4 hydroxy 4 methyl 2 pentanone (2011)

7/29/2019 4 Hydroxy 4 Methyl 2 Pentanone (2011)

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Fluka - 31450 Page 1

SIGMA-ALDRICH sigma-aldrichMaterial Safety Data She

VersioRevision Date 01/12/

Print Date 11/21/

1. PRODUCT AND COMPANY IDENTIFICATION

Product name : 4-Hydroxy-4-methyl-2-pentanone

Product Number : 31450Brand : FlukaProduct Use : For laboratory research purposes.

Supplier : Sigma-Aldrich Canada, Ltd2149 Winston Park DriveOAKVILLE ON L6H 6J8CANADA

Manufacturer : Sigma-Aldrich Corporation3050 Spruce St.St. Louis, Missouri 63103USA

Telephone : +1 9058299500Fax : +1 9058299292Emergency Phone # (For

both supplier andmanufacturer)

: 1-800-424-9300

Preparation Information : Sigma-Aldrich CorporationProduct Safety - Americas Region1-800-521-8956

2. HAZARDS IDENTIFICATION

Emergency Overview

Target Organs

Blood, Liver, Kidney

WHMIS Classification

B3D2B

Combustible Liquid Combustible LiquidModerate eye irritant

GHS ClassificationFlammable liquids (Category 3)Acute toxicity, Oral (Category 5)Acute toxicity, Inhalation (Category 3)Serious eye damage (Category 1)

GHS Label elements, including precautionary statements

Pictogram

Signal word DangerHazard statement(s)H226 Flammable liquid and vapour.H303 May be harmful if swallowed.H318 Causes serious eye damage.H331 Toxic if inhaled.

Precautionary statement(s)P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.P280 Wear protective gloves/ eye protection/ face protection.P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,

present and easy to do. Continue rinsing. P311 Call a POISON CENTER or doctor/ physician.


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HMIS ClassificationHealth hazard: 2Chronic Health Hazard: *Flammability: 2Physical hazards: 0

Potential Health Effects

Inhalation May be harmful if inhaled. Causes respiratory tract irritation.Skin May be harmful if absorbed through skin. Causes skin irritation.

Eyes Causes eye irritation.Ingestion May be harmful if swallowed.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Synonyms : Diacetone alcohol

Formula : C6H12O2

Molecular Weight : 116.16 g/mol

CAS-No. EC-No. Index-No. Concentration

4-Hydroxy-4-methylpentan-2-one

123-42-2 204-626-7 603-016-00-1 -

4. FIRST AID MEASURES

General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.

If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contactWash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contactRinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowedDo NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult aphysician.

5. FIRE-FIGHTING MEASURES

Conditions of flammabilityFlammable in the presence of a source of ignition when the temperature is above the flash point. Keep away fromheat/sparks/open flame/hot surface. No smoking.

Suitable extinguishing mediaFor small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply wafrom as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water

may be ineffective. Cool all affected containers with flooding quantities of water.Special protective equipment for fire-fightersWear self contained breathing apparatus for fire fighting if necessary.

Hazardous combustion productsHazardous decomposition products formed under fire conditions. - Carbon oxides

Explosion data - sensitivity to mechanical impactno data available

Explosion data - sensitivity to static dischargeno data available


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Further informationUse water spray to cool unopened containers.

6. ACCIDENTAL RELEASE MEASURES

Personal precautionsWear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources ofignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapoucan accumulate in low areas.

Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning upContain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place incontainer for disposal according to local regulations (see section 13).

7. HANDLING AND STORAGE

Precautions for safe handlingAvoid contact with skin and eyes. Avoid inhalation of vapour or mist.Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Conditions for safe storageStore in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened mube carefully resealed and kept upright to prevent leakage.

Store under inert gas.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Components with workplace control parameters

Components CAS-No. Value Controlparameters

Basis

4-Hydroxy-4-methylpentan-2-one

123-42-2 TWA 50 ppm238 mg/m3

USA. ACGIH Threshold Limit Values (TLV)

TWA 50 ppm238 mg/m3

Canada. Alberta, Occupational Health and Safety Code(table 2: OEL)

TWA 50 ppm238 mg/m3

Canada. Alberta, Occupational Health and Safety Code(table 2: OEL)

TWA 50 ppm Canada. British Columbia OEL

TWAEV

50 ppm240 mg/m3

Canada. Ontario OELs

STEV 75 ppm360 mg/m3

Canada. Ontario OELs

TWA 50 ppm

238 mg/m3

Canada. Quebec OELs

Personal protective equipment

Respiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purposecombination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If therespirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and componentstested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Hand protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touchingglove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use inaccordance with applicable laws and good laboratory practices. Wash and dry hands.


