5/22/2018 33 Varan Alel CYP2A6

1/15

CYP2A6allele nomenclatureAllele Protei

n

Nucleotide changes Trivial

name

Effect Enzyme activi ty Referenc

es

cDNA*

*To be

consideredCYP2A6*1A,

the cDNA reference

sequence must be

changed to 51G.

Gene*

*To be consideredCYP2A6*1A,the

genomic reference sequence must

be changed to 51G.

I nvivo Invit

ro

CYP2A6*1A CYP2A6.1

None None Normal Normal

Yamano et

al., 1990

CYP2A6*1B1(formerly CYP2A6*1B,has also been calledCYP2A6*1E)

CYP2A

6.1gene conversion in 3 flanking region Incr.? Yamano et

al., 1990

Nakajima e

t al., 2001

Pitarque et

al., 2004

CYP2A6*1B2(has also been calledCYP2A6*1B)

CYP2A

6.1gene conversion in the

3' flanking region-1013A>G; gene conversion in the

3' flanking regionOscarson e

t al.,

1999b

Ariyoshi et

al., 2000

Pitarque et

al., 2004

CYP2A6*1B3(formerly CYP2A6*1C)

CYP2A

6.1gene conversion in 3flanking region

-395G>A; gene conversion in 3flanking region

Kiyotani etal., 2002

http://www.ncbi.nlm.nih.gov/nuccore/NM_000762http://www.ncbi.nlm.nih.gov/nuccore/ng_008377.1http://www.expasy.ch/cgi-bin/niceprot.pl?P11509http://www.expasy.ch/cgi-bin/niceprot.pl?P11509http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11180041http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.expasy.ch/cgi-bin/niceprot.pl?P11509http://www.expasy.ch/cgi-bin/niceprot.pl?P11509http://www.ncbi.nlm.nih.gov/nuccore/ng_008377.1http://www.ncbi.nlm.nih.gov/nuccore/NM_000762

5/22/2018 33 Varan Alel CYP2A6

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CYP2A6*1B4 CYP2A

6.1gene conversion in 3

flanking regiongene conversion in 3 flanking

region, gene conversion at 7073-

7082

Mwenifum

bo et al.,

2010

CYP2A6*1B5Tentative allele

CYP2A

6.1

gene conversion in 3

flanking region

-1680A>G; -1579T>C;

-1301A>C; -1289G>A;-1013A>G; 1620T>C; gene

conversion in 3 flanking region

Haberl et

al., 2005

CYP2A6*1B6Predicted haplotype/Tentative allele

CYP2A

6.1gene conversion in 3

flanking region-1680A>G; -1579T>C;

-1301A>C; -1289G>A;

-1013A>G; 1620T>C; 6285A>G;

6293T>C; gene conversion in 3

flanking region

Haberl et

al., 2005

CYP2A6*1B7Predicted haplotype/

Tentative allele

CYP2A

6.1gene conversion in 3

flanking region-1680A>G; -1579T>C;

-1464A>T; -1301A>C;

-1289G>A; 1620T>C; gene

conversion in 3 flanking region

Haberl et

al., 2005

CYP2A6*1B8Tentative allele

CYP2A

6.1gene conversion in 3

flanking region-1680A>G; -1579T>C;

-1464A>T; -1301A>C;

-1289G>A; -1013A>G; 1620T>C;

gene conversion in 3 flanking

region

Haberl et

al., 2005

CYP2A6*1B9Predicted haplotype/Tentative allele

CYP2A

6.1gene conversion in 3

flanking region-1680A>G; -1579T>C;

-1464A>T; -1301A>C;

-1289G>A; -1013A>G; 1620T>C;

6390C>G; gene conversion in 3

flanking region

Haberl et

al., 2005

CYP2A6*1B10Predicted haplotype/

Tentative allele

CYP2A

6.1gene conversion in 3

flanking region-1680A>G; -1579T>C;

-1464A>T; -1301A>C;

-1289G>A; -1013A>G; 1620T>C;6389C>G; gene conversion in 3

flanking region

Haberl et

al., 2005

CYP2A6*1B11Predicted haplotype/Tentative allele

CYP2A

6.1gene conversion in 3

flanking region-1680A>G; -1579T>C;

-1464A>T; -1301A>C;

-1289G>A; -1013A>G; 1620T>C;

