. Killinger, D. Köhler, P. Rosenberger, S. Beer-Hammer B. Nürnberg (Tübingen/DE)

09:45 Absence of Gαi2 in brown and white adipocytes impedes diet-induced obesity18 V. Leiss, (Tübingen/DE), T. Gnad (Bonn/DE), A. Schönsiegel, T. Sartorius J. Machann, H.-U. Häring (Tübingen/DE), A. Pfeifer (Bonn/DE) B. Nürnberg (Tübingen/DE)

10:00 Differential interaction of LARG and p115-RhoGEF with G13 subunits19 F. Redlin, A.-L. Krett, M. Bünemann (Marburg/DE)

10:15 tba N. N.

09:00–10:30 Short talks HS 10 Ion channels and membrane transportersChair N. Khajavi (Munich/DE)

09:00 Identification of aurintricarboxylic acid as a potent allosteric antagonist of21 P2X3 receptors A. Obrecht, A. Kless, J. E. Meents, N. Urban, M. Schaefer (Leipzig/DE) A. Lampert, G. Schmalzing, R. Hausmann (Aachen/DE)

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09:15 Angiotensin-II-induced pathological cardiac remodeling – ORAI1 in 22 cardiomyocytes as protective agent J. E. Camacho Londoño, S. Segin, M. Berlin, C. Richter, R. Medert (Heidelberg/DE) V. Flockerzi (Homburg/DE), P. Worley (Baltimore/US) M. Freichel (Heidelberg/DE; Baltimore/US)

09:30 Dispensability of all seven TRPC proteins for the acute neurohumoral 23 Ca2+-signaling induced by Angiotensin II in murine cardiac fibroblasts A. E. Kraft, J. E. Camacho Londoño, A. Marx, A. Schürger C. Richter (Heidelberg/DE), L. Birnbaumer (Buenos Aires/AR, Durham, NC/US) A. Dietrich (Munich/DE), M. Freichel (Heidelberg/DE)

09:45 Physiological function of TRPV6 channels during pregnancy24 M. Winter, P. Weissgerber, C. Fecher-Trost, V. Flockerzi (Homburg/DE)

10:00 Identification of OCaR1 as a gatekeeper of lysosomal-granular Ca2+ release25 and regulated exocytosis V. Tsvilovskyy, U. Kriebs, A. Bach (Heidelberg/DE), A. Jha (Bethesda, MD/US) A. Wirth (Heidelberg/DE), C. Grimm (Munich/DE), U. Wissenbach (Homburg/DE) K. Zimmermann (Bonn/DE), P. Weissgerber (Homburg/DE), D. Vogt D.Schumacher, J. Camacho Londoño (Heidelberg/DE), C. Wahl-Schott (Munich/DE) A. Pfeifer (Bonn/DE), M. Biel (Munich/DE), P. Lipp, V. Flockerzi (Homburg/DE) S. l. Muallem (Bethesda, MD/US), M. Freichel (Heidelberg/DE)

10:15 Agonist-dependent switching of ion selectivity in a lysosomal ion channel26 Y.-K. Chao, S. Gerndt, C.-C. Chen (Munich/DE), Y. Yuan (London/GB) A. Scotto Rosato, E. Krogsaeter (Munich/DE), N. Urban (Leipzig/DE) O. N. P. Nguyen, M. Keller, A. M. Vollmar, T. Gudermann J. Schredelseker (Munich/DE), M. Schaefer (Leipzig/DE), M. Biel (Munich/DE) C. Wahl-Schott (Hannover/DE), F. Bracher (Munich/DE), S. Patel (London/GB) C. Grimm (Munich/DE)

10:45–11:00 Opening ceremony HS 9 Welcome note by the conference chairs M. Schaefer, A. Aigner, A. Richter (Leipzig/DE), H. Barth (Ulm/DE)

11:00–11:45 Plenary lecture I – PharmacologyHS 9

Chair M. Schaefer (Leipzig/DE)

11:00 Cellular therapeutics – CAR-T cells and beyond U. Köhl (Leipzig/DE)

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12:00–13:30 Symposium 1 HS 9 New therapeutic trendsChairs J. Stingl (Aachen/DE), P. Most (Heidelberg/DE)

12:00 Novel targets for heart failure therapy P. Most (Heidelberg/DE)

12:30 Novel approaches of antibody-based immunotherapy C. Kellner (Munich/DE)

13:00 Regulation of ATMPs – novel trends R. Sanzenbacher (Langen/DE)

12:00–13:30 Forum Young ScientistsHS 2 Photopharmacology and optogenetics – switching on the light in therapyChairs C. Klenk (Zurich/CH), A. Ahles (Munich/DE)

12:00 Photopharmacology of G-protein coupled receptors R. Leurs (Amsterdam/NL)

12:22 Photopharmacology to control the cytoskeleton O. Thorn-Seshold (Munich/DE)

12:44 The adhesion-GPCR CIRL promotes mechanosensory signal discrimination R. J. Kittel (Leipzig/DE)

13:06 Optogenetics to enlighten G protein signalling in the heart T. Brügmann (Göttingen/DE) 12:00–13:30 Symposium 2HS 4 Adenine nucleotides in immunity and inflammationChairs A. Guse (Hamburg/DE), A. Pfeifer (Bonn/DE)

12:00 Tools and drugs for purinergic targets – important players in inflammation and immunity C. Müller (Bonn/DE)

12:27 Initial calcium microdomains in T cells B.-P. Diercks (Hamburg/DE)

12:54 Neuromodulation by adenosine in health and disease D. Hirnet (Hamburg/DE)

13:11 Nanobodies as modulators of purinergic signalling B. Rissiek (Hamburg/DE)

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12:00–13:30 Symposium 3HS 10 Air pollution related chronic inflammatory diseases – from molecular mechanism to disease controlChairs M. Schmidt (Groningen/NL), H. Barth (Ulm/DE)

12:00 In vitro models to study pulmonary diseases M. Frick (Ulm/DE)

12:22 Targeted modulation of monocyte/macrophages in intensive care unit models H. Barth (Ulm/DE)

12:44 Effects of traffic related air pollution on mouse lung and brain R. Schins (Düsseldorf/DE)

13:06 Air pollution and its impact on the lung-brain axis M. Schmidt (Groningen/NL)

12:00–13:30 Symposium 4 HS 15 Microbiota and toxicology – links and questionsChairs C. Esser, K. Hochrath (Düsseldorf/DE)

12:00 Role of microbiota in chemical toxicity S. Sturla (Zurich/CH)

12:30 Dietary heme iron, microbiota and intestinal carcinogenesis J. Fahrer (Kaiserslautern/DE)

13:00 Coal tar and the skin microbiome E. van den Bogaard (Nijmegen/NL)

13:30–14:15 Get-together Location Foyer (see page 71)

14:30–16:00 Symposium 5 HS 10 Mechanisms of chemosensation – SFB-TRR 152Chair T. Gudermann (Munich/DE)

14:30 Chemosensation in olfactory organs F. Zufall (Homburg/DE)

15:00 Deciphering molecular mechanisms of irritant sensing S.-E. Jordt (New York, NY/US)

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15:30 Pulmonary effects of alkylating agents D. Steinritz (Munich/DE)

15:45 Chemosensation via TRPA1 – possible roles in mediating adverse effects of drugs M. Schaefer (Leipzig/DE)

15:15–16:00 Meet the companyHS 2 (see page 88)Chair K. Bestehorn (Zell/DE)

16:15–17:45 Symposium 6 HS 9 Stratified pharmacotherapies in oncologyChairs J. Wolf, U. Fuhr (Cologne/DE)

16:15 NSCLC – non small cell lung cancer J. Wolf (Cologne/DE)

16:45 Malignant melanoma M. Ziemer (Leipzig/DE)

17:15 Chronic myeloid leukemia – mechanisms of resistance M. Kähler (Kiel/DE)

16:15–17:45 Symposium 7HS 2 Existence and relevance of thresholds of genotoxic carcinogensChairs M. Esselen (Münster/DE), A. Cartus (Kaiserslautern/DE)

16:15 Approaches for risk assessment of genotoxic carcinogens A. Hartwig (Karlsruhe/DE)

16:45 Threshold vs. cut-off – impact of genotoxicity testing for pesticide risk assessment K. Meurer (Ludwigshafen/DE)

17:15 Deriving occupational exposure limits for natural substances A. Thiel (Kaiseraugst/CH)

16:15–17:45 Symposium 8 HS 4 Structural dynamics of G protein-coupled receptorsChairs A. Beck-Sickinger, T. Schöneberg (Leipzig/DE)

16:15 Activation of adhesion GPCRS T. Schöneberg (Leipzig/DE)

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16:37 Mechanical force sensing through adhesion-type G protein-coupled receptors T. Langenhahn (Leipzig/DE)

16:59 Allosteric modulators of the pancreatic polypeptide receptor A. Beck-Sickinger (Leipzig/DE)

17:22 It is high-time for GPCR structure-based drug discovery J. Meiler (Leipzig/DE)

16:15–17:45 Symposium 9HS 10 Antiobesic drug – new hopes or riding a dead horse?Chairs M. Blüher (Leipzig/DE), M. Kleinert (Munich/DE)

16:15 Obesity is a disease! M. Blüher (Leipzig/DE)

16:37 Multivalent peptide agonists to treat obesity M. Kleinert (Munich/DE)

17:00 Consequences of obesity on the vasculature S. Steiner (Leipzig/DE)

17:23 Novel pharmacological strategies for lipid disorders U. Laufs (Leipzig/DE)

18:00–19:30 General meeting HS 9 Gesellschaft für Toxikologie (GT)

18:00–19:30 General meeting HS 2 Deutsche Gesellschaft für Pharmakologie (DGP)

18:00–19:00 General meeting HS 4 Deutsche Gesellschaft für Klinische Pharmakologie und Therapie (DGKliPha)

19:30–20:15 Social evening Forum Young Scientists – Science slamLocation Beyerhaus Leipzig (see page 71)

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scIenTIfIc PRoGRaMMe • WeDnesDay, 4 MaRch

08:30–09:30 Short talksHS 9 Toxic compoundsChair A. Braeuning (Berlin/DE)

08:30 Reduced wound healing ability of mesenchymal stem cells in chronic 27 senescence after sulfur mustard exposure S. Rothmiller, N. Jäger (Munich/DE), A. Bürkle (Konstanz/DE), D. Steinritz H. Thiermann, A. Schmidt (Munich/DE)

08:45 The pyrrolizidine alkaloid senecionine destroys metabolism-dependent 28 hepatic sinusoidal cells and induces cholestasis in vivo S. Hessel-Pras, A. Braeuning, (Berlin/DE), G. Guenther, A. Adawy (Dortmund/DE) A.-M. Enge, J. Ebmeyer (Berlin/DE), C. J. Henderson (Dundee/GB) J. G. Hengstler (Dortmund/DE), A. Lampen (Berlin/DE), R. Reif (Dortmund/DE)

09:00 Carbon monoxide – a novel stress response mediator?29 D. Stucki, J. Steinhausen, D. Brilhaus, P. Westhoff, A. P. M. Weber W. Stahl (Düsseldorf/DE)

09:15 Consequences of manganese overload in C. elegans – oxidative stress and 30 DNA damage M. M. Nicolai (Wuppertal/DE), J. Baesler(Berlin/DE), M. Aschner (Bronx NY/US) T. Schwerdtle (Potsdam/DE), J. Bornhorst (Wuppertal/DE)

09:30–10:30 Short talks HS 9 ToxinsChair R. Gerhard (Hannover/DE)

09:30 A hidden treasure – discovery of an endogenous inhibitor against 31 Clostridium botulinum C2 toxin from human hemofiltrate peptide library S. Fischer, P. Gauckler, L. Staendker, A. Rodriguez-Alfonso (Ulm/DE) W.-G. Forssmann (Hannover/DE), H. Barth (Ulm/DE)

09:45 Eschericia coli subtilase cytotoxin enters human cells without a transport subunit32 K. Sessler, P. Papatheodorou, F. Weiß, J. Michaelis (Ulm/DE) M. Krause (Hohenheim/DE), H. Schmidt (Hohenheim/DE), H. Barth (Ulm/DE)

10:00 The transporter molecule PA63 from Bacillus anthracis delivers the tumor 33 metastasis suppressor protein NDPK-A/NME1 into human breast cancer cells I. Felix, H. Barth (Ulm/DE), T. Wieland (Mannheim/DE)

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10:15 Human motor neurons differentiated from pluripotent stem cells as 34 superior target cells for botulinum neurotoxin potency testing M. Schenke (Hannover/DE), B.-M. Schjeide, G. P. Püschel (Nuthetal/DE) B. Seeger (Hannover/DE)

09:00–10:30 Short talks HS 2 Disease models and drug development IChair U. Storch (Munich/DE)

09:00 Generation of malignant transformed monoclonal cell lines for metabolic 35 cancer research F. Meyer, R. Thierbach (Jena/DE)

09:15 The human engineered connective tissue model – a versatile tool for 36 understanding cardiac fibroblast behavior and drug testing G. L. Santos, F. Meyer, A. DeGrave, H. Schröder, T. Meyer, W.-H. Zimmermann S. Lutz (Göttingen/DE)

09:30 Neonatal seizures and long-term consequences in a novel rat model of birth37 asphyxia respond to treatment with midazolam B. Gailus, W. Löscher (Hannover/DE)

09:45 Mechanism of artemisinin activation in Leishmania tarentolae and its link to38 heme degradation L. Gille, G. Geroldinger, M. Tonner, J. Quirgst, M. Walter (Vienna/AT) S. De Sarkar (Kolkata/IN), L. Monzote (Havana/CU), K. Stolze, J. C. Duvigneau K. Staniek (Vienna/AT), M. Chatterjee (Kolkata/IN)

10:00 New OCaR2 proteins at lysosomal-SR junction controls cardiomyocyte-Ca2+

39 signaling, pathological remodeling including transcriptome profile and determine fatal ventricular arrhythmias J. E. Camacho Londoño, M. Berlin, S. Meyer, C. Hofmann V. Kuryshev (Heidelberg/DE), S. Gerndt (Munich/DE), R. Ottenheijm, A. Wirth L. Bacmeister, U. Kriebs (Heidelberg/DE), V. Flockerzi (Homburg/DE), M. Völkers F. Leuschner (Heidelberg/DE), C. Wahl-Schott (Hannover/DE), M. Biel, F. Bracher C. M. Grimm (Munich/DE), C. Dieterich, M. Freichel (Heidelberg/DE)

10:15 iPSC modelling of a novel patient-specific compound heterozygous titin 83 mutation causing cardiomyopathy M. Poetsch (Dresden/DE), J. Qi (Göttingen/DE), C. Mehnert (Dresden/DE) M. Gautel (London/GB), K. Guan (Dresden/DE)

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09:00–10:30 Short talks HS 4 Cardiac pharmacology and treatment IChair V. Leiss (Tübingen/DE)

09:00 Stabilization of HIF-1 signalling protects from reoxygenation injury in 41 engineered human myocardium E. Levent, C. Noack, L. Zelarayan, D. Katschinski, W.-H. Zimmermann M. Tiburcy (Göttingen/DE)

09:15 A novel hypoxia-reoxygenation model to study the protective effect of 42 hypoxia or opioid preconditioning using cardiac tissue engineering and induced pluripotent stem cell technology S. Funcke (Hamburg/DE), T. Werner (Brisbane/AU, Hamburg/DE) M. Hein (Aachen/DE), B. Ulmer, A. Hansen, T. Eschenhagen M. Hirt (Hamburg/DE)

09:30 MiR-21 in cardiac macrophages regulates cardiac remodelling43 D. P. Ramanujam, A. P. Schön, C. Beck, G. Felician, A. Dueck S. Engelhardt (Munich/DE)

09:45 Protective effects of Gαi3-deficiency in a mouse model of β1-adrenoceptor44 mediated cardiomyopathy T. Schröper, D. Mehrkens (Cologne/DE), V. Leiss (Tübingen/DE) S. Engelhardt (Munich/DE), S. Herzig (Köln/DE) L. Birnbaumer (Research Triangle Park/DE), B. Nürnberg (Tübingen/DE) J. Matthes (Cologne/DE)

10:00 The LXR Agonist AZ876 attenuates cardiac damage in an isoproterenol 45 induced cardiomyopathy model D. Ritter, C. Jaeger, R. Klopfleisch, A. Foryst-Ludwig, U. Kintscher (Berlin/DE)

10:15 Protease-activated receptor PAR4 drives cardiac inflammation in diabetes46 A. Fender, S. Stolte, K. Leineweber, M. Kamler, D. Dobrev (Essen/DE)

09:00–10:30 Short talks HS 10 Signal transduction and second messengersChair S. Lutz (Göttingen/DE)

09:00 The role of semaphorins in the intestinal epithelium47 F. Hub (Marburg/DE), M. Looso (Bad Nauheim/DE), M. Mazzola (Boston/US) I. Shcheglova, H.-J. Gröne (Marburg/DE), T. Worzfeld (Marburg, Bad Nauheim/DE)

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09:15 Plexin signaling controls epidermal stem cell fate in mammalian epidermis 48 during development and cancer C. Jiang, L. Kaiser, L. Zhou, D. Brandt, D. Zhao (Marburg/DE) T. Worzfeld (Bad Nauheim, Marburg/DE)

09:30 Impact of NO-GC1 on Ang II-induced cardiac hypertrophy and vascular 49 remodelling K. Broekmans, M. Russwurm, D. Koesling, E. Mergia (Bochum/DE)

09:45 A cardio-safe peptide-based targeting strategy protects from pathological 50 ERK1/2 signalling T. Brand, C. Schanbacher, A. Tomasovic, S. Kramer, M. Hümmert (Würzburg/DE) O. Müller (Kiel/DE), D. Dobrev (Essen/DE), A. El-Armouche (Dresden/DE) F. Cuello (Hamburg/DE), K. Lorenz (Würzburg/DE)

10:00 Optical mapping reveals that spatiotemporal cAMP signaling is controlled 52 by attoliter-sized compartments A. Bock, P. Annibale, C. Konrad, S. Anton, M. J. Lohse (Berlin/DE) S. Sivaramakrishnan (Minneapolis/US), I. Maiellaro (Würzburg/DE) M. J. Lohse (Berlin/DE)

10:15 Genetically-encoded FRET-based biosensors to monitor cAMP dynamics in 51 nanodomains R. Thomas, C. Konrad, S. Anton, M. J. Lohse, A. Bock (Berlin/DE)

09:00–10:30 AGAH Workshop – introduction to physiologically-based pharmacokinetic HS 15 (PBPK) modeling and the Open Systems Pharmacology (OSP Suite) (PK-Sim® & MoBi®) IChairs A. Kovar (Frankfurt a. M./DE), T. Lehr (Saarbrücken/DE)

09:00 Introduction to PBPK modeling and quantitative systems pharmacology (QSP) J. Schlender (Leverkusen/DE)

09:45 PBPK predictions for FIH using PK-SIM: A case study D. Teutonico (Paris/FRA)

11:00–12:30 Symposium 10HS9 Paul-Martini-Symposium – Modellierungen und Simulationen in Hinblick auf Wirksamkeit und Sicherheit von ArzneimitteltherapienChairs K. Diefenbach (Berlin/DE), K. Bestehorn (Zell/DE)

11:00 Modell-basiertes Management von drug drug interactions und anderen klinisch relevanten Kovariaten S. Frechen (Leverkusen/DE)

26


11:22 Data Science und mathematische Modelle zur Optimierung der Arzneimittelentwicklung P. Nörtersheuser (Ludwigshafen/DE)

11:44 Modellbasierte Entscheidungsfindung im klinischen Alltag T. Lehr (Saarbrücken/DE)

12:06 Modell- und Physiologie-basierte Toxikokinetik von Aluminium als Adjuvans in Arzneimitteln G. Wangorsch (Langen/DE)

12:40–14:10 Workshop – Was bedeutet der NKLM2 für die Pharmakologie/Toxikologie? HS 10

Chairs R. Seifert (Hannover/DE), R. Maas (Erlangen/DE)

12:40 Die Implementierung pharmakologischer Inhalte in den NKLM2 und GK2 Medizin R. Seifert (Hannover/DE)

13:10 Die Sicht der Klinischen Pharmakologie R. Maas (Erlangen/DE)

13:40 Die Sicht der Toxikologie I. Just (Hannover/DE)

12:40–17:40 AGAH Workshop – introduction to physiologically-based pharmacokinetic HS 15 (PBPK) modeling and the Open Systems Pharmacology (OSP Suite) (PK-Sim® & MoBi®) IIChairs A. Kovar (Frankfurt a. M./DE), T. Lehr (Saarbrücken/DE)

12:40 PBPK modeling in pediatric and geriatric populations J. Schlender (Leverkusen/DE)

13:25 PBPK modeling in renally impaired patients N. Hanke (Saarbrücken/DE)

14:10 Break

14:25 Assessment and prediction of drug drug interactions utilizing PBPK modeling S. Frechen (Leverkusen/DE)

15:10 Modeling of glucose homeostasis in the diabetes QSP plattform S. Schaller (Saterland/DE)

27


15:55 Break

16:10 Drug delivery via skin – implications for PBPK modelling D. Selzer (Saarbrücken/DE)

16:55 Application of PBPK modeling for forensic assessments T. Lehr (Saarbrücken/DE)

