6 gpat 2011 ans

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Pharmacrystal:

GPAT 201 1

Q.l A glycoalkaloid,

[P] cont a ins sulphur in addi t ion to n i t ro gen in i ts molecule

[Q] is glycosidic in natu re.

[R] can be hydr olysed to an alkaloid.

[S] alw ays cont ains endo cyclic nitro gen in i ts mo lecule.

Choose the correct op t ion.

(A) P & R (B) Q & S (C) Q & R

Ans.B

Q.2 Which of th e fo l low ing statem ents are t rue for g inseng root?

[PI I t is amo ng the m ost t raded p lant m ater ia l o f Brazi l .

[Q] I t is obt a ined f rom Panax g inseng and Panax quinquefo l ium .

[R] I t is obta ined f rom young p lants of s ix mo nth s to one year age.

[S] I t contains derivat ives of pr ot opan axadiol.

(A) P & Q (B) R & S (C) Q & R (D)

Ans.D

Q.3 Which of t he fo l low ing drugs is a t r i terpen oid conta in ing root?

(A) Valerian (B) Brahm i (C) Satav ari (D) Adu sa

Ans. A

Q.4 Wh ich of th e fo l low ing alka lo ids is der ived f rom tyrosine?

(A) Quin ine t (B) M orph ine (C) Atrop ine (D) Ephedr ine

Ans.B

Q.5 The fo l low ing opt ion s carry th e name o f t he p lant , par t u sed and i ts fami ly . Find a W RONG

combina t ion .

(A) Aegle marm elos, f ru i t & Rutaceae

(B) Conium m aculatum , f ru i t & Um bel l i ferae

(C) Glycyrrhiza glabra, root and stolo n & Legum inosae

(D) Str oph anth us gratus, seed & Scroph ular iaceae

Ans. D

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(A) Zeatin (B) 2,4-Dichlorop heno xyacetic acid

(C) Indo leaceti c acid (D) Piclor am

ANS.A

Q.13 Phenylethyl isoquino l ine is the precursor o f w hich of t he fo l low ing a lka lo ids?

(A) Colch icine (B) Papaver ine (C) Em et ine (D) Ceph aline

ANS.A

Q.14 A pow dered d rug has the f o l low ing m icroscopic characters: Anth er ce l ls, arenchym a,

pollen grains, phloem f iber s, volat i le oi l cel ls and ston e cel ls. The po w der is

ob ta ined f rom w h ich o f t he fo l lowings?

(A) Clove bud p ow der (B) Clove bud po w der w i th sta lk

(C) M ot her Clove (D) None of the above

ANS.B

Q.15 Arrange th e fo l low ing fat ty acids in decreasing order of the ir unsatu rat ion (h ighest to

lowest) :

[P] Stearic [Q] Oleic acid | R] Lmo lenic acid | S] Linoleic acid

(A) P > Q > R > S (B) S > R > P > Q (C) R > S > Q > P (D) Q > P > R > S

ANS.C

Q.16 Determ ine the correctness or ot herw ise of t he fo l low ing Asser t ion [a] and th e Reason [ r ] :

Assert ion (a): Tannin s are po lyphen olic substances occurr ing in p lant cel l sap. Hydro lysable and

condensed t annins are d i f ferent ia ted by m atch st ick test .

Reason (r) : The cond ensed tann ins are resistant to acid hydro lysis th erefo re stain th e l ignin

present in m atch st ick.

( A ) Bot h (a) and (r) are tru e, and (r) is a correct r eason f or (a)

(B) Both (a) and (r) are t rue, bu t (r) is NOT th e correct reason for (a)

(C) (a) is true b ut (r) is NOT th e correct reason for (a)

(D) Bot h (a) and (r) are false

AN S. B


Assert ion (a): Casto r o i l is solub le in alcoho l and is used as pur gative.

Reason (r) : The oi l cont ains r icinoleic acid having a hydro xyl group at C-12 posit ion w hich is

responsib le for i ts so lubi l i ty in a lcohol and i ts purgat ive act ion.

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(A) Bot h (a) and (r) are tr ue bu t (r) is NOT the corr ect reason for (a)

(B) (a) is tr ue bu t (r) is NOT th e correct reason for (a)

(C) Both (a) and (r) are tr ue and (r) is th e correct reason f or (a)(D) Bot h (a) and (r) are false

ANS.C

Q.18 In acetate m evalonate path w ay geranyl pyrophosphate leads to f orm at ion of

m onot erpenes, the m ajor const i t uents of vo lat i le o i ls.

[P] Geranyl pyrophosphate conta ins tw o isoprene uni ts

[Q] M onoterpenes have 15 carbon a tom s

[R] The tw o isoprene un i ts condense in head to t a i l fashion t o g ive mono terpenes

[S] Isopr ene un it has mo lecular form ula of C5 Hs.

W hich one of t he g iven statem ents is correct?

(A) P is t ru e. Q is false, R is t ru e, S is false

(B) P is false. Q is tr ue , R is tr ue , S is false

(C) P is t ru e. Q is t ru e, R is false, S is tru e

(D) P is tr ue. Q is false, R is tru e, S is tr ue

ANS.D

Q.19 Tw o genet ic types of Cannabis i .e. drug type and Hem p t ype are cul t ivated.

[P] Drug typ e cannab is is r ich in (-)A9-rarcs-tet rahydr ocannabino l .

[Q] Hem p t ype cannabis is r ich in cannabid io l

[R] Drug typ e cannabis is r ich in cannabid iol

[S] Hem p typ e cannab is cont ains elongated b ast f ib res

W hich one of t he g iven statem ents is correct?

(A) P is t ru e, Q is tru e, R is tru e, S is tru e

(B) P is tr ue , Q is false, R is false, S is tr ue

(C) P is t ru e, Q is tr ue, R is false. S is tru e

(D) P is false, Q is false, R is tr ue , S is false

ANS.D

Q.20 Each of the fo l low ing opt ion s lists a phyto const i tu ent , i ts phyto chemical grouping,

pharm acological act ivit y and correspond ing sem isynt het ic analogue. Find a M ISM ATCHING

opt ion .

(A) Podoph yllot oxin, l ignan, anticancer, eto poside

(B) Senno side, ant hraqu inon e, laxative, sinigr in

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(C) Atropine, alkaloid, anticholinergic, homatropine

(D) THC, terp enop heno lic, psychoactive, nabilo ne

ANS.B

Q.21 Inhib i t ion / induct ion o f w hich of the fo l lowing Cytochrom e P450 enzym e system is m ost

l ike ly to b e involved in impor tant drug-drug in teract ions?

(A) CYP3A4 (B) CYP2D6 (C) CYP2C9 (D ) CYP1A2

Ans .A

Q.22 Wh ich of the f o l low ing mechanism s is NOT re lated t o p late let aggregat ion inh ib i t ory

act ion?

