4life tf glucoach slides
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http://my4life-transferfactor.com - slides explain the ingredients and functions of TF Glucoach by 4Life Research.TRANSCRIPT
Diabetes and the Pancreas
The New Epidemic
William J. Hennen, PhD
1
Latest update!!(World Health Organization Survey)
Worldwide Diabetic Population
1997 135 million
2025 300 million (est.)
• 1 in 3 people in their 60’s will get diabetes.
Diabetes Mellitus
SingaporeYear % population with diabetes
1975 1.5
1984 4.7
1992 8.6
1998 9.6
Number of people with diabetes is rising.
2
Diabetes Mellitus
MalaysiaYear % population with diabetes1960 0.61982 2.11995 7.71996 8.32004 9.0
Number of people with diabetes is rising.
2
Ethic Differences
In Malaysia and Singapore,
diabetes is most common in:
Indians 16 %
Malays 4.7 %
Chinese limited data
Latest update!!
• Population of diabetics in Singapore is 300,000.
• Accounts for 1 in 10 deaths in Singapore.
Cost $$$$
• Costs depends on how serious the disease is.
• A diabetic person spends $ 1,600/yr on unsubsidized specialist outpatient care in public hospital.
Cost $$$$
• He spends $ 650/yr for subsidized outpatient care at a polyclinic.
• If his kidney fails, he will have to pay $ 12,400 / year for dialysis and diabetic treatment.
• Quality of Life???
Latest update!!• For every two known diabetics, there is
at least one person who is unaware he has the condition.
• Type 2 diabetes is no longer seen as a disease of the middle age or old age.
• 10 Year old children suffering from Type1 & Type 2 diabetes are common
Diabetes Mellitus
• Far reaching effects–Non-traumatic amputations (60%)
–Blindness ( 53 %)
–Kidney disease (40% of all new cases)
–200%-400% increased risk of cardiovascular disease
The New Epidemic
4
Blood Glucose
• Stress
• General health
• Activity
• Consumption of food
Factors
5
Diabetes Mellitus
• Children and adolescents (age <40)
• Frequent drinking, eating, urination
• Autoimmune• Requires insulin
Type I (5-10%)
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Diabetes Mellitus
• Late onset, usually age >40
• Insulin resistance and/or decreased insulin production
• Requires insulin in late stages
• Possible genetic link
• Immune component
Type II (90-95%)
7
Diabetes Mellitus
• Vision (cataracts and glaucoma)
• Kidneys (loss of kidney function)
• Nerves (loss of sensation in hands and feet)
• Heart/Circulation (increased risk of heart attack and stroke, poor circulation)– Leading cause of death among diabetics.
Secondary Conditions
8
Diabetes and Supplements
• Transfer Factor
• Fenugreek
• Bitter melon
• Gymnema
• Indian kino
• Korean ginseng
• Alpha Lipoic Acid
• Chromium
• Vanadium
9
Diabetes and Supplements
• Reduced blood sugar in mice. (Biotherapy. 1996;9(1-3):149-57)
• Type I diabetes has a dominant autoimmune component. (J Clin Invest. 2004 Feb;113(3):451-63.)
– May be initiated through viral infections. (J Immunol. 2004 Mar 1;172(5):3173-80.)
• Increased immune activation and low-grade inflammation in type II diabetes.
(Diabetes Care. 2004 Mar;27(3):813-23.)
– Autoimmune mechanism possible. (Minerva Endocrinol. 2003 Dec;28(4):297-312.)
Transfer Factor - Immunity
10
Diabetes and Supplements
• Stimulates ß-cell activity.
(Am J Physiol 1999 Oct;277(4 pt 1):E617-23.;Diabetes 1998 Feb;47(2):206-10.)
• Synergistic with vanadium: lower dose & improved safety.
(Indian J Exp Biol 1999 Feb;37(2):193-5.;Indian J Exp Biol 1999 Feb;37(2):196-9.)
• Lowers plasma glucose.
(East Mediterr Health J 2000 Jan;6(1):83-8.;Eur J Clin Nutr 1988 Jan;42(1):51-4.)