14:45–16:15 Young Scientists – award selection talksHS 9

14:45 Rasal1 – the missing GAP downstream of plexins55 C. Höß, D. Brandt, H.-J. Gröne (Marburg/DE), R. Xu T. Worzfeld (Marburg, Bad Nauheim/DE), J. M. Swiercz, R. Lu S. Offermanns (Bad Nauheim/DE), N. Petersen (Copenhagen/DK)

15:00 Targeting phosphodiesterase 2 – an innovative strategy to protect against 56 cardiac arrhythmia M. Fahmi, M. Günscht, J. Siegert, F. Dutt, K. Richter, M. Wagner, A. El-Armouche S. Kämmerer (Dresden/DE), N. Dybkova (Göttingen/DE) S. Sossalla (Göttingen, Regensburg/DE)

15:15 Novel effects of the helix loop helix factor Id3 on hyaluronan-rich matrix 57 in adipose tissue A. Misiou, J. Fischer, M. Grandoch (Düsseldorf/DE), D. Harmon, J. Hensien J. Garmey, C. McSkimming, V. Osinski, M. Marshall C. McNamara (Charlottesville, Va/US)

15:30 The insulin-like growth factor binding protein 5 (IGFBP5) in the transition to58 heart failure M. Jassyk, C. Rocha, M. Woelfer, S. Khadjeh, L. M. Iyer, M. Tiburcy M. Patapia Zafeiriou, G. Hasenfuss, K. Toischer, L. C. Zelarayan (Göttingen/DE) O. Müller (Hamburg, Kiel/DE)

15:45 Mixture effects on toxicologically relevant liver proteins after pesticide 53 treatment in HepaRG cells F. Schmidt, A. Steinhilber, T. Joos, O. Pötz (Reutlingen/DE), A. Mentz J. Kalinowski (Bielefeld/DE), D. Lichtenstein, A. Braeuning (Berlin/DE)

16:00 Bacterial exotoxin-based biohybrid transporters for delivery of therapeutic54 peptides into the cytosol or across the blood-brain barrier M. Fellermann, F. Wondany, R. Noschka, S. Carle, S. Stenger, J. Michaelis H. Barth (Ulm/DE)

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14:45–16:15 Symposium 11HS 2 Nanomedicine and theranosticsChairs A. Aigner (Leipzig/DE), T. Lammers (Aachen/DE)

14:45 Theranostic nanomedicine T. Lammers (Aachen/DE)

15:15 Biomedical applications of iron oxide nanoparticles – the SEON concept C. Alexiou (Erlangen/DE)

15:45 Bacterial nanocellulose – pharmacological insights in the application of a natural polymer D. Fischer (Jena/DE)

14:45–16:15 Symposium 12HS 4 ADME research and PGxChairs I. Cascorbi (Kiel/DE), M. Schwab (Stuttgart/DE)

14:45 Impact of ABC transporters in Alzheimer’s disease J. Pahnke (Oslo, Norway)

15:15 Use of organoids for ADME research M. Schwab (Stuttgart/DE)

15:45 Impact of ABC transporters in Alzheimer’s disease in clinical routine R. van Schaik (Rotterdam/NL)

14:45–16:15 Symposium 13HS 10 Novel aspects of bacterial toxins – Joint symposium SFET/GTChairs K. Ernst (Ulm/DE), M.-R. Popoff (Paris/FR)

14:45 Pertussis toxin K. Ernst (Ulm/DE)

15:07 Clostridium difficile toxins R. Gerhard (Hannover/DE)

15:29 Clostridial toxins M.-R. Popoff (Paris/FR)

15:51 Bordetella pertussis toxins D. Ladant (Paris/FR)

29


16:30–17:15 Plenary lecture II – Clinical PharmacologyHS 9 Chair I. Cascorbi (Kiel/DE)

16:30 Tumor immunology from bench to bedside and back – rationale for T cell deinhibition for cancer therapy S. Kobold (Munich/DE)

17:30–18:30 Short talks – in vitro toxicology IHS 9

Chair N. Schupp (Düsseldorf/DE)

17:30 Microphysiometry-based prediction models from cell suspensions to 3D 59 tissue constructs J. Wiest (Kronburg/DE)

17:45 Prediction of human drug-induced liver injury (DILI) in relation to oral doses60 and blood concentrations W. Albrecht, F. Kappenberg, T. Brecklinghaus, K. Edlund (Dortmund/DE) I. Gardner (Sheffield/GB), J. Rahnenführer, J. G. Hengstler (Dortmund/DE)

18:00 Direct detection of mutations arising at a damage site in DNA7 M. Rodriguez-Alvarez, L. Sarmini, D. Kim, A. Khobta (Mainz/DE)

18:15 HepaChip-MWP – an organ-like perfusable cell culture system in 62 multiwell plate format for toxicity testing M. Busche, S. Werner, B. Hagmeyer, M. Pawlak (Reutlingen/DE), H. Becker J. Schnabel (Jena/DE), K. Gall, R. Hemmler (Osnabrück/DE), G. Damm (Leipzig/DE) S. Beuck, T. Klaassen (Bergheim/DE), J. Moer, A. Ullrich (Schwerin/DE) M. Matz-Soja, R. Gebhardt (Leipzig/DE), M. Stelzle (Reutlingen/DE)

17:30–18:30 Short talks – CNS/endocrine pharmacology and treatmentHS 2

Chair F. Richter Assencio (Hannover/DE)

17:30 Mental effects of analgesic drugs – review of literature data and concept for63 a placebo-controlled clinical trial A. Sachkova, J. Brockmöller, T. Prukop, J. Stingl (Göttingen/DE)

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17:45 Limited association between 5-HT receptor gene polymorphisms and treatment64 response in antidepressant treatment-free patients with depression T. Ochi (Groningen/NL), N. Vyalova, I. Losenkov, D. Paderina I. Pozhidaev (Tomsk/RU), A. Loonen (Groningen, Halsteren/NL), G. Simutkin N. Bokhan, S. Ivanova (Tomsk/RU), B. Wilffert (Groningen/NL)

18:00 Endogenous brain endothelial thrombomodulin protects the ischemic brain65 by affecting capillary diameter and vessel proliferation J. Wenzel, J. Assmann, M. Khan, M. Schwaninger (Lübeck/DE)

18:15 Telmisartan induces a specific signature of gut microbiota, which may 66 participate to its anti-obese potency L. Beckmann, A. Künstner, I. Stölting, S. Ibrahim, M. Freitag E. Langan, J. Knobloch, W. Raasch (Lübeck/DE)

17:30–18:30 Short talks – Cardiac pharmacology and treatment IIHS 4

Chairs S. Kämmerer (Dresden/DE), A. Ahles (Munich/DE)

17:30 Novel mitochondrial Ca2+ enhancers for the treatment of cardiac arrhythmia67 P. Sander, D. Arduino, F. Wilting, M. Schweitzer, T. Gudermann, F. Perocchi J. Schredelseker (Munich/DE)

17:45 Inactivation of HDAC2 attenuates atrial structural and functional 68 remodeling in CREM-IbΔC-X transgenic mice, a mouse model of spontaneous onset atrial fibrillation J. S. Schulte, J. P. Reinhardt, S. Hamer, B. Scholz, M. D. Seidl F. U. Müller (Münster/DE)

18:00 Profound differences in transcriptomics between reticulated and 69 non-reticulated platelets from healthy donors, CCS and STEMI patients by next generation sequencing (NGS) L. Hille, T. Nührenberg, L. Hein, F.-J. Neumann, D. Trenk (Bad Krozingen/DE)

18:15 Role of B lymphocytes in regulating vascular function70 N. Xia, S. Hasselwander, R. Schüler, S. Karbach, P. Wenzel, A. Daiber, T. Münzel N. Hövelmeyer, A. Waisman, H. Li (Mainz/DE)

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17:30–18:30 Short talks – Nuclear receptors, enzymes and other targetsHS 10

Chair H. Bruckmüller (Kiel/DE)

17:30 Degron-mediated depletion reveals NCBP1 as a multimodal executer of 71 cytokine functions J. Meier-Sölch, D. Newel, H. Weiser, N. Biber, U. Tenekeci M. Kracht (Giessen/DE)

17:45 Role of the pyridoxal phosphatase PDXP in red blood cell vitamin B6 72 metabolism E. Jeanclos, L. Witzinger, A. Keller, A. Gohla (Würzburg/DE)

18:00 Ligand-specific regulation of non-canonical aryl hydrocarbon receptor 73 signaling and its impact on prostaglandin D2 metabolism C. Vogeley (Düsseldorf/DE), M. Nakamura (Düsseldorf/DE, Nagoya/JP), S. Maaß M.Pollet (Düsseldorf/DE), C. F. A. Vogel (Davis/US), J. Krutmann C. Esser (Düsseldorf/DE), D. Lang (Wuppertal/DE) T. Haarmann-Stemmann (Düsseldorf/DE)

18:15 Triarylmethane class of compounds as potential modulators of the aryl 74 hydrocarbon receptor (AhR) – synthesis and in vitro evaluation E. Goya-Jorge (València/ES), R. Gozalbes, S. J.Barigye (València/ES) M. Sylla-Iyarreta Veitía (Paris/FR), R. M. Giner (València/ES)

18:30–19:30 Award ceremonyHS 9

20:00–23:15 Social evening – RatskellerLocation Ratskeller Leipzig (see page 71)

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scIenTIfIc PRoGRaMMe • ThuRsDay, 5 MaRch

08:30–09:30 Short talks – in vitro toxicology IIHS 9

Chair L. T. Anger (San Francisco, CA/US)

08:30 Chemotaxis of polarized macrophages induced by nanoparticles – a model 75 for the differentiation of local and systemic biological effects N. Kaiser, N. Rosenkranz, C. Monsé, D. Weber, G. Johnen, A. Brik, T. Brüning J. Bünger, G. Westphal (Bochum/DE)

08:45 Structural alerts for predicting skin sensitization – in silico model derived 79 from a data set of 1982 organic compounds G. Schüürmann (Leipzig/DE), M. Hillebrand (Dessau-Roßlau/DE), R. Kühne R.-U. Ebert (Leipzig/DE)

09:00 Adherens junction reorganization as endpoint to identify estrogenic substances77 M. Kornhuber, S. Klutzny, S. Dunst, M. Oelgeschläger, G. Schönfelder (Berlin/DE)

09:15 QSAR and read across for the evaluation of the genotoxic potential of plant78 protection residues – an industry perspective M. Frericks, D. Urbisch (Limburgerhof/DE), F. Kluxen (Cologne/DE) A. Patel (Rochelle/US), A. Lee (Midland/US), M. Corvaro, J. Zhang E. Shipp (Wilmington/US), S. Wijesalere (Rochelle/US), L. Brierley A. Booth (Basel/CH), A. Hueser (Wilmington/US; Monheim/DE)

09:30–10:30 Short talks – in vitro toxicology IIIHS 9

Chair A. Mangerich (Konstanz/DE)

09:30 In vitro metabolome and biochemical pathway analysis of nephrotoxicants76 in NRK-52E cells B. Birk, S. Sperber, S. Wallisch (Ludwigshafen/DE), M. Herold V. Haake (Berlin/DE), M. Amma (Ludwigshafen/DE), T. Walk (Berlin/DE) H. Kamp, B. van Ravenzwaay (Ludwigshafen/DE)

09:45 Uptake and transport of hepatotoxic pyrrolizidine alkaloids in HepaRG cells80 A.-M. Enge, J. Waizenegger (Berlin/DE), H. Hammer, O. Pötz (Reutlingen/DE) F. Kaltner, C. Gottschalk (Munich/DE), A. Lampen, A. Braeuning S. Hessel-Pras (Berlin/DE)

10:00 In vitro and in vivo (geno)toxicity testing of industrially relevant quartz 81 species, covalently surface-modified to reduce lung toxicity C. Ziemann (Hannover/DE), E. Monfort, M. J. Ibáñez, A. López-Lilao (Castellón/ES) G. Bonvicini (Bologna/IT), O. Creutzenberg (Hannover/DE)

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10:15 Responses of human monocyte-derived macrophages and differentiated 82 THP-1 cells exposed to silica and copper oxide particles J. Lichter, K. Hertz (Trier/DE), P. Schumacher, A. Hartwig (Karlsruhe/DE), U. Bock B. Blömeke (Trier/DE)

09:00–10:30 Short talks – Disease models, drug development IIHS 2

Chair B. Renner (Dresden/DE)

09:00 Investigating calcium channels modulation of a novel phenylethylamine 40 compound in Caenorhabditis elegans Y.-Y. Mak, F.-K. Lee, K.-H. Lim, C. Kong (Semenyih/MY), Y. Mbaki (Nottingham/GB) S.-M. Then, K.-N. Ting (Semenyih/MY)

09:15 Vioprolide A impairs angiogenic processes in human endothelial cells 84 in vitro – inhibition of protein translation as central mechanism? L. D. Burgers, B. Luong (Frankfurt/DE), S. Zahler (Munich/DE) R. Müller (Saarbrücken/DE), R. Fürst (Frankfurt/DE)

09:30 Adipose tissue – heart crosstalk – pharmacological inhibition of non-cardiac85 ATGL by atglistatin improves myocardial stiffness in a murine model of cardiac fibrosis A. Thiele, N. Beyhoff, A. Blumrich, D. Ritter, R. Klopfleisch, J. Grune, E. Smeir K. Lüttges (Berlin/DE), R. Zechner, R. Breinbauer (Graz/AT), U. Kintscher A. Foryst-Ludwig (Berlin/DE)

09:45 Protective effects of wheat germ oil against erectile and endothelial 86 dysfunction in streptozotocin-induced diabetic rats H. Guven (Istanbul/TR), N. Durmus, N. Hocaoglu, O. Guner, S. Acar, P. Akan O. Gursoy Calan (Izmir/TR)

10:00 Pharmacological targeting of phosphoglycolate phosphatase87 A. Gohla, E. Jeanclos, J. Schloetzer (Würzburg/DE), J. P. von Kries (Berlin/DE) H. Schindelin (Würzburg/DE)

10:15 The small GTPase Rab27a contributes to the processing of pain88 T. Groß, G. Wack, K. Syhr(Frankfurt/DE), T. Tolmachova (London/GB) M. C. Seabra (Lisbon/PT), A. Schmidtko (Frankfurt a. Main/DE) W. Kallenborn-Gerhardt (Frankfurt a. Main/DE)

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09:00–10:30 Short talks – Immunopharmacolgy/inflammation/antiinfectivesHS 4

Chair H. Mühl (Frankfurt a. M./DE)

09:00 Investigation of protein protein interactions of the P2X7 > receptor by 89 cross-linking mass spectrometry R. Kopp (Munich/DE), S. Chaturvedi (Lucknow/IN), V. Agarwal N. Prasad (Lucknow/IN)

09:15 Generation and activation of myeloid derived suppressor cells using 90 prostaglandin E2 and EP receptor agonists in a murine model of asthma C. van Geffen, S. Kolahian (Tübingen/DE)

09:30 Rapamycin prolongs skin allograft survival in obese mice through 91 myeloid-derived suppressor cells A. Deißler, A. Della Penna, C. van Geffen, B. Nürnberg, A. Königsrainer M. Quante, S. Kolahian (Tübingen/DE)

09:45 Hepatic transcriptome analyis for identification of novel factors 92 determining experimental paracetamol-induced liver injury S. Gonther, M. Bachmann, I. Goren, J. Pfeilschifter, H. Mühl (Frankfurt a. M./DE)

10:00 Lipopolysaccharide reduces urethral smooth muscle contractility 93 independently of TLR4 activation – implication of caspase-1 and cyclooxygenase activation F. Beraldi Calmasini, E. Costa Alexandre, M. Gonçalves Oliveira F. H. da Silva (Campinas/BR), A. G. Soares, S. K. Pereira Costa (São Paulo/BR) E. Antunes (Campinas/BR)

10:15 Preliminary results from systematic review and meta-analysis on psychiatric94 adverse events in tenofovir-based HIV-medication and prophylaxis M. S. Schaefer, L. E. Villagomez Fuentes, K. Allers, T. Schneider, R. Kreutz T. G. Riemer (Berlin/DE)

09:00–10:30 Short talks – Drug transport, pharmacokinetics and PK/PD modelingHS 10

Chairs R. Böhm (Kiel/DE), D. Ramanujam (Munich/DE)

09:00 Evaluation of dosing strategies for the oral one-compartment model to 95 reach the therapeutic window following multiple oral drug administration A. Ring (Bloemfontein/ZA), M. Juma (M’Bour/SN)

09:15 Evaluating uncertainty and variability in quantitative in vitro to in vivo 96 extrapolation approach – empirical PBTK model versus physiological 26 compartment PBTK model E. Fabian, P. Kalra, B. van Ravenzwaay, R. Landsiedel (Ludwigshafen/DE)

35


09:30 A whole body pharmacokinetics model based on residence time theory, 97 implemented in Python A. Ring (Bloemfontein/ZA), L. Frenzel (Wedel/DE)

09:45 Pharmacogenomics analysis of the pharmacokinetics and 98 pharmacodynamics of loop diuretic drugs C. Dücker, S. V. Vormfelde (Göttingen/DE), E. Schäffeler (Stuttgart/DE) M. Schwab (Stuttgart, Tübingen/DE), J. Brockmöller (Göttingen/DE)

10:00 Development and pharmacokinetic assessment of tetrahydrocurcumin 99 solid lipid nanoparticles H. R. Shiek Abdul Kadhar Mohamed Ebrahim (Kuala Lumpur/MY) T. T. Chungath (Ernakulam/IN), H. Ranganathan, S. Muthusamy (Coimbatore/IN)

10:15 Caffeic acid derivatives and tetraenes from Echinacea purpurea alter the 100 expression and not the activity of ABCB1 C. Awortwe, M. Kaehler, H. Bruckmüller, I. Cascorbi (Kiel/DE)

10:45–11:30 Plenary lecture III – ToxicologyHS 9 10:45 Exploiting the human peptidome for novel antimicrobial and anticancer agents Frank Kirchhoff (Ulm/DE)

11:45–13:15 Symposium 14HS 9 Uncertainty of toxicological assessmentsChairs M. Batke (Hannover/DE), R. Buesen (Ludwigshafen/DE)

11:45 Identifying and addressing uncertainty in toxicological databases and in silico models to improve regulatory acceptance M. Cronin (Liverpool/GB)

12:07 Quality assessment of in vivo studies and data bases M. Wehr (Hannover/DE)

12:29 Confidence in AOPs and the in vitro methods populating them S. Hoffmann (Paderborn/DE)

12:51 Quantifying the borderline range and implications for decision-making M. Mathea (Ludwigshafen/DE)

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11:45–13:15 Symposium 15HS 2 RNAs as pharmacological drugs or targetsChairs A. Aigner (Leipzig/DE), S. Hüttelmaier (Halle a. d. S./DE)

11:45 Development of noncoding RNA therapeutics for cardiac disease T. Thum (Hannover/DE)

12:15 Systemic mRNA vaccines for cancer immunotherapy J. Diekmann (Mainz/DE)

12:45 RNA binding proteins and microRNAs – from pharmacological targets to novel therapeutic strategies S. Hüttelmaier (Halle a. d. S./DE)

11:45–13:15 Symposium 16HS 4 Joint SPS/DGPT symposium on the translation of advanced therapy medicinal productsChairs W.-H. Zimmermann (Göttingen/DE), F. Hock (Dieburg/DE)

11:45 The Genentech story – all started with somatostatin D. Stevens (San Francisco, CA/US)

12:07 Genome editing in duchenne muscular dystrophy C. Kupatt (Munich/DE)

12:29 Development of ATMPs for rare diseases G. Carey (Boston, MA/US)

12:51 Remuscularization of the failing heart – from bench to bedside W.-H. Zimmermann (Göttingen/DE)

11:45–13:15 Symposium 17HS 10 Cannabis and cannabinoids – regulatory framework, research and clinical experienceChairs P. Cremer-Schaeffer (Bonn/DE), B. Hinz (Rostock/DE)

11:45 Cannabis-based medicinal products in a specific regulatory framework P. Cremer-Schaeffer (Bonn/DE)

12:15 Cannabinoids – a pharmacological perspective B. Hinz (Rostock/DE)

12:45 Implications of cannabinoid receptors in neuropsychiatric disorders U. Havemann-Reinecke (Göttingen/DE)

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13:30–15:00 Symposium 18HS 9 Bomben, Minen, weißer Phosphor – ökologische und gesundheitliche Risiken durch Kriegsaltlasten im MeerChairs E. Maser, C. Böttcher (Kiel/DE)

13:30 Munition im Meer – eine gesamtgesellschaftliche Aufgabe? Ausgewählte Fakten und Lösungsansätze aus Deutschland und der Welt C. Böttcher (Kiel/DE)

13:50 Toxikologie von Explosivstoffen für Mensch und Umwelt – das UDEMM projekt J. Strehse (Kiel/DE)

14:10 Chemische Kampf- und Explosivstoffe in der Ostsee – das DAIMON projekt M. Brenner (Bremerhaven/DE)

14:30 Molekulare Biomarker zur Explosivstoff-Detektion E. Maser (Kiel/DE)

14:50 Diskussion

13:30–15:00 Symposium 19HS 2 Medicine informatics and educationChairs J. Coleman (Birmingham/GB), R. Maas (Erlangen/DE)

13:30 Medicine informatics initiative M. Löffler (Leipzig/DE)

14:00 Use cases T. Ganslandt (Mannheim/DE)

14:30 Safe prescribing J. Coleman (Birmingham/GB)

13:30–15:00 AGAH symposium – clinical and economic aspects of medical application ofHS 4 biologicsChairs F. Donath (Erfurt/DE), G. Wensing (Wuppertal/DE)