5628C>T; gene conversion in 3

Haberl et

al., 2005

http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358

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flanking region

CYP2A6*1B12Predicted haplotype/Tentative allele

CYP2A

6.1

51G>A; gene

conversion in 3flanking region

51G>A; gene conversion in 3

flanking region

Haberl et

al., 2005

CYP2A6*1B13 CYP2A6.1

22C>T; 1545C>G; gene

conversion in 3

flanking region

-745A>G; 22C>T; 6691C>G; gene

conversion in 3-UTRNakajima e

t al., 2006

CYP2A6*1B14 CYP2A6.1

51G>A; gene

conversion in 3'-UTR;

1636C>G

51G>A; 338T>C; gene conversion

in 3'-UTR; 6782C>G;

6935_6936insCACTT; 7160A>G

Mwenifum

bo et al.,

2007

CYP2A6*1B15 CYP2A6.1

gene conversion in 3'-

UTR; 1636C>G-1301A>C; -1289G>A;

-967A>C; 1381_1382CT>TC;

1471_1476delCTCTCT; 1620T>C;

3225A>G; gene conversion in 3'-

UTR; 6782C>G;

6935_6936insCACTT;

6960_6961insGAAAAG;

7160A>G

Mwenifum

bo et al.,

2007

CYP2A6*1B16 CYP2A6.1

22C>T; 1191T>C; gene

conversion in 3'-UTR;

1636C>G

-1301A>C; -1289G>A;

-745A>G; 22C>T; 1630T>C;

5684T>C; gene conversion in 3'-

UTR; 6782C>G;

6935_6936insCACTT;

6960_6961insGAAAAG;

6989A>G;7008_7009TC>GCTCTA;

7160A>G

Mwenifum

bo et al.,

2007

CYP2A6*1B17 CYP2A6.1

51G>A; 1005C>T;

gene conversion in 3'-

UTR

51G>A; 1620T>C; 1646C>T;

2296C>T; 2483G>A; 2994T>C;

3788C>T; 4071delA; 4636A>C;

4850C>T; 4977C>T; 5668A;

6143C>A; geneconversion in 3'-

UTR; 6782C>G; 6832A>G;

6835C>A; 6935_6936insCACTT;

Mwenifum

bo et al.,

2008

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16952495&query_hl=5&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16952495&query_hl=5&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16952495&query_hl=5&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16952495&query_hl=5&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17522595&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16952495&query_hl=5&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16952495&query_hl=5&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8

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6960_6961insGAAAAG;

6989A>G; 7160A>G

CYP2A6*1C See CYP2A6*1B3

CYP2A6*1DPredicted haplotype CYP2A6.1 -1013A>G Pitarque etal., 2004

CYP2A6*1E See CYP2A6*1B1

CYP2A6*1F CYP2A6.1

1224C>T 5717C>T Nakajima et al., 2004

CYP2A6*1G CYP2A6.1

1224C>T 5717C>T; 5825A>G Nakajima e

t al., 2004

CYP2A6*1HPredicted haplotype

CYP2A

6.1

-745A>GDecr.?

von

Richter et

al., 2004

CYP2A6*1JPredicted haplotype

CYP2A

6.1

-1013A>G; -745A>G vonRichter et

al., 2004

CYP2A6*1KCYP2A

6.1459G>A; 657C>T

-1301A>C; -1289G>A;

-1199_-1198ins316bpAlu; -

686A>G; 51G; 431C>T; 1620T>C;

1779G>A; 2483G>A; 2994T>C;

3378C>T; 3904G>A 4074delA;

5668A; 6354T>C; 7160A>G

Mwenifum

bo et al.,

2008

CYP2A6*1L CYP2A6.1 Gene conversion at 7073-7082

Mwenifum

bo et al.,2010

CYP2A6*1X2ACYP2A

6.1Breakpoint at intron 8 - 3'-UTR

CYP2A6gene

duplication

Rao et al.,

2000

CYP2A6*1X2BCYP2A

6.1Breakpoint at 5.2 - 5.6 kb downstream

from stop codon

CYP2A6gene

duplicationFukami et

al., 2007

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17267622&query_hl=4&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17267622&query_hl=4&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17267622&query_hl=4&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17267622&query_hl=4&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17267622&query_hl=4&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17267622&query_hl=4&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10999944http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225612http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974084&dopt=Abstract

