5/24/2015 management of the acute diabetic developed by: institute for emergency medical education
TRANSCRIPT
![Page 1: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/1.jpg)
04/18/23
Management of the Acute DiabeticManagement of the Acute Diabetic
Developed by:
Institute for Emergency Medical Education
![Page 2: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/2.jpg)
04/18/23
Purpose:Purpose:
To enhance the EMT's understanding of the normal physiology as it applies to transportation and utilization of glucose, and how it fits into the Krebs' Cycle
Improve the EMT's understanding of the pathophysiology of Diabetes and how to appropriately mange an acute Diabetic state
To enhance the EMT’s understanding of electronic glucose monitoring
![Page 3: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/3.jpg)
04/18/23
Learning Objectives:Learning Objectives:
Student will have a basic understanding of the normal functioning transport system for glucose and how it is utilized by the body and will have a working knowledge of the Pancreas and the Krebs' Cycle.
Students will understand the Pathophysiology of the Diabetic disease process
![Page 4: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/4.jpg)
04/18/23
Learning Objectives:Learning Objectives:
Students will be able to identify the Acute Hyperglycemic (DKA) patient and appropriately treat him/her to the EMT's level of training, utilizing both clinical judgment and blood glucose testing devices
![Page 5: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/5.jpg)
04/18/23
Learning Objectives:Learning Objectives:
Students will be able to identify the Acute Hypoglycemic patient and treat appropriately to the level of the EMT's training, utilizing both clinical judgment and blood glucose testing devices.
The Basic EMT will know how to operate an electronic glucose monitor
![Page 6: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/6.jpg)
04/18/23
Overview Overview
A & P as it pertains to Diabetes and Glucose metabolism
Pathophysiology of Diabetes as it relates to Hyperglycemia and Hypoglycemia
Assessment and management of Diabetic Emergencies
Glucose measurement
![Page 7: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/7.jpg)
04/18/23
Anatomy and Physiology: Anatomy and Physiology: DiabetesDiabetes Pancreas
– Located in the abdomen attached to the intestines but behind the stomach
– Responsible for the Production of the hormone Insulin
![Page 8: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/8.jpg)
04/18/23
Hormone: InsulinHormone: Insulin Secretion by the Pancreas from the Beta Cells on
the Islets of Langerhan It is required by for the intracellular metabolism
of glucose Its release is primarily stimulated by glucose
levels Other stimulus for the its release include
– Amino Acids– Fatty Acids– Ketones
![Page 9: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/9.jpg)
04/18/23
How is Insulin used in Liver How is Insulin used in Liver cells?cells? Glucose enters Liver cells Insulin is needed to activate the hormone
Glucokinase– Glucokinase Promotes phosphorylation of
glucose – First step in glucose metabolism
Activates the hormone Glycogen Synthetase– Necessary for glycogen formation
![Page 10: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/10.jpg)
04/18/23
What is Glycogen?What is Glycogen?
It is stored sugar We use it as a reserve energy supply We only store sugar when insulin is
present– Insulin doesn’t do the work Glycogen
Synthetase does– But insulin must start the process off
![Page 11: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/11.jpg)
04/18/23
How does Insulin used in Muscle How does Insulin used in Muscle cells?cells? Resting muscle
– Insulin is needed to transport glucose across the cell membrane
– Insulin increases glycogen synthetase– Insulin inactivates the enzyme Phosphurylase– Insulin's presence facilitates Amino acid
uptake and protein synthesis while preventing protein catabolism
![Page 12: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/12.jpg)
04/18/23
How does Insulin used in Muscle How does Insulin used in Muscle cells?cells? Active muscle
– Glucose can enter without insulin– Glucose is oxidized to CO2 and H2O for
energy production
![Page 13: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/13.jpg)
04/18/23
How does Insulin used in How does Insulin used in Adipose tissue?Adipose tissue? Insulin is necessary for transport of
glucose across cellular membrane Promotion of glucose metabolism, fatty
acid synthesis Insulin will combine with fatty acids
produced in the liver and in fat cells to form Triglycerides
Insulin presence decreases Lipolysis
![Page 14: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/14.jpg)
04/18/23
Lets watch a Movie…..Lets watch a Movie…..
