5 - pharmacotherapi of endocrine.ppt

8/11/2019 5 - Pharmacotherapi of Endocrine.ppt

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Pharmacotherapi of Endocrine

dr. R. Setiadji, M.Sc


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The related drugs

Hipolipidemik

Hipoglikemik oral - Insulin

Antiobesit

Antit!roid


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Memilih obat P

$etapkan diagnosis$etapkan diagnosis

$etapkan tujuan pengobatan$etapkan tujuan pengobatan

Susun da%tar obat manjurSusun da%tar obat manjur

&ili! obat manjur berdasar tujuan&ili! obat manjur berdasar tujuan


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(!oose e%ecti)e drug based on

IndicationIndication

Side e%%ectSide e%%ect

A)ailabilit*&osologA)ailabilit*&osolog


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Mengobati Pasien

. $etapkan masala!na

2. $egaskan tujuan terapi

3. &eriksa kecocokan obat &

". $uliskan resepna#. &enjelasan tentang aturan pakai dan

keaspadaan

'. &antau !entikan/ pengobatan


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List of NIDDM Drugs

&arenteral1 Insulin

ral1

Sul%onliurea

4iguanida $!ia5oldinedion

Farmakologi dan Terapi Edisi 4, hal 467-481


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List of Thyroid Drugs

Hormon $iroid

Anti tiroid

Antitiroid

&eng!ambat transport ion odida 7odida

7odium radioakti%


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Pharmacotherapy of Dyslipidemia


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Drug Therapy

HMG Co !eductase Inhibitors "#tatins$

Reduce 898-( 0##: ; $< +3=:

Raise H98-( ##:

Major side e%%ects

Mopat!

Increased li)er en5mes

(ontraindications

Absolute1 li)er disease

Relati)e1 use it! certain drugs


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HMG Co !eductase

Inhibitors "#tatins$

#tatin Dose !ange

8o)astatin 2=0= mg

&ra)astatin 2="= mg

Sim)astatin 2=0= mg

>lu)astatin 2=0= mg

Ator)astatin =0= mg

(eri)astatin =."=.0 mg


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HMG Co !eductase

Inhibitors "#tatins$ "continued$

Demonstrated Therapeutic %enefits

Reduce major coronar e)ents

Reduce (H9 mortalit

Reduce coronar procedures &$(A*(A4


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Drug Therapy

%ile cid #e&uestrants

Major actions

Reduce 898-( #3=:

Raise H98-( 3#:

Ma increase $< Side e%%ects


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%ile cid #e&uestrants

Drug Dose !ange

(!olestramine "' g

(olestipol #2= g

(olese)elam 2.'3.0 g


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%ile cid #e&uestrants "continued$



Reduce (H9 mortalit


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Drug Therapy

Nicotinic cid

Major actions

8oers 898-( #2#:

8oers $< 2=#=: Raises H98-( #3#:

Side e%%ects1 %lus!ing, !perglcemia, !peruricemia,

upper


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Nicotinic cid

Drug 'orm Dose !ange

Immediate release .#3 g

crstalline/

@tended release 2 g

Sustained release 2 g


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Nicotinic cid "continued$


Reduces major coronar e)ents

&ossible reduction in total mortalit


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Drug Therapy

'ibric cids

Major actions

8oer 898-( #2=: it! normal $


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'ibric cids

Drug Dose


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'ibric cids "continued$


Reduce progression o% coronar lesions



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List of antiobesity(

5 - pharmacotherapi of endocrine.ppt

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