IV Trans[us. Sci. Vol. 17, No. 4

5523302

AROMATIC COMPOUNDS CONTAINING BASIC AND ACIDIC

TERMINI USEFUL AS FIBRINOGEN RECEPTOR

ANTAGONISTS

Cain Gary A; Eyermann Charles J; Wilmington, DE, UNITED STATES assigned to The Du Pont Merck Pharmaceutical Company

This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

5523322

METHOD FOR INHIBITING BLOOD-PLATELET

AGGREGRATION WITH BETA-NAPHTHOQUINONE

COMPOUNDS

Blache Denis; Bloy Christian; Hercelin Bemard; Chevigny Saint Sauveur, FRANCE assigned to Roussel UCLAF

A method of inhibiting blood-platelet aggregation in warm-blooded animals comprising administering to warm-blooded animals a blood-platelet aggregation inhibiting effective amount of a compound selected from the group consisting of a compound of the formula (*See Patent for Chemical Structure*) I wherein R is selected from the group consisting of -NH-CO-NH2, -NH-CO-CH3, -OH and their non-toxic, pharmaceutically acceptable acid addition salts.

5529691

ENHANCED YIELD PLATELET COLLECTION SYSTEMS AND

METHOD

Brown Richard 1; Northbrook, IL, UNITED STATES assigned to Baxter International lnc

plasma and platelets from whole blood rotate a chamber about an axis to create within the chamber a low-G zone radially close to the axis and a high-G zone spaced radially further from the axis than the low-G zone. The systems and methods introduce whole blood into an inlet region of the chamber to initiate separation of red blood cells toward the high-G zone of the inlet region. This creates a strong flow of plasma that moves radially toward the low-G zone of the inlet region and elutes platelets into suspension with it. The systems and methods direct the radial flow of plasma and eluted platelets within the inlet region to a port in the inlet region for transport out of the chamber. The systems and methods also drag the interface into this radial plasma flow, duting even the largest of platelets into suspension for collection.

5529821

CONTAINER FOR STORING BLOOD OR BLOOD COMPONENT

lshikawa Kenji; Kora Shinichi; Yokoo Yoshihiro; Mochizuki Akira; Shinonome Osami; Isehara, JAPAN assigned to Terumo Kabushiki Kaisha

There is a disclosure of a method and a container for storing a blood or blood component, including a sheet material having a plurality of layers and wherein the layers are adhered to each other, at least a portion of the layer which contacts blood or blood components is composed of a block copolymer having a micro-phase separating structure. In accordance with the present invention, there is provided a container which has excellent properties in relation to the storage of platelet, gas permeability and mechanical strength. Also, there is a disclosure of a method and a tube for transfusing blood or a blood component, including a tube material having a plurality of the same layers as the above.

5529902

DIRECT FLUORESCENCE-CONJUGATED IMMUNOASSAY FOR PLATELET

ACTIVATION

Kottke Bruce A; Wen Deyong; Lakeland, FL, UNITED STATES assigned to Mayo Foundation for Medical Education and Research

A method is provided to measure the extent of Systems and methods for separating a suspension of platelet activation by fluorometrically determining