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Dutch Universities: Research with Focus on Top Sectors. Cooperation with Russia in

Field of Life-Science & Health

Sibrandes Poppema

400 years ofPassion & Performance

Since 1614

Scientific output 2002-2012

1. USA 3,250,380 51,546,027 15.862. PEOPLES REP CHINA 1,022,597 6,653,426 6.513. GERMANY 845,448 11,340,845 13.414. JAPAN 803,857 8,390,864 10.445. ENGLAND 747,867 11,306,492 15.126. FRANCE 603,328 7,556,253 12.527. CANADA 493,736 6,588,762 13.348. ITALY 470,648 5,689,120 12.099. SPAIN 382,658 4,079,695 10.6610. AUSTRALIA 338,947 4,098,351 12.0911. INDIA 334,660 2,059,832 6.1512. SOUTH KOREA 325,403 2,385,604 7.3313. NETHERLANDS 276,918 4,376,263 15.8014. RUSSIA 275,325 1,371,065 4.98

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3

Publications In Nature or Science

University rankings

Nature Publishing Index: 85

Scientist Best Places to Work in Academia: 24

New York Times Employability: 81

University-Business cooperation(Netherlands)

Public-Private Partnerships in top-institutes (investigator driven, precompetitive with industry)

Intermediate (industry driven, with investigators)

New: top-sector policy (9 areas, government policy).

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Horticulture Agri & FoodWaterLife sciences & HealthChemistryHigh techEnergyLogisticsCreative industryHead offices

Topsector Life Sciences

Source: Topsectorplan Life Sciences and Health

Healthy

Ageing

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University Medical Center

1797

1797

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Zernike Science Campus

1. Healthy ageing (HANNN)• Biobank & Cohort study Lifelines (165,000 participants)• European Research Institute on the Biology of Ageing ERIBA

2. Energy (Energy Valley) • Energy Academy Europe EAE• Energy Delta Institute EDI• Groningen Centre of Energy Law

Relevance to SocietyMultidisciplinary, University, Industry, Governments & Public Participation

ENTRANCE: multitesting facilityEnergy Academy Europe

3. Sustainable Society

Relative contributions of genetics and life style to health and disease

LifeLines is a prospective cohort study and Biobank that will follow 165,000 participants in a 3-generation design for at least 30 years. The focus is on multifactorial, age-related disorders.

Funding: ~120 Million Euro

www.lifelines.nl

September 2012:100.000th participant

Healthy Ageing: LifeLines

LifeLines cohort dimensions

Index persons(25-50 years)

partner

father

mother

partner’sfather

partner’smother

child

child

Aselect: 45.000

Partner: 30.000

Children: 35.000

Total number ofparticipants:

165.000

Parents alive:

55.000child

www.lifelines.nl

Healthy Ageing: LifeLines

European Research Institute on the Biology of Ageing ERIBA

Fundamental questions on the biological causes of stem cell ageing

European Research Institute on the Biology of Ageing

Dr. Christian RiedelTeam Leader: Laboratory of Molecular Mechanisms in Lifespan Regulation.

Dr. Peter Lansdorp Scientific DirectorTeam Leader: Laboratory of Genetic Instability, Ageing and CancerERC advanced grant 2011Dr. Gerald de HaanScientific Co-DirectorTeam Leader: Laboratory of Ageing Biology and Stem Cells

Dr. Michael ChangTeam Leader: Laboratory of Telomeres and Genome Integrity

Dr. Eugene BerezikovTeam Leader: Laboratory of Stem Cell Regulation and Mechanisms of RegenerationERC starting grant 2012

Dr. Floris FoijerTeam Leader: Laboratory of Genomic Instability in Development and Disease

Dr. Victor GuryevTeam Leader: Laboratory of Genome Structure and Ageing

Dr. Ellen NollenTeam Leader: Laboratory of Molecular Neurobiology of AgeingERC starting grant 2011

Dr. Liesbeth Veenhoff Team Leader: Laboratory of Cellular Biochemistry: Role of nuclear transport in cellular ageing

Healthy Ageing

International team, prestigious European ERC grants

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersDarren J. Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K. LeBrasseur, Bennett G. Childs, Bart van de Sluis, James L. Kirkland & Jan M. Van Deursen Nature 479, 232–236 (10 November 2011)

Prevents ageing: kyphosis, cataract etc

According to Science one of the top 10 scientific discoveries of 2011

Alliance for Healthy Ageingwith Mayo Clinics

Skolkovo TechResearch Investment Strategy

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Skolkovo Institute of Science and Technology 2012

Skolkovo Tech Strategy – BioMedicine (1)

Computational and systems biology – profoundly different approaches to study biological systems, including complex data, in order to support both basic, as well as applied research involving discovery of new drugs and drug targets [high priority] Immunology and infectious disease - in terms of diseases caused by multi-drug resistant bacteria and viral pandemics, the role of microbiome in human health, and organized response to and treatment of disease [high priority, center in negotiation] Gene- and nano-medicine - impacting the understanding of disease, therapeutics and drug delivery [high priority, center in negotiation]

Regenerative medicine - stem cell research as well as tissue and organ fabrication [high priority, center in negotiation with ERIBA, University of Groningen]

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THANK YOU FOR YOUR

ATTENTION

Hey Charles,

Where are you going?

To the University of Groningen, always good to get some additional

schooling