13:30 Targets and collateral damage in dermatooncology R. Herbst (Erfurt/DE)

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14:00 Single, very low rituximab doses in healthy volunteers – a pilot and a randomized trial – implications for dosing and biosimilarity testing B. Jilma (Vienna/AT)

14:30 Clinical and economic decision criteria for strategic buying of biosimilars D. Fenske (Erfurt/DE)

13:30–15:00 Symposium 20 HS 10 Pharmakologie-historisches ForumChairs A. Philippou (Innsbruck/AT), H. Greim (Munich/DE)

13:30 Einleitung A. Philippou (Innsbruck/AT)

13:35 Der Papyrus Ebers: Ein anonymer Schreiber und sein Entdecker R. Scholl (Leipzig/DE)

13:45 Fritz Kurt Hauschild: Leben und Wirken H. Wellhöner (Hannover/DE)

14:15 Reinhard Ludewig: Leben und Wirken I. Kästner (Leipzig/DE)

14:45 Diskussion

14:55 Schlussworte H. Greim (Munich/DE)

15:00–15:30 Closing ceremonyHS 9

39

PosTeR sessIons

Poster session I

Deutsche Gesellschaft für Pharmakologie (DGP), Deutsche Gesellschaft für Klinische Pharmakologie und Therapie (DGKliPha)

Pharmacology – Cancer pharmacology and treatment .............................. P1–P12Pharmacology – G protein-coupled receptors ............................................ P13–P29Pharmacology – Ion channels and membrane transporters ...................... P30–P52Pharmacology – Pharmacoepidemiology and drug safety ......................... P53–P67Pharmacology – Drug transport/delivery and metabolism ........................ P68–P74Pharmacology – Pharmacological education .............................................. P75–P79

Deutsche Gesellschaft für Toxikologie (GT)

Toxicology – Food toxicology ...................................................................... P80–P87Toxicology – Organ toxicology ..................................................................... P88–P94 | LP1Toxicology – Biotransformation and toxicokinetics .................................... P95–P99Toxicology – Genotoxicity and carcinogenesis ............................................ P100–P112 | LP2 | LP3Toxicology – Nanomaterials ........................................................................ P113–P124Toxicology – Toxicological education .......................................................... P125–P127

Poster session II

Deutsche Gesellschaft für Pharmakologie (DGP), Deutsche Gesellschaft für Klinische Pharmakologie und Therapie (DGKliPha)

Pharmacology – Disease models, drug development I ............................... P128–P143Pharmacology – Cardiac pharmacology and treatment ............................. P144–P160Pharmacology – Signal transduction and second messengers ................... P161–P177Pharmacology – CNS / endocrine pharmacology and treatment ............... P178–P184Pharmacology – Nuclear receptors, enzymes and other targets ............... P185–P191Pharmacology – Immunopharmacology / inflammation / antiinfectives ... P192–P195Pharmacology – Pharmacokinetics and PK/PD modeling ........................... P196–P203

Deutsche Gesellschaft für Toxikologie (GT)

Toxicology – Toxic compounds .................................................................... P204–P216Toxicology – Toxins ...................................................................................... P217–P255

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PosTeR sessIon I • TuesDay, 3 MaRch

14:15–15:15 Poster session I – Foyer

Pharmacology – Cancer pharmacology and treatment

P1 Change of gene expression and DNA methylation through generation of tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells Meike Kähler, Merit Litterst, Ruwen Böhm, Henrike Bruckmüller (Kiel/DE) Julia Kolarova, Ole Ammerpohl (Kiel, Ulm/DE), Ingolf Cascorbi, Inga Nagel (Kiel/DE)

P2 Effects of TRPM7 on TGF-β-induced signaling in lung cells Sarah Zeitlmayr, Thomas Gudermann, Andreas Breit (Munich/DE)

P3 Glioma tissue slice tandem-cultures for the quantitation of inhibitory effects of drugs on tumor invasion and growth Vasile Sidorcenco, Luisa Krahnen, Marion Schulz (Leipzig/DE), Janina Remy Donat Kögel (Frankfurt a. M./DE), Achim Temme (Dresden/DE), Ute Krügel Heike Franke, Achim Aigner (Leipzig/DE)

P4 Functional analysis of phospholipase C-γ2 C2 domain mutants mediating ibrutinib resistance in malignant B cells Sascha Endres, Claudia Walliser, Peter Gierschik, Martin Wist, Jennifer Haas Panagiotis Papatheodorou (Ulm/DE)

P5 The role of the activated coagulation factor X (FXa) in the progression of malignant tumors Ulrike Meyer, Sarah Polster, Bernhard H. Rauch (Greifswald/DE)

P6 Betulinic acid exhibits a distinctive antimelanoma effect by interfering with epithelial-to-mesenchymal transition (EMT) Dorina Coricovac, Ioana Macasoi, Iulia Pinzaru, Cristina Dehelean (Timisoara/RO)

P7 Inhibition of sphingosine-1-phosphate receptors impairs growth and migration of glioblastoma multiforme cells in vitro Fan Chen, Sandra Bien-Möller, Yong Xiao, Sascha Marx, Eileen Moritz Robert Hofstetter, Andreas Link, Henry Schroeder, Bernhard Rauch (Greifswald/DE)

P8 Anti-invasive and antimetastatic effects of the monoacylglycerol lipase inhibitor JZL184 on human lung cancer cells Robert Ramer, Jan Lukas Prüser, Felix Wittig, Ivanov Igor, Jutta Merkord Burkhard Hinz (Rostock/DE)

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P9 Inhibition of monoacylglycerol lipase reduces angiogenic properties of endothelial cells by releasing tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells Felix Wittig, Lino Henkel, Robert Ramer, Burkhard Hinz (Rostock/DE)

P10 Analyzing the effect of histamine on viability, metabolism and proliferation of human colon cancer cell lines Martin König, Bastian Schirmer, Tamina Rother, Roland Seifert Detlef Neumann (Hannover/DE)

P11 Cancer associated microRNAs interact with the inducible dual-specificity phosphatases Henrike Bruckmüller (Kiel/DE; Tromsö/NO), Victoria Tenhaken (Kiel/DE) Bjarne Johansen (Tromsö/NO), Inga Nagel, Ingolf Cascorbi (Kiel/DE) Ole Morten Seternes (Tromsö/NO)

P12 Nanoparticle-based miRNA-24-3p replacement exerts tumor inhibitory effects in pancreatic cancer cell lines, including induction of cell death and downregulation of c-myc/survivin Hannes Borchardt, Achim Aigner (Leipzig/DE)

Pharmacology – G protein-coupled receptors

P13 Analysis of molecular determinants for voltage dependent activation of the µ-opioid receptor with different opioid analgesics Sina B. Kirchhofer, Julia G. Ruland, Peter Kolb, Moritz Bünemann (Marburg/DE)

P14 Interaction of amitriptyline and histamine in the heart of H2 receptor transgenic mice Maximilian Binter, Ulrich Gergs, Joachim Neumann (Halle a. d. S./DE)

P15 Influence of phosphodiesterases on cardiac histamine signaling in H2 receptor transgenic mice Rafaela Voss, Ulrich Gergs, Joachim Neumann (Halle a. d. S./DE)

P16 Arrhythmias induced by hypothermia in isolated 5-HT4 receptor overexpressing mouse right atrial preparations Tobias Brückner, Ulrich Gergs, Joachim Neumann (Halle a. d. S./DE)

P17 Metoclopramide but not domperidone affect cardiac contractility via 5-HT4 receptors in transgenic mice Tom Seidler, Ulrich Gergs, Joachim Neumann (Halle a. d. S./DE)

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P18 A novel role of helix 8 for the mechanosensitivity of GPCRs Jasmin Becker, Laura Danner, Serap Erdogmus, Thomas Gudermann, Ursula Storch Michael Mederos y Schnitzler (Munich/DE)

P19 Production of fluorescent small protein ligands to study their function in living cells Moritz Volk-Heise, Sandra Beier, Giovanna Stadler, Lobna Abdella, Mariana Lang Barbara Moepps (Ulm/DE)

P20 The N-terminus of AC5 is essential and sufficient for the interaction between AC5 and AnxA4 Manuel Domnik, Alexander Heinick, Andre Klemme, Christina Rolfes Frank Ulrich Müller (Münster/DE)

P21 Store-operated calcium entry inhibition exerts anti-fibrotic actions in cardiac fibroblasts Abdul Rehman, Susanne Lutz, Wolfram-Hubertus Zimmermann (Göttingen/DE)

P22 Coupling of the human Mas-related G protein-coupled receptor D to the β-arrestin pathway Diana Magdy Fahim Hanna, Michael Arbogast, Sabrina Müller Ivar von Kügelgen (Bonn/DE)

P23 Identification of amino acids that govern the intracellular trafficking of arrestin3 Nadja Mösslein, Moritz Bünemann, Cornelius Krasel (Marburg/DE)

P24 Monitoring β1-adrenoceptor phosphorylation in human heart Andrea Ahles, Laura Hinz, Jennifer Herrmann, Sandro Meunier Regina Feederle (Munich/DE), Hendrik Milting (Bad Oeynhausen/DE) Stefan Engelhardt (Munich/DE)

P25 Transcriptome analysis in murine Gαi3-deficient platelets Isabel Anna Maria Groh (Tübingen/DE), Volkan Cakir, Diana LeDuc Anne Butthof (Leipzig/DE), Veronika Leiss, Bernd Nürnberg (Tübingen/DE) Torsten Schöneberg (Leipzig/DE)

P26 Investigating the impact of the sphingosine-1-phosphate receptors on autocrine platelet activation Celine Tolksdorf, Eileen Moritz, Robert Wolf, Andrea Simunovic, Katharina Schott Mladen Tzvetkov, Gabriele Jedlitschky, Bernhard H. Rauch (Greifswald/DE)

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P27 µ-opioid receptor phosphorylation profile of novel opioid ligands Sebastian Fritzwanker, Stefan Schulz, Andrea Kliewer, Frank Schmiedel (Jena/DE) Meritxell Canals (Nottingham/GB)

P28 Insights into molecular mechanisms of class B GPCR activation obtained from structural studies and directed evolution of parathyroid hormone receptor 1 Christoph Klenk, Janosch Ehrenmann, Jendrik Schöppe Andreas Plückthun (Zurich/CH)

P29 RGS3L as potential mediator of the non-neuronal acetylcholine-induced contractility in smooth muscle Magdolna Levay, Timo Scholz, Lena Throm, Eva Wollmann, Sebastian Berlit Marc Sütterlin, Thomas Wieland (Mannheim/DE)

P29 A Influence of simulated core body temperature on signalling and gene expression in a mouse hypothalamic cell line D. Faro (Munich/DE)

Pharmacology – Ion channels and membrane transporters

P30 Characterization and function of TRPV2 in mouse microglia Mahsa Malihpour, Thabet Belkacemi, Veit Flockerzi, Andreas Beck (Homburg/DE)

P31 Unpredictable alterations of insulin secretion by the NMDA receptor inhibitor dextromethorphan Anne Gresch, Martina Düfer (Münster/DE)

P32 Synergistic effects of MCT4 and mitochondrial respiration inhibition in renal cell carcinoma Lena-Sophie Menig, Ute Hofmann, Anna Reustle (Tübingen, Stuttgart/DE) Jörg Hennenlotter, Viktoria Stühler (Tübingen/DE), Jens Bedke (Heidelberg, Tübingen/DE) Matthias Schwab (Tübingen, Heidelberg, Stuttgart/DE) Elke Schaeffeler (Stuttgart, Tübingen/DE)

P33 Behavioural consequences of two-pore channel 1 inactivation in the mouse brain Robert Theodor Mallmann, Bernd Heimrich, Norbert Klugbauer (Freiburg i. B./DE)

P34 Role of calcium channel subunits in endothelial cell function Nicolas Kaiser, Barbara Wardas, Veit Flockerzi, Anouar Belkacemi (Homburg/DE)

P35 Electrophysiological characterization of TPC2 polymorphisms Julia Böck, Yu-Kai Chao, Einar Krogsaeter, Christian Grimm (Munich/DE)

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P36 The role of membrane transporters in hepatic cGMP signaling Charlotte Kölz (Stuttgart, Tübingen/DE), Moritz Lehners (Tübingen/DE) Stefan Winter (Stuttgart, Tübingen/DE), Elke Schaeffeler, Kathrin Klein Matthias Schwab (Tübingen, Stuttgart/DE), Robert Feil (Tübingen/DE) Anne T. Nies (Stuttgart, Tübingen/DE)

P37 Role of TRPM7 channels in insulin secretion Noushafarin Khajavi, Dimitrije Spasic, Sabrina Syamsul Thomas Gudermann (Munich/DE)

P38 Calcium-dependence of TRPV6 variants Tobias Schaffrath, Veit Flockerzi, Andreas Beck, Ulrich Wissenbach (Homburg/DE)

P39 Electrophysiological analysis of de novo designed (-)-englerin A mimetics Aaron Treder (Munich/DE), Lukas Friedrich, Ryan Byrne (Zurich/CH) Inderjeet Singh (Munich/DE), Christoph Bauer (Zurich/CH) Thomas Gudermann (Munich/DE), Gisbert Schneider (Zurich/CH) Michael Mederos y Schnitzler, Ursula Storch (Munich/DE)

P40 The normalized slope conductances of current-voltage relations represent a novel approach for characterization of TRPC channels Christian Hermann, Aaron Treder, Marius Näher, Roman Geiseler Thomas Gudermann, Michael Mederos y Schnitzler, Ursula Storch (Munich/DE)

P41 Essential functions of TRPV4 channels in alveolar epithelium Suhasini Rajan, Jonas Weber, Yu-Kai Chao, Martina Kannler (Munich/DE) Gabriela Krasteva-Christ (Homburg/DE), Ali Önder Yildirim (Munich/DE) Monika Brosien (Giessen/DE), Johann Schredelseker (Munich/DE) Norbert Weissmann (Giessen/DE), Christian Grimm, Thomas Gudermann Alexander Dietrich (Munich/DE)

P42 Statins inhibit cytosolic effects of the farnesoid X receptor in murine β-cells by an HMGCoA reductase-dependent mechanism Simon Lüdtke, Theresa Hoffmeister (Münster/DE), Gisela Drews (Tübingen/DE) Martina Düfer (Münster/DE)

P43 The glucagonotropic effect of sulfonylureas Eike-Henrik Früh, Christin Elgert, Theresa Wittrien, Ingo Rustenbeck (Braunschweig/DE)

45


P44 Electrophysiological and biochemical characterization of the human P2X7B receptor in Xenopus laevis oocytes Sanaria Hawro Yakoob, Ralf Hausmann, Günther Schmalzing Aparna Sai Malisetty (Aachen/DE), Elena Adinolfi, Francesco Di Virgilio (Ferrara/DE) Fritz Markwardt (Halle a. d. S./DE)

P45 Comparative analysis of two bac-transgenic P2X7 reporter mouse models reveals highly divergent GFP exression patterns Antonio Ramírez-Fernández (Munich/DE), Giorgia Conte (Dublin/IE), Robin Kopp Nicolas Scalbert (Munich/DE), Björn Rissiek (Hamburg/DE), Tobias Engel (Dublin/IE) Annette Nicke (Munich/DE)

P46 Changed to oral presentation – see on page 33

P47 A novel TRPV3 blocker 26E01 inhibits TRPV3 channels functionally expressed in colonic epithelial cells Maria Bischof, Stefan Olthoff, Michael Schaefer, Kerstin Hill (Leipzig/DE)

P48 KS0365 is a new and potent TRPV3 agonist Marion Maier, Stefan Olthoff, Kerstin Hill (Leipzig/DE), Thomas Magauer Lukas Wein (Innsbruck/AT), Michael Schaefer (Leipzig/DE)

P49 The dithiolane X10056 inhibits TRPV2 channels endogenously expressed in primary macrophages Rick Raudszus (Leipzig/DE), Anke Deckers, Stefan Bräse (Karlsruhe/DE) Michael Schaefer, Kerstin Hill (Leipzig/DE)

P50 Glucose-induced [Ca+2] oscillations in β cells are composed of trains of spikes within a subplasmalemmal microdomain Georg Langlhofer, Alexander Kogel, Michael Schaefer (Leipzig/DE)

P51 Calcium initiated masking of PI(4,5)P2 via TRPA1 activates MARCKS function independent of PKC Thomas Büch, Nicole Urban, Achim Aigner, Michael Schaefer Hermann Kalwa (Leipzig/DE)

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P52 Expression analysis of bile salt and organic anion transporters during rat development from embryo to adult Anastasia Weyrich, Markus Frericks, Thomas Hofmann, Steffen Schneider Bennard van Ravenzwaay (Ludwigshafen/DE)

Pharmacology – Pharmacoepidemiology and drug safety

P53 Parallel topical treatment of adult acne vulgaris patients with nadifloxacin cream and adapalene Claudia Neumeister (Bamberg/DE), Rolf-Hasso Bödeker (Gießen/DE) Claudia Borelli (Tübingen/DE), Ulrich Schwantes (Bamberg/DE)

P54 Acne vulgaris in adolescents – parallel topical treatment with nadifloxacin and adapalene Claudia Neumeister (Bamberg/DE), Rolf-Hasso Bödeker (Gießen/DE) Claudia Borelli (Tübingen/DE), Ulrich Schwantes (Bamberg/DE)

P55 Sufentanil concentrations in urine samples do not correlate to serum concentrations at 24 hours up to 96 hours after termination of sufentanil therapy Rebecca Schütte, Sebastian Schwartze, Matthias Wittstock, Thomas Domning Udo Walther (Rostock/DE)

P56 In-house standards for antibiotic prophylaxis of infective endocarditis in patients with predisposing cardiac conditions – a nationwide survey of oral and maxillofacial surgery clinics in Germany Susanne Hafner, Mohammed Albittar, Emaad Abdel-Kahaar, Oliver Zolk (Ulm/DE)

P57 The new combination of ibuprofen and caffeine in self-treatment of headache and migraine – results from a consumer survey in German community pharmacies Anette Lampert, Heidemarie Gräter, Thomas Weiser (Frankfurt a. M./DE)

P58 Polypharmacy in dogs and cats – a retrospective analysis Marie Tarillion, Iris Weber, Romy M. Heilmann, Angelika Richter Robert Hertzsch (Leipzig/DE)

P59 Psychiatric and asthenic symptoms as adverse events during abiraterone therapy: interim results from a systematic review and meta-analysis Paul Schiller, Linda E. Villagomez Fuentes, Norbert Kathmann, Reinhold Kreutz Juliane Bolbrinker, Thomas G. Riemer (Berlin/DE)

P60 Comparison of ten validated scales and a novel instrument to assess the influence of anticholinergic burden on the cognitive performance of geriatric patients Jakob Mailahn, Laura Herzer, Andrea Lohse, Ulrike Kronberg, Nora Karara Felix Bermpohl, Reinhold Kreutz, Thomas G. Riemer (Berlin/DE)

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P61 An overview of dapaglipflozin serious adverse reactions caused by potential interactions Claudiu Morgovan, Anca Butuca, Anca Maria Juncan, Luca Liviu Ru Andrei Catalin Muntean, Loredana Vonica, Adina Frum, Carmen Maximiliana Dobrea Felicia Gligor (Sibiu/RO), Steliana Ghibu (Cluj-Napoca/RO)

P62 A case report of a pregnant woman with chronic hepatitis B – use of tenofovir during pregnancy Hulya Guven (Istanbul/TR), M. Aylin Arici, Gozde Akturk, Ozge Guner (Izmir/TR)

P63 Modification of the Institute for Healthcare Improvement Medication Module Trigger Tool to enable its digital implementation in a Swiss university hospital Amina El Saghir, Scholer Miriam, Patrick Heinrich, Klaus Baumgartl René Schwendimann, Stephan Krähenbühl, Anne Leuppi-Taegtmeyer (Basel/CH)

P64 Interferons′s adverse reactions, an impediment in the adherence to treatment Anca Butuca, Adina Frum, Felicia Gabriela Gligor, Anca Maria Juncan Andrei Catalin Muntean, Liviu Luca Rus, Carmen Maximiliana Dobrea Adriana Aurelia Chis, Claudiu Morgovan (Sibiu/RO)

P65 Evolution of paracetamol overdose patient with acute renal failure Bán Erika, Patzelt Simon Andreas (Tirgu Mures/RO)

P66 Why pharmacotherapy is inefficient in rural Transylvania? Bán Erika, Patzelt Simon Andreas (Tirgu Mures/RO)

P67 Prevalence of fatal adverse drug reactions reported for single enantiomer esomeprazole compared to racemic drug omeprazole Anca Maria Arseniu, Anca Butuca, Maria Totan, Gabriela Cormos Claudiu Morgovan, Maria Muresan, Adriana Aurelia Chis (Sibiu/RO)

Pharmacology – Drug transport/delivery and metabolism

P68 Variability and heritability of baseline concentrations and high dose pharmacokinetics of thiamine (Vitamin B1) Ole Jensen, Johannes Matthaei, Felix Blome (Göttingen/DE) Matthias Schwab (Stuttgart, Tübingen/DE), Mladen Tzvetkov (Greifswald/DE) Jürgen Brockmöller (Göttingen/DE)

P69 Restoration of MARCKS enhances chemosensitivity in cancer Tim Wenzel, Thomas Büch, Nicole Urban, Achim Aigner, Michael Schaefer Hermann Kalwa (Leipzig/DE)