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CYP2A6*2 CYP2A6.2

51G>A;479T>A 51G>A;1799T>A v1 L160H None None Yamano etal., 1990

Hadidi et

al., 1997

Oscarson e

t al., 1998

CYP2A6*3 CYP2A6.3

CYP2A6/CYP2A7hybrid v2 ? ? Fernandez-Salgueroet

al., 1995

CYP2A6*4A CYP2A6 deleted CYP2A6del,

E-type

CYP2A6deleted None Oscarson et al., 1999a

Nunoya et

al., 1999a

Nunoya et

al., 1999b

Ariyoshi et

al., 2000

CYP2A6*4B CYP2A6 deleted CYP2A6deleted None Nunoya etal.,

1998

Ariyoshi et

al., 2002

Ariyoshi et

al., 2004

CYP2A6*4C Identical to the CYP2A6*4A allele (see above)

CYP2A6*4D CYP2A6 deleted CYP2A6 deleted None Oscarson etal., 1999b

CYP2A6*4E CYP2A6 deleted CYP2A6 deleted Mwenifumbo et al., 2008

CYP2A6*4F CYP2A6 deleted CYP2A6 deleted Mwenifumbo et al., 2008

http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10217419http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10217419http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10217419http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10217419http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10087035http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10087035http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10087035http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10087035http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10423536http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10423536http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10423536http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10423536http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18360915?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454735&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12172220&query_hl=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9682269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11186131http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10423536http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10423536http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10087035http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10087035http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10217419http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10217419http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7668294http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9827545http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9409631http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2322567http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1801272

5/22/2018 33 Varan Alel CYP2A6

6/15

CYP2A6*4G CYP2A6 deleted CYP2A6 deleted Mwenifumbo et al., 2010

CYP2A6*4H CYP2A6 deleted CYP2A6 deleted Mwenifumbo et al., 2010

CYP2A6*5 CYP2A6.5

1436G>T;geneconversion in the 3

flanking region

6582G>T;gene conversion in the 3flanking region

G479V None None Oscarson etal., 1999b

CYP2A6*6CYP2A

6.6383G>A

1703G>A R128Q Decr.

Kitagawa et

al., 2001

CYP2A6*7CYP2A

6.7

1412T>C;gene

conversion in the 3'

flanking region

6558T>C;gene conversion in the 3'

flanking regionI471T (Decr.) Decr.

Ariyoshi et

al., 2001

Xu et al.,

2002

CYP2A6*8CYP2A

6.8

1454G>T;gene

conversion in the 3'

flanking region

6600G>T;gene conversion in the 3'flanking region

R485L NormalAriyoshi et

al., 2001

Xu et al.,

2002

CYP2A6*9ACYP2A

6.1

-1013A>G;-48T>G

TATA box Decr . Decr.

Pitarque et

al., 2001

Yoshida et

al., 2003

Kiyotani et

al., 2003

von

Richter et

al., 2004

CYP2A6*9BCYP2A

6.11547C>G

-1680A>G: -1301A>C;

-1289G>A; -1013A>G;

-48T>G;1620T>C; 1836G>T;

6354T>C; 6692C>G

TATA box Haberl et al.,

2005

http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11278503http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11278503http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11278503http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11278503http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11394901http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11394901http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11394901http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11394901http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14583682&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14583682&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14583682&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14583682&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15247629http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14583682&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14583682&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12844137http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11394901http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11394901http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11237731http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11278503http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11278503http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=4986891http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10544257http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031017http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358http://www.ncbi.nlm.nih.gov/pubmed/20136358

5/22/2018 33 Varan Alel CYP2A6

7/15

CYP2A6*10CYP2A

6.10

1412T>C;1454G>T;

gene conversion in the

3' flanking region

6558T>C;6600G>T;gene

conversion in the 3' flanking regionI471T;R485L Decr.

Yoshida et

al., 2002

Xu et al.,

2002

CYP2A6*11 CYP2A6.11 670T>C 3391T>C

S224P Decr. Decr. Daigo et al.,2002

CYP2A6*12ACYP2A

6.12exons 1-2 of CYP2A7 origin; exons 3-9 of CYP2A6origin

10 aa

substitutionsDecr. Decr.