(A) ADP recept or ant agonism

(B) Glycopr ot ein I lb/ I I Ia receptor ant agonism

(C) Phospho diesterase inhibit ion

(D) Prostacycl in inhibit ion

AN S. D

Q.23 Choose the correct s tatem ent about the g iven fo ur d iseases?

[P] Cardiom yopathy [Q] Rheumato id ar thr i t is

[R] M yasth enia gravis [S] Ulcerat ive col i t is

(A) Q & S are auto im m une d isorders

(B) P & Q are auto imm une d isorders

(C) P & R are not auto im m une d isorders

(D) R & S a re no t au to imm une d isorders

AN S. A

Q.24 W hich of the fo l low ing species is being inact ivated b y t he enzyme Dipept idy l pept idase-4?

(A) Oxyto cin (B) Vasopre ssin (C) Incret m (D) Glucagon

AN S. C

Q.25 Pat ients tak ing isosorb ide m onon i t rate o r n i t roglycer ine should be advised not to take

sildenafi l . This dru gdrug inter act ion causes w hich of th e fol low ing act ion s?

(A) Respirat ory fai lure vJcB) Severe hypo ten sion

(C) Prolo ngation of QT int erval (D) M yocardial ischem ia

AN S. B

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Q.26 Wh ich of the fo l low ing drugs does NOT induce m ydr iasis'?

(A)" At rop ine (B) Ephed rine (C) Phent olam ine '(D) Cocaine

AN S C

Q.27 W l i ich o f t he f o l low ing statem ents is TRUE for angiotensm-I I?

(A) Causes m yocyte hyp ert rop hy

(B) Decreases the act ion of sym path etic nervo us system

(C) Increases force of m yocardia l contract ion

(D) Decreases th e synth esis and release of aldostero ne

AN S. A

Q.28 Wh ich of the f o l low ing beta b lockers has been show n c l in ica l ly to reduce m ort a l ity in

pat ients of symp tom at ic hear t fa i lure?

(A) Ateno lol (B) Carvedilol (C) Prop rano lol (d) Esm olol

AN S. B

Q.29 Al l o f t he g iven four drugs cause vasodi la tat ion. Choose th e correct s tatem ent about

t h e m .

[P] Bradykim n [Q] M inoxidi l [R] Acetylcholin e [S] Hydralazine

(A) P & Q cause release of n itr ic oxide

(B) Q & R do n ot cause release of n itr ic oxide

(C) R & S cause release of n it ric oxid e

(D) P & S do n ot cause release of n itr ic oxide

AN S. A

Q.30 Rhabdo m yolysis is th e side effect associated w ith w hich of t he fo l low ing classes of d rugs?

(A) ACE inh ibit or s (B) Stat ins

(C) Calcium channel b lockers (D) Sodiu m channel b lockers

AN S. B

Q.31 Blood level m oni to r ing of HbAlc is imp or t ant in w hich of t he g iven d iseased states?

(A) Hypercho lester olem ia (B) Diabetes mell i t us

(C) M yocardial infarct io n (D) Congestive heart fai lure

AN S. B

Q.32 M ost of the em ergency cont racept ives have which one of t he fo l low ing act ive

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ingredients?

(A) Estradiol (B) Nor eth indr on

(C) M isopr ostol (D) Levono rgester elAns .D

Q.33 Which of t he fo l low ing ant ib iot ics produ ces concentrat ion depend ent bacter ic idal act ion

and also po ssesses post-antib iot ic effect?

(A) Ceft azidim e (B) Azith rom ycin l-(C) Am ikacin (D) Piperaci l l in

AN S. C

Q.34 Antiret roviral Raltegravir is uniq ue, because of w hich of i ts fol low ing act io ns9

(A) Integrase inhibit ion (B) CCR5 Co-recepto r ant agonism

(C) Fusion inh ibit ion (D) Reverse transcriptase inhibit ion

AN S. A

Q. 35 W hat is chemot axis?

(A) Toxicity of chem icals

(B) Taxono m y of chem icals

(C) Inhib i t ion of In f lamm at ion

(D) M ovem ent of leucocytes in in f lam m at ion

AN S. D

Q.36 Wh ich on e of t he fo l low ings is NOT an example of G-prot e in coupled receptor?

(A) M uscarinic cholinergic recept or (B) Alpha adreno cepto r

(C) Nicotinic cholinergic receptor (D) Beta adrenocept or

AN S. C

Q.37 Which of t he fo l low ings used in th e t reatm ent o f rheum atoid ar th r i t is is NOT a b io logic

response mo di f ier?

(A) Anakinra (B) Leflun om ide (C) Etaner cept V" (6) Inf l ixim ab

AN S. B

Q.38 W hich of t he fol lo w ing stat em ent s is FALSE for art em isinin?

(A) I t is a sesquit erpen e lacto ne end oper oxide

(B) I t is a dru g of choice in pr oph ylaxis of m alar ia

(C) I t does not cure relapsing malar ia

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(D) I t is usefu l in t reatm ent of cerebra l fa lciparum m alar ia

AN S. B

Q.39 Wh ich of the f o l low ings is a noncom pet i t ive inh ib i tor of the en zyme r everse t ranscr ip tase

m HIV?

(A) Lam ivudin e (B) Nevirapine (C) Abacavir (D) Tenofo vir

AN S. B

Q.40 Wh ich of the f o l low ings is the m ost ef fect ive mo not herapy for r a ising HDL cholestero l?

(A) St atin s (B) Niacin

(C) Ezetim ibe (D) t o-3-Fatt y acids

AN S. B

Q.41 Which of the fo l low ing paramet ers f rom plasm a concentrat ion t im e prof i le stud y g ives

indicat ion o f the rate of d rug absorpt ion?

(A) Cm ax (B) Tm ax (C) AUC (D) t l/ 2

Ans. B

Q.42 Wh ich of the fo l low ing pairs has h igh b inding af f in i ty for 5a-reductase?

(A) Letr ozole and andro sten edion e (B) Finaster ide and t esto lactone

(C) Finaster ide an d 5-DHT (D) Finaster ide and testo steron e

AN S. C

Q.43 Wh ich of the fo l low ing skeleta l muscle re laxants acts d i rect ly on t he cont ract i le

m echanism of t he m uscle f ibers?

(A) Pancuron ium (B) Baclofen

(C) Dant rolen e (D) Chlorzoxazone

AN S. C

Q.44 W hich is th e mo lecular target fo r th e vinca alkaloids as ant icancer agents?

(A) Tyrosine kin ase (B) DNA

(C) Ribo som es (D) Tubu lin

AN S. D

Q.45 Choose the correct pair o f t he neuro degenerat ive d isorders f rom tho se g iven below .

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(A) Parkinson's disease and Alzheim er's disease

(B) Schizoph renia and M ania

(C) Alzheim er's disease and Schizoph ren ia(D) Parkin son's disease and Au ti sm

AN S .A

Q.46 A 64 year o ld w om an w i th a h istory of Type I I d iabetes is d iagnosed wi t h hear t fa i lure.

