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57121745 liposome drug delivery system

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LIPOSOMAL DRUG DELIVERY SYSTEM LIPOSOMAL DRUG DELIVERY SYSTEM Visit Visit www.bpharmstuf.com www.bpharmstuf.com For more For more ppt’s ppt’s

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  • LIPOSOMAL DRUG DELIVERY SYSTEMVisit www.bpharmstuf.com For more ppts

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  • LIPOSOMES*www.bpharmstuf.com

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  • ADVANTAGES 1) Effective encapsulation of both small and large molecules with a wide range of hydrophobicity levels and Pk.

    2) Prolonging and targeting release of therapeutic agents by modification of liposome surface

    3) Minimizing clinical drug dose and reducing toxicity effects

    4 Increased stability via encapsulation

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  • Phospholipids*www.bpharmstuf.com

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  • Classification of liposomes

    Structural parameters: Multi lamellar vesicles. Oligo lamellar vesicles. Unilamellar vesicles. Small unilamellar vesicles. Large uni lamellar vesicles. Multi vesicular vesicles.

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  • METHOD OF PREPARATION:

    Single or oligo lamellar vesicles by REV.Multi lamellar vesicles by REV.Vesicles prepared by extrusion method.Dehydration method.

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  • BASED ON COMPOSITION AND APPLICATION:

    Conventional liposomes

    Fusogenic liposomes.

    Long circulatory liposomes Ph sensitive liposomes.

    Cationic liposomes.

    Immuno liposome . *www.bpharmstuf.com

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  • CLASSIFICATION METHOD OF LIPOSOMS PREPARATION

    Passive loading active loading

    mechanical dispersion method solvent dispersion method detergent removal method*www.bpharmstuf.com

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  • Mechanical dispersion methods

    lipid film hydration by hand shaking, non handshaking method. micro emulsification. french pressure. membrane extrusion. dried reconstituted. freeze-thawed.

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  • DETERGENT REMOVAL METHOD:

    Detergent removal from mixed micelles.Dialysis.Column chromatography.Dilution.*www.bpharmstuf.com

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  • Solvent dispersion methods:

    Ethanol injection. Ether injection. Double emulsion. Reverse phase evaporation.

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  • MATERIALS USED FOR PREPARATION OF LIPOSOME1.Natural phospholipids2.Synthetic phospholipids3. Sphingolipids4. Glycosphingolipids5.Steroid6. Polymeric material

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  • Thin film hydration using hand shaking &non shaking method

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  • French pressure cell*www.bpharmstuf.com

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  • Sonication method*www.bpharmstuf.com

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  • Membrane extrusion method*www.bpharmstuf.com

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  • Freeze taw liposomes & dried reconstituted vesicles*www.bpharmstuf.com

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  • Ethanol &ether injection method*www.bpharmstuf.com

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  • Reverse phase evaporation vesicles*www.bpharmstuf.com

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  • ACTIVE LOADING TECHNIQUE*www.bpharmstuf.com

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  • DETERGENT REMOVAL MEHODSSTAGE:1At low concentrations Detergent Lipid vesicular Lipid Water

    STAGE:2Size of vesiclesCritical detergent concentrationsMembrane structure is unstableTransforms gradually into micellesSTAGE:3 All Lipids exists in mixed micelle Form*www.bpharmstuf.com

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  • DIALYSISDetergents High CMCRemoval is facilitatedEgg Pc + Sodium cholatedialysisFormation of vesicles*www.bpharmstuf.com

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  • Stealth LiposomesMajor problem in use of liposomes for delivery of drug by injection in to blood stream is the specific uptake of the liposome by reticuloendothelial system . avoid the uptake by the RES are called stealth liposomes.*www.bpharmstuf.com

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  • CHACTERIZATION OF LIPOSOMES Internal volume.Encapsulation efficiency.Lamellarisity.Size & size distribution..Phase behaviour of liposomes

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  • Therapeutic applicationLiposome as drug/protein delivery vehicles.Liposomes in anti microbial ,anti fungal anti viral therapy.Liposome in tumour therapy.Liposomes in gene delivery.Liposomes in immunology.Liposomes as radiopharmaceutical and radiodiagnostic carriers.Liposoms in cosmetics and dermatology.Liposomes in bioreactor technology.

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  • REFERENSES REFERNCES:Alpes H., Allmann K., Plattner H., Reichert J., Rick R. and Schulz S. (1986). Biochim.Biophys. Acta. 862: 294.Bangham A.D., Standish M.M. and Watlins J.C. (1965). J. Mol. Biol. 13: 238.Bangham A.D., Hill M.W. and Miller N.G.A. (1974). In: Methods in Membrane Biology(Koln N.D., ed.) Plenum. N.Y., Vol.1, p.l.Batzri S. and Korn E.D. (1973). Biochim. Biophy. Acta. 298: 1015.Cestaro B., Pistolesi E., Hershkowitz N. and Galt S. (1982). Biochim. Biophys. Acta. 685:Cullis R.P., Hope M.J., Bally M.B., Madden T.D. and Janoff AS. (1987). In: Liposomes from Biophysics to Therapeutics (Ostro M. J., Ed.) Marcel Dekker, N.Y., Chapter Deamer D. and Bangham A.D. (1976). Biochim. Biophys. Acta. 443: 629.Enoch H.G. and Strittmatter P. (1979). Proc. Natl. Acad. Sci. USA. 76: 145.Fiona J., James A., Hayward A. and Chapman D. (1987). Biochim. Biophys. Acta.341.Friese J. (1984). In: Liposome Technology (Gregoriadis G., ed.) CRC Press, Florida,

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