394 PATENT ABSTRACTS

and type 2 and having high safety and high effec- tiveness, which comprises as an active component a highly purified glycoprotein gB which is a component common to Herpes sim- plex virus type 1 and type 2. and a method for preparing the herpes simplex virus subunit vac- cine and also a lyophilized preparation of the vaccine.

4661350

D E N T A L V A C C I N E F O R I N H I B I T I N G P E R I O D O N T I T I S

Takash Tsurumizu, Takash Hashimoto, Takash Takahashi, Chiba, Japan assigned to Kitasato Kenkyusho

A vaccine for preventing or at least inhibiting periodontitis of humans and animals, which is induced or deteriorated by the action of oral microorganisms, which comprises an antigen isolated from the pili of an oral microorganism capable of inducing and/or deteriorating periodontitis and having the pili on the cell sur- face. For example, antigens isolated from the pili of Actinomyces viscosus, Actinomyces naeslun- dii, Actinobacillus actinomycem comitans, Bacteroides gingivalus and mutant strains thereof may be used solely or in combination for the preparation of the present vaccine. In one embodiment, the vaccine comprises an antigen isolated from the pili of Actinomyces viscosus which is a representative periodontitis-inducing oral microorganisms in association with one or more other antigens isolated from other virulent oral microorganisms. The antigen isolated from the pili may effectively inhibit the adherence (in- fection) of the virulent oral microorganisms of at least same species to the surfaces of teeth and/or mucous membrane of an oral cavity.

4663160

V A C C I N E S F O R G R A M - N E G A T I V E B A C T E R I A

Grace C Tsay, Michael Collins assigned to Miles Laboratories inc

An immunizing composition is disclosed and comprises a detoxified polysaccharide from a gram-negative bacterium covalently coupled to a detoxified protein from said gram-negative bac- terium by means of a 4£14 12 carbon moiety. To prepare the above immunizing agent, the lipid A portion of lipopolysaccharide from a gram-

negative bacterium is separated to give a detox- ified polysaccharide. Reactive aldehyde groups are generated on the detoxified polysaccharide by selective oxidation. The detoxified poly- saccharide is then covalently coupled to a detox- ified protein from said gram-negative bacterium by means of a 4+ 14 12 carbon moiety having functionalities reactive to the aldehyde groups on the detoxified polysaccharide and to the car- boxylic groups on the detoxified protein. + RE

4663161

L I P O S O M E M E T H O D S A N D C O M P O S I T I O N S

Raphael Mannino, Susan Fogerite

The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an etficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method has been ex- emplified with the use of glycoproteins of in- fluenza (A/PR8/34) and Sendai (parainfluenza type 1) viruses.

4663280

E X P R E S S I O N A N D S E C R E T I O N V E C T O R S A N D M E T H O D O F C O N S T R U C T I N G V E C T O R S

Alan Sloma assigned to Public Health Research Institute of the City of New York

The present invention relates to an expression and secretion vector which comprises the signal and promoter sequence of the Bacillus cereus (herein £37 +I B. cereus+38 +L ) gene which codes for penicillinase and to the construction of veclors and the use of the vectors in the expres- sion and secretion of one or more exogenous polypeptides in microorganisms for example, +1 B. subt i l i s .+RE+RE+RE

4663436

L E U K E M I A - A S S O C I A T E D V I R U S I M M U N O G E N , V A C C I N E A N D

A S S A Y

John H Elder, Richard A Houghten assigned to Scripps Clinic and Research Foundation