W hich of t he fo l low ings w ould b e a POOR choice in cont ro l l ing her d iabetes?

(A) M etf orm in (B ) Pioght azone (C) Glipizide (D) Exenatid e

AN S. B

Q.47 M ifepr iston e and gem eprost combinat ion is used for m edical term inat ion of pregnancy.

The act ion is caused due to w hich of the fo l low ing mechanism s?

(A) M ifepr iston e is an ant iest ro gen w hi le gemepro st is a prostaglandin E receptor agonist .

(B) M i fepr iston e is an ant iprogest in w hi le gemeprost is a prostaglandin E recepto r agonist .

(C) M i fepr iston e is an ant iandrogen w hi le gemepro st is a prostaglandin E receptor agonist .

(D) M i fepr iston e is an ant iprogest in w hi le gemeprost is a prostaglandin E receptor ant agonist

AN S. B

Q. 48. W hich one of t he fo l low ings is a beta lactam ase inhib i tor ?

(A) Penicillan ic acid (B) Em bo nic acid

(C) Ceph alospo rani c acid (C) Clavulan ic acid

Ans .D

Q.49 All of t he fo l low ings are indicat io ns for u se of ACE inhib ito rs EXCEPT for one. Ident ify t hat .

(A) Hyper tension (B) M yocardia l in farct ion

(C) Lef t ventr icu lar dysfunct ion (D) Pheochrom ocytom a

AN S. D

Q.50 Neural tube defects may occur by w hich one of t he fo l low ing ant i -se izure dru gs?

(A) Eth osuximid e (B) Vigabatn n (C) Valproic acid (D) Prim idon e

AN S. C

Q.51 Which w ater is used for h and w ashing in a change room of ph armaceut ica l m anufactur ing

plant?

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(A) Pot able wat er (B) Pur i f ied w ater (C ) Disinfectant w ater (D) Soap w ater

AN S. A

Q.52 Which one of th e fo l low ing dry ing m etho ds is comm only used in pharm a industry for

dryin g of soft shell capsules?

(A) Truck dr ying . (B) Fluid b ed d rying

(C) Vacuum dry ing (D) M icrowave dry ing

AN S. C

Q.53 Which one of t he fo l low ings does NOT af ford a m acrom olecular inc lusion com poun d?

(A) Zeolit es .(B) Dext rin s (C) Silica gels (D) Cyclod ext rin s

AN S. C

Q.54. If C is th e concentr at ion o f dissolved dr ug and Cs is th e satur at ion con centr at ion . In w hich

case t he s ink condi t ions are said to be m ainta ined?

(A) C < 20% o f Cs (B) C > 20 % of Cs (C) C < 10% o f Cs (D) C > 1 0% o f Cs

AN S. C

Q.55 Wh ich condi t ion do es not apply as per Indian law w hi le conduct ing single dose

bioavailab i li ty s tudy o f an im m ediate re lease prod uct?

(A) Samp l ing per iod should be at least t hree t 1/ 2 e l

(B) Sam pling should rep resent pr e-exposure, peak exposure and post-expo sure phases

(C) There should be at least four samp ling point s dur ing el iminat ion ph ase

(D) Sam pling shou ld be cont inued t i l l m easured AUC is at least equal to 80% of AUC

AN S. C

Q.56 Upon standing som et im es gel system shr inks a b i t and l i t t le l iqu id is pressed out . W hat is

th is phenomenon know n as?

(A) Oozing (B) Syner esis (C) Shr inkin g (D) Desolvat ion

Ans.B

Q.57 Wh ich of the f o l low ing routes of adm inist rat ion of dru gs is associated w i th Phlebi t is?

(A) Subcut eneou s ( B ) ! Int ravenou s (C) Intraspinal (D) Int radur al

Ans.B

Q.58 Stud y the fo l low ing tw o statem ents and choose the correct answ er:

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[P] Ant ibo dies are serum prot e ins provid ing imm uni ty.

[Q] IgG provides imm uni ty t o new born b abies w hi le IgM is th e f i rst generated ant ibod y.

(A) P is corr ect and Q is incorrect (B) P is incorrect an d Q is corr ect(C) Both P and Q are corr ect (D) Bot h P and Q are incorr ect

AN S. C

Q.59 W hich m icrobe is used fo r va l idat ion of ster i l izat ion by f i l t ra t ion p rocess?

(A) Bacil lus stearo th erm oph ilus (B) Pseudom onas dimin ut a

(C) Bacillus sub t ilis 'D) Pseud om on as aeru gino sa

AN S. B

Q.60 Non- l inear pharm acokinet ics can be expected d ue to

[P] Enzyme ind uctio n

[Q] Active secret ion

Choose th e correct answer.

(A) Both P and Q are tr ue (B) P is tr ue, Q is false

(C) Q is tru e. P is false (D) Both P and Q ar e false

Ans. A

Q.61 Which w avelength of t he UV l ight provides maximum germic idal act ion?

(A) 253.7 nm (B) 275.5 nm (C) 283.5 nm (D) 240.0 nm

ANS.A

Q.62 W hich of th e fo l low ing statem ent s is INCORRECT ?

(A) Chick M art in t est u ses organic mat t er in m edia

(B) The o rganism in Rideal-W alker t est is S. typ hi

(C) Rideal-W alker test uses organic m att er in m edia

(D) The or ganism in Chick M art in test is S. typh i

Ans.C

Q.63 Wh ich of the f o l low ing forces contr ibu te t o stabi l ity o f charge- t ransfer com plexes?

(A) Resonance forces

(B) Resonan ce and Londo n d isper sion for ces

(C) Dipole-dipole int eract ion s and Lond on dispersion for ces

(D) Resonance forces and dip ole-dipo le interact ions

ANS.D

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Q.64 W hich of the fo l low ing isoth erm s are produced when t he heat of condensat ion of

successive layers is m ore t han t he heat o f adsorpt ion of f irst layer?(A) Type III and IV (B) Type II and V

(C) Type I and III (D) Type III and V

ANS.D

Q.65 Wh ich of the fo l low ings act as a non- ionic emu lsi fy ing agent?

(A) Tr ie thanolam ine o leate

(B) Polyoxyethylene sorb i tan m onoo leate

(C) N-Cety l -N-eth ylmor phol in ium etho sul fate

(D) Dioctyl sulph osuccinate

ANS.B

Q.66 The m in imal ef fect ive f low r ate of a i r in lam inar f low hood should b e not less than h ow

m any cub ic feet p er m inu te?

(A) 10 .(B) 50 (C) 100 (D) 10 00

ANS.C

Q.67 W hich of the fo l low ing Schedules inc lude shel f l i fe of drugs?

(A) Sched ule F (B) Sched ule M (C) Sched ule G (D) Sched ule P

ANS.D

Q.68 Wh ich of the fo l low ing pum ps is used in handl ing of corrosive liqu ids?