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P70 Efficient therapeutic nucleic acid delivery through polymer-based nanoparticles, analyzed in vitro, ex vivo and in vivo Michael Karimov, Alexander Ewe, Achim Aigner (Leipzig/DE)

P71 Searching for the missing heritability in metoprolol pharmacokinetics Christof Dücker, Johannes Matthaei, Daniel Sehrt (Göttingen/DE) Elke Schäffeler (Stuttgart/DE), Matthias Schwab (Tübingen, Stuttgart/DE) Jürgen Brockmöller (Göttingen/DE)

P72 A comprehensive multi-omics analysis of the key target of hepatitis viruses and bile acid and drug transporter NTCP Roman Tremmel, Barbara A.C. van Eijck (Stuttgart/DE), Niklas Handin (Uppsala/SE) Mathias Haag, Stefan Winter, Florian Büttner, Pascale Fisel, Ute Hofmann Kathrin Klein (Stuttgart/DE), Per Hoffmann (Bonn/DE; Basel/CH) Markus M. Nöthen (Bonn/DE), Fabienne Z. Gaugaz, Per Artursson (Uppsala/SE) Anne T. Nies (Stuttgart/DE), Matthias Schwab (Tübingen, Stuttgart/DE) Elke Schaeffeler (Stuttgart/DE)

P73 Effects of genetic variants in the organic cation transporter PMAT on the cellular uptake and on the pharmacokinetics of metformin Sayed-Mohammad Hasheminasab (Göttingen/DE) Sierra Strebe (Greifwald/DE), Jürgen Brockmöller (Göttingen/DE) Mladen V. Tzvetkov (Greifwald/DE)

P74 Effects of a common duplication at the exon7-intron7 border on OCT1 splicing, expression, and function Sarah Römer, Marleen J. Meyer (Greifswald/DE), Marek Drozdzik (Szczecin/PL) Jürgen Brockmöller (Göttingen/DE), Mladen V. Tzvetkov (Greifswald/DE)

Pharmacology – Pharmacological education

P75 PubPharm – the search platform for pharmacology, toxicology & pharmacy-specific literature Christina Draheim, Denitsa Eckweiler, Kristof Keßler, Hermann Kroll Janus Wawrzinek, Stefan Wulle, Wolf-Tilo Balke, Katrin Stump (Braunschweig/DE)

P76 Assessing and improving medical students’ ability to convey information in a simulated physician-patient conversation on a new drug treatment – an educational approach Verena Kirsch, Jan Matthes (Cologne/DE)

P77 Blended PbL – mixing Computer- and Problem-based Learning for 3rd year medical students Jan Matthes, Ulrike Servos, Birger Reiß, Christoph Stosch, Yassin Karay (Cologne/DE)

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P78 The Papyrus Ebers, its scribe and explorer Reinhold Scholl (Leipzig/DE)

P79 Development and use of E-learning programs to improve case studies and practical experiments of undergraduate pharmacy courses – cancelled Abdalla Wedn, Sahar Elgowilly (Alexandria/EG)

Toxicology (GT) – Food toxicology

P80 Chlorinated paraffins – sources, exposure, toxicology and regulation Sebastian Zellmer, Thomas Tietz, Oliver Kappenstein, Stefan Merkel Andreas Luch (Berlin/DE)

P81 Comparison of microsomal and cell culture metabolite profiles of hepatotoxic pyrrolizidine alkaloids Ina Geburek (Berlin, Kaiserslautern/DE), Lukas Rutz Dieter Schrenk (Kaiserslautern/DE), Anja These (Berlin/DE)

P82 Risk assessment regarding the use of Annona muricata in food supplements Ancuta Cristina Raclariu-Manolica (Berlin/DE; Parma/IT), Nadiya Bakhiya Alfonso Lampen, Karen Hirsch-Ernst (Berlin/DE)

P83 Urinary biomarker for the internal exposure to the Food Contaminants 2-Monochloropropane-1,3-diol (2-MCPD) and 3-Monochloropropane-1,2-diol (3-MCPD) Bernhard Monien, Nick Bergau, Zhiyong Zhao, Klaus Abraham (Berlin/DE)

P84 Simultaneous quantification of eight hemoglobin adducts by use of Isotope-dilution UHPLC-MS/MS Fabian Gauch, Alfonso Lampen, Klaus Abraham, Bernhard Monien (Berlin/DE)

P85 LC-MS/MS quantification of N-(trans-isoestragole-3’-yl)-valine in hemoglobin – a novel biomarker for the internal exposure to estragole and anethole Nick Bergau, Uta Herfurth, Benjamin Sachse, Klaus Abraham Bernhard Monien (Berlin/DE)

P86 Derivation of a chemical-specific adjustment factor – the example of phosphate in re-evaluating food additives Ursula Gundert-Remy, Camilla Smeralda, Alessandra Giarola (Berlin/DE)

P87 Proposed criteria for grouping of plant protection active ingredients with reproductive properties Stephanie Melching-Kollmuss (Limburgerhof/DE), Mary Moxon (Congleton, Cheshire/GB) Giovanna Semino-Beninel (Sophia Antipolis/FR)

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Toxicology – Organ toxicology

P88 Development of an HPLC-MS/MS multi-method for the determination of sesquiterpene lactones Franziska Kolrep, Eileen Mähnert, Matthias Gehling, Oliver Kappenstein (Berlin/DE)

P89 In vitro hepatotoxicity of an aqueous extract from Colchicum autumnale L. Antonia Müller, Petra Molnar-Pfitzner, Jennifer E. Felenda, Margit B. Müller Claudia Turek, Nora Mörbt, Peter Vögele Florian C. Stintzing (Bad Boll, Eckwälden/DE)

P90 Standardization of a DIO inhibition in vitro assay based on human microsomes Andreas Georg Weber, Barbara Birk, Hans-Albrecht Hüner (Ludwigshafen/DE) Kostja Renko (Berlin/DE), Sandra Coecke (Ispra/IT), Steffen Schneider Bennard van Ravenzwaay, Robert Landsiedel (Ludwigshafen/DE)

P91 Study on e-liquid – risk of poisoning and effectiveness of legal regulation Mine Vatansever, Nina Glaser, Antje Engel (Berlin/DE), Andreas Stürer (Mainz/DE) Wolfgang Klumb (Bonn/DE), Andreas Schaper (Göttingen/DE) Florian Eyer (Munich/DE), Susanne Rohdenburg (Freiburg/DE) Michael Deters (Erfurt/DE), Erol Tutdibi (Homburg/DE), Kathrin Begemann Reinhold Kreutz, Daniela Acquarone (Berlin/DE)

P92 A structure-based grouping approach for evaluating the toxicity of e-cigarette flavor ingredients v – a 5-week inhalation study in A/J mice Karsta Luettich (Neuchatel/CH), Ee Tsin Wong (Singapore/SG) Davide Sciuscio (Neuchatel/CH), Kumar Ashutosh (Richmond, VA/US) Patrice Leroy (Neuchatel/CH), Kyonghee (Monica) Lee (Richmond, VA/US) Patrick Vanscheeuwijck, Manuel Peitsch, Julia Hoeng (Neuchatel/CH)

P93 Microbial pattern changes in the murine gut after TCDD treatment measured by high-resolution flow cytometry Katrin Hochrath, Jonas Kupschus (Düsseldorf/DE), Rene Maier Hyuan-Dong Chang (Berlin/DE), Stefan Janssen (Giessen/DE) Charlotte Esser (Düsseldorf/DE)

P94 Mixtures of triazole fungicides induce alteration in thyroid hormone levels at high doses Benjamin Fischer, Matthias Peiser, Tanja Heise, Olena Kucheryavenko Carsten Kneuer, Vera Ritz, Philip Marx-Stoelting, Marize Marzo-Solano (Berlin/DE)

LP1 Human expositions to liquid laundry detergent capsules across the EU E. Feistkorn (Berlin/DE), H. Desel(Berlin/DE), M. Schaefer (Leipzig/DE) A. Graefe (Leipzig/DE), H. Franke2, A. Hahn (Berlin/DE)

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Toxicology – Biotransformation and toxicokinetics

P95 The explosive trinitrotoluene (TNT) induces carbonyl reductase sniffer in the blue mussel (Mytilus spp.) Jennifer Susanne Strehse (Kiel/DE), Matthias Brenner (Bremerhaven/DE) Michael Kisiela, Katrin Köbsch, Edmund Maser (Kiel/DE)

P96 A human bioavailability study of soluble tattoo ink ingredients – preliminary modelling and study design Susanne Kochs, Dimitra Eleftheriadou, Christoph Hethey (Berlin/DE) Milena Foerster, Joachim Schüz (Lyon/FR), Andreas Luch, Ines Schreiver (Berlin/DE)

P97 Detection and stability of furan metabolites as urinary exposure biomarkers in humans Jonathan Kremer, Dorothea Karlstetter, Carina Klier, Jan Rothermund Hannah Thomas, Hanna Becker, Lukas Lang, Tamara Bakuradze Gerhard Eisenbrand, Elke Richling (Kaiserslautern/DE)

P98 Novel approaches for evaluation of xenobiotic-mediated liver enzyme induction Annika Heckmanns, Natascha Schmieder, Simone Betzer, Bärbel Moos Eric Fabian (Ludwigshafen/DE), Brandy Riffle, Mao Wang, Anita Samuga Jingjing Dong, Peifeng Ren (Research Triangle Park/US), Helen Hammer Felix Schmidt, Oliver Pötz (Reutlingen/DE), Bennard van Ravenzwaay Robert Landsiedel (Ludwigshafen/DE)

P99 Estrogen levels within bones derived from a rat model identify hydroxysteroid 17-beta dehydrogenases as potential targets for the prevention of postmenopausal osteoporosis Leane Lehmann, Tine Albrecht, Daniela Pemp (Würzburg/DE) Sebastian Müller (Dresden/DE), Lukas Häfner (Würzburg/DE) Günter Vollmer (Dresden/DE)

Toxicology – Genotoxicity and carcinogenesis

P100 The role of (xeno)estrogens and GPER1/GPR30 receptor for centrosome amplification-mediated chromosomal instability as a trigger for colon tumorigenesis Miriam Bühler, Gilbert Schönfelder, Marlon R. Schneider, Aline Stolz (Berlin/DE)

P101 Effects of food-relevant non-carcinogenic PAH on BP-dependent AhR activation, metabolite and DNA adduct formation Lisa Gödtke (Berlin/DE), Andrea John (Grosshansdorf/DE) Albert Braeuning (Berlin/DE), Albrecht Seidel (Grosshansdorf/DE), Alfonso Lampen Stefanie Hessel-Pras (Berlin/DE)

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P102 Aldosterone infusion induces renal damage and activation of Nrf2 in distal tubule cells in kidneys of mice Ronja Balhorn, Nicole Schupp (Düsseldorf/DE)

P103 Nuclear functions of the small Rho-GTPase Rac1 in the doxorubicin-induced DNA damage response Rebekka Kitzinger, Gerhard Fritz, Christian Henninger (Düsseldorf/DE)

P104 Obesity, cancer risk and reduction of genomic damage after weight loss Ezgi Eyluel Bankoglu, Florian Seyfried, Helga Stopper (Würzburg/DE)

P105 DNMT gene expression in Cantareus asperses snails exposed to low cadmium dose George Andrei Draghici, Dragos Nica, Cristina Dehelean, Razvan Susan Monica Susan (Timisoara/RO)

P106 Plexins control epithelial growth in the intestine Dandan Zhao, Ivana Matkovic, Hana Sustova (Marburg/DE) Thomas Worzfeld (Marburg, Bad Nauheim/DE)

P107 Assessment values in biological material for carcinogenic substances by the example of 1,4-dichlorobenzene Wobbeke Weistenhöfer, Hans Drexler (Erlangen/DE) Andrea Hartwig (Karlsruhe/DE), Simone Schmitz-Spanke (Erlangen/DE)

P108 Read-across prediction of mutagenicity – in silico model derived from a data set of 7719 organic compounds Gerrit Schüürmann, Ralph Kühne, Ralf-Uwe Ebert (Leipzig/DE)

P109 Role of Pten in oxidative DNA damage in a whole-body Pten haplodeficient mouse model Helga Stopper, Ezgi Eylül Bankoglu, Geema Kodandaraman Andreas Geier (Würzburg/DE)

P110 Investigation of the genotoxic potential of green smoothies in silico and in-vitro Markus Frericks, Jessica Reinhard, Thomas Hofmann, Michael Speitling Bennard van Ravenzwaay (Limburgerhof/DE)

P111 DAZAP2 acts as a phosphorylation-dependent specifier of the p53 response controlling cancer cell chemosensitivity Magdalena Liebl, Thomas Hofmann (Mainz/DE)

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P112 Impact of cellular localization of survivin on the resistance of glioblastoma cells against the monoalkylating anticancer drugs Thomas Reich, Sven Unger, Fabian Mühlhäusler, Birgit Rasenberger Teodora Nikolova, Irem Baymaz, Petra Beli, Markus Christmann Maja T Tomicic (Mainz/DE)

LP2 Applicability of HepaRGTM cell line for automated assessment of DNA strand breaks by AUREA gTOXXs I. Pfitzner (Esslingen/DE), G. Daniel (Esslingen/DE), D. Dressler (Esslingen/DE) K. Engelhart-Jentzsch (Esslingen/DE), Ch. Chesné (Saint Grégoire/FR) A. Sharma (Saint Grégoire/FR), R. Li3, I. Hanegraaff (Tuttlingen/DE) P. Braun (Tuttlingen/DE), F.K. Gehring (Tuttlingen/DE)

LP3 DNA strand breaks assessment using the hepatocyte-like HepaRGTM cell line: comparison of the automated UREA gTOXXs and alkaline Comet assay P. Braun, I. Pfitzner, T. Downs, G. Daniel, D. Dressler, K. Engelhart-Jetzsch, I. Hanegraaff A. Sharma, R. Li, C. Chesne, S. Pfuhler, F. K. Gehring (Tuttlingen/DE)

Toxicology – Nanomaterials

P113 Risk assessment review of microplastics found in food Sofiya Shopova, Holger Sieg, Albert Braeuning, Alfonso Lampen (Berlin/DE)

P114 Impact of zinc oxide nanoparticles on human intestinal cells Anna Mittag (Jena/DE), Jochen Kuckelkorn, Christian Höra Alexander Kämpfe (Bad Elster/DE), Martin Westermann, Michael Glei (Jena/DE)

P115 Impact of digestion conditions on physicochemical properties of orally ingested polydisperse metal oxide nanoparticles Thomas Schneider, Jevin Büttner, Alina Singer, Michael Glei (Jena/DE)

P116 Development of an integrated approach to testing and assessment (IATA) for inhaled particles within the EU project GRACIOUS Lan Ma-Hock (Ludwigshafen/DE), Hedwig Braakhuis, Susanne Dekkers (Bilthoven/NL) Fiona Murphy (Edinburgh/GB), Johannes Georg Keller Robert Landsiedel (Ludwigshafen/DE)

P117 Establishment of a lung cell co-culture model for nanoparticle aerosol exposition Diana Schneider, Berit Schumann, Felix Glahn, Oliver Krings, Lara Tomisch Sarah Thomas (Halle a. d. S./DE), Merve Bacanli (Ankara/TR), Patrick Mai Andreas Schober (Ilmenau/DE), Heidi Foth (Halle a. d. S./DE)

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P118 Rutin and its fatty acid esters in a biocompatible nanoform – toxicological safety and photoprotection/phototoxicity assessments on 2D skin cells and 3D reconstructed human tissue model Iulia Andreea Pinzaru, Dorina Elena Coricovac, Claudia Watz, Sergio Liga Cristina Adriana Dehelean (Timisoara/RO)

P119 Effects of engineered nanomaterials in an inflamed-like intestinal triple culture: acute vs repeated exposure Veronika Büttner, Angela Kämpfer, Mathias Busch, Catrin Albrecht Roel Schins (Düsseldorf/DE)

P120 In-vitro skin sensitization testing of nanomaterials according to OECD testguideline Barbara Birk, Lan Ma-Hock, Natascha Partosa, Britta Wareing, Jutta Steinbrenner Chantal Müller, Susanne Kolle, Wendel Wohlleben, Bennard van Ravenzwaay Robert Landsiedel (Ludwigshafen/DE)

P121 Repetitive exposure to carbon nanoparticles induce cell cycle arrest, senescence and loss of gap junctional communication in lung epithelial cells Tim Spannbrucker, Niloofar Ale-Agha, Tamara Hornstein, Nadine Dyballa-Rukes Philipp Jakobs, Christine Goy, Judith Haendeler, Klaus Unfried (Düsseldorf/DE)

P122 Delayed neutrophilic apoptosis after carbon nanoparticle treatment – a toxicologically relevant endpoint for nanoparticle safety Tamara Hornstein, Tim Spannbrucker, Klaus Unfried (Düsseldorf/DE)

P123 Toxicological and pharmacological evaluation of various polyethylenimine (PEI)-based nanoparticles for siRNA delivery Sandra Noske, Michael Karimov, Alexander Ewe, Achim Aigner (Leipzig/DE)

P124 Intestinal mucin profile and inflammatory response following engineered nanomaterial exposure – an in vitro/in vivo comparison Roel Schins, Gerrit Bredeck, Catrin Albrecht, Angela Kämpfer, Adriana Sofranko, Tina Wahle (Düsseldorf/DE)

Toxicology – Toxicological education

P125 Weiterbildung im Fach Toxikologie – Postgradualstudium „Toxikologie und Umweltschutz“ an der Universität Leipzig Franke Heike, Graefe Adelgunde (Leipzig/DE)

P126 Statisticians want to retire statistical significance – should we care? Felix Kluxen (Cologne/DE)

P127 Deriving historical control limits for toxicological bioassays Ludwig Hothorn (Hannover/DE), Felix Kluxen (Cologne/DE)

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PosTeR sessIon II • WeDnesDay, 4 MaRch

12:45–14:45 Poster Session II – Foyer

Pharmacology – Disease models, drug development I

P128 Stability, solubility and molecular size of the retinal relaxing factor from chicken retina Johan Van de Voorde, Laura Vanden Daele, Jolien De Waele, Charlotte Boydens Evelien Wynendaele, Bart De Spiegeleer (Ghent/BE)

P129 Bacteria are new targets of farnesyltransferase inhibitors Lea Weber, Jila Kaltenhäuser, Manuela Besser, Anna Hagemann, Ewa Stürmer Hagen S. Bachmann (Witten/DE)

P130 Changes in plasma and liver lipid profiles in glucose-intolerant mice during gestation Moritz Liebmann, Katharina Grupe, Stephan Scherneck (Braunschweig/DE)

P131 Metabolic changes during pregnancy in a polygenic mouse model with impaired glucose tolerance Katharina Grupe, Melissa Asuaje Pfeifer, Moritz Liebmann, Ingo Rustenbeck Stephan Scherneck (Braunschweig/DE)

P132 Oxaprozin derivatives exert beneficial effects on in vitro key features of tissue repair Iris Bischoff, Sebastian Gehlen-Breitbach, Tom Teichmann, Felix Lillich Viktoria Planz, Maike Windbergs, Eugen Proschak, Robert Fürst (Frankfurt a. M./DE)

P133 Comparison of arrhythmic features in mouse and human models of hypertrophic cardiomyopathy, based on mutations in MYBPC3 Frederik Flenner, Christiane Jungen, Antonia Ibel, Nadine Küpker, Anna Rinas Antonia Zech, Christian Meyer, Thomas Eschenhagen, Torsten Christ Lucie Carrier (Hamburg, Kiel, Lübeck/DE)

P134 Non-invasive assessment of the A2A adenosine receptor expression in the murine heart with [18F]FLUDA by positron-emission tomography (PET) Daniel Gündel, Thu Hang Lai, Sladjana Dukic-Stefanovic, Magali Toussaint Winnie Deuther-Conrad, Rodrigo Teodoro (Leipzig/DE), Peter Boknik (Münster/DE) Ulrich Gergs, Joachim Neumann (Halle a. d. S./DE), Peter Brust (Leipzig/DE)

P135 Impact of selenium on in vitro carcinogenesis – cancelled Kathrin Stamms, Felix Meyer, Leonie Plachetka, Dörte Hölzer, Anna P. Kipp René Thierbach (Jena/DE)

P136 Relevance of the BALB/c 3T3 cell transformation assay in the identification of molecular mechanisms of butyrate in cancer treatment Sonja Spangel, Felix Meyer, Caroline Meyer, René Thierbach (Jena/DE)

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P137 The effects of therapeutic metformin treatment on transformed BALB/c cells Stefanie Hoppe, Felix Meyer, Christiane Leovsky, Sonja Spangel René Thierbach (Jena/DE)

P138 Optimized isolation method for primary murine vascular smooth muscle cells Carolin Schlabs, Matthias Dodo Seidl, Burkhard Greve (Münster/DE) Stefan Offermanns (Bad Nauheim/DE), Frank Ulrich Müller (Münster/DE)

P139 Effects of alpha-lipoic acid treatment in a rat model of heart failure associated with obesity Cristina Pop, Laurentiu Stoicescu, Dana-Maria Muntean Georgia Stefan (Cluj-Napoca/RO), Benjamin Lauzier (Nantes/FR) Claudiu Morgovan (Sibiu/RO), Bela Kiss, Felicia Loghin, Cristina Mogosan Steliana Ghibu (Cluj-Napoca/RO)

P140 Hyaluronan synthase 3 deficiency results in adverse remodeling and reduced macrophage and fibroblast abundance after acute cardiac ischemia Marco Piroth, Daniel Gorski, Anne Petz, Simone Gorressen, Maria Grandoch Jens W. Fischer (Düsseldorf/DE)