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Eye protectionTightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approveunder appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin and body protectionComplete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protectiveequipment must be selected according to the concentration and amount of the dangerous substance at the specificworkplace.

Hygiene measures

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product

Specific engineering controlsUse mechanical exhaust or laboratory fumehood to avoid exposure.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance

Form clear, liquid

Colour light yellow

Safety data

pH no data available

Melting/freezingpoint

no data available

Boiling point 166 C (331 F) - lit.

Flash point 58 C (136 F) - closed cup

Ignition temperature no data available

Autoignitiontemperature

no data available

Lower explosion limit 1.8 %(V)

Upper explosion limit 6.9 %(V)

Vapour pressure no data availableDensity 0.931 g/mL at 25 C (77 F)

Water solubility no data available

Partition coefficient:n-octanol/water

no data available

Relative vapourdensity

4.01- (Air = 1.0)

Odour no data available

Odour Threshold no data available

Evaporation rate no data available

10. STABILITY AND REACTIVITY

Chemical stabilityStable under recommended storage conditions.

Possibility of hazardous reactionsno data available

Conditions to avoidHeat, flames and sparks.

Materials to avoidOxidizing agents, Strong bases


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Hazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbon oxidesOther decomposition products - no data available

11. TOXICOLOGICAL INFORMATION

Acute toxicity

Oral LD50LD50Oral - rat - 2,520 mg/kg

Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on seizure threshold. Liver:Other changes.

Inhalation LC50LC50Inhalation - rat - 4 h - 1500 ppm

Dermal LD50LD50Dermal - rabbit - 13,500 mg/kg

Other information on acute toxicityno data available

Skin corrosion/irritationSerious eye damage/eye irritationEyes - rabbit - Severe eye irritation - 24 h

Respiratory or skin sensitizationno data available

Germ cell mutagenicityno data available

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable,possible or confirmed human carcinogen by IARC.

ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as acarcinogen or potential carcinogen by ACGIH.

Reproductive toxicity

no data available

Teratogenicity

no data available

Specific target organ toxicity - single exposure (Globally Harmonized System)no data available

Specific target organ toxicity - repeated exposure (Globally Harmonized System)no data available

Aspiration hazardno data available

Potential health effects

Inhalation May be harmful if inhaled. Causes respiratory tract irritation.Ingestion May be harmful if swallowed.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.

Signs and Symptoms of Exposure


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Central nervous system depression, Symptoms and signs include headache, dizziness, fatigue, muscular weakness,drowsiness and in extreme cases, loss of consciousness., Blood disorders, Dermatitis, Blurred vision, Effects due toingestion may include:, To the best of our knowledge, the chemical, physical, and toxicological properties have not bethoroughly investigated.

Synergistic effectsno data available

Additional InformationRTECS: SA9100000

12. ECOLOGICAL INFORMATION

Toxicity

Toxicity to fish LC50 - Lepomis macrochirus (Bluegill) - 420 mg/l - 96 hToxicity to daphniaand other aquaticinvertebrates.

EC50 - Daphnia magna (Water flea) - 9,000 mg/l - 24 h

Persistence and degradabilityno data available

Bioaccumulative potentialno data available

Mobility in soilno data available

PBT and vPvB assessmentno data available

Other adverse effects

no data available

13. DISPOSAL CONSIDERATIONS

ProductBurn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this mater

is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensedprofessional waste disposal service to dispose of this material.

Contaminated packagingDispose of as unused product.

14. TRANSPORT INFORMATION

DOT (US)UN-Number:1148 Class: 3 Packing group: IIIProper shipping name: Diacetone alcoholMarine pollutant: NoPoison Inhalation Hazard: No

IMDGUN-Number: 1148 Class: 3 Packing group: III EMS-No: F-E, S-DProper shipping name: DIACETONE ALCOHOLMarine pollutant: No

IATAUN-Number:1148 Class: 3 Packing group: IIIProper shipping name: Diacetone alcohol

15. REGULATORY INFORMATION

DSL StatusAll components of this product are on the Canadian DSL list.


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WHMIS ClassificationB3D2B

Combustible Liquid Combustible LiquidModerate eye irritant

This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and thMSDS contains all the information required by the Controlled Products Regulations.

16. OTHER INFORMATION

Further information

Copyright 2011 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.The above information is believed to be correct but does not purport to be all inclusive and shall be used only as aguide. The information in this document is based on the present state of our knowledge and is applicable to theproduct with regard to appropriate safety precautions. It does not represent any guarantee of the properties of theproduct. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with theabove product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

4 hydroxy 4 methyl 2 pentanone (2011)

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