(A) Turb ine pum p (B) Volute pum p

(C) Air binding pum p (D) Peristalt ic pum p

ANS.D

Q.69 By addi t ion of w hich of t he fo l low ings the shel ls of sof t ge lat in capsules m ay be m ade

elastic?

(A) Polyet hylene glycol (B) Sorb ito l

(C) Prop ylene glycol (D) Dibut yl pht halate

ANS.B

Q.70 Conver t 90% v/v a lcohol t o Proof st rength. Choose the correct answ er.

(A) 57.77 und er p roo f (B) 57.77 over pro of

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(C) 47.41 over pro of (D) 47.41 und er p roo f

ANS.B

Q.71 Depar tm ent o f Transpor t Test (DOT) is per form ed for w hich of th e fo l low ings?

(A) St rip p acking (B) Aero sols

(C) Inje ctio n packin g (D) Glass con t ainer s

ANS.B

Q.72 What is the Heat of vapor izat ion of w ater at 100C?

(A) 2790 cal / m ole (B) 7290 cal / m ole

(C) 7920 cal / m ole (D) 9720 cal / m ole

ANS.D


Asser t ion [a] : For a ph armaceut ica l powd er t r ue densi ty is greater t han t he granule density .

Reason [ r ] : M ercury d isp lacem ent u sed for determ in ing granule density , a l low s penetrat ion of

l iqu id in to in ternal por es of t he par t ic les.

(A) [a] is tr ue bu t [ r ] is false

(B) Both [a] and [ r ] are false

(C) Both la ] and [ r ] are t rue and [ r ] is the correct r eason f or [a ]

(D) Both [a] and [ r ] are t rue but [ r ] is NOT the correct r eason fo r [a ]

ANS.A

Q.74 Determ ine the correctness or ot herw ise of the fo l low ing statem ents:

[P] Rheopexy is the p henom enon w hen a sol form s gel mo re readi ly when sheared gent ly . IQ] In

a rheopect ic system , sol is the equi l ibr ium form .

[R] Rheopexy is a phenom enon w hen a sol form s gel when t he m ater ia l is kept at rest .

(A) [R] is true b ut [P] and [Q] are false (B) [P] is true b ut [Q] an d [Rl are false

(C) [P], [Q] and [R], all are f alse (D) [P], [Q] and [R], all are t rue

ANS.B

Q.75 Define Plasm aphere sis? Choo se th e correct answer .

(A) The pro cess of co l lect ing p lasm a and retu rn ing th e red b lood cel ls concent rate t o t he do nor

(B) The pro cess of co l lect ing red b lood cells concentrate and r eturn ing the p lasm a to the dono r

(C) The pro cess of separating w hit e blood cel ls fro m bloo d

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(D) The process of gener ating art i f icial bloo d plasma expander s

ANS.B

Q.76 M olecules in the sm ect ic l iqu id crysta ls are character ized by w hich one o f t he fo l lowings?

(A) M obi l i ty in th ree d i rect ions and rot at ion in one axis

(B) M obi l i ty in tw o d i rect ions and rotat ion in one axis

(C) M obi l i ty in tw o d i rect ions and no rotat ion

(D) M obi l i ty in three d i rect ions and no ro tat ion

ANS.B

Q.77 Choo se th e correct sequen ce of M oistur e Vapor Transmission Rate in p ackaging

materials?

(A) Paper > Alum inium foi l > PVC > PVdC

(B) Alum iniu m fo il > PVC > PVdC > Paper

(C) Alum iniu m fo il > PVdC > PVC > Paper

(D) Paper > PVC > PVdC > Alum inium foi l

ANS.D

Q.78 How m any mL of 50% (w/ v) dextro se solut ion and h ow m any mL of 5% (w / v) dextro se

solut ion are required to p repare 4500 mL of a 10% (w/ v) so lut ion ?

(A) 500 mL of 50% and 4000 m L of 5%

(B) 1000 m L of 50% and 3500 m L of 5%

(C) 4000 m L of 50 % and 500 m L of 5%

(D) 1500 m L of 50% and 3000 m L of 5%

AN S. A

Q.79 A drug is administered t o a 65 Kg pat ient as 500 m g tablets every 4 hour s. Hal f - l i fe of th e

drug is 3 h, vo lum e of d is t r ibut ion is 2 li ter / Kg and ora l b ioavai lab i l i ty of t he drug is 0.85.

Calculate t he steady state concentr at ion o f t he dru g?

(A) 5.05mcg/m l (B) 4.50 m cg/ m l (C) 3.53 m cg/ m l (D) 3.00 m cg/ m l

ANS.D

Q.80 P-Glycoprot e in pum p is responsib le for w hich one of t he fo l low ings?

(A) Transpor t ing the drugs f rom the ent erocytes in to t he gut lum en

(B) Transpor t ing the drugs f rom gut lum en into enterocytes

(C) Transpor t ing t he dru gs f rom ora l m ucosa in to b lood capi l lar ies

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(D) Transpor t ing th e drugs f rom Peyer 's patches in to the gut lum en

ANS.A

Q.81 Stat em ent [ X] :Hofm eister series grades coagulat ing pow er of electro lytes as per t heir

ion ic size.

Stat em ent [Y]: [P] The relat ive coagulat ing pow er is given by:

[P] Al+++ > Ba++ [Q] Li - > FCho ose

the cor rect sta tement :

(A) Stat em ent X is true b ut P, Q and R are false in Stat em ent Y

(B) Stat em ent X is false and P, Q and R are false in Stat em ent Y

(C) Stat em ent X is true and Q and R are false in Stat em ent Y

(D) Stat em ent X is false and P is false in Stat em ent

ANS.D

Q.82 The f i rst s tage of w et t ing on addi t ion of a granulat ing agent to the p ow ders is

character ized by w hich one of t he fo l low ings?

(A) Capil lary state (B) Pendu lar state

(C)Funicular state (D) Drop let state

ANS.A

Q.83 Larger va lues of Ky in th e Heckel Plot ind icate f orm at ion o f w hat q ual i ty of t ab lets?

(A) Harder t ablets (B) Soft er tab lets

(C) Fluff y tab lets (D) Brit t le tablet s

ANS.D

Q.84 The degree of f locculat ion o f a suspension is 1.5 and the sedim entat ion volum e is 0.75.

W hat w i l l be the u l t imat e volume of d ef locculated suspension?

(A) 2.0 (B) 1.5 (C) 0.75 (D) 0.5

ANS.A

Q.85 What w i l l be the t ime requ ired for a drug exhib i t ing f i rst ord er rate constant o f 4 .6/h r to

be degraded f rom

in i t ial concent rat ion o f 100 mg/ m l to 10 mg/ ml?

