inflammation cytokine Nitric oxide COX (NSAID)

1

2 ( )self, nonself autoimmune diseasesallergy

cyclosporine, azathiopurine, cyclophosphamidecorticosteroids and methotrexate, NSAIDs

3 - Inflammation

(inflammation) 5 (redness), (heat), (swelling), (pain), (loss of function) cytokines, nitric oxide, prostaglandin, lysosomal enzyme, free radicals Inflammatory stimultipro-inflammatory cytokine NOS, COX NO, PG

4

5Anti-inflammatory Therapeutic TargetsCytokine Nitric oxide Cyclooxygenase (NSAID)

6Target 1. Inflammatory signal pathway

7Target 2. Inflammatory Cytokines

8Target 3. Inflammation & Nitric oxide

Nitric oxide (NO) vascular tone neurotransmissionimmune cytotoxicity

NOS (nitric oxide synthase)eNOSnNOSiNOS

9Target 4. Inflammation & NSAID

10

Cyclooxygenase (COX)COX-1COX-2prostaglandins (PGs) PGE2NSAIDs (Non-steroidal anti-inflammatory drugs)Selective COX-2 inhibitorCelecoxibRofecoxib

Target 4. Inflammation & NSAID

11 , , ,

12 , , , , , , , , , , , , , , , , , , , , , , , , , , , ()

13BBRC 338:1920~1927. 2005NF-B saikosaponin T

14Cancer Letters 145:151~157. 1999 iNOS

15Journal of Ethnopharmacology 111:667~670. 2007 COX-2

16Clinica Chimica Acta 330:165~171. 2003

17Immunobiology 211:359~368. 2006 baicalein baicalin

18Immunobiology 211:359~368. 2006 baicalein baicalin

19Immunobiology 211:359~368. 2006 baicalein baicalin

20Kor. J. Pharmacogn. 36(2):116~120. 2005 paeonol methylpaeonol

21Mitochondrion 7 :101~105. 2007 Tanshinone IIA

22

Journal of Ethnopharmacology 114:425~431. 2007

23

Journal of Ethnopharmacology 107:59~66. 2006

*immune system.pdf - * *NF-B is inactive without stimulation. It is activated byextracellular signals such as TNF- (Isral et al., 1989;Osborn et al., 1989), IL-1, LPS, UV, and phorbol esters