23.08.2011 copyright® raisio effects of 2 low-fat stanol ester-containing margarines on serum...
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23.08.2011 Copyright® Raisio
Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects
Hallikainen MA & Uusitupa MIJ Am J Clin Nutr 1999
Hallikainen & Uusitupa, 1999 2
Objective
To investigate the cholesterol-lowering effects of two low-fat plant stanol ester containing margarines as a part of a low-fat diet recommended for hypercholesterolemic subjects (resembling that of the National Cholesterol Education Program’s Step II diet)
Hallikainen & Uusitupa, 1999 3
Methods I
Double-blind, parallel, randomized study
N=60, TC 5.4–7.5 mmol/L
4-week run-in diet (high-fat)8-week experimental period (low-fat and low-ch)
• Control margarine• Wood stanol ester margarine (~2,31 g/d plant
stanols)• Vegetable oil stanol ester margarine (~2,16 g/d
plant stanols)
Hallikainen & Uusitupa, 1999 4
Methods II
week
Run-in
Low-fat diet; randomization to
study groups
0 2 4 8
Fasting blood samples; TC, LDL, HDL, VLDL, TAG, β-carotene, fat-soluble vitamins, apo A, apo B, plant sterols
-4
Hallikainen & Uusitupa, 1999 5
Results
Adherence to low-fat diet was very good:Mean energy intake:
• 26 E-% from fat • 7 E-% SAFA • 20 mg/MJ chol
Hallikainen & Uusitupa, 1999 66
Effective as part of different kind of diets – strict cholesterol-lowering diet example
EFFECTIVE AS PART OF A STRICT CHOLESTEROL- LOWERING DIET
Cholesterol-lowering diet n=17
*Plant stanol ester specific effect; a= significantly different from wk 0 p<0.01; b=significantly different from wk 0 p<0.001; significantly different vs. control p<0.01
Cholesterol- lowering diet + plant stanolester (2.3 g/d plant stanol) n=38
Chan
ge %
in L
DL
chol
este
rol
Total cholesterol LDL cholesterol
aa
b
b
Hallikainen & Uusitupa, 1999 7
Conclusions
Low-fat diet reduces serum total and LDL cholesterol levels significantly
Adding plant stanol ester containing spread to a low-fat diet reduced TC and LDL-C levels significantly more than diet alone
Plant stanol ester has additional benefit on cholesterol lowering also when used as part of a low-fat diet recommended for hypercholesterolemic subjects (resembling that of the National Cholesterol EducationProgram’s Step II diet)
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Thank You!