(A) 2 hr (B) 4hr (C) 9 hr (D) 0.5 hr

AN S. D

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Q.86 W hat w i l l be the dose requ i red to m a in ta in therapeut ic concent rat ion o f 20 m icrogram/ ml

fo r 24 h r o f a

drug exhib i t ing to ta l c learance of 2 L/hr ?(A) 96 mg (B) 480 m g (C) 960 m g (D) 48 m g

ANS.D

Q.87 Wh at w i l l be the ur ine t o p lasm a rat io of a w eakly acid ic drug having pKa of 5? [Ur ine (pH

= 5) plasma (pH= 7)]

(A) 1:101 B 1:20 1 (C) 2:101 (D) 1:20 2

ANS.B

Q.88 The Reynolds num ber w idely used t o c lassi fy f low behavior of f lu ids is the rat io of w hich

one o f the

fo l lowings: '

(A) Inert ial forces to gravitat ional fo rces (B) Inert ial forces to viscous for ces

(C) Viscous forces to inert ial forces (D) Viscous forces to gravitat io nal for ces

ANS.B

Q.89 If the dist i l lat ion graph u sing M cCabe Thiele m eth od is paral lel to X-axis, th en th e feed is

w h ich one o f the

fo l lowings?

(A) Satu rated l iquid (B) Satur ated vap or

(C) Super heat ed l iqu id (D) Super heated vapor

ANS.A

Q.90 Wh at for the b af f les are provided in a shell and tub e heat exchanger?

(A) To increase turb ulence (B) To decrease tu rbu lence

(C) To pr even t co rr osion (D) To increase shell side passes

ANS.A

Q. 91 S O S m eans w hich on e of t he fo l low ings?

(A) Take o ccasionally (B) Take im m ediately

(C) Take w hen necessary (D) Take as dir ecte d

ANS.C

Q.92 W hich stat em ent is FALSE for Associat ion Colloid s?

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(A) They are also cal led am phip hiles (B) They cont ain aggregated m olecules

(C) They show part ial solvat io n (D) They are also cal led m icel les

ANS.C

Q.93 Wh ich of the f o l low ings is NOT a reciprocat ing pum p?

(A) Plunger pum p (B) Diaphragm pum p

(C) Gear pum p (D) Pisto n pu m p

ANS.C

Q.94 Wh ich is NOT appl icable to p rot e in b inding?

(A) Klot z recipro cal plot (B) Sandb erg mo dif ied eq uatio n

(C) Blanchard eq uatio n (D) Detl i plot

ANS.D

Q.95 Stat em ent [P] : Soft gelat in capsules cont ain 12-15 % mo istu re.

Stat em ent [ Q] : Hard gelat in capsule shells cont ain 6-10 % m oistur e.

Choose the correct s tatem ent?

(A) Both of t he above statem ents P & Q are t rue

(B) Both of the above statem ents P & Q are fa lse

(C) Stat em ent P is tr ue and Q is false

(D) Stat em ent P is false and Q is tr ue

ANS.B

Q.96 Accord ing to USP, the speed regulat ing device of the d issolut ion apparatus should be

capable of

m ainta in ing the speed w i th in l im i ts of w hat % of th e selected speed?

(A) 1 % (B) 2 % (C) 4 % (D) 5 %

ANS.A

Q.97 A drug wh ose solubi l i ty is 1 g/ L in w ater , wh en g iven ora l ly at a dose of 500 m g is

absorbed upt o 95% of the adm inistered d ose. The dru g belongs to w hich c lass accord ing t o t he

BCS classification?

(A) Class I (B) Class II (C) Class III (D ) Class IV

ANS.A

Q.98 Which statem ent is NOT t ru e for s team dist i l lat ion ?

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(A) It is also cal led dif f erent ial dist i l lat ion

(B) I t can be u sed fo r separat ion of im m iscib le l iqu ids

(C) I t can be applied f or vo lat i le substances(D) I t can be used for separatio n of m iscible l iquids

ANS.D

Q.99 The area of clear open ing of any t w o successive sieves according t o Tyler stan dard is in th e

ra t io o f ,

(A) 1 : 4 (B) 1 : 6 (C) 1 : v2 (D) 1 : v 3

ANS.C

Q.100 W hat is Pr im ogel?

(A) Substit ut ed HPM C for dir ect com pression

(B) M odi f ied m icrocrysta l l ine cel lu lose for d i rect com pression

(C) Hydrogel ling porym er for gel form at ion

(D) M odi f ied starch for d isin tegrat ion

ANS.D

Q.101 A tooth paste cont a ins stannou s f luor ide and calc ium pyro pho sphate a long w i th ot her

form ulat ion const i t uents. Choose the correct statem ent ou t of t he fo l low ings?

(A) Stan nou s f luo ride is an anticar ies agent w hile calcium p yrop hosphat e is a dent ifr ice

(B) Stan nou s f luo ride is a dent ifr ice w hile calcium pyro pho sphate is a desensit izing agent

(C) Stan nou s f luoride is a desensit izing agent w hile calcium pyro pho sphat e is an ant icar ies

agent

(D) Both are de nt ifr ices w hile calcium pyro pho sphat e is addit ionally a desensit izing agent

ANS.D

Q.102 Hydro gen pero xide solut ion (20 volu m es) is used to pical ly as a mild an tisept ic. I t is m ainly

used for c leaning of w ound s w hich could be due t o som e of the fo l lowing act ions of hydrogen

peroxide.

[P] Astr ingent act io n [Q] Nascent h ydro gen releasing act ion

[R] Oxidizing act ion [S] M echanical cleansing act ion

Choose the correct s tatem ents for t he use of hydrogen peroxide as c leaning agent for w ound s?

( A ) P & R (B) P & Q (C) R & Q (D) R & S

ANS.C

Q.103 M agnesium t r is i licate is considered to be a bet t er antacid than a lum in ium hydroxide due

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to i t s fo l low ing addi t ion al proper t ies:

[P] It has a f ixed chem ical com posit io n

[Q] I t for m s col loidal si l icone dioxide[R] M agnesium ions overcom e const ipat ion

[S] M agnesium ions cause h igher inh ib i t ion of pepsin t han a lum in ium ions

Choose the correct comb inat ion of s tatem ents?

(A) Q & S (B) R & S (C) P & Q (D) Q & R

ANS.C

Q.104 Bor ic acid is a weak acid (pKa 9.19) w hich cannot be t i t ra ted w i th a standard solut ion of

sodium hydroxide using phenolpht hale in as ind icator . This t i t ra t ion becom es possib le on

addi t ion o f g lycero l due t o on e of t he fo l low ing react ions. Choose the correct react ion?

(A) Bor ic acid becom es boronic acid on react ion w i th g lycero l

(B) Bor ic acid g ives a m onop rot ic te t ravalent bor on ester w i th g lycero l

(C) Boric acid gives a tr ibasic acid on r eaction w ith glycerol

(D) Tw o b or ic acid m olecules com bine t o g ive an anhydr ide in presence of g lycero l

ANS.D

Q.105 An i ron com poun d used as heamat in ic agent m ust meet t w o requirem ents i .e . i t should

be b io logica l ly avai lab le and be non- i r r i ta t ing. Wh ich one of th e fo l low ing com poun ds meet t he

above tw o requirem ents most c losely?

