PATENT ABSTRACTS

5175255

M E T H O D S F O R P U R I F I C A T I O N O F P L A T E L E T - D E R I V E D

G R O W T H F A C T O R

Arlen Thomason, Margery A Nicolson assigned to Amgen Inc

Monoclonal antibodies specific for epitopes found on the B chain of PDGF (including v-sis, c-sis and platelet-derived forms) may be bound to columns and used for purification of rPDGF B. A solution containing a polypeptide poss- essing at least part of the structural conforma- tion of rPDGF B is passed over such a column and the rPDGF B is bound to the antibody. The rPDGF B may then be eluted from the column to yield rPDGF B of greater than 95~ purity as determined by SDS-PAGE.

5175257

R A D I O L A B E L E D P R O T E I N S F O R D I A G N O S T I C O R T H E R A P E U T I C

U S E

Sudhaka Kasina, Ananthachari Srinivasan, John M Reno, Linda M Gustavson, Jeffrey N Fitzner, David Jones assigned to NeoRx Cor- poration

Chelating compounds of specified N2S2 N3S derived structure are useful for radiolabeling tar- geting molecules such as antibodies. Cleavable ester orthioester linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved bio- distribution properties, including reduced localization within the intestines and kidneys.

5175385

V I R U S - R E S I S T A N T T R A N S G E N I C M I C E

Thomas E Wagner, Xiao-Zhu Chen assigned to Ohio University/Edison Animal Biotechnolgy Center

A transgenic mouse with enhanced viral resistance transmissible to its offspring is pre- pared by introduction of a gene encoding a human interferon having antiviral activity into a

367

host mouse. The gene encodes the interferon of a different animal species and therefore its expres- sion product is less toxic to the host at an em- bryonic, fetal, neonatal or junvenile stage of development. Preferably, the human beta inter- feron gene is introduced into the cells of a mouse.

5176911

P H A R M A C E U T I C A L C O M P O S I T I O N S C O M P R I S I N G

S E L E C T E D L A C T O B A C I L L U S S T R A I N S

Silvana Tosi, Giancarla Dondi, Vittorio Bot- tazzi, Franco Dellaglio, Lorenzo Morelli, Novara, Italy assigned to Universita Cattolica del Sacro Cuore; Dr A Tosi Farmaceutici S r 1

Topical pharmaceutical compositions, suited for the use in gynecology and urology, comprise as active principles selected Lactobacillus strains isolated from vaginal or urologic habitat of asymptomatic patients.

5177000

M O N O C L O N A L A N T I B O D I E S S E L E C T I V E F O R P R O S T A T E C A N C E R A N D D I A G N O S T I C

I M M U N O A S S A Y F O R P R O S T A T E C A N C E R

Michel Bazinet, Richard Cote, Lloyd J Old as- signed to Sloan Kettering Institute for Cancer Research

Four monoclonal antibodies are found which selectively identify prostate cancer. These mono- clonals are therefore useful in diagnosis and dif- ferential diagnosis of prostate cancer.

5177014

M O N O C L O N A L A N T I B O D I E S T O F E L I N E - T - L Y M P H O T R O P I C

L E N T I V I R U S

Thomas P O'Connor, Quentin Tonelli, Philip Andersen assigned to Idexx Laboratories Inc

Monoclonal antibodies specific for an epitope of an FIV-encoded antigen.