3d printed medicines: a digital pharmacy era€¦ · 3d printed medicines: a digital pharmacy era....
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3D Printed Medicines: A Digital Pharmacy Era
Sarah Trenfield, MPharmSenior Formulation Scientist, FabRx Ltd.
[email protected]@FabRx_3DP@SarahTrenfield1
Evolution of TechnologyA Historical Perspective
2016 2017 2018
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1784
• Steam• Water• Mechanised Production
1st Industrial Revolution
A Historical Perspective
2017 2018
You can simply impress your audience and add a unique zing and appeal to your Presentations. .
Your Text Here
You can simply impress your audience and add a unique zing and appeal to your Presentations. .
Your Text Here
Evolution of Technology
1784 1870
• Steam• Water• Mechanised Production
1st Industrial Revolution
• Division of Labour• Electrical Energy• Mass Production
2nd Industrial Revolution
A Historical Perspective
Evolution of Technology
1784 1870 1969
• Steam• Water• Mechanised Production
1st Industrial Revolution
• Division of Labour• Electrical Energy• Mass Production
2nd Industrial Revolution
• Electronics• IT• Automated Production
3rd Industrial Revolution
1784 1870 1969 Now
• Steam• Water• Mechanised Production
1st Industrial Revolution
• Division of Labour• Electrical Energy• Mass Production
2nd Industrial Revolution
• Electronics• IT• Automated Production
3rd Industrial Revolution
• IoT• Mass Customisation• 3D Printing
4th Industrial Revolution (?)
A Historical Perspective
Evolution of Technology
Current 3D Printing Applications
Medical Applications
Tissue engineering
Dentistry
Medical devices & prosthetics 3D Printed Tablets
Current 3D Printing Applications
Medical Applications
Tissue engineering
Dentistry
Medical devices & prosthetics 3D Printed Tablets
The 3 Ds of 3D Printing Medicines
CAD software
Design Develop Dispense
Excipient selectionPrinting parameters
On-site printlet production and dispensing
Personalised Medicines
A Need for Personalisation
Differences in:• Age• Gender• Ethnicity• Comorbidities• Body type• Polypharmacy
Motivations for 3D Printing
1. Dose Flexibility
1. Dose Flexibility
• Mass produced• Fixed strength
Conventional Manufacture
1. Dose Flexibility3D Printing Medicines
• Variety of strengths
• Dosing accuracy
• Personalisation
Motivations for 3D Printing
1. Dose Flexibility 2. DecentralisedProduction
2. Decentralised Production
Motivations for 3D Printing
1. Dose Flexibility 2. DecentralisedProduction
3. Patient Centered Design
3. Patient Centered Design
Choice of:
• Shape• Size• Colour• Flavour• Formulation Type
3. Patient Centered Design
Sphere
Torus
DiscTilte
d
Capsu
le0
20
40
60
80
100
Parti
cipa
nts
(%)
Shapes
5 4 3 2 1
Post-swallowing
Patient reported outcome (PRO)
Patient acceptability of 3D printed tablets
Motivations for 3D Printing
1. Dose Flexibility 2. DecentralisedProduction
3. Patient Centered Design
4. Unique Dosage Forms
4. Unique Dosage FormsPolypills
4. Unique Dosage Forms
Personalised Polypills
4. Unique Dosage Forms
Personalised Polypills
4. Unique Dosage FormsFast-dissolving Printlets
• Immediate release
• Orally disintegrating in ~2 seconds
Improved Patient Outcomes
Paediatrics and Geriatrics Complex Regimes
Tailored dosage forms
Reduced side effects Improved efficacy Improve medication adherence
Our Vision… A Digital Pharmacy
Therapeutic Need
Digital Prescription
3D PrinterPersonalisation
Digital DesignAdministration
FDA-Approved 3D Printed Tablet
Well-defined niche;High-dose (250, 500, 750 & 1000 mg)Oro-dispersible tablet
Spritam® (levetiracetam): Aprecia Pharmaceuticals
Conclusion• 3DP could cause a paradigm shift in pharmaceuticals• Don’t judge the technology from the early manifestations
– We are required to come together!
Thank you!