P141 A co-culture cell model of the intestinal mucosa for pharmacological investigation of phytotherapeutic approaches in inflammatory bowel diseases (IBD) Laura Weber (Leipzig, Langenhagen/DE), Bartosz Lipowicz (Langenhagen/DE) Cica Vissiennon (Leipzig, Langenhagen/DE)

P142 Effects of histamine antagonists (H1/H4) in a mouse model of calcipotriol induced skin inflammation Hilke Oltmanns, Viviane Filor, Paula Hagedorn, Kathrin Becker Wolfgang Baumgärtner, Manfred Kietzmann (Hannover/DE)

P143 Efficacy enhancement of antibacterials against Escherichia coli by Histamine H1 receptor antagonists Gustav Bruer, Manfred Kietzmann (Hannover/DE)

Pharmacology – Cardiac pharmacology and treatment

P144 Increased calcium buffering promotes proarrhythmogenic calcium alternans in human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) Philipp Jung, Fleur Elisabeth Mason, Funsho Emmanuel Fakuade, Antje Ebert Niels Voigt (Göttingen/DE)

P145 Nutritional modulation of the toxicity of environmental pollutants – Implications in atherosclerosis Bernhard Hennig, Pan Deng (Lexington, KY/US)

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P146 Sildenafil versus ambrisentan in a rat model of pulmonary arterial hypertension Peter B. Senese, Teresa Martinez, Kimberly R. Doherty, Jian Bi, Hongjian Wang Melissa D. Zammit, Michael R. Gralinski (Chicago, IL/US), Franz Hock (Dieburg/DE)

P147 Enhanced environmental stress augments the protein folding machinery in human cardiac fibroblasts Alisa DeGrave, Gabriela L. Santos, Helen Schröder, Susanne Lutz (Göttingen/DE)

P148 Two-cell type cardiac tissue engineering for screening of anti-fibrotic interventions Bangfen Pan, A. M. Stella Stoter (Hamburg, Kiel, Lübeck/DE) Tessa R. Werner (Brisbane/AU; Hamburg/DE) Alexandra Madsen (Hamburg, Kiel, Lübeck/DE), Grit Höppner (Hamburg/DE) Roger S.Y. Foo (Singapore/SG), Thomas Eschenhagen, Marc N. Hirt Justus Stenzig (Hamburg, Kiel, Lübeck/DE)

P149 Inhibition of miR-21 mediates cardioprotection by its preferential target regulation in non-myocytes Christina Beck, Deepak Prabhu Ramanujam, Anna Patricia Schön Stefan Engelhardt (Munich/DE)

P150 AT2 activation reduces ACE activity Ehsan Gholamreza-Fahimi, Michael Krybus, Marion Bisha Thomas Kurz (Düsseldorf/DE), Finn Kristian Hansen (Leipzig/DE) Georg Kojda (Düsseldorf/DE)

P151 Relative importance of NO and prostaglandins as mediators of bradykinin-induced skin edema in mice Michael Krybus, Ehsan Gholamreza-Fahimi, Farbod Khosravani, Marion Bisha Georg Kojda (Düsseldorf/DE)

P152 The molecular changes underlying disturbed cardiomyocyte calcium cycling after MI show spatiotemporal differences Florian Funk, Annette Kronenbitter, Martina Krüger Joachim P. Schmitt (Düsseldorf/DE)

P153 PLK2 is a novel regulator of osteopontin-driven myofibrosis and left ventricular diastolic dysfunction Stephan Künzel, Erik Klapproth, Karolina Künzel, Johanna Rausch, Manja Newe Christopher Piorkowski (Dresden/DE), Manuel Mayr (London/GB), Miachel Wagner Mario Günscht, Silvio Weber (Dresden/DE), Ursula Ravens (Freiburg/DE) Ali El-Armouche (Dresden/DE)

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P154 Development of a micro-physiological system for improved structural maturation of iPSC-CMs Mario Schubert (Dresden/DE), Tomasz Kolanowski (Poznan/PL), Mathias Busek Anna Dmitrieva, Björn Binnewerg, Jessie Pöche, Konstanze Fischer Florian Schmieder, Stefan Grünzner, Sinah Hansen, Andreas Richter Ali El-Armouche, Frank Sonntag, Kaomei Guan (Dresden/DE)

P155 RKIP improves cardiac function and survival in a mouse model of human dilated cardiomyopathy Bettina T. Baumgarten (Dortmund/DE), Theresa Brand (Würzburg, Dortmund/DE) Sabrina Denzinger (Würzburg/DE), Joachim P. Schmitt (Düsseldorf/DE) Kristina Lorenz (Würzburg, Dortmund/DE)

P156 The role of the Rac1 activator Tiam1 in cardiac stress remodeling Jian Yuan Pan, Matthias Dewenter, Johannes N. van Heuveln, Nicklas Tzschöckel Elise Betz, Laura Knödler, Johannes Backs (Mannheim, Heidelberg/DE) Thomas Wieland (Mannheim/DE), Christiane Vettel (Mannheim, Heidelberg/DE)

P157 Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart Rebekka Medert, Lucas Bacmeister (Heidelberg/DE), Andy Pironet Rudi Vennekens (Leuven/BE), Marc Freichel (Heidelberg/DE)

P158 Biomimetic potentials of marine demosponges Ianthella labyrinthus and aplysia aerophoba Björn Binnewerg, Mario Schubert (Dresden/DE) Marcin Wysokowski (Poznan/PL, Freiberg/DE), Iaroslav Petrenko, Andriy Fursov Yvonne Joseph, Hermann Ehrlich (Freiberg/DE), Kaomei Guan (Dresden/DE)

P159 Sirtuin1 dysfunction in perivascular adipose tissue of diet-induced obese mice Ning Xia, Gisela Reifenberg, Christian Schirra, Huige Li (Mainz/DE)

P160 Store-operated calcium entry in cytoplasm and nucleus of rat ventricular myocytes Julia Hermes, Vesela Borisova, Jens Kockskämper (Marburg/DE)

Pharmacology – Signal transduction and second messengers

P161 Anti-proliferative effects of cCMP in mammary carcinoma cell lines Sabine Wolter, Thomas Brömsen, Sarah Sharifi, Malte Glüsen Roland Seifert (Hannover/DE)

P162 Deletion of IRAG in spleens influences expression of cGMP-signalling pathway proteins Michael Majer, Jens Schloßmann (Regensburg/DE)

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P163 Strengths and weaknesses of ThermoFluor to investigate the ligand-induced thermostabilisation of nitric oxide sensitive guanylyl cyclase Christin Elgert, Anne Rühle (Braunschweig/DE), Peter Sandner (Wuppertal/DE) Soenke Behrends (Braunschweig/DE)

P164 Immunomodulatory effect of 3’,5’-cyclic UMP on T cells Bastian Schirmer, Christian Kaiser, Jannik Boog, Solveig Kälble Roland Seifert (Hannover/DE)

P165 Cardiac overexpression of PP2Cβ in mice leads to differential gene expression Paula Bollmann, Ulrich Gergs (Halle a. d. S./DE), Igor Buchwalow (Hamburg/DE) Joachim Neumann (Halle a. d. S./DE)

P166 Hydrogen sulfide regulates the expression of interleukin 1 receptor antagonist in mouse mesangial cells Frederic Haedge, Sebastian Longen, Letícia Arãgao Santiago, Josef Pfeilschifter Karl-Friedrich Beck (Frankfurt a. M./DE)

P167 Functional analysis of short CREM isoforms calls the PDE3A–ICER feedback loop into question Matthias Dodo Seidl, Alexandra Sternberg, Benedikt Fels Kristina Grimm (Münster/DE), Nobuhiko Kojima (Gunma/DE) Shogo Endo (Tokio/DE), Jan S. Schulte, Sabine Hamer Frank Ulrich Müller (Münster/DE)

P168 Glucose dependent gene expression in hypothalamic cells Leonhard Webert, Andreas Breit, Thomas Gudermann (Munich/DE)

P169 Phosphodiesterase 2 affects calcium handling and heart performance Mario Günscht, Mirna Fahmi, Carla Bauermeister, Susann Quickert (Dresden/DE) Christiane Vettel (Mannheim/DE), Susanne Kämmerer Ali El-Armouche (Dresden/DE)

P170 CREM isoforms ICER and smICER – detailed analysis of novel interaction partners Dominique Koppenhöfer, Hanna Kremer, Kristina Grimm, Matthias Seidl Sabine Hamer, Simone König, Frank Ulrich Müller (Münster/DE)

P171 Effect of the mRNA processing, p-body containing protein Dcp1a on gene expression and function of LPS-stimulated murine macrophages Daniel Heylmann, Knut Beuerlein, Petra Kronich, Elisabeth Zieschè, Monika Heiner Jochen Wilhelm (Gießen/DE), Andre Schneider, Thomas Braun (Bad Nauheim/DE) Michael Kracht (Gießen/DE)

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P172 Interplay of cAMP and cGMP signalling in splenocytes and its possible effects Evanthia Mergia, Malte Verheyen, Marcus Peters, Doris Koesling (Bochum/DE)

P173 Locus-specific isolation of chromatin-associated inflammatory interactomes Jana Juli, Lisa Leib, Michael Kracht (Gießen/DE)

P174 An enlarged map of the IL-1 signalling network – Analyzing responses to inflammatory stimuli by visualizing changes of mRNA and protein levels side by side Axel Weber, Moritz Bleymehl (Giessen/DE), Peter Wasiliew (Bad Hersfeld/DE) Oliver Dittrich-Breiholz (Hannover/DE), Hongbo Gu (Danvers, MA/US) Michael Kracht (Giessen/DE)

P175 In-situ cGMP imaging reveals NO-GC as a potential drug target for melanoma treatment Daniel Stehle, Moritz Lehners, Susanne Feil, Robert Feil (Tübingen/DE)

P176 Pharmacological targeting of mechano-cGMP in platelets Michael Böttcher, Susanne Feil, Hendrick von Eysmondt, Frank Regler Sascha Geue, Meinrad Gawaz, Oliver Borst, Tilman Schäffer Robert Feil (Tübingen/DE)

P177 Epac1 and β-Catenin synergize in β-adrenoceptor-activated YAP in the tumor vasculature Sepp Jansen, Yohanes Wibowo, Thomas Wieland (Mannheim/DE)

Pharmacology – CNS / endocrine pharmacology and treatment

P178 Expression of the metabotropic glutamate 5 receptor and influence of positive modulation in a mouse model of DYT1 dystonia Stefanie Perl (Leipzig/DE), Franziska Richter (Hannover/DE) Angelika Richter (Leipzig/DE)

P179 Development of an LC-MS/MS method for the quantification of neurotransmitters in murine microdialysate Christin Helmschrodt, Susen Becker, Stefanie Perl, Anja Schulz Angelika Richter (Leipzig/DE)

P180 Examinations of brevican in a genetic mouse model of DYT1 dystonia Anika Lüttig, Stefanie Perl (Leipzig/DE), Franziska Richter (Hannover/DE) Markus Morawski, Angelika Richter (Leipzig/DE)

P181 In vivo optogenetics – a method to examine the role of striatal interneurons in the pathophysiology of movement disorders Anja Schulz (Leipzig/DE), Franziska Richter (Hannover/DE), Stefanie Perl Angelika Richter (Leipzig/DE)

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P182 Deep brain stimulation as a therapeutic option in dystonia – effects of different frequencies in a phenotypic animal model by using an optimized stimulator Maria Paap, Stefanie Perl, Anika Lüttig (Leipzig/DE), Franz Plockstieß Christoph Niemann, Dirk Timmermann, Christian Bahls, Ursula van Rienen Denise Franz, Monique Zwar, Marco Rhode, Rüdiger Köhling (Rostock/DE) Angelika Richter (Leipzig/DE)

P183 CRISPR-Cas9 mediated knock-out in hamster beta cells reveals a role of dual leucine zipper kinase (DLK, MAP3K12) for beta cell identity Kyra Köster, Jorge Duque Escobar, Elke Oetjen (Hamburg, Kiel, Lübeck/DE)

P184 Influence of antiepileptic drugs on serum lipid levels in patients with vascular epilepsy Radu Carcalici, Corina Roman-Filip, Luca-Liviu Rus (Sibiu/RO)

Pharmacology – Nuclear receptors, enzymes and other targets

P185 Spironolactone at 200 mg/d is not effective against fibromyalgia but well tolerated Paul Westermann, Ruwen Böhm, Henning Ohnesorge, Martin Gleim Ingolf Cascorbi, Matthias Grünewald, Thomas Herdegen (Kiel/DE)

P186 Putative self-binding capacity of truncated farnesyltransferase alpha-subunits Sandro Tasillo, Anna Hagemann, Hagen S. Bachmann (Witten/DE)

P187 Identification and characterization of four new transcript variants of the human farnesyltransferase β-subunit Anna Hagemann (Witten/DE), Corinna Henne (Witten, Essen/DE), Chantalle Träger Grit Müller, Iris Manthey (Essen/DE), Hagen S. Bachmann (Witten, Essen/DE)

P188 Expression and functional characterization of human farnesyltransferase α-subunit mutants Sonja Hinz, Dominik Jung, Anna Hagemann, Raffaela Maltaner Hagen S. Bachmann (Witten/DE)

P189 Inactivation of HDAC2 alters basal intracellular calcium dynamics in mice Jan Peter Reinhardt, Jan Sebastian Schulte, Sabine Hamer, Matthias Dodo Seidl Frank Ulrich Müller (Muenster/DE)

P190 Characterization of cyclic nucleotide phosphodiesterases potentially involved in pain processing Tilman Groß, Jonas Petersen, Lea Kennel, Jessica Schlaudraff, Domenico Del Turco Ruirui Lu, Wiebke Kallenborn-Gerhardt, Achim Schmidtko (Frankfurt a. M./DE)

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P191 Characterization of hepatocyte-specific sphingosine-1-phosphate lyase knockout mice Anna Katharina Spohner, Katja Jakobi, Dominique Thomas Sandra Trautmann (Frankfurt a. M./DE), Julie Saba (Oakland, CA/US) Edith Hintermann (Frankfurt a. M./DE), Dieter Lütjohann, Anja Kerksiek (Bonn/DE) Dagmar Meyer zu Heringdorf (Frankfurt a. M./DE)

Pharmacology – Immunopharmacology/inflammation/antiinfectives

P192 Meta-analysis of clinical studies on the efficacy of the fixed-dose combination lysozyme+bacitracin+papain (FDC-LBP) for the treatment of sore-throat associated symptoms Christina Bitou (Athens/GR), Thomas Weiser (Frankfurt a. M./DE)

P193 Single cell-based analyses of the dynamically regulated NFκB signalling by proximity ligation assay Christin Mayr-Buro, Eva Schlereth, Knut Beuerlein, Ulas Tenekeci Johanna Meier-Sölch, M. Lienhard Schmitz, Michael Kracht (Giessen/DE)

P194 Investigations into the pharmacological potential of lichen extracts in the context of cancer and inflammation via a concerted screening approach Rebecca Ingelfinger, Jürgen Otte, Marina Henke, Thomas Ulshöfer, Anjuli Calchera Garima Singh, Imke Schmitt, Robert Fürst, Susanne Schiffmann (Frankfurt a. M./DE)

P195 The synthetic carbazole derivative C81 affects the inflammatory activation of endothelial cells G. Melissa Krishnathas, Iris Bischoff (Frankfurt a. M./DE), Laura Mittmann Christoph Reichel, Benjamin Strödke (Munich/DE), Stefan Knapp (Frankfurt a. M./DE) Franz Bracher (Munich/DE), Robert Fürst (Frankfurt a. M./DE)

Pharmacology – Pharmacokinetics and PK/PD modeling

P196 Pharmacokinetic (PK) properties of ambroxol prolonged-release hard capsules (PRHC), effervescent tablets (EFT) and standard immediate-release tablets (IRT): An open-label, randomized, multi-dose, three-period crossover study in healthy male and female volunteers. Ulrike Sent, Thomas Weiser (Frankfurt a. M./DE)

P197 Population kinetics of cefuroxime in plasma and uptake into bone and intervertebral disc of patients Richard Okoniewski, Lina Becker, Ulrich Gergs, Karl-Stefan Delank Joachim Neumann (Halle a. d. S./DE)

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P198 Assessing saturation of metabolism in the gut wall Ursula Gundert-Remy, Hans Mielke (Berlin/DE)

P199 Prediction of points of departure for neurological toxicity of amiodarone in humans based on in vitro toxicity data and physiologically based pharmacokinetic modelling Ursula Gundert-Remy, Engi Algharably (Berlin/DE), Emma Di Consiglio Emanuela Testai (Rome/IT), Reinhold Kreutz (Berlin/DE)

P200 Development of curcumin (nutraceutical) loaded solid lipid nanoparticle and its pharmacokinetic assessment Telny Thomas Chungath (Kochi/IN) Habibur Rahman Shiek Abdul Kadhar Mohamed Ebrahim (Taman Connaght/MY) Hariprasad Ranganathan, Sivaselvakumar Muthusamy (Coimbatore/IN)

P201 Haplotypes of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin Chih-hsuan Hsin, Marc Stoffel, Malaz Gazzaz (Cologne/DE), Elke Schaeffeler Matthias Schwab (Stuttgart, Tübingen/DE), Xia Li, Uwe Fuhr Max Taubert (Cologne/DE)

P202 In silico estimation of the systemic availability of inhaled ciprofloxacin using in vitro and ex vivo generated data Norman Nowak, Nico Sonnenschein, Tanja Hansen, Katharina Blümlein Katharina Schwarz (Hannover/DE)

P203 Simplification and validation of a three-compartment model of iohexol to estimate plasma clearance in patients with impaired kidney function Max Taubert (Cologne/DE), Natalie Ebert (Berlin/DE), Peter Martus (Tübingen/DE) Markus van der Giet (Berlin/DE), Uwe Fuhr (Cologne/DE) Elke Schaeffner (Berlin/DE)

Toxicology – Toxic compounds

P204 Effect of HEMA and TEGDMA on angiogenic differentiation of dental pulp stem cells (DPSC) in vitro André Jochums, Joachim Volk, Peter Schertl Silvana Taubeler-Gerling (Hannover/DE), Athina Bakopoulou (Thessaloniki/GR) Werner Geurtsen (Hannover/DE)

P205 Risk assessment review for printing inks Elisa Beneventi, Ingo Ebner, Nicole Hellwig, Thomas Tietz, Andreas Luch (Berlin/DE)

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P206 A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates preserved bone integrity after e-vapor products” aerosol exposure relative to cigarette smoke exposure Marie K. Reumann (Tübingen/DE), Bjoern Titz (Neuchatel/CH), Weidong Wenig Romina H Aspera-Werz (Tübingen/DE), Ee Tsin Wong (Singapore/SG) Justyna Szostak, Patrice Leroy (Neuchatel/CH), Wei Teck Tan (Singapore/SG) Arkadiusz Kuczaj (Neuchatel/CH), Fabian Springer, Andreas Badke (Tübingen/DE) Peter Augat (Murnau/DE), Leticia Quentanilla-Fend (Tübingen/DE) Kyonghee Monica Lee (Richmond, VA/US), Manuel C Peitsch Julia Hoeng (Neuchatel/CH), Andreas K Nussler (Tübingen/DE)

P207 Release of formaldehyde and melamine from plastic cups and bowls – exposure estimation and risk assessment Thomas Tietz, Nicole Hellwig, Ingo Ebner, Nastasia Bartsch, Claudia Lorenz Oliver Kappenstein, Stefan Merkel, Andreas Luch (Berlin/DE)

P208 Molecular and electrophysiological analysis of platinum-induced neurotoxicity Anna Wellenberg (Düsseldorf/DE), Julia Bornhorst (Wuppertal/DE), Gerhard Fritz Sebastian Honnen (Düsseldorf/DE)

P209 Impact of the photoinitiator camphorquinone on the expression of genes related to oxidative stress and inflammation in oral cells Renke Perduns, Joachim Volk, Melanie Plum, Sarah Wielgosz, Angela Beckedorf Werner Geurtsen (Hannover/DE)

P210 HEMA-induced transcriptional modulation of oral cells using an artificial mucosal 3D-model Melanie Plum, Renke Perduns, Joachim Volk, Frank Gutzki, Sarah Wielgosz Angela Beckedorf, Volkhard Kaever, Geurtsen Werner (Hannover/DE)

P211 Nicotinamide riboside supplementation – implications for mitigation of sulfur mustard toxicity. Joanna Ruszkiewicz (Konstanz/DE), Annette Schmidt (Munich/DE) Alexander Bürkle, Aswin Mangerich (Konstanz/DE)

P212 Tricresyl phosphates and organophosphate induced delayed neuropathy (OPIDN) Ruth Lohmann, Veronika Meischner, Rüdiger Bartsch Gerlinde Schriever-Schwemmer, Gunnar Jahnke, Andrea Hartwig (Karlsruhe/DE)

P213 The sulfur mustard surrogate CEES inhibits the Transient Receptor Potential Ion Channel V4 (TRPV4) Bernhard Stenger, Lorenz Thumann, Florian Eggerbauer, Dirk Steinritz Thomas Gudermann (Munich/DE)

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P214 Measurement and quantification of TRP-channel activation by alkylating compounds with the whole-cell patch clamp method Florian Eggerbauer, Lorenz Thumann, Dirk Steinritz, Thomas Gudermann Bernhard Stenger (Munich/DE)

