5292636 therapeutic and diagnostic methods using soluble t cell surface molecules
TRANSCRIPT
Cell Transplantation, Vol. 4, No. 4, pp. VII-X, 1995
Pergamon Copyright 0 1995 Elsevier Science Ltd Printed in the USA. All rights reserved
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NEW PATENTS
This section contains abstracts and, where appropriate, illustrations of recently issued United States patents and published patent application filed from over 30 countries under the Patent Cooperation Treaty. This information was obtained from recent additions to the PATSEARCH% online database in accordance with interest profiles developed by the Editors.
5292252
STIMULATOR HEALING CAP
Bruce L Nickerson, Chad J Patterson, Richard A Smolowitz assigned to Impla-Med Inc
A stimulator healing cap is disclosed for en- hancing and speeding the growth of bone cells and bone tissue surrounding a dental implant. The stimulator healing cap includes a threaded portion which is engagable with an interior threaded portion of the implant and a top por- tion containing a current source. In one embodi- ment; the top portion and the threaded portion are conductive and are connected by a middle in- sulated portion; the threaded portion being coupled to one pole of the current source and the top portion being coupled to the other pole of the current source. In another embodiment, the cur- rent source is coupled to a coil wound around a longitudinal core inside the threaded portion. The healing cap provides a current path or elec- tromagnetic field in the vicinity of bone tissue surrounding the implant which stimulates the growth of the bone tissue and speeds up the primary healing phase after the implant is sur- gically inserted.
soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis, staging, and therapy of diseases and disorders. Specific embodiments involve the diagnosis and monitoring of therapy using absolute values of such soluble molecules. Further embodiments involve detecting a change in the levels of such soluble molecules, in the diagnosis and therapy of diseases and disorders. In specific embodi- ments, measurements of interleukin-2 receptor levels can be made to detect lung cancer, or to stage squamous cell lung carcinoma. In other embodiments, detection of increases in both soluble IL2R and creatinine in the body fluid of a transplant patient can be used to differentially diagnose renal allograft rejection from infection. The invention is also directed to methods for measurement of soluble CD4 antigens, which measurements can be used, in a specific embodi- ment, to diagnose a state of immune activation, to diagnose rheumatoid arthritis, to monitor therapeutic efficacy (e.g. of AIDS treatments), or to stage adult T cell leukemia in a patient. In another aspect, the invention relates to the detec- tion, staging, and monitoring of therapy of dis- eases and disorders by measuring a plurality of soluble T cell markers.
5292636 5294446
THERAPEUTIC AND DIAGNOSTIC METHODS USING
SOLUBLE T CELL SURFACE MOLECULES
Patrick C Kung, Stephen Ip, Michael C Brown, Linda A MacKeen assigned to T Cell Dia- gnostics Inc
COMPOSITION AND METHOD OF PROMOTING HARD TISSUE
HEALING
Herman W Schlameus, William C Fox, Donald Mangold, Robert G Triplett, George Holt, Thomas B Aufdemorte assigned to Southwest Research Institute
The present invention is directed to the measure- Osteoprogenifor cells encapsulated in alginate ment of soluble T cell growth factor receptors, and alternatively, additionally encapsulated in
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