(A) Ferr ic chlor ide (B) Ferr ic amm oniu m sulph ate

(C) Ferr ic amm oniu m citrat e (D) Ferro us thioglycollate

ANS.B

Q.106 Iodine-131 as sodium iodid e solut ion is used as a radioph arm aceutical for diagnostic and

therapeut ic purposes. I ts usage is dependent on the re lease of the fo l low ing emissions:

[P] Alpha part icles [Q] Positron s [R] Beta em ission [ S] Gamm a radiat ion

Choose the correct comb inat ion of s tatem ents?

(A) R & S (B) Q & S (C) P & R (D) P & S

ANS.C

Q.107 Arrange the fo l low ing Low ry-Bronsted acids in to their decreasing order of acid i ty

(h ighest to low est)?

[P] C2H5OH [ Q] H 3C-C=CH [R] H2 0 [ S] CH3NH2

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(A) R > P > Q > S (B) P > R > Q > S (C) P > Q > R > S (D) R > Q > P > S

ANS.A

Q.108 Alkenes show typ ica l e lectrophi l ic addi t ion react ions. I f an e lectro n w i thdr awing group is

a t tached to one o f t he carbons bear ing the doub le bond, w hat w i l l happen to the m echan ism o f

the addi t ion react ion?

(A) I t rem ains electro phil ic (B) It becom es free radical addit io n

(C) I t becom es pericycl ic reactio n (D) I t becom es nucleop hil ic

ANS- A

Q.109 Aprot ic po lar so lvents increase th e rate of SN2 react ions mani fo ld. Enhancem ent in t he

rate of such react ions is due t o w hich one of t he fo l low ing ef fects?

(A) Solvat ion of the anion by t he solvent leaving the cat ion unaf fected

(B) Solvatio n of b ot h of t he ionic species

(C) Desolvat ion of the cat ion and solvat ion of t he anion

(D) Solvat ion of th e cat ion by t he solvent leaving the anion unaf fected

AN S. D

Q.110 Five-m em bered hetero arom at ic comp ound s show a much h igher rate of e lectro phi l ic

arom at ic subst i tu t ion react ions than the s ix-m em bered on es. This is due t o w hich one of the

fo l low ing reasons?

(A) Five-m emb ered hetero arom at ic com poun ds have h igher c ircu lat ing e lectro n densi ty in t he

r ing than the six-m em bered ones

(B) Five-m em bered het eroarom at ic com poun ds have low er c i rcu lat ing e lectro n densi ty in th e

r ing than the six-m em bered ones

(C) Five-mem bered r ings are sm aller in size th an th e six mem bered o nes which affect s th eir

react ion r ates

(D) Six mem bered het eroarom at ic r ings are f la t w hi le the f ive-mem bered on es arc puckered

AN S. A

Q. ll l Pyr id ine is more basic than p yrro le. This is due t o w hich of the fo l low ing facts?

(A) Lone p air of elect ron s on N in p yrro le is local ized

(B) Lone p air of elect ron s on N in pyr idine is localized

(C) Ni t rogen of pyrro le has one hydro gen ato m at tached to i t w hi le pyr id ine does not have any

(D) Pyr id ine has thr ee double bo nds wh i le pyrro le has only tw o

AN S . B

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Q.112 Die ls-Alder react ion can be carr ied out in w hich of t he fo l low ing heterocyclic com poun ds

m ost readi ly?(A) Pyrro le (B) Thiophen e (C) Furan (D) Pyridine

ANS.C

Q.113 In nucleop hil ic al iphat ic substi t ut ion reaction s arrange the fo l low ing leaving grou ps in

decreasing order o f th eir leaving capacity?

[P] Brosyl [Q] Hydro xyl [R] Chloro [ S] M esyl

(A) S > R > P > Q (B) P > S > R > Q

(C) R > Q > S > P (D) R > S > Q > P

ANS.B


Asser t ion (a) : Quaternary am m onium phase t ransfer cata lysts can enh ance the rat e of

nucleophi l ic a liphat ic subst i t u t ion react ions in b iphasic system s w i th w ater so luble n ucleophi les.

Reason ( r ) : Quaternary am m onium comp ound s are h ighly polar , posi t ive ly charged w ater

soluble comp ound s.

(A) Both (a) and ( r ) are t rue bu t ( r ) is not the correct reason fo r (a)

(B) Both (a) and (r) are tru e and (r) is th e correct r eason fo r (a)

(C) (a) is tr ue (r) is false

(D) Bot h (a) and (r) are false

AN S. B

Q.115 Wh ich on e of t he g iven com poun ds can be used as pr im ary standard f or s tandardizat ion

of p erchlor ic acid so lut ion in non -aqueous t i t ra t ions?

(A) Potassium hydr ogen pht halate (B) Sodiu m b icarbonat e

(C) Potassium dihydrogen p hosphate (D) Sodium m etho xide

ANS.A

Q.116 In cont ext of comp lexom etry (com plexomet r ic t i t ra t ions), the tw o term s labi le and iner t

comp lexes, are used f requent ly . Choose the correct s tatem ent abou t t hem ?

(A) Labi le com plexes are form ed instant ly w hi le iner t com plexes take hou rs or days in t heir

fo rmat ion

(B) Labi le comp lexes take m uch longer t ime in fo rm at ion t han iner t com plexes

(C) Labi le com plexes get hydro lyzed in w ater im m ediate ly w hi le iner t comp lexes are stable in

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wate r

(D) Labi le com plexes get decom posed on m i ld heat ing in aqueo us solut ion s whi le iner t

comp lexes do not decomp oseANS.C

Q.117 Indicators used in com plexom etr ic t i t rat io ns are chelat ing agents. Choo se the correct

sta tement about them ?

(A) Indicator-met a l ion comp lex should have h igher stabi l i ty t han EDTA-M etal ion com plex

(B) Indicator-m eta l ion com plex should have low er stabi li ty t han EDTA-M etal ion com plex

(C) Indicato r-m etal ion com plex shou ld have equal stabi l i t y as EDTA-M etal ion com plex

(D) Stabi l i ty of the ind icator-m eta l ion complex is not an im por t ant cr i ter ion in complexom etr ic

t i t ra t ions

ANS.B

Q.118 In co lor im etr ic est im at ion o f a dru g, the fo l low ing sequence of react ions is carr ied ou t :

t rea tment o f t he aqueous so lu t ion o f the d rug w i th sod ium n i t r i te so lu t ion in ac id ic med ium

fol low ed by addi t ion o f su lpham ic acid and then t reatm ent w i th N-( l -naphth yl)ethylene-

d iamine in s l ight ly basic medium to obt a in a p ink colour ; w hich is m easured at a f ixed

w avelength to corre late the quant i ty of the drug w i th th e opt ica l density . Ident i fy th e drug

under est imat ion?