P215 Chemical pneumonitis caused by inhalation of a hydrocarbon containing paint – a case report Canet Incir, Basak Bayram, Ayse Coskun Beyan, Yesim Tuncok (Izmir/TR)

P216 Human biomonitoring in the resident population in the vicinity of natural gas production facilities in Lower Saxony (Germany) Thomas Göen, Kerstin Zethner, Kristina Zethner (Erlangen/DE) Klaus-Michael Wollin (Hannover/DE)

Toxicology – Toxins

P217 Cytotoxic necrotizing factor S – a functional hybrid of CNF1 and CNFY Julian Schöllkopf, Gudula Schmidt (Freiburg/DE)

P218 Vimentin and integrin are involved in uptake of Clostridium botulinum C3 exoenzyme Julia Christin Wehmeyer, Sandra Hagemann, Astrid Rohrbeck Ingo Just (Hannover/DE)

P219 Evaluation of chondroitin sulfate proteoglycan-4 and frizzled-1,2,7 for cytopathic and cytotoxic effects of TcdB from historic and hypervirulent Clostridioides difficile strains Daniel Henkel, Helma Tatge, Ralf Gerhard (Hannover/DE)

P220 Intracellular delivery and persistence of the glucosyltransferase domain of Clostridium difficile TcdB Carmen Schneider, Moritz Sandmann, Helma Tatge, Ralf Gerhard (Hannover/DE)

P221 Low density lipoprotein receptor related protein 1 (LRP1) contributes to Clostridium difficile Toxin A endocytosis. Dennis Schöttelndreier, Harald Genth, Robert Lindner, Anna Langejürgen (Hannover/DE)

P222 Optimized hepatogenic differentiation of human adipose tissue-derived MSCs using a silicone-based cell culture system for human-based assays Peggy Stock (Leipzig/DE), Janis Hildebrand, Gunter Böttcher (Radeberg/DE) Bruno Christ (Leipzig/DE)

P223 (Q)SAR assessment of potentially mutagenic impurities in pharmaceuticals and medical devices according to ICH M7(R1) Madeleine Joel, Laura-Katharina Bertels, Roman Föll, Geertje Lewin (Münster/DE)

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P224 Investigations of health hazards caused by plastic nanoparticles in an in vitro 3D-triple-culture model of the human intestine Mathias Busch, Angela Kämpfer, Catrin Albrecht, Roel Schins (Düsseldorf/DE)

P225 Synergistic accumulation of triglycerides in HepaRG cells induced by combinations of LXR and RXR agonists Alexandra Lasch, Jimmy Alarcan, Alfonso Lampen, Albert Braeuning Dajana Lichtenstein (Berlin/DE)

P226 iPSC and iPSC-derived proximal tubular cells differ in their response to nephrotoxic and oxidative substances Cornelia Hirsch, Dominik Bähr, Gerhard Fritz, James Adjaye Nicole Schupp (Düsseldorf/DE)

P227 Authenticated lung and gingival fibroblasts cell models for in vitro toxicity testing Gabriela Sanchez (Wesel/DE)

P228 Chemoassay profiling to characterize the skin sensitization potential and potency of organic electrophiles Alexander Böhme (Leipzig/DE), Johannes Moldrickx Gerrit Schüürmann (Leipzig, Freiberg/DE)

P229 Chemoassay profiling of benzoates and salicylates to assess their skin sensitization potential Alexander Böhme, Annalena Werner (Leipzig/DE) Johannes Moldrickx (Freiberg, Leipzig/DE), Ben Ebersbach Monika Mazik (Freiberg/DE), Gerrit Schüürmann (Leipzig, Freiberg/DE)

P230 Restoring circadian synchrony in vitro facilitates physiological responses to environmental chemicals Johanna Ndikung, Dorothe Storm, Norman Violet, Achim Kramer Gilbert Schönfelder, Michael Oelgeschläger, Norman Ertych (Berlin/DE)

P231 Natural compounds as a source of new anticancer agents targeting mechanisms of the DNA damage response Jana van Stuijvenberg, Peter Proksch, Gerhard Fritz (Düsseldorf/DE)

P232 Establishment of arylhydrocarbon receptor deficient monocytic THP-1 cells by CRISPR/Cas technology Anna Sonnenburg, Ralf Stahlmann, Reinhold Kreutz, Matthias Peiser (Berlin/DE)

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P233 The benefit of more complex in vitro assays for the prediction of safety aspects in drug formulation Julia Katharina Metz, Lara Scharnowske, Fabian Hans, Miriam Klepper Christopher Ruf (Saarbrücken/DE), Udo Bock, Jutta Lichter Brunhilde Blömeke (Trier/DE), Barbara Birk, Lan Ma-Hock Robert Landsiedel (Ludwigshafen/DE), Katharina Knoth, Henrik Groß Claus-Michael Lehr, Marius Hittinger (Saarbrücken/DE)

P234 Human in vitro co-culture systems for the investigation of the influence of macrophage polarization on hepatotoxicity Andrea Zimmermann, Kilian Gemünden, Gerda Schicht, Christiane Rennert Daniel Seehofer, Georg Damm (Leipzig/DE)

P235 RHE COCAT, an in vitro coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals Niklas Peter, Mario T Schellenberger, Marta Silva e Sousa Brunhilde Blömeke (Trier/DE)

P236 Caenorhabditis elegans – an elegant model to investigate mixture toxicity Paul Wittkowski, Michael Oelgeschläger, Philip Marx-Stoelting, Norman Violet Gilbert Schönfelder, Silvia Vogl (Berlin/DE)

P237 Evaluation of lung injury induced by organophosphorus compounds using precision cut lung slices (PCLS) Jonas Tigges, Horst Thiermann, Franz Worek, Timo Wille (Munich/DE)

P238 Prediction of N-acetyltransferase 2 (NAT2) slow and ultra-slow genotypes by two tagging SNPs available on SNP chips Silvia Selinski, Meinolf Blaszkewicz, Jörg Reinders, Katja Ickstadt, Jan G. Hengstler Klaus Golka (Dortmund/DE)

P239 Establishment of a direct 2D osteoblast–osteoclast coculture model that represents the bone microenvironment in vitro Weidong Weng, Tatjana Uynuk-Ool, Andreas K Nüssler (Tübingen/DE) David Bovard, Filippo Zanetti, Julia Hoeng (Neuchâtel/CH) Romina H Aspera-Werz (Tübingen/DE)

P240 The importance of being earnest – Development of protocols to further regulatory acceptance of in silico toxicity predictions Lennart T. Anger (San Francisco, CA/US), Markus Frericks (Ludwigshafen/DE) Glenn Myatt (Columbus, CH/US)

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P241 Simplification and optimization of a human cell based in vitro angiogenesis assay for testing angiogenesis modulators Barbara Birk, Nadine Roth, Burkhard Flick, Bennard van Ravenzwaay Robert Landsiedel (Ludwigshafen/DE)

P242 Competence of cytokine release in PMA-differentiated THP1-cells Barbara Birk, Lan Ma-Hock, Andreas Verlohner, Johannes Keller (Ludwigshafen/DE) Julia Metz, Marius Hittinger (Saarbrücken/DE), Wendel Wohlleben Bennard van Ravenzwaay, Robert Landsiedel (Ludwigshafen/DE)

P243 Which threshold of toxicological concern (TTC) is applicable to non-DNA-reactive carcinogens? Monika Batke (Hannover/DE), Heli Hollnagel (Horgen/CH) Mark Cronin (Liverpool/GB), Chihae Yang (Nuremberg/DE) James Rathman (Columbus, OH/US), Fatemeh Moradi Afrapoli, Matthias Wehr Sylvia Escher (Hannover/DE)

P244 Machine-learning QSAR models to predict six key events of thyroid adverse outcome pathways Marina Garcia de Lomana (Vienna/AT; Ludigshafen/DE) Andreas Georg Weber, Miriam Mathea, Barbara Birk, Robert Landsiedel Klaus-Jürge Schleifer (Ludigshafen/DE)

P245 Development of in silico off-target activity prediction models for Estrogen/Androgen receptors Alexander Gurjanov, Caroline Gomes, Miriam Mathea Robert Landsiedel (Ludwigshafen/DE)

P246 The kinetic direct peptide reactivity assay (kDPRA) – an in chemico method to characterize the skin sensitization potency of chemicals Britta Wareing, Susanne Kolle (Ludwighshafen/DE) Andreas Natsch (Kemptthal/CH), Nathalie Alepee (Aulnay sous Bois/DE) Barbara Birk (Ludwighshafen/DE), Tina Haupt (Kemptthal/CH) Rishil Kathawala (Gaithersburg, MD/US), Petra Kern (Brussels/BE) Laurent Nardelli (Aulnay sous Bois/DE), Hans Raabe (Gaithersburg, MD/US) Marian Rucki (Praha/CZ), Cindy Ryan (Mason, CH/US), Sjoerd Verkaart Walter Westerwink (DD‘s-Hertogenbosch/NL), Robert Landsiedel (Ludwighshafen/DE)

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P247 Determination of the total and free concentrations of selected compounds in Balb/c 3T3 cells and culture medium Eric Fabian, Dunja Dimitrijevic, Beate Nicol, Ian Sorell (Ludwigshafen/DE) Caroline Gomes (Ludwigshafen/DE), Bennard van Ravenzwaay Robert Landsiedel (Ludwigshafen/DE)

P248 Toxicity assessment of pristine and thermally treated carbon fibres Silvia Diabaté, Susanne Fritsch-Decker, Sonja Mülhopt, Manuela Wexler Manuela Hauser, Werner Baumann (Eggenstein-Leopoldshafen/DE) Matthias Hufnagel, Alexandra Friesen, Andrea Hartwig (Karlsruhe/DE) Dieter Stapf, Carsten Weiss (Eggenstein-Leopodshafen/DE)

P249 Applying machine learning approaches for early prediction of drug-induced phospholipidosis – can we replace some of our in vitro testing in the near future? Lennart T. Anger, Kai Connie Wu, Catrin Hasselgren (San Francisco, CA/US)

P250 Liposomes loaded with soy isoflavones/soy extract as skin depigmenting or protective agents Crina Dorina Petean, Iulia Andreea Pinzaru, Oana Andrada Iftode Dorina Elena Coricovac, Claudia Watz, Cristina Adriana Dehelean (Timisoara/RO)

P251 Multiplexing analyses of cytokines in human THP-1 cells after stimulation by active substances from pesticides Benjamin Fischer, Denise Bloch, Carsten Kneuer, Matthias Peiser (Berlin/DE)

P252 Mixture effects of co-formulants and active substances in pesticides Mawien Shareef, Benjamin Fischer, Katreece Brown, Denise Bloch, Carsten Kneuer Philip Marx-Stoelting (Berlin/DE)

P253 Impact of physiological and anthropometric parameters in human biomonitoring: results from multilinear regression modelling of data from German GerES and ESB data sets Oliver Licht (Hannover/DE), Tim Lorbsach (Mainz/DE) Axel Wibbertmannn (Hannover/DE), André Conrad, Maria Rüther Marike Kolossa-Gehring, Petra Apel (Berlin/DE)

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P254 EU-ToxRisk guidance for new approach methods (NAM)-supported read-across Hennicke Kamp (Ludwigshafen/DE) Susanne Hougaard Bennekou (Ludwigshafen/DE; Copenhagen/DK), Annette Bitsch Sylvia Escher (Ludwigshafen/DE; Copenhagen/DK; Hannover/DE) Dinant Kroese (Ludwigshafen/DE; Copenhagen/DK; Hannover/DE; Zeist/NL) Martijn Mone (Ludwigshafen/DE; Copenhagen/DK; Hannover/DE; Zeist, Leiden/NL) Gladys Ouedraogo (Ludwigshafen/DE; Copenhagen/DK; Hannover/DE; Zeist, Leiden/NL; Paris/FR), Sharon Stuart (Ludwigshafen/DE; Copenhagen/DK; Hannover/DE; Zeist, Leiden/NL; Paris/FR; Mason, OH/US)

P255 The impact on classifications for carcinogenicity, mutagenicity, reproductive and specific target organ toxicity after repeated exposure in the first ten years of the REACH regulation Panagiotis Karamertzanis, Palmi Atlason, Alexis V. Nathanail, Jeroen Provoost Andrea Richarz, Jochen vom Brocke, Elina Karhu, Mike Rasenberg (Helsinki/FI)

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socIal PRoGRaMMe

Tuesday, 3 MarchGet together You are invited to join the Get together with drinks and snacks during the lunch break in the industrial exhibition. Allow yourself interesting conversations with colleagues, old friends, exhibitors and make new acquaintances.Time 13:30–14:15Location Industrial exhibitionPrice Included in conference fee © kautzphotographie l Fotolia.com

Social evening – Forum Young Scientists Every young researcher is invited to the social evening of the the Forum Young Scientists. The highlight of the evening is a science slam. The audience will decide by applause, who will be awarded with the “Schäfer-Barth-Award” 2020.

Time 19:30–21:00Location Beyerhaus Leipzig

© smolaw11 l Fotolia.com

Ernst-Schneller-Straße 6 04107 LeipzigDistance from venue 0,9 km walking distancePrice 15 EUR

Wednesday, 4 MarchSocial evening of the conference The “Ratskeller” is one of the best traditional restaurants in Leipzig. You are welcome to a marvelous evening with delicious food and beverages as well as interesting conversations.

Time 19:30–23:30Location Ratskeller Leipzig Lotterstraße 1

© Ratskeller Leipzig

04109 Leipzig Distance from venue 0,7 km walking distancePrice 60 EUR

GeneRal InfoRMaTIon

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VenueLeipzig UniversityCampus Augustusplatz | Augustusplatz 10 | 04109 Leipzig

@

Conference websitewww.gpts-kongress.de

General terms and conditionsPlease find our general terms and conditions at www.gpts-kongress.de.

CloakroomThere is the possibility to hand in your coat on the second floor at no charge. Please note that the organizer is not liable for lost property.

Online programme For current detailed information regarding the scientific programme, please have a look at our session planner at programm.conventus.de/dgpt2020. Compose your individual programme and review it at any time on your way.

Conference languageThe conference language is English. Some presentations and sessions will be held in German. They are marked in the detailed programme. Short talks have to be presented in English only.

EvaluationPlease take a few moments to fill out the evaluation form to help us refine and improve the upcoming conferences. There will be an online evaluation possible after the confer-ence at www.gpts-kongress.de/evaluation.

Catering During breaks coffee water will be available in the exhibition area. There will be no cater-ing during lunchtime (except during the Get together on Tuesday).The venue has a canteen in the ground floor where participants can buy food and beverages.

Publication of abstractsAll abstracts will be published online in the “Naunyn-Schmiedeberg‘s Archives of Pharmacology” of the publisher Springer Nature Switzerland (Basel/CH) and are avail-able online on the conference website www.gpts-kongress.de one week before and two weeks after the conference.

GeneRal InfoRMaTIon

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CertificationWe applied for certification at the medical chamber of Saxony.

Certificate of attendancePlease scan your EFN barcode daily at the EFN certification counter near the check-in. The certificate of attendance will be printed automatically. The points will be transferred to the medical chamber of Saxony electronically.

A general certificate of attendance can be printed with the barcode on your name badge at the certification counter. Your name badge also provides access to the scientific sessions and to the industrial exhibition. Therefore, please wear your name badge during the whole conference.

AwardsDuring the German Pharm-Tox Summit the following prizes will be awarded during the award ceremony on 4 March, 18:30–19:30, HS 9:• Merck-Young-Scientist Award• GT-Toxicology-Award• Fritz-Külz-Preis der DGPT

Additionally the best posters and short talks selected from abstract submissions will be honored with an award. A selected jury will review the presentations during the confer-ence. We would like to invite all abstract authors to participate. The following awards will be given:

Toxicology• GT Poster award• Toxins-Award (best poster in the field of biological toxins)• GT short talk-award

Pharmacology• Poster awards• Award short talks (Thieme-Verlag)

Clinical pharmacology• Poster awards• Award short talks (Thieme-Verlag)

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GeneRal hInTs foR auThoRs anD PResenTeRs

Presentation upload – media check-inSpeakers can upload their presentation in the speakers’ ready room. For submission, please use a USB flash drive, CD or DVD disc that is not protected by any software. Professional staff and equip-ment will be available for you to arrange and preview your presentation.

Time allocationPlease prepare your presentation for the allotted amount of time. Chairs and moderators may inter-rupt should you overrun your time limit. Speakers of short talks have a time frame of 10 minutes (including 5 minutes of discussion time).

PostersPlease note that the poster session will be split into two parts. The allocation of topics to the poster sessions is shown on page 39. The authors re asked to be present at their poster during the respective session for questions and discussion.

Poster Session I • Tuesday, 3 March, 14:15–15:15.Posters should be hung by Monday or Tuesday morning and be removed by Tuesday, 3 March, 18:00.Poster Session II • Wednesday, 4 March, 12:45–14:45.Posters should be hung by Wednesday morning and be removed by Wednesday, 4 March, 17:30.

Pins will be provided on your poster board. Please do not use any other type of pins than those provided. All poster boards will be labelled with a poster number. You can find your poster number in this programme booklet.

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InDex of auThoRs anD chaIRs

AAbdel-Kahaar, E. 46Abdella, L. 42Abraham, K. 49Acar, S. 33Acquarone, D. 50Adawy, A. 22Adelgunde, G. 54Adinolfi, E. 45Adjaye, J. 66Agarwal, V. 34Ahles, A. 18, 30, 42Aigner, A. 17, 28, 36 40, 41, 45, 47, 48, 54Akan, P. 33Akturk, G. 47Alarcan, J. 66Albittar, M. 46Albrecht, C. 54, 66Albrecht, T. 50, 51Albrecht, W. 29Ale-Agha, N. 54Alepee, N. 68Alexiou, C. 28Algharably, E. 63Allers, K. 34Allmann, S. 14Amma, M. 32Ammerpohl, O. 15, 40Anger, L. T. 32, 67, 69Annibale, P. 25Anton, S. 25Antunes, E. 34Apel, P. 69Arãgao Santiago, L. 59Arbogast, M. 42Arduino, D. 30Arici, M. A. 47Arseniu, A. M. 47Artursson, P. 48Aschner, M. 22Ashutosh, K. 50Aspera-Werz, R. H. 64, 67Assmann, J. 30Asuaje Pfeifer, M. 55Atlason, P. 70Augat, P. 64Awortwe, C. 35

BBacanli, M. 53Bach, A. 17Bachmann, H. S. 55, 61Bachmann, M. 34Backs, J. 58Bacmeister, L. 23, 58Badke, A. 64Baesler, J. 22Bahls, C. 61Bähr, D. 66Bakhiya, N. 49Bakopoulou, A. 63Bakuradze, T. 51Balhorn, R. 52Balke, W.-T. 48Bankoglu, E. E. 52Barigye, S. J. 31Barth, H. 17, 19, 22, 27Bartsch, N. 64Bartsch, R. 64Batke, M. 35, 68Bauer, C. 44Bauermeister, C. 59Baumann, W. 69Baumgarten, B. T. 58Baumgartl, K. 47Baumgärtner, W. 56Baymaz, I. 53Bayram, B. 65Beck, A. 20, 21, 43, 44Beck, C. 24, 57, 59Beck, K.-F. 59Beck-Sickinger, A. 20, 21Beckedorf, A. 64Becker, H. 29, 51Becker, J. 42Becker, K. 56Becker, L. 62Becker, S. 60Beckmann, L. 30Bedke, J. 43Beer-Hammer, S. 16Begemann, K. 50Behrends, S. 59Beichert, L. 16Beier, S. 42Beli, P. 53Belkacemi, A. 43Belkacemi, T. 43

Beneventi, E. 63Beraldi Calmasini, F. 34Bergau, N. 49Berlin, M. 17, 23Berlit, S. 43Bermpohl, F. 46Bermudez, M. 16Bertels, L.-K. 65Besser, M. 55Bestehorn, K. 20, 25, 81Betz, E. 58Betzer, S. 51Beuck, S. 29Beuerlein, K. 59, 62Beyhoff, N. 33Bi, J. 57Bialke, A. 16Biber, N. 31Biel, M. 17, 23Bien-Möller, S. 16, 40Binnewerg, B. 58Binter, M. 41Birk, B. 32, 50, 54, 67, 68Birnbaumer, L. 17, 24Bischof, M. 45Bischoff, I. 55, 62Bisha, M. 57Bitou, C. 62Bitsch, A. 70Biyanee, A. 15Blaszkewicz, M. 67Bleymehl, M. 60Bloch, D. 69Blome, F. 47Blömeke, B. 33, 67Blüher, M. 21Blümlein, K. 63Blumrich, A. 33Bock, A. 25Böck, J. 43Bock, U. 33, 67Bödeker, R.-H. 46Boehm, R. 15Boekhoff, I. 16Boengler, K. 15Böhm, R. 34, 40, 61Böhme, A. 66Bokhan, N. 30Boknik, P. 55Böl, G.-F. 11