Oscarson et

al., 2002

CYP2A6*12B CYP2A6.12

exons 1-2ofCYP2A7 origin;

exons 3-9

ofCYP2A6origin;

1547C>G

exons 1-2 of CYP2A7 origin;

exons 3-9 ofCYP2A6origin;

1620T>C; 3396G>A; 4489C>T;

5163G>A; 5545G>C; 5717C>G;

6692C>G

10 aa

substitutions

Haberl et al.,

2005

CYP2A6*12C CYP2A6.12

exons 1-2

ofCYP2A7 origin;

exons 3-9

ofCYP2A6origin;

1547C>G

exons 1-2 of CYP2A7 origin;

exons 3-9 ofCYP2A6origin;

1620T>C; 1630G>C; 3396G>A;

4489C>T; 5163G>A; 5545G>C;

5717C>G; 6692C>G

10 aa

substitutions

Haberl et al.,

2005

CYP2A6*13 CYP2A6.13

13G>A -48T>G;13G>A G5R Kiyotani etal., 2002

CYP2A6*14 CYP2A6.14

51G>A;86G>A 51G>A;86G>A S29N Kiyotani etal., 2002

CYP2A6*15 CYP2A6.15

580A>G -48T>G;2134A>G K194E Kiyotani etal., 2002

CYP2A6*16 CYP2A6.16

607C>A 2161C>A R203S Kiyotani etal., 2002

CYP2A6*17 CYP2A6.17

459G>A;1093G>A;

1224C>T209C>T; 1779G>A;

4489C>T;5065G>A;5163G>A;

5717C>T; 5825A>G

V365M Decr. Decr. Fukami etal., 2004

CYP2A6*18A CYP2A6.18

1175A>T 5668A>T Y392F Decr Fukami etal., 2005a

http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12042667http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12042667http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12042667http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12042667http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12325023http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12325023http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12325023http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12325023http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15592323http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15592323http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15592323http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15592323http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1809810http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1809810http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15900015&query_hl=6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15900015&query_hl=6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15900015&query_hl=6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15900015&query_hl=6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15900015&query_hl=6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15900015&query_hl=6http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1809810http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1809810http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=1809810http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15592323http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15592323http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399454http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=56256500http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399435http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618701http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399433http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399434http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041240&query_hl=8http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12325023http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12325023http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12042667http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12042667http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=28399447http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11779172http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12445030http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=28399468http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=5031016

5/22/2018 33 Varan Alel CYP2A6

8/15

CYP2A6*18B CYP2A6.18

51G>A;1175A>T;

1191T>C; 1209T>C51G>A;5668A>T;5684T>C;

5702T>CY392F Decr. Fukami et

al., 2005a

CYP2A6*18CPredicted haplotype

CYP2A

6.181175A>T;1546C>G -1680A>G: -1579T>C;

-1464A>T; -1301A>C;

-1289G>A; -1013A>G;1620T>C;5668A>T;6692C>G

Y392F Haberl et al.,2005

CYP2A6*19 CYP2A6.19

1175A>T;1412T>C;

gene conversion in the

3' flanking region

5668A>T;6354T>C:6558T>C;

gene conversion in the 3' flanking

region

Y392F;I471T Decr. Fukami etal., 2005a

CYP2A6*20 CYP2A6.20

51G>A;587_588delAA

; 1191T>C; 1546C>G51G>A; 2141_2142delAA ;

2296C>T; 5684T>C; 6692C>G196Frameshift Decr. None Fukami et

al., 2005b

Mwenifumb

o et al., 2008

CYP2A6*21Predicted haplotype

CYP2A

6.2151G>A;1427A>G 51G>A;6573A>G K476R Decr. Haberl et al.,

2005

Mwenifumb

o et al., 2008

CYP2A6*22Predicted haplotype

CYP2A

6.2251G>A;474C>G;478C

>A51G>A;1794C>G;1798C>A D158E; L160I Haberl et al.,

2005

CYP2A6*23 CYP2A6.23

607C>T 2161C>T R203C Decr. Decr. Hoet al.,2008

CYP2A6*24A CYP2A6.24

312A>G;328G>C;1312

A>T-1301A>C; -1289G>A;

-1013A>G; 51G;

578A>G;594G>C;720G>A;

1137C>G; 1620T>C; 2483G>A;

3225A>G; 5668A; 6218A>G;

6282A>G; 6293T>C;

6354T>C;6458A>T;gene

conversion in 3'-UTR; 6782C>G;

7160A>G

V110L;N438Y Decr. Mwenifumbo et al., 2008

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