(A) Strept om ycin sulphate (B) Thiam ine hydr ochlor ide

(C) Dexamet hasone (D) Sulph am eth oxazole

ANS.D

Q.119 Name t he com poun d used for standardizat ion of Kar l -Fisher reagent in aquam etry?

(A) Sodium tar t r ate d ihydrat e (B) Copper su lphate p entahydrate

(C) Sodiu m iodid e (D) Sodiu m th iosulphat e

ANS.A

Q.120 In the e lectro chemical ser ies, the standard reduct ion pot ent ia ls of copper and zinc are +

0.337 V and - 0.763 V, respect ive ly. I f the hal f ce l ls of b ot h of these met a ls are connected

external ly to each ot her th rough an external c ircu i t and a sal t br idge, w hich one of t he fo l low ing

pro cesses w il l take place?

(A) Zinc met a l e lectrode w i l l star t d issolv ing in solut ion w hi le copper ions wi l l star t deposi t ing

on th e copper e lectrode.

(B) Copper m eta l e lectro de w i l l star t d issolv ing in so lut ion w hi le zinc ions wi l l s tar t d eposit ing

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on t he z inc e lectro de

(C) Both of the m eta l e lectro des wi l l star t d issolv ing in the solut ion

(D) Both t ypes of ions wi l l s tar t depo si t ing on their r espect ive e lectro desAN S.A

Q.121 In polarograph y. DM E has a num ber of advan tages. One of t he advant ages is th at

m ercury has large hydrogen overpot ent ia l . I t m eans w hich one of t he fo l low ings?

(A) Hydrogen ions get easi ly reduced on t he DM E

(B) Hydro gen gas gets easi ly reduced o n t he DM E

(C) Hydrogen ions require h igh pot ent ia l to be reduced at DM E

(D) W ater is d if f icu l t to get ox id ized at DM E

ANS.A

Q.122 Follow ing are the d esirable pro pert ies of t he l iquid phase used in GLC EXCEPT for o ne of

the fo l lowings. Ident i fy that .

(A) I t should b e iner t t o th e analytes

(B) I t should have h igh v iscosity at op erat ing tem perature

(C) It should have low vapour pressure at t he operat ing tem perature

(D) I t should h ave a high resolving pow er

ANS.B

Q.123 In HPLC analysis w hat t ype of co lumn w ould you prefer?

(A) A column w i th h igh HETP and h igh num ber of p lates

(B) A column w i th low HETP and low n um ber of p lates

(C) A colum n w i th h igh HETP and low num ber of p lates

(D) A column w i th low HETP and h igh num ber of p lates

ANS.D

Q.124 To synthesize sulph onyl ur ea antidiabet ics, which of t he fol lo w ing reactions can be used?

(A) Reacting a suitably substi t ut ed sulph on yl chlor ide w ith a desired urea derivat ive und er basic

condi t ions

(B) Reacting a suitably substi t ut ed sulphon am ide w ith a desired isocyanate der ivat ive

(C) Reacting a suit ably substi t ut ed sulpho nic acid w ith a desired isocyanate d erivat ive

(D) Reacting a suitably substi t ut ed sulphoxide w ith a desired urea derivat ive

ANS.B

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Q.125 In an op t ica lly act ive organic com poun d a chira l carbon h as the fo l low ing at tached

groups:

[R] -CH = CH2 [S] -C=C

Using 'Sequence Rules' choose the correct ord er of pr ior i ty of t he groups?

(A) Q > P > S > R (B) P > Q > R > S

( C ) Q > P > R > S ( D ) P > Q > S > R

ANS.A

Q.126 The fo l low ing statem ents are g iven:

[P] Confo rm at ional isom ers are in terconver t ib le by rot at ion around a single bond w hi le

conf igurat ional isom ers cannot be in terconver ted w i thou t breaking a bond .

[Q] Conf igurat ional isom ers could b e opt ical ly act ive or opt ical ly inact ive w hi le conform at ional

isom ers are opt ically inact ive

[R] Geomet r ic isom ers m ust have a doub le bond in t heir st ru ctures

[S] Geom etr ic and o pt ica l isom ers are t he t w o d ist inct categor ies of conf igurat ional isom ers.

Choose the correct comb inat ion of s tatem ents.

(A) P, Q & S are t ru e w hile R is false (B) P, R & S are t ru e w hile Q is false

(C) Q, R & S are t ru e w hile P is false (D) P, Q & R are t ru e w hile S is false

ANS.B

Q.127 A carbocat ion w i l l NOT show one of the f o l low ing proper t ies. Choose that .

(A) Accept an electr on t o give a carbene

(B) El iminate a pro ton to af ford an a lkene

(C) Com bine w ith a negative ion

(D) Abstract a hydr ide ion to form an a lkane

ANS.A

Q.128 Determine the correctness or oth erw ise of the fo l low ing Asser t ion (a) and th e Reason ( r ) :

Asser t ion (a) : Form aldehyde and benzaldehyde b ot h un dergo Cannizaro react ion w hi le

acetaldehyd e and phen yacetaldehyd e under go Aldol conden satio n. Reason (r) : Aldehydes can

undergo b oth Cannizaro as wel l as Aldol condensat ion w hi le ketones

und ergo only Cannizaro reactio n.

(A) Both (a) and (r) are false (B) (a) is tr ue b ut (r) is false

(C) (a) is false bu t (r) is true (D) Bot h (a) and (r) are tr ue

ANS.B

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Q.129 Choo se th e FALSE statem ent for E2 m echanism in el im inatio n reaction s?

(A) These reactions are accom panied by rearran geme nt s(B) These reaction s show a large hydr ogen isoto pe effect .

(C) These reactions show a large element effect

(D) These reactions are not accom panied by h ydro gen exchange

ANS.A

Q.130 Choose the correct s tatem ent for w r i t ing the sequence of am ino acids in a polypept ide?

(A) Am ino term inal is to be w r i t t en on th e le f t hand side wh i le the carboxyl terminal is to be

w r i t ten on the r igh t hand side

(B) Carboxyl term inal is to be w r i t t en on t he le f t hand s ide whi le th e amino t erm inal is to b e

w r i t ten on the r igh t hand side

(C) Any of the am ino acid term inals can be w r i t t en on any sides but i t is to b e men t ioned b y

speci fy ing the am ino term inal and t he carboxyl term inal in abbreviat ions

(D) I t var ies f rom autho r to author how the sequence of amino acids in a polypept ide is to be

wr i t t en

ANS.A

Q.131 BETA-Carbolin e r in g system is present in

(A) Em etin e (B) Ribof lavine

(C) Deserpidine (D) d-Tubo curarine

ANS.C

Q.132 Wh ich one of the f o l low ings is NOT a b io isoster ic pair?

