New Patents xiii

4835178

METHYLENDIOXY- PHENATHRENE AND STILBEN DERIVATIVES, PROCESS FOR

THE PREPARATION THEREOF, PHARMACEUTICAL

COMPOSITIONS USING THESE, AND THERAPEUTIC

APPLICATIONS

Klaus Gorier, Gunter Krumbiegel, Michael Hanack, Lakshmina R Subramanian, Bergisch Gladbach, Federal Republic Of Germany as- signed to Dr Madaus & Co

Roesch, Schriesheim, Federal Republic Of Ger- many assigned to Boehringer Mannheim GmbH

The present invention provides Indolines of the formula: See Patent for Chemical Structure (II) Het-XOCHNNHR1R2T (III) ps useful to pro- vide pharmaceutically active pyrroloben- zimidazoles or tautomers thereof, of the formula: See Patent for Chemical Structure (I) These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an in- crease in cardiac output and/or a change in micro-circulation.

The present invention provides compounds of the general formula: See Patent for Chemical Structure (I) wherein R 1 is a hydrogen atom or a methoxy or ethoxy radical and R2 and R3 are hydrogen atoms or R2 and R3 together represent an aromatic carbon-carbon bond and R1 is a hydrogen atom, a hydroxyl group or an ethoxy radical; and the pharmaceutically ac- ceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them, as well as their use in therapy.

4835184

NOVEL PHARMACEUTICAL COMPOSITIONS INTENDED TO

THE TREATMENT OF NEUROPATHIES AND

PROMOTING THE NERVOUS REGENERATION

Andre Hugelin, Claude Thal, Neuilly S/Seine, France assigned to Albert Rolland SA

Compositions and method of treating neuropathies resulting from diabetic, non- diabetic, toxic or viral origin and insuring regeneration of damaged nerve fibers by ad- ministration of the N,N-dimethyl-biguanide salt of p-chlorophenoxy-acetic acid.

4837213

PHARMACEUTICAL VEHICLE FOR ACTIVE SUBSTANCES IN

THE FORM OF AN ANHYDROUS GEL

Daniele Caron, Braham Shroot, Valbonne, France assigned to Centre Internatinal de Recherches Dermatologiques C I R D

A pharmaceutical vehicle used for administering and protecting active substances, in the form of an anhydrous gel and having a viscosity of at least 540 cps, comprising paraffin oil, at least one fatty acid alkyl ester and a polyvinyldimethyl siloxane-type elastomeric silicone, used as a thickener.

4837227

AMINOALKYLTHIODI- BENZOXEPINS AND

PHARMACEUTICAL USE

Helen H Ong, Vernon B Anderson, James Pro- fitt assigned to Hoechst-Roussel Pharma- ceuticals Inc

4835280

INDOLINE COMPOUNDS FOR SYNTHESIS OF

PHARMACEUTICALLY ACTIVE PYRROLOBENZIMIDAZOLES

Alfred Martens, Jens-Peter Holck, Herbert Ber- ger, Bernd Muller-Beckman, Klaus Strein, Egon

Novel aminoalkylthiodibenzoxepins, phys- iologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as anal- gesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also dis- closed.