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2018 Pathology

Resident In-Service Examination Item Descriptors and References

American Society for Clinical Pathology 2018 Resident In-Service Examination Item Descriptors

ANATOMIC PATHOLOGY CYTOPATHOLOGY

1) Corpora amylacea 2) Cerebrospinal fluid plasma cells; multiple sclerosis 3) Urine; diagnose polyomavirus 4) Papillary thyroid carcinoma; common genetic lesion 5) Identification; squamous cell carcinoma 6) Cervicovaginal smear; diagnose low grade squamous intraepithelial lesion 7) Recognition of atrophy in Papanicolaou smears 8) Identification of radiation changes in Papanicolaou smears 9) Morphologic features of conventional renal cell carcinoma 10) Medullary carcinoma of the thyroid 11) Pneumocystis cast 12) Risk factors for Warthin tumor 13) Mesothelial windows 14) Identification of fecal contamination 15) Benign mesothelial cells 16) Left parotid mass; identify adenoid cystic carcinoma 17) Pancreatic endocrine neoplasm (PEN) 18) Low-grade squamous intraepithelial lesion (LSIL) 19) Neck nodule; diagnose epidermal inclusion cyst from Papanicolaou stain 20) Reserve cells, ciliated columnar cells and pulmonary alveolar macrophages 21) Carcinoid