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Bolbrinker, J. 46Bollmann, P. 59Bonvicini, G. 32Boog, J. 59Booth, A. 32Borchardt, H. 41Borelli, C. 46Borisova, V. 58Bornhorst, J. 22, 64Borst, O. 60Böttcher, C. 37Böttcher, G. 65Böttcher, M. 60Bovard, D. 67Boydens, C. 55Braakhuis, H. 53Bracher, F. 17, 23, 62Braeuning, A. 14, 22, 27 32, 51, 53, 66Brand, T. 25, 58Brandt, D. 25, 27Bräse, S. 45Braun, T. 59Brecklinghaus, T. 29Bredeck, G. 54Breinbauer, R. 33Breit, A. 16, 40, 59Brenner, M. 37, 51Brierley, L. 32Brik, A. 32Brilhaus, D. 22Brockmöller, J. 29, 35, 47, 48Broekmans, K. 25Brömsen, T. 58Brosien, M. 44Brown, K. 69Bruckmüller, H. 31, 35, 40, 41Brückner, T. 41Bruer, G. 56Brügmann, T. 18Brüning, T. 32Brunner, T. 14Brust, P. 55Büch, T. 15, 45, 47Buchmüller, J. 14Buchwalow, I. 59Buesen, R. 35Bühler, M. 51Bünemann, M. 16, 41, 42Bünger, J. 32

Burgers, L. D. 33Bürkle, A. 14, 15, 22, 64Busch, M. 29, 54, 66Busche, M. 29Busek, M. 58Butthof, A. 42Büttner, F. 48Büttner, J. 53Büttner, V. 54Butuca, A. 47Byrne, R. 44

CCakir, V. 42Calchera, A. 62Camacho Londoño, J. E. 17, 23Canals, M. 43Carcalici, R. 61Carey, G. 36Carle, S. 27Carrier, L. 55Cartus, A. T. 14Cascorbi, I. 15, 28, 29 35, 40, 41, 61Chang, H.-D. 50Chao, Y.-K. 17, 43, 44Chatterjee, M. 23Chaturvedi, S. 34Chen, C.-C. 17Chen, F. 40Chis, A. A. 47Christ, B. 65Christ, T. 55, 67Christmann, M. 14, 53Chungath, T. T. 35, 63Coecke, S. 50Coleman, J. 37Conrad, A. 69Conte, G. 45Coricovac, D. E. 54, 69Cormos, G. 47Corvaro, M. 32Coskun Beyan, A. 65Costa Alexandre, E. 34Cremer-Schaeffer, P. 36Creutzenberg, O. 32Cronin, M. 35, 68Cuello, F. 25

DDaiber, A. 30Damm, G. 29, 67Danner, L. 42de Lomana, M. G. 68De Sarkar, S. 23De Spiegeleer, B. 55De Waele, J. 55Deckers, A. 45DeGrave, A. 23, 57Dehelean, C. A. 54, 69Deißler, A. 34Dekkers, S. 53Del Turco, D. 61Delank, K.-S. 62Della Penna, A. 34Deng, L. 16Deng, P. 56Denzinger, S. 58Deters, M. 50Deuther-Conrad, W. 55Dewenter, M. 58Di Consiglio, E. 63Di Virgilio, F. 45Diabaté, S. 69Diefenbach, K. 25Diekmann, J. 36Diercks, B.-P. 18Dieterich, C. 23Dietrich, A. 17, 44Dimitrijevic, D. 69Dittrich-Breiholz, O. 60Dmitrieva, A. 58Dobrea, C. M. 47Dobrev, D. 24, 25Doherty, K. R. 57Döhring, J. 14Domnik, M. 42Domning, T. 46Donath, F. 37Dong, J. 51Draghici, G. A. 52Draheim, C. 48Drews, G. 44Drexler, H. 52Drozdzik, M. 48Dücker, C. 35, 48Dueck, A. 24Düfer, M. 43, 44Dukic-Stefanovic, S. 55

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Dunst, S. 32Duque Escobar, J. 61Durmus, N. 33Dutt, F. 27Duvigneau, J. C. 23Dyballa-Rukes, N. 54Dybkova, N. 27

EEberhardt, W. 15Ebersbach, B. 66Ebert, A. 56Ebert, N. 63Ebert, R.-U. 32, 52Ebmeyer, J. 14, 22Ebner, I. 63, 64Eckweiler, D. 48Edlund, K. 29Eggerbauer, F. 64, 65Ehrenmann, J. 43Ehrlich, H. 58Eisenbrand, G. 51El Saghir, A. 47El-Armouche, A. 25, 27, 57 58, 59Eleftheriadou, D. 51Elgert, C. 44, 59Elgowilly, S. 49Endo, S. 59Endres, S. 15, 40Enge, A.-M. 22, 32Engel, A. 42, 45, 50, 57Engel, T. 45Engelhardt, S. 24, 57Erdogmus, S. 42Erika, B. 47Ernst, K. 28Ertych, N. 66Eschenhagen, T. 24, 55, 57Escher, S. 56, 68, 70Esselen, M. 20Esser, C. 19, 31, 50Esser, D. 15Ewe, A. 48, 54Eyer, F. 50

FFabian, E. 34, 51, 67, 69Fahmi, M. 27, 59Fahrer, J. 14, 15, 19

Fakuade, F. E. 56Faro, D. 16, 43Fecher-Trost, C. 17Feederle, R. 42Feil, R. 44, 60Feil, S. 60Felenda, J. E. 50Felician, G. 24Felix, I. 22, 47Fellermann, M. 27Fels, B. 59Fender, A. 24Fenske, D. 38Ferrando-May, E. 14Fiack, S. 11Filor, V. 56Fink, M. A. 16Fischer, B. 50, 69Fischer, D. 28Fischer, J. W. 56Fischer, K. 58Fischer, S. 22Fisel, P. 48Flenner, F. 55Flick, B. 68Flockerzi, V. 17, 23, 43, 44Foerster, M. 51Föll, R. 65Foo, R. S. Y. 57Forssmann, W.-G. 22Foryst-Ludwig, A. 24, 33Foth, H. 53Franke, H. 40, 50Franz, D. 61Frechen, S. 25, 26Freichel, M. 17, 23, 58Freitag, M. 30Frenzel, L. 35Frericks, M. 32, 46, 52, 67Frick, M. 19Friedrich, L. 44Friesen, A. 69Fritsch-Decker, S. 69Fritz, G. 52, 64, 66Fritzwanker, S. 43Früh, E.-H. 44Frum, A. 47Fu, J. 15Fuentes, L. E. V. 46Fuhlbrueck, J. A. 14

Fuhr, U. 13, 20, 63Funcke, S. 24Funk, F. 57Fursov, A. 58Fürst, R. 33, 55, 62

GGailus, B. 23Gall, K. 29Ganslandt, T. 37Garcia Soares, A. 34Gardner, I. 29Garmey, J. 27Gauch, F. 49Gauckler, P. 22Gaugaz, F. Z. 48Gautel, M. 23Gawaz, M. 60Gazzaz, M. 63Gebhardt, R. 29Geburek, I. 49Gehlen-Breitbach, S. 55Gehling, M. 50Geier, A. 52Geiseler, R. 44Gemünden, K. 67Genth, H. 65Gergs, U. 41, 55, 59, 62Gerhard, R. 22, 28, 52, 65, 66Gerndt, S. 17, 23Geroldinger, G. 23Geue, S. 60Geurtsen, W. 63, 64Ghibu, S. 47, 56Gholamreza-Fahimi, E. 57Giarola, A. 49Gierschik, P. 15, 40Gille, L. 23Giner, R. M. 31Glahn, F. 53Glaser, N. 50Glei, M. 53Gleim, M. 61Gligor, F. 47Gligor, F. G. 47Glüsen, M. 58Gnad, T. 16Gödtke, L. 51Göen, T. 65Gohla, A. 31, 33

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Golka, K. 67Gomes, C. 68, 69Gonçalves Oliveira, M. 34Gonther, S. 34Goren, I. 34Gorressen, S. 56Gorski, D. 56Gottschalk, C. 32Goy, C. 54Goya-Jorge, E. 31Gozalbes, R. 31Gralinski, M. R. 57Grandoch, M. 27, 56Gräter, H. 46Greim, H. 38Gresch, A. 43Greve, B. 56Grimm, C. 17, 43, 44Grimm, C. M. 23Grimm, K. 59Groh, I. A. M. 42Gröne, H.-J. 24, 27Groß, H. 67Groß, T. 33, 61Grube, M. 16Grune, J. 33Grünewald, M. 61Grünzner, S. 58Grupe, K. 55Gu, H. 33, 60, 63Guan, K. 23, 58Gudermann, T. 16, 17, 19 30, 40, 42, 44, 59, 64, 65Guenther, G. 22Gündel, D. 55Gundert-Remy, U. 49, 63Guner, O. 33, 47Günscht, M. 27, 57, 59Gurjanov, A. 68Gursoy Calan, O. 33Guse, A. 18Gutman, O. 15Gutzki, F. 64Guven, H. 33, 47

HHaag, M. 48Haake, V. 32Haarmann-Stemmann, T. 31Haas, J. 15, 40

Haedge, F. 59Haendeler, J. 54Haeussler, K. 15Häfner, L. 51Hafner, S. 46Hagedorn, P. 56Hagemann, A. 55, 61Hagemann, S. 65Hagmeyer, B. 29Halwachs, S. 14Hamer, S. 30, 59, 61Hammer, H. 32, 51Handin, N. 48Hanke, N. 26Hanna, D. M. F. 42Hans, F. 67Hansen, A. 24, 57, 58Hansen, F. K. 57Hansen, S. 58Hansen, T. 63Häring, H.-U. 16Harmon, D. 27Hartwig, A. 14, 20, 33 52, 64, 69Hasenfuss, G. 27Hasheminasab, S.-M. 48Hasselgren, C. 69Hasselwander, S. 14, 30Haupt, T. 68Hauser, M. 69Hausmann, R. 16, 45Havemann-Reinecke, U. 36Hawro Yakoob, S. 45Heckmanns, A. 51Heike, F. 54Heilmann, R. M. 46Heimrich, B. 43Hein, L. 30Hein, M. 24Heiner, M. 59Heinick, A. 42Heinrich, P. 47Heise, T. 50Hellwig, N. 63, 64Helmschrodt, C. 60Hemmler, R. 29Henderson, C. J. 22Hengstler, J. G. 22, 29Henis, Y. I. 15Henke, M. 62

Henkel, D. 65Henkel, L. 41Henne, C. 61Hennenlotter, J. 43Hennig, B. 56Henninger, C. 52Henrique da Silva, F. 34Hensien, J. 27Herbst, R. 37Herdegen, T. 61Herfurth, U. 49Hermann, C. 44Hermes, J. 58Herold, M. 32Herrmann, J. 42Hertz, K. 33Hertzsch, R. 46Herzer, L. 46Herzig, S. 24Herzog, S. 16Hessel-Pras, S. 14, 22, 32, 51Hethey, C. 51Heylmann, D. 59Hildebrand, J. 65Hill, K. 45Hille, L. 30Hillebrand, M. 32Hintermann, E. 62Hinz, B. 36Hinz, L. 42Hinz, S. 61Hirnet, D. 18Hirsch, C. 66Hirsch-Ernst, K. 49Hirt, M. N. 57Hittinger, M. 67, 68Hocaoglu, N. 33Höcherl, K. 12Hochrath, K. 19, 50Hock, F. 36, 57Hoeng, J. 50, 64, 67Hoffmann, P. 48Hoffmann, S. 35Hoffmann, W. 16Hoffmeister, T. 44Hofmann, C. 23Hofmann, T. 43, 46, 48, 52Hofmann, U. 43, 48Hofstetter, R. 40Hollnagel, H. 68

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Hölzer, D. 55Honnen, S. 64Honscha, W. 14Hoppe, S. 56Höppner, G. 57Höra, C. 53Hornstein, T. 54Höß, C. 27Hothorn, L. 54Hougaard Bennekou, S. 70Hövelmeyer, N. 30Hsin, C.-h. 63Hub, F. 24Huber, M. 15Hueser, A. 32Hufnagel, M. 14, 69Hümmert, M. 25Hüner, H.-A. 50Hüttelmaier, S. 36

IIbáñez, M. J. 32Ibel, A. 55Ibrahim, S. 30Ickstadt, K. 67Iftode, O. A. 69Igor, I. 40Incir, C. 65Ingelfinger, R. 62Ivanova, S. 30Iyer, L. M. 27

JJaeger, C. 24Jäger, N. 22Jahnke, G. 64Jakobi, K. 62Jakobs, P. 54Jansen, S. 60Janssen, S. 50Jassyk, M. 27Jeanclos, E. 31, 33Jedlitschky, G. 42Jensen, O. 47Jha, A. 17Jiang, C. 25Jilma, B. 38Jochums, A. 63Joel, M. 65Johansen, B. 41

John, A. 51Johnen, G. 32Joos, T. 27Jordt, S.-E. 19Joseph, Y. 58Juli, J. 60Juma, M. 34Juncan, A. M. 47Jung, D. 61Jung, P. 56Jungen, C. 55Just, I. 26, 65

KKaehler, M. 15, 35Kaever, V. 64Kähler, M. 20, 40Kaiser, C. 59Kaiser, L. 25Kaiser, N. 32Kaiser, Ni. 32, 43Kälble, S. 59Kaleta, C. 15Kalinowski, J. 27Kallenborn-Gerhardt, W. 33, 61Kalra, P. 34Kaltenhäuser, J. 55Kaltner, F. 32Kalwa, H. 45, 47Kamler, M. 24Kämmerer, S. 27, 30, 59Kamp, H. 27, 31, 70Kämpfe, A. 53Kämpfer, A. 54, 66Kannler, M. 44Kappenberg, F. 29Kappenstein, O. 49, 50, 64Karamertzanis, P. 70Karara, N. 46Karay, Y. 48Karbach, S. 30Karhu, E. 70Karimov, M. 48, 54Karlstetter, D. 51Kästner, I. 38Kathawala, R. 68Kathmann, N. 46Katia Pereira Costa, S. 34Katschinski, D. 24Keller, A. 31

Keller, J. G. 53Keller, M. 17Kellner, C. 18Kennel, L. 61Kerksiek, A. 62Kern, P. 68Keßler, K. 48Khadjeh, S. 27Khajavi, N. 16, 44Khan, M. 30Khobta, A. 29Khosravani, F. 57Kietzmann, M. 56Killinger, S. 16Kim, D. 29Kintscher, U. 24, 33Kipp, A. P. 55Kirchhofer, S. B. 41Kirchhoff, F. 35Kirsch, V. 48Kisiela, M. 51Kiss, B. 56Kittel, R. J. 18Kitzinger, R. 52Klaassen, T. 29Klapproth, E. 57Klein, K. 44, 48Kleinert, M. 21Klemme, A. 42Klenk, C. 18Klepper, M. 67Kless, A. 16Klier, C. 51Kliewer, A. 43Klopfleisch, R. 24, 33Klugbauer, N. 43Klumb, W. 50Klutzny, S. 32Kluxen, F. 32, 54Knapp, S. 62Kneuer, C. 50, 69Knobloch, J. 30Knödler, L. 58Knoth, K. 67Kobold, S. 29Köbsch, K. 51Kochs, S. 51Kockskämper, J. 58Kodandaraman, G. 52Koesling, D. 25, 60

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Kogel, A. 45Kögel, D. 40Köhl, U. 17Köhler, D. 16Köhling, R. 61Kojda, G. 57Kojima, N. 59Kolahian, S. 34Kolanowski, T. 58Kolb, P. 41Kolle, S. 54, 68Kolossa-Gehring, M. 69Kolrep, F. 50Kölz, C. 44Kong, C. 33König, J. 13König, M. 41König, S. 59Königsrainer, A. 34Konrad, C. 25Kopp, R. 34, 45Koppenhöfer, D. 59Kornhuber, M. 32Köster, K. 61Kovar, A. 25, 26Kracht, M. 31, 59, 60, 62Kraft, A. E. 17Krähenbühl, S. 47Krahnen, L. 40Kramer, A. 66Kramer, S. 25Krasel, C. 16, 42Krasteva-Christ, G. 44Krause, M. 22Kremer, H. 59Kremer, J. 51Krett, A.-L. 16Kreutz, R. 34, 46, 50, 63, 66Kriebs, U. 17, 23Krings, O. 53Krishnathas, G. M. 62Kroese, D. 70Krogsaeter, E. 17, 43Kroll, H. 48Kronberg, U. 46Kronenbitter, A. 57Kronich, P. 59Krügel, U. 40Krüger, A. 14Krüger, M. 57

Krutmann, J. 31Krybus, M. 57Kucheryavenko, O. 50Kuckelkorn, J. 53Kuczaj, A. 64Kühne, R. 52Kuhnert, L. 14Künstner, A. 30Künzel, K. 57Künzel, S. 57Kupatt, C. 36Küpker, N. 55Kupschus, J. 50Kuryshev, V. 23Kurz, T. 57

LLadant, D. 28Lai, T. H. 55Lammers, T. 28Lampen, A. 14, 22, 32 49, 51, 53, 66Lampert, A. 16, 46Landsiedel, R. 34, 50, 51 53, 54, 67, 68, 69Lang, D. 31Lang, L. 51Lang, M. 42Langan, E. 30Langejürgen, A. 65Langenhahn, T. 21Langlhofer, G. 45Lasch, A. 66Laufs, U. 21Lauzier, B. 56LeDuc, D. 42Lee, A. 32, 50Lee, F.-K. 33Lee, K. M. 64Lehmann, L. 51Lehners, M. 44, 60Lehr, C.-M. 67Lehr, T. 25, 26, 27Leib, L. 60Leineweber, K. 24Leiss, V. 16, 24, 42Leovsky, C. 56Leroy, P. 50, 64Leuppi-Taegtmeyer, A. 47Leurs, R. 18

Leuschner, F. 23Levay, M. 43Levent, E. 24Lewin, G. 65Li, H. 18, 30, 33, 58, 59Li, X. 63Licht, O. 69Lichtenstein, D. 27, 66Lichter, J. 33, 67Liebl, M. 52Liebmann, M. 55Liga, S. 54Lilienblum, W. 11Lillich, F. 55Lim, K.-H. 33Lindner, R. 65Link, A. 40Linnebacher, M. 15Lipowicz, B. 56Lipp, P. 17Litterst, M. 40Löffler, M. 37Loghin, F. 56Lohmann, R. 64Lohse, A. 46Lohse, M. J. 25Longen, S. 59Loonen, A. 30Looso, M. 24López-Lilao, A. 32Lorbsach, T. 69Lorenz, C. 64Lorenz, K. 25, 58Löscher, W. 23Losenkov, I. 30Lu, R. 27, 38, 51, 61Luch, A. 49, 51, 63, 64Lüdtke, S. 44Luettich, K. 50Luong, B. 33Lütjohann, D. 62Lüttges, K. 33Lüttig, A. 60, 61Lutz, S. 23, 24, 42, 57

MMa-Hock, L. 53, 54, 67, 68Maas, R. 12, 26, 37Maaß, S. 31Macasoi, I. 40

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Machann, J. 16Mack, M. 15Madsen, A. 57Magauer, T. 45Mähnert, E. 50Mai, P. 53Maiellaro, I. 25Maier, M. 45Maier, R. 50Mailahn, J. 46Majer, M. 58Mak, Y.-Y. 33Malihpour, M. 43Mallmann, R. T. 43Maltaner, R. 61Mangerich, A. 14, 32, 64Manthey, I. 61Markwardt, F. 45Marschall, T. 14Marshall, M. 27Martinez, T. 57Martus, P. 63Marx, A. 14, 17Marx, A. 14, 17Marx, S. 14, 18, 40Marx-Stoelting, P. 50, 67, 69Marzo-Solano, M. 50Maser, E. 37, 51Mason, F. E. 56Mathea, M. 35, 68Matkovic, I. 52Matthaei, J. 47, 48Matthes, J. 24, 48Matthias Hufnagel, M. 14, 69Matz-Soja, M. 29Mayr, M. 57Mayr-Buro, C. 62Mazik, M. 66Mazzola, M. 24Mbaki, Y. 33McNamara, C. 27McSkimming, C. 27Mederos y Schnitzler, M. 42, 44Medert, R. 17, 58Meents, J. E. 16Mehnert, C. 23Mehrkens, D. 24Meier, L. 15Meier-Sölch, J. 31, 62Meiler, J. 21

Meischner, V. 64Meisel, P. 16Melching-Kollmuss, S. 49Menig, L.-S. 43Mentz, A. 27Mergia, E. 25, 60Merkel, S. 49, 64Merkord, J. 40Metz, J. K. 67Meunier, S. 42Meurer, K. 20Meyer, Ca. 55Meyer, Ch. 55Meyer, Fe. 23, 55, 56Meyer, Fr. 23Meyer, M. J. 48Meyer, S. 23Meyer, T. 23Meyer, U. 40Meyer zu Heringdorf, D. 62Michaelis, J. 22, 27Mielke, H. 63Milting, H. 42Miriam, S. 47, 67, 68Mirsberger, N. 15Misiou, A. 27Mittag, A. 53Mittmann, L. 62Moepps, B. 16, 42Moer, J. 29Mogosan, C. 56Moldrickx, J. 66Molnar-Pfitzner, P. 50Mone, M. 70Monfort, E. 32Monien, B. 49Monsé, C. 32Monzote, L. 23Moos, B. 51Moradi Afrapoli, F. 68Morawski, M. 60Mörbt, N. 50Morgovan, C. 47, 56Moritz, A. 15Moritz, E. 40, 42, 60Mösslein, N. 16, 42Most, P. 18Moxon, M. 49Muallem, S. I. 17Mühl, H. 34

Mühlhäusler, F. 53Mülhopt, S. 69Müller, A. 50, 51, 54Müller, C. 18, 42, 54 56, 59, 61Müller, F. U. 30, 42, 56, 59, 61Müller, G. 61Müller, M. B. 50Müller, O. 25, 27Müller, R. 33Müller, Sa. 42Müller, Se. 51Muntean, A. C. 47Muntean, D.-M. 56Münzel, T. 30Muresan, M. 47Murphy, F. 53Muthusamy, s. 35, 63Myatt, G. 67