Fenugreek (Trigonella foenum-graecum)
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Diabetes and Supplements
• Improved glucose utilization in humans; lowering fasting and meal-time levels.
(J Ethnopharmacol 1986 Sep;17(3):277-82.;Bangladesh Med Res Counc Bull 1999 Apr;25(1):11-3.)
• May have insulin-like or insulin-stimulating action.
(Int J Biochem 1989;21(2):149-55.;J Ethnopharmacol 1985 Jul;13(3):313-21.)
• May help repair damaged ß cells. (J Ethnopharmacol 2000 Nov;73(1-2):71-9.; Diabetes Res Clin Pract 1998 Jun;40(3):145-51.)
• Lowers synthesis of glucose. (Biochem J 1993 May 15;292(pt1):267-70.)
Bitter Melon (Momordica charantia)
12
Diabetes and Supplements
• Lowered plasma glucose in both type I and type II diabetics.
(J Ethnopharmacol 1990 Oct;30(3):295-300.; J Ethnopharmacol 1990 Oct;30(3):281-94.)
• Increased insulin release. (J Endocrinol 1999 Nov;163(2):207-12.)
• Decreased glucose absorption. (J Vet Med Sci 1997 Apr;59(4):245-51.)
Gymnema (Gymnema sylvestre)
13
Diabetes and Supplements
• Insulin-like properties (Acta Diabetol Lat 1989 Oct-Dec;26(4):291-300.)
• Lowers plasma glucose. (J Ethnopharmacol 2002 Jan;79(1):95-100.; J Nat Prod 1983 Mar-Apr;46(2):232-
4.)
• Able to reverse experimentally-induced diabetes in animals.
(J Nat Prod 1983 Mar-Apr;46(2):232-4.)
Indian Kino (Pterocarpus marsupium)
14
Diabetes and Supplements
• Benefits in both short-term and long-term plasma glucose control in humans. (Diabetes Care 1995 Oct;18(10):1373-1375)
– Possibly due to increased insulin sensitivity and/or secretion.
– Other research suggests effects on glucose receptors and enzymes.
(J Pharmacobiodyn 1981 Jun;4(6):410-417; Biol Pharm Bull 1996 Sep;19(9):1238-1240)
Korean Ginseng (Panax ginseng)
15
Diabetes and Supplements
• May increase insulin sensitivity. (Diabetes Care 1999 Feb;22(2):280-7.)
• May prevent or reduce the symptoms of nerve damage.
(Diabetes Care 2003 Mar;26(3):770-6.;Bull Exp Biol Med 2000 Oct;130(10):986-90.)
–Improves peripheral nerve conduction
–Antioxidant properties.
Alpha Lipoic Acid
16
Diabetes and Supplements
• Improves diabetic glucose levels w/o affecting individuals with normal or low blood sugar.– Increases insulin receptor numbers and
insulin binding at the receptor. (J Am Coll Nutr. 1999 Feb;18(1):6-12.;J Am Coll Nutr. 1998 Dec;17(6):548-55.)
– 1-2 months of dosing may be necessary
• Lowers serum insulin and
glycosylated hemoglobin levels. (J Fam Pract. 1998 Jan;46(1):83-6.)
Chromium
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Diabetes and Supplements
• Inhibits the glucose from leaving cells.
(Mol Cell Biochem 2002 Feb;231(1-2):23-35.;Metabolism 2000 Mar;49(3):400-10.)
• Targets muscle cells. (Physiol Behav 1993 Aug;54(2):407-9.;Mol Cell Biochem 1992 Feb 12;109(2):157-62.)
• May also lower insulin requirements in type I diabetics, based on rodent research.
(Mol Cell Biochem. 2000 Mar;206(1-2):177-82.)
Vanadium
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Diabetes and Supplements
• Diabetes is one of the fastest growing diseases.– A major contributor to illness and death
worldwide.
• Many supplements can aid the diabetic condition.– Increasing insulin secretion and/or
sensitivity– Modifying the absorption of sugar– Altering the cellular movement of
glucose.
Key Points
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