KREB Cycle Video
![Page 15: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/15.jpg)
04/18/23
General Pathophysiology of General Pathophysiology of Diabetes MellitusDiabetes Mellitus This condition is caused by either
– Absolute or relative lack of Insulin – Or ineffective utilization of Insulin
In Insulin Dependent– Absolute lack of Insulin
In Noninsulin Dependent– Normal or near normal levels of Insulin
![Page 16: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/16.jpg)
04/18/23
When Insulin levels are normal When Insulin levels are normal
It is usually ineffective utilization of Insulin – Caused by a decrease number of Insulin
Receptor Cells Or Impaired Binding of Insulin to body
cell– Caused by a receptor defect
![Page 17: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/17.jpg)
04/18/23
Problems associated with Problems associated with alterations in metabolismalterations in metabolism The are seen when there is a lack,
deficiency or under utilization of Insulin These problems are
– Hyperglycemia– Hypoglycemia– Diabetic Ketoacidosis– Nonketonic Hyperosmolar Coma
![Page 18: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/18.jpg)
04/18/23
HyperglycemiaHyperglycemia Caused by several factors Over production of glucose due to an increase
in – Glucogenesis
The formation of glycogen from noncarbohydrate sources such as Amino Acids or Fatty Acid
– Glycogenolysis Hydrolysis of glycogen into glucose
– And a decrease in peripheral utilization of glucose
![Page 19: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/19.jpg)
04/18/23
HyperglycemiaHyperglycemia
Caused by Protein Catabolism and loss of Amino Acids from muscle.
Caused by impaired Triglycerides Synthesis– Which increases the release of Free Fatty
Acids from Adipose Tissue which increases Beta Oxidation of Fats
![Page 20: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/20.jpg)
04/18/23
Diabetic Ketoacidosis (DKA)Diabetic Ketoacidosis (DKA) Most frequently seen in IDDM (Insulin
Dependent Diabetes Mellitus) Caused by Acute Insulin Insufficiency and is
usually precipitated in the known Diabetic by stressors that increase Insulin needs
When there is insufficient Insulin for appropriate metabolism of glucose, fats, proteins
This causes inappropriate utilization of glucose, resulting in Hyperglycemia
![Page 21: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/21.jpg)
04/18/23
What does this mean to us?What does this mean to us?
Hyperglycemia increases dehydration and Lactic Acid build up
Hyperglycemia causes Acidosis Acidosis results in hypoxia and coma
![Page 22: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/22.jpg)
04/18/23
Who will we see like this?Who will we see like this?
New onset (undiagnosed) Diabetics– Particularly young kids between 7 and 13
years old Noncomplient IDDM patients
![Page 23: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/23.jpg)
04/18/23
Frequent precipitating factors:Frequent precipitating factors:
Infection (serious local or systemic)
Urinary infections Respiratory
infections Major Surgery
Trauma Major illness Therapy with
Steroids Emotional upset or
excessive stress
![Page 24: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/24.jpg)
04/18/23
Signs and Symptoms of Signs and Symptoms of DKA/HyperglycemiaDKA/Hyperglycemia Are usually associated with acidosis and
the bodies compensatory mechanisms Of Gradual onset
– Usually greater than 48 hours
![Page 25: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/25.jpg)
04/18/23
Signs and Symptoms of Signs and Symptoms of DKA/Hyperglycemia by Body SystemsDKA/Hyperglycemia by Body Systems
Respiratory system – Body's trying to remove
acid by elimination of Ketones which causes
– Acetone Breath (fruity)– Kussmaul's Respiration’s
Central Nervous System– Change in mental status– Caused by Dehydration
Acidosis & lack of glucose
GI & GU Systems– Nausea and Vomiting
Caused by acidosis
– Polyuria attempting to remove
ketones Which causes
dehydration
Circulatory System– Hypotension
![Page 26: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/26.jpg)
04/18/23
Other Signs and Symptoms of Other Signs and Symptoms of DKA/HyperglycemiaDKA/Hyperglycemia Loss of skin turgor/dry mucosa
– Dehydration Polydipsia
– Dehydration Polyphasia Warm/dry skin Tachycardia to Normal pulse
![Page 27: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/27.jpg)
04/18/23
HypoglycemiaHypoglycemia
Major complication for patients treated with Insulin and Oral Hypoglycemic agents
Usually caused by too little food or too much Insulin/Oral Hypoglycemic agents
![Page 28: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/28.jpg)
04/18/23
HypoglycemiaHypoglycemia
Alterations in mental status and bizarre behavior are caused by Brain cells being starved for food
The longer the duration of decrease, or no glucose, reaching Brain cells, the greater the chance of/or increasing the amount of damage sustained
![Page 29: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/29.jpg)
04/18/23
Signs and Symptoms of Signs and Symptoms of HypoglycemiaHypoglycemia Quick onset of
symptoms Headache/blurred
vision Diaphoresis/Pallor Tachycardia with
weak pulse/Palpitations
Numbness of lips and tongue
Alteration in mental status or Coma– Emotional changes– Confusion– Irritability/Nervous– Bizarre behavior
Weakness/Fatigue Seizures/Trembling Incoherent speech Hunger