NNagel, G. 15, 40, 41Nagel, I. 15, 40, 41Näher, M. 44Nakamura, M. 31Nardelli, L. 68Nasrullah, U. 15Nathanail, A. V. 70Natsch, A. 68Ndikung, J. 66Neitzel, C. 15Neumann, D. 41Neumann, F.-J. 30Neumann, J. 41, 55, 59, 62Neumeister, C. 46Newe, M. 57Newel, D. 31Nguyen, O. N. P. 17Nguyen, T. N. 16Nica, D. 52Nicke, A. 45Nicol, B. 69Nicolai, M. M. 22Niemann, C. 61Nies, A. T. 44, 48Nikolova, T. 53Noack, C. 24Nörtersheuser, P. 26Noschka, R. 27Noske, S. 54

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Nöthen, M. M. 48Nowak, N. 63Nührenberg, T. 30Nürnberg, B. 16, 24, 34, 42Nussler, A. K. 64Nüssler, A. K. 67

OObrecht, A. 16Ochi, T. 30Oelgeschläger, M. 32, 66, 67Oetjen, E. 61Offermanns, S. 27, 56Ohnesorge, H. 61Okoniewski, R. 62Olthoff, S. 45Oltmanns, H. 56Omieczynski, C. 16Osinski, V. 27Osteresch, P. 15Oswald, S. 13Otte, J. 62Ottenheijm, R. 23Ouedraogo, G. 70

PPaap, M. 61Paderina, D. 30Pahnke, J. 28Paland, H. 16Pan, B. 57Pan, J. Y. 58Papatheodorou, P. 22, 40Partosa, N. 54Patel, A. 32Patel, S. 17Pawlak, M. 29Peiser, M. 50, 66, 69Peitsch, M. C. 64Pemp, D. 51Perduns, R. 64Perl, S. 60, 61Perocchi, F. 30Petean, C. D. 69Peter, N. 27, 67Peters, M. 60Petersen, J. 61Petersen, N. 27Petrenko, I. 58Petz, A. 56

Pfeifer, A. 16, 17, 18Pfeilschifter, J. 15, 34, 59Philippou, A. 38Pinzaru, I. A. 54, 69Piorkowski, C. 57Pironet, A. 58Piroth, M. 56Plachetka, L. 55Planz, V. 55Plockstieß, F. 61Plückthun, A. 43Plum, M. 64Pöche, J. 58Poetsch, M. 23Pollet, M. 31Polster, S. 40Pop, C. 56Popoff, M.-R. 28Pötz, O. 27, 32, 51Pozhidaev, I. 30Prasad, N. 34Proksch, P. 66Proschak, E. 55Provoost, J. 70Prukop, T. 29Prüser, J. L. 40Püschel, G. P. 23

QQi, J. 23Quante, M. 34Quentanilla-Fend, L. 64Quickert, S. 59Quirgst, J. 23

RRaabe, H. 68Raasch, W. 30Raclariu-Manolica, A. C. 49Rahnenführer, J. 29Rajan, S. 44Ramanujam, D. P. 24, 57Ramer, R. 40, 41Ramírez-Fernández, A. 45Ranganathan, H. 35, 63Rank, L. 14Rasenberg, M. 70Rasenberger, B. 14, 53Rasinger, J. D. 14Rathman, J. 68

Rauch, B. H. 40, 42Raudszus, R. 45Rausch, J. 57Ravens, U. 57Reber, J. 14Rech, C. 14Redlin, F. 16Regler, F. 60rehman, a. 42Reich, T. 53Reichel, C. 62Reif, R. 22Reifenberg, G. 58Reinders, J. 67Reinhard, J. 52Reinhardt, J. P. 30, 61Reiß, B. 48Remy, J. 40Ren, P. 51Renko, K. 50Renner, B. 33Rennert, C. 67Reumann, M. K. 64Reustle, A. 43Rhode, M. 61Richarz, A. 70Richling, E. 14, 51Richter, And. 17, 58Richter, Ang. 17, 46, 58, 60, 61Richter, C. 17Richter, K. 27, 46, 60, 61Richter Assencio, F. 29Riemer, T. G. 34, 46Riffle, B. 51Rinas, A. 55Ring, A. 34, 35Rissiek, B. 18, 45Ritter, D. 24, 33Ritz, V. 50Rocha, C. 27Rodriguez-Alfonso, A. 22Rodriguez-Alvarez, M. 29Rohdenburg, S. 50Rohrbeck, A. 65Rolfes, C. 42Roman-Filip, C. 61Römer, S. 48Rosenberger, P. 16Rosenkranz, N. 32Rösler, R. 15

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Roth, N. 41, 68Rother, T. 41Rothermund, J. 51Rothmiller, S. 22Rucki, M. 68Ruf, C. 67Rühle, A. 59Ruland, J. G. 41Rus, L. L. 47Russwurm, M. 25Rustenbeck, I. 44, 55Ruszkiewicz, J. 64Rüther, M. 69Rutz, L. 49Ryan, C. 68

SSaba, J. 62Sachkova, A. 29Sachse, B. 49Sai Malisetty, A. 45Samuga, A. 51Sanchez, G. 66Sander, P. 30Sandmann, M. 65Sandner, P. 59Santos, G. L. 23, 57Sanzenbacher, R. 18Sarmini, L. 29Sartorius, T. 16Scalbert, N. 45Schaefer, M. S. 34Schaefer, M. 16, 17, 20 45, 47, 50Schaeffeler, E. 43, 44, 48, 63Schaeffner, E. 63Schäffeler, E. 35, 48Schäffer, T. 60Schaffrath, T. 44Schaller, D. 16Schaller, S. 26Schanbacher, C. 25Schaper, A. 50Scharnowske, L. 67Schellenberger, M. T. 67Schenke, M. 23Scherneck, S. 55Schertl, P. 63Schicht, G. 67Schiffmann, S. 62

Schiller, P. 46Schindelin, H. 33Schins, R. 19, 54, 66Schirmer, B. 41, 59Schirra, C. 58Schjeide, B.-M. 23Schlabs, C. 56Schlaudraff, J. 61Schleifer, K.-J. 68Schlender, J. 25, 26Schlereth, E. 62Schloetzer, J. 33Schloßmann, J. 58Schmalz, M. 14Schmalzing, G. 16, 45Schmidt, And. 22, 33Schmidt, Ann. 22, 33, 64Schmidt, F. 27, 51Schmidt, G. 65Schmidt, H. 22Schmidt, M. 19Schmidtko, A. 33, 61Schmiedel, F. 43Schmieder, F. 58Schmieder, N. 51Schmitt, I. 62Schmitt, J. P. 57, 58Schmitz, M. L. 62Schmitz-Spanke, S. 52Schnabel, J. 29Schneider, A. 53, 59Schneider, C. 65Schneider, D. 53Schneider, G. 44Schneider, M. R. 51Schneider, S. 46, 50Schneider, T. 34, 53Schnell, M. 16Schober, A. 53Scholl, R. 38, 49Schöllkopf, J. 65Scholz, B. 30Scholz, T. 43Schön, A. P. 24, 57Schöneberg, T. 20, 42Schönfelder, G. 32, 51, 66, 67Schönsiegel, A. 16Schöppe, J. 43Schott, K. 42Schöttelndreier, D. 65

Schredelseker, J. 17, 30, 44Schreiver, I. 51Schrenk, D. 49Schriever-Schwemmer, G. 64Schröder, H. 23, 57Schroeder, H. 16, 40Schröper, T. 24Schubert, M. 58Schuh, W. 11Schüler, R. 30Schulte, J. S. 30, 61Schulz, A. 43, 60Schulz, M. 40Schulz, S. 43Schumacher, D. 17Schumacher, P. 33Schumann, B. 53Schupp, N. 29, 52, 66Schürger, A. 17Schütte, R. 46Schütz, K. 14Schüürmann, G. 32, 52, 66Schüz, J. 51Schwab, M. 28, 35, 43 44, 47, 48, 63Schwaninger, M. 30Schwantes, U. 46Schwartze, S. 46Schwarz, K. 63Schwarzenbach, C. 14Schweinlin, K. 15Schweitzer, M. 30Schwendimann, R. 47Schwerdtle, T. 14, 22Sciuscio, D. 50Scotto Rosato, A. 17Seabra, M. C. 33Seeger, B. 23Seehofer, D. 67Segin, S. 17Sehrt, D. 48Seidel, A. 51Seidl, M. D. 30, 56, 59, 61Seidler, T. 41Seifert, R. 12, 26, 41, 58, 59Seiwert, N. 14, 15Selinski, S. 67Selzer, D. 27Semino-Beninel, G. 49Senese, P. B. 57

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Sent, U. 62Servos, U. 48Sessler, K. 22Seternes, O. M. 41Seyfried, F. 52Shareef, M. 69Sharifi, S. 58Shay, J. 14Shcheglova, I. 24Shi, Z. 15Shiek Abdul Kadhar Mohamed Ebrahim, H. R. 35, 63Shipp, E. 32Shopova, S. 53Sidorcenco, V. 40Sieg, H. 53Siegert, J. 27Silva e Sousa, M. 67Simon Andreas, P. 47Simunovic, A. 42Simutkin, G. 30Singer, A. 53Singh, G. 62Singh, I. 44Sivaramakrishnan, S. 25Smeir, E. 33Smeralda, C. 49Sofranko, A. 54Sonnenburg, A. 66Sonnenschein, N. 63Sonntag, F. 58Sorell, I. 69Sossalla, S. 27Spangel, S. 55, 56Spannbrucker, T. 54Spasic, D. 44Speitling, M. 52Sperber, S. 32Spohner, A. K. 62Springer, F. 64Sribar, D. 16Stadler, G. 42Staendker, L. 22Stahl, W. 22Stahlmann, R. 66Stamms, K. 55Staniek, K. 23Stapf, D. 69Stefan, G. 48, 56, 60Stehle, D. 60

Steinberg, P. 14Steinbrenner, J. 54Steiner, S. 21Steinhausen, J. 22Steinhilber, A. 27Steinritz, D. 20, 22, 64, 65Stelzle, M. 29Stenger, B. 64, 65Stenger, S. 27Stenzig, J. 57Stepanov, D. 16Sternberg, A. 59Stevens, D. 36Stingl, J. 18, 29Stintzing, F. C. 50Stock, P. 65Stoffel, M. 63Stoicescu, L. 56Stolte, S. 24Stölting, I. 30Stolz, A. 51Stolze, K. 23Stopper, H. 52Storch, U. 23, 42, 44Storm, D. 66Stosch, C. 48Stoter, A. M. S. 57Strebe, S. 48Strehse, J. S. 51Strödke, B. 62Stroh, S. 15Stuart, S. 70Stucki, D. 22Stühler, V. 43Stump, K. 48Stürer, A. 50Sturla, S. 19Stürmer, E. 55Susan, M. 52Susan, R. 52, 54, 57, 59, 60Sustova, H. 52Sütterlin, M. 43, 52Swiercz, J. M. 27Syamsul, S. 44Syhr, K. 33Sylla-Iyarreta Veitía, M. 31Szostak, J. 64

TTan, W. T. 64Tang, Y. 15Tarillion, M. 46Tasillo, S. 61Tatge, H. 65Taubeler-Gerling, S. 63Taubert, M. 63Teichmann, T. 55Temme, A. 40Tenekeci, U. 31Tenhaken, V. 41Teodoro, R. 55Testai, E. 63Teutonico, D. 25Then, S.-M. 33These, A. 49Thiel, A. 20, 33Thiele, A. 33Thierbach, R. 23, 55, 56Thiermann, H. 22, 67Thomas, D. 52, 61, 62Thomas, H. 51Thomas, R. 25, 40, 46 49, 55, 58, 59Thomas, S. 42, 46, 53Thorn-Seshold, O. 18Throm, L. 43Thum, T. 36Thumann, L. 64, 65Tiburcy, M. 24, 27Tietz, T. 49, 63, 64Tigges, J. 67Timmermann, D. 61Ting, K.-N. 33Titz, B. 64Toischer, K. 27Tolksdorf, C. 42Tolmachova, T. 33Tomasovic, A. 25Tomicic, M. T. 53Tomisch, L. 53Tonner, M. 23Totan, M. 47Toussaint, M. 55Träger, C. 61Trautmann, S. 62Treder, A. 44Tremmel, R. 48Trenk, D. 30

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Trussina, I. R. E. A. 14Tsvilovskyy, V. 17Tuncok, Y. 65Turek, C. 50Tutdibi, E. 50Tzschöckel, N. 58Tzvetkov, M. V. 16, 48

UUllrich, A. 29Ulmer, B. 24Ulshöfer, T. 62Unfried, K. 54Unger, B. 15Unger, S. 53Urban, N. 16, 17, 45, 47Urbisch, D. 32Uynuk-Ool, T. 67

VVan de Voorde, J. 55van den Bogaard, E. 19van der Giet, M. 63van Eijck, B. A. C. 48van Geffen, C. 34van Heuveln, J. N. 58van Ravenzwaay, B. 32, 34, 46 50, 51, 52, 54, 68, 69van Rienen, U. 61van Schaik, R. 28van Stuijvenberg, J. 66Vanden Daele, L. 55Vanscheeuwijck, P. 50Vatansever, M. 50Vater, I. 15Vennekens, R. 58Verheyen, M. 60Verkaart, S. 68Verlohner, A. 68Vettel, C. 58, 59Vieth, S. 15Villagomez Fuentes, L. E. 34, 46Violet, N. 66, 67Vissiennon, C. 56Vogel, C. F. A. 31Vogel, D. 15Vögele, P. 50Vogeley, C. 31Vogelgesang, S. 16Vogl, S. 67

Vogt, D. 17Voigt, N. 56Volk, J. 63, 64Volk-Heise, M. 42Völkers, M. 23Vollmar, A. M. 17Vollmer, G. 51vom Brocke, J. 70von Eysmondt, H. 60von Kries, J. P. 33von Kügelgen, I. 42Vonica, L. 47Vormfelde, S. V. 35Voss, R. 41Vyalova, N. 30

WWack, G. 33Wagner, M. 27Wahl-Schott, C. 17, 23Wahle, T. 54Waisman, A. 30Waizenegger, J. 32Walk, T. 32Wallisch, S. 32Walliser, C. 15, 40Walter, M. 23Walther, U. 46Wang, H. 57Wang, M. 51Wangorsch, G. 26Wardas, B. 43Wareing, B. 54, 68Wasiliew, P. 60Watz, C. 54, 69Wawrzinek, J. 48Weber, A. G. 50, 68Weber, A. P. M. 22Weber, A. 44, 60Weber, D. 32Weber, I. 46, 57Weber, J. 44Weber, La. 56Weber, Le. 55Weber, S. 57Webert, L. 59Wecklein, S. 14Wedn, A. 49Wehmeyer, J. C. 65Wehr, M. 35, 68

Wein, L. 45Weiß, F. 22Weiser, H. 31Weiser, T. 46, 62Weiss, C. 69Weissgerber, P. 17Weissmann, N. 44Weistenhöfer, W. 52Weitmann, K. 16Wellenberg, A. 64Wellhöner, H. 38Weng, W. 67Wensing, G. 37Wenzel, J. 30Wenzel, P. 30Wenzel, T. 47Werner, A. 66Werner, G. 64Werner, M. 11Werner, S. 29Werner, T. 24Werner, T. R. 57Westermann, M. 53Westermann, P. 61Westerwink, W. 68Westhoff, P. 22Westphal, G. 32Wewetzer, H. 11Wexler, M. 69Weyrich, A. 46Wibbertmannn, A. 69Wibowo, Y. 60Wiebel, F. 15Wieland, T. 22, 43, 58, 60Wielgosz, S. 64Wiese, S. 15Wiest, J. 29Wijesalere, S. 32Wilffert, B. 30Wilhelm, J. 59Wille, T. 67Wilting, F. 30Windbergs, M. 55Winter, M. 17Winter, S. 44, 48Wirth, A. 17, 23Wissenbach, U. 17, 44Wist, M. 15, 40Wittig, F. 40, 41Wittig, I. 15, 40, 41

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Wittkowski, P. 67Wittrien, T. 44Wittstock, M. 46Witzinger, L. 31Woelfer, M. 27Wohlleben, W. 54, 68Wolber, G. 16Wolf, J. 20Wolf, R. 42Wollin, K.-M. 65Wollmann, E. 43Wolter, S. 58Wondany, F. 27Wong, E. T. 50, 64Worek, F. 67Worley, P. 17Worzfeld, T. 24, 25, 27, 50Wu, K. C. 69Wulle, S. 48Wynendaele, E. 55Wysokowski, M. 58

XXia, N. 30, 40, 58Xiao, Y. 40Xu, R. 27

YYang, C. 68Yildirim, A. Ö. 44Yuan, Y. 17

ZZafeiriou, M. P. 27Zahler, S. 33Zammit, M. D. 57Zanetti, F. 67Zech, A. 55Zechner, R. 33Zeitlmayr, S. 40Zelarayan, L. C. 27Zellmer, S. 49Zethner, K. 65

Zethner, K. 65Zhang, J. 32Zhao, D. 25, 52Zhao, Z. 49Zhou, L. 25Ziemann, C. 32Ziemer, M. 20Zieschè, E. 59Zimmermann, A. 67Zimmermann, K. 17Zimmermann, W.-H. 23, 24 36, 42Zolk, O. 46Zubel, T. 14Zufall, F. 19Zwar, M. 61

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Thinking outside

the box

As a full-service PCO, we provide you with intelligent and innovative solutions in an advisory and implementing manner.

www.conventus.de©

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MeDIa cooPeRaTIons

InDusTRIal PRoGRaMMe

Deutscher Apotheker VerlagArzneimitteltherapie (AMT)Medizinische Monatsschrift für Pharmazeuten (MMP)

Gesellschaft für Toxikologische und Forensische ChemieToxikologische und Forensische Chemie

LJ-Verlag GmbH & Co. KGLaborjournal

Mediengruppe Oberfranken - Fachverlage GmbH & Co. KGDeutsche Zeitschrift für Klinische Forschung

Springer-Verlag GmbHEuropean Journal of Clinical PharmacologyArchives of ToxicologyNaunyn-Schmiedeberg’s Archives of PharmacologyBioSpektrum

Technische Universität BraunschweigPubPharm Rechercheplattform

“toxins” an open access journal by MDPIState at printing

Tuesday, 3 March

15:15–16:00 Meet the company HS 2

Chair K. Bestehorn (Zell/DE)

AnaPath Services GmbH bio.logis GIM GmbH LGC Standards GmbH PDS Lifesciences PortaCellTec Biosciences GmbH Stemcell Technologies Germany GmbH

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noTes

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sPonsoRs anD exhIbIToRs

We would like to thank the following sponsors and exhibitors for their crucial support!

SponsorsWebers GmbH Chemical Research in Toxicology

ExhibitorsCompany Booth numberAnaPath Services GmbH 10bio.logis Genetic Information Management GmbH 14Biomol GmbH 13Biotrend Chemikalien GmbH 2Dorner GmbH & Co. KG 11ICCR-Roßdorf GmbH 18I&L Biosystems GmbH 5LGC Standards GmbH 1OMNILAB-LABORZENTRUM GmbH & Co.KG 9PDS Lifesciences 16Peprotech GmbH 17PhenoSys GmbH 7PortaCellTec Biosciences GmbH 19Proteintech Europe 6Sanvitra GmbH 8Stemcell Technologies Germany GmbH 4Sysmex Deutschland GmbH 3TSE Systems GmbH 15ToxPlanet 12

State at printing

Scientific supportersThe German Pharm-Tox Summit is funded by:

Fonds der Chemischen Industrie

Paul-Martini-Stiftung

Financial supportAnaPath Services GmbH: 1,800 EUR (booth), bio.logis Genetic Information Management GmbH: 1,650 EUR (booth), Biomol GmbH: 2,000 EUR (booth, inlay), Biotrend Chemikalien GmbH: 1,500 EUR (booth), Chemical Research in Toxicology: 449,61 EUR (online banner & logo-linking), Dorner GmbH & Co. KG: 1,450 EUR (booth), ICCR-Roßdorf GmbH: 1,500 EUR (booth), I&L Biosystems GmbH: 1,530 EUR (booth), LGC Standards GmbH: 1,500 EUR (booth), OMNILAB-LABORZENTRUM GmbH & Co.KG: 1,500 EUR (booth), PDS Lifesciences: 1,000 EUR (booth), Peprotech GmbH: 1,000 EUR (booth), PhenoSys GmbH: 1,000 EUR (booth), PortaCellTec Biosciences GmbH: 1,000 EUR (booth), Proteintech Europe: 2,400 EUR (booth, display), Sanvitra GmbH: 1,500 EUR (booth), Stemcell Technologies Germany GmbH: 1,500 EUR (booth), Sysmex Deutschland GmbH: 1,500 EUR (booth), TSE Systems GmbH: 1,000 EUR (booth), ToxPlanet: 1,200 EUR (booth), Webers GmbH: 1,000 EUR (wrinting pads & pens)

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Save the Date

6th GERMAN PHARM-TOX SUMMIT

© I

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Adob

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1–4 MARCHBONN l 2021

87. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT)

in Zusammenarbeit mit der AGAH

www.gpts-kongress.de

86. jahrestagung der deutschen gesellschaft für ... · 5th german pharm-tox summit 2–5 march...

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