23.08.2011 copyright® raisio effects of 2 low-fat stanol ester-containing margarines on serum...

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23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects Hallikainen MA & Uusitupa MIJ Am J Clin Nutr 1999

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Page 1: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

23.08.2011 Copyright® Raisio

Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects

Hallikainen MA & Uusitupa MIJ Am J Clin Nutr 1999

Page 2: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

Hallikainen & Uusitupa, 1999 2

Objective

To investigate the cholesterol-lowering effects of two low-fat plant stanol ester containing margarines as a part of a low-fat diet recommended for hypercholesterolemic subjects (resembling that of the National Cholesterol Education Program’s Step II diet)

Page 3: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

Hallikainen & Uusitupa, 1999 3

Methods I

Double-blind, parallel, randomized study

N=60, TC 5.4–7.5 mmol/L

4-week run-in diet (high-fat)8-week experimental period (low-fat and low-ch)

• Control margarine• Wood stanol ester margarine (~2,31 g/d plant

stanols)• Vegetable oil stanol ester margarine (~2,16 g/d

plant stanols)

Page 4: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

Hallikainen & Uusitupa, 1999 4

Methods II

week

Run-in

Low-fat diet; randomization to

study groups

0 2 4 8

Fasting blood samples; TC, LDL, HDL, VLDL, TAG, β-carotene, fat-soluble vitamins, apo A, apo B, plant sterols

-4

Page 5: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

Hallikainen & Uusitupa, 1999 5

Results

Adherence to low-fat diet was very good:Mean energy intake:

• 26 E-% from fat • 7 E-% SAFA • 20 mg/MJ chol

Page 6: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

Hallikainen & Uusitupa, 1999 66

Effective as part of different kind of diets – strict cholesterol-lowering diet example

EFFECTIVE AS PART OF A STRICT CHOLESTEROL- LOWERING DIET

Cholesterol-lowering diet n=17

*Plant stanol ester specific effect; a= significantly different from wk 0 p<0.01; b=significantly different from wk 0 p<0.001; significantly different vs. control p<0.01

Cholesterol- lowering diet + plant stanolester (2.3 g/d plant stanol) n=38

Chan

ge %

in L

DL

chol

este

rol

Total cholesterol LDL cholesterol

aa

b

b

Page 7: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

Hallikainen & Uusitupa, 1999 7

Conclusions

Low-fat diet reduces serum total and LDL cholesterol levels significantly

Adding plant stanol ester containing spread to a low-fat diet reduced TC and LDL-C levels significantly more than diet alone

Plant stanol ester has additional benefit on cholesterol lowering also when used as part of a low-fat diet recommended for hypercholesterolemic subjects (resembling that of the National Cholesterol EducationProgram’s Step II diet)

Page 8: 23.08.2011 Copyright® Raisio Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic

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Thank You!