![Page 30: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/30.jpg)
04/18/23
Diabetic Assessment & Diabetic Assessment & ManagementManagement Assessment
– Scene Size Up Scene Safety Body Substance
Isolation
Interventions– Scene Size Up
Make scene safe Retreat from scene Take appropriate BSI
precautions
![Page 31: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/31.jpg)
04/18/23
Diabetic Assessment & Diabetic Assessment & ManagementManagement Assessment
– Initial Assessment Nature of Illness General Impression AVPU Airway Breathing Circulation Baseline Vital Signs
Interventions– Initial Assessment
Open Airway Suction Insert Adjunct Intubation if
necessary Apply High Flow
Oxygen or Ventilate Transportation
![Page 32: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/32.jpg)
04/18/23
Diabetic Assessment & Diabetic Assessment & ManagementManagement Assessment
– Rapid/Focused History & Physical Exam (BLS & ALS)
History of Diabetes Hx of present illness Onset Duration Last Dextrose Stick
by patient
Interventions– Rapid/Focused
History & Physical Exam (BLS & ALS)
Oral Glucose– If able to protect
own airway
– May use household items
Close monitor of airway with suction available
![Page 33: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/33.jpg)
04/18/23
Diabetic Assessment & Diabetic Assessment & ManagementManagement
Assessment– Rapid/Focused History &
Physical Exam (ALS Only)
Obtain current Dextrose level
Obtain Pre I.V. Blood Tubes
Cardiac Monitor Repeat Dextrose 3-5
minutes Post D50W administration
Interventions– Rapid/Focused History &
Physical Exam (ALS Only) Initiate IV access 0.9%
Sodium Chloride Administer Dextrose 50% in
Water if D-Stick is below 100mg/dl
Administer Thiamine 100mg IV or IM
Administer Glucagon IM if no IV access
![Page 34: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/34.jpg)
04/18/23
Note for ALS ProvidersNote for ALS Providers Consult with Medical control for additional Amp(s) of
D50W The Need for additional dosages of D50W is rare but
should be guided by repeated dextrose analysis Post D50W administration
– you can expect a Glycogen Stores release
– This may occur approximately an hour after the D50W which will raise the blood glucose again, but only if there are any glycogen stores left
![Page 35: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/35.jpg)
04/18/23
Diabetic Assessment & Diabetic Assessment & ManagementManagement Assessment
– Detailed Exam Take a full SAMPE
history Look for secondary
problems
– On Going Exam Reassess interventions Revisit Initial &
Focused Assessment Reassess Vital Signs
Interventions– Detailed Exam
Based upon specific Findings
– On Going Exam Additional or new
Therapies may be employed
![Page 36: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/36.jpg)
04/18/23
Electronic Glucose MonitorsElectronic Glucose Monitors
Normal values– 60 - 150 mg/dl
Abnormally low– Below 60 mg/dl
– Less than 20 is very dangerous
Abnormally high– Above 200 mg/dl
Extremely High Above 700 mg/dl
REMEMBER: IT is all Relative to the persons Normal RangeYour patient can show signs of Hypoglycemia with a blood sugarOf 100mg/dl
![Page 37: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/37.jpg)
04/18/23
Long Term Complications of Long Term Complications of DiabetesDiabetes Vascular changes
– Decreased peripheral circulation (Caused by atherosclerosis & arteriosclerosis)
– Thickening of capillary walls– Increase infection potential and severity,
particularly in lower extremities Secondary to decreased circulation
![Page 38: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/38.jpg)
04/18/23
Long Term Complications of Long Term Complications of DiabetesDiabetes Nervous System damage
– Peripheral Degeneration causing tremors Decreased sensory functions
– Spinal Slowed conduction through spinal tracts
– CNS Degeneration of brain tissues causing memory
disturbances Loss of/decrease in fine motor control
![Page 39: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/39.jpg)
04/18/23
Long Term Complications of Long Term Complications of DiabetesDiabetes Cardiovascular
– Coronary Artery Disease– CVA/TIA– MI– Angina
![Page 40: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/40.jpg)
04/18/23
Long Term Complications of Long Term Complications of DiabetesDiabetes Renal
– Changes in structures and function– Lesions– Causing
Hypertension Edema Nephrotic Syndrome
![Page 41: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/41.jpg)
04/18/23
Long Term Complications of Long Term Complications of DiabetesDiabetes Vision changes
– Blindness– Cataracts– Caused by prolonged periods Hyperglycemia– Retinopathy– Lesions/Aneurysms on retinal vessels
![Page 42: 5/24/2015 Management of the Acute Diabetic Developed by: Institute for Emergency Medical Education](https://reader036.vdocuments.mx/reader036/viewer/2022062714/56649d1f5503460f949f39d8/html5/thumbnails/42.jpg)
04/18/23
SummarySummary Diabetes is a disease that effects the bodies ability
to properly use glucose for metabolism The conditions of Diabetes we see are caused by
the body compensatory mechanism when the disease is unchecked
Management of a Diabetic in an acute setting is to stabilize the ABCs and provide sugar
Long term management is designed to prevent peaks and valleys in blood sugar which are the causes of long term diabetic problems