(A) Divalent eth er (-0-) and am ine (-NH) (B) Hydro xyl (-OH) and t hiol (-SH)

(C) Carb oxylat e (C02-) and sulf on e (S02) (D) Hydro gen (-H) and flu or ine (-F)

ANS.A

Q.133 Of the f our stereoisomers of ch loram phenicol w hich one is the b io logical ly act ive

isomer?

(A) L-Eryt hr o (B) L-Threo (C) D-Eryt h ro (D) D-Thre o

ANS.D

Q.134 The cata lyt ic t r iad in acety lchol inesterase is com posed of w hich of t he fo l low ing amino

acid residues?

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(A) Serine, Hist idine and Glutam ate (B) Serine, Arginine and Glutam ate

(C) Threo nine, Hist id ine and Aspartat e (D) Threonin e, Arginine and Glut am ate

ANS.A

Q.135 Fajan 's meth od o f t i t r im etr ic analysis involves detect ion o f th e end po int o n t he basis of

w hich one the fo l low ings?

(A) Colou r change (B) Appearan ce of a precipit ate

(C) Neutr a l izat ion r eact ion (D) Adsorpt ion phenom enon

ANS.B

Q.136 W hich of the fo l low ing statem ents is t ru e?

(A) Aliphat ic prot ons have chem ical shif ts > 7 ppm

(B) Spin quant um num ber of pro ton is 1

(C) Chem ical shif t describes electro nic environm ent o f a pro to n

(D) Vicinal couplin g constant is alw ays higher t han gem inal coupling constant

ANS.C

Q.137 ' In FT-IR instrum ent s M ichaelson int erfero m eter is used in place of grat ing. The fun ction

of th e in ter ferom eter is to act as a modu lator ' . What do you u nderstand by th is statem ent?

(A) The funct ion o f the in t er ferom eter is to act as a mon ochrom ator

(B) The funct ion of t he in ter ferom eter is to conver t h igh f requency radiat ions in to low ones

(C) The funct ion of t he in ter fero m eter is to conver t low f requency radiat ions in to h igh ones

(D) The funct ion of t he in ter ferom eter is to conver t f req uency domain spectra in to t im e dom ain

spectra

ANS.A

Q.138 Polyam ine polystyren e resins belong to w hich category of ion -exchange resins?

(A) Str ongly Acidic Catio n Exchange Resins

(B) St ro ngly Basic Anio n Exchange Resins

(C) W eakly Acid ic Catio n Exchan ge Resins

(D) W eakly Basic Anio n Exchan ge Resins

ANS.D

Q.139 Discrepancies in pot ent ial measurem ent s involvin g facto rs like 'alkaline erro r ' and

'asymm etry pot ent ia l ' are associated w i th w hich of the fo l low ing e lectrodes9

(A) Hydrogen e lectrode (B) Quinhydron e e lectro de

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(C) Satu rated calomel electro de (D) Glass Electro de

ANS.A

Q.140 Which amo ngst t he fo l low ing auxochrom es prod uces a shi f t t ow ards h igher energy w ave

length?

(A) -CH3 (B) -NH CH3 (C) -CI (D) -C=0

AN S. B

Q.141 W hat is the w avenumber equ iva len t o f 400 nm w avelength?

(A) 0.0025 cm-1 (B) 0.25 cm-1 (C) 2500 cm -1 (D) 25000 cm -1

ANS.D

Q.142 Chlor ofo rm is stored in d ark colored bo tt les because it is oxidized in presence of l ight and

air to a tox ic comp ound. Ident i fy that .

(A) CH2 C12 (B) COCl2 (C) CO (D) CC14

ANS.B

Q.143 Al l o f the g iven compo unds show n > a* t ransi t ion. Ident i fy wh ich one wi l l have the

highest Am ax?

(A) M ethano l (B) M ethy lam ine

(C) M ethyl iod ide (D) M ethyl brom ide

ANS.D

Q.144 Given are the four statem ents about NM R:

[P] 13CM R is a less sensit ive t echniqu e th an PM R

[Q] Both 13C and :H have I=1/ 2

[R] Precessional f requency of the nucleus is d i rect ly pr opor t ional to the appl ied m agnet ic f ie ld

[S] Deuter ium exchange stud ies can be per form ed t o ascer ta in pro ton s at t ached t o

he te roa toms.

Choose the correct comb inat ion of s tatem ents.

(A) P, Q & R are t ru e w hile S is false (B) R, S & Q are t ru e w hile P is false

(C) S, P & Q are t rue w hile R is false (D) All are t rue

ANS.D

Q.145 Which of t he fo l low ing statem ents is W RONG?

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(A) The energy- required for rem oving an e lectron f ro m a molecule var ies in the g iven order :

lone pair < conjugated n < non conjugated n < a

(B) Isoto pic rat io is par t icu lar ly usefu l for the detect ion and est imat ion of n um ber of S, CI and Bra toms in the compound in M S

(C) Neutra l f ragm ents and m olecules do not get detected in the det ector in M S

(D) The mo st in tense peak in the M S is cal led the m olecular ion peak

ANS.D

Q.146 Wh ich on e is an example o f a bulk p roper t y detector used in HPLC?

(A) Fluor escence detecto r (B) Photo d iode array det ector

(C) Refract ive ind ex detect or (D) UV detect or

AN S. C

Q.147 The prot ons or tho t o the n i t r o group in p-n i t roto luene are examp les of w hich one of the

fo l low ing types9

(A) Chem ical ly equivalent but m agnet ica l ly non-equivalent pr oto ns

(B) Chem ical ly and m agnet ica lly equivalent prot ons

(C) Chem ical ly and m agnet ica lly no nequivalent p rot ons

(D) Chem ical ly nonequivalent bu t m agnet ica lly equivalent prot ons

ANS.A

Q.148 A 250 ug/m l so lut ion of a dru g gave an absorbance of 0.500 at 250 nm at a path length of

10 m m . What is the specif ic absorbance of t he drug at 250 nm 9

(A) 0.002 cm -1 gm-1 l i t r e (B) 0.002 cm -1 gm-1 dl (C) 20 cm-1 gm -1 l i t re

(D) 20 cm-1 gm -1 d l

Ans.D

Q.149 The peak at m / z 91 in t he m ass spectrum for a lky lbenzenes is due t o w hich one of t he

fo l lowings?

(A) Alpha f ission

(C) Retr o Diels-Alder rearrangem ent

(B) M c-Laf far tey rearrangem ent

(D) Tropyl ium ion form at ion

AN S. D

Q.150 Follow ing stat em ent s are given for a chem ical reaction : Change in Gibb's free ener gy of

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th e reaction h as a negative value. Change in Ent halpy of t he reactio n has a negative value

Change in Ent rop y of th e reaction has a posit ive value Based on th e above stat em ent s choo se

the correct answ er.(A) The reactio n is spon taneo us.

(B) The reaction is non-spont aneou s.

(C) The react ion could e i ther be spont aneous or non -spont aneous.

(D) The reactio n can never be spon tan eous.

ANS.A

6 gpat 2011 ans

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