3 sodium hyaluronate pharma
TRANSCRIPT
KUMAR ORGANIC PRODUCTS LIMITED
Ingredients for us
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
SODIUM HYALURONATE (KOPURON)
Pharma grade
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Sodium hyaluronate
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
• INCI name: Sodium hyaluronate
• CAS No. 9057-32-7
• Product name: Poly-(sodium--D-glucuronate-[1-3}- N-acetyl-D-glucosamine-[1-4]
• Other names: Hyaluronic acid, Hyaluron, Hyaluronan
• EINECS/ELNICS: 232-678-0
Sodium Hyaluronate - Structure
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Sodium hyaluronate – (sodium salt of hyaluronic acid) is a linear chain muco-polysaccharide composed of disaccharide units formed from D-glucuronic acid & N- acetylglucosamine held together by -1,3-linkages
Sodium Hyaluronate
BIO/002/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
• Polymer produced by the growth of the bacterium Streptococcus equi zooepidemicus; produced by bacterial fermentation; not of animal origin
• Non GMO; free of contaminants such as glycosaminoglycans & animal proteins
• Highly solubility; insoluble in water immiscible solvents
• Highly pure product; excellent transparency & stability
• Moisture retention; free radical scavenging, cell proliferation
Process Flow Diagram
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Sodium hyaluronate & the eye
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
• Hyaluronic acid – significant constituent of human skin, connective tissue, vitreous humor of the eye, lubricant in joints,
Sodium hyaluronate & the eye
• Hyaluronic acid is present in a high concentration inside the eyeball.
•Vitreous humor inside the eye is almost completely made up of hyaluronic acid
•The hyaluronic acid has gel like properties which give shock absorbing effect •Transports nutrients into the eye
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Sodium hyaluronate & the eye
Other ophthalmic applications of Sodium hyaluronate
• Opthalmic drops – for post eye surgery care
• Contact lens solutions
• Artificial tears
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Sodium hyaluronate & the eye
Sodium hyaluronate
BIO/002/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
• With age, the hyaluronic acid in our joints decreases; leads to loss of cushioning & joint pains & aches. • Injections with Hyaluronic acid & cross linked hyaluronic acid gel give the joint lubrication & cushioning for load bearing
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
•Intra–articular injections to alleviate joint pains in senior citizens, sports persons, patients recovering from fractures of bones
Sodium hyaluronate
Sodium hyaluronate
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
• Tissue engineering & scaffolds & dermal fillers for cosmetic surgery
• Pharma grade hyaluronic acid is cross linked to form a gel
• Cross linked hyaluronic acid gels are more stable & get degraded more slowly by the enzyme hyaluronidase than non cross linked hyaluronic acid
• The frequency of injections can be reduced
Sodium Hyaluronate
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Dermal filler application to remove wrinkles & fill out naso-labial folds
Before & after dermal filler treatment
Sodium hyaluronate
BIO/003/2012-13Dr. Lakshmi Sridhar
18th Sep 2012
Biodegradable & eco-friendly
Sodium hyaluronate is completely natural
Produced by bacterial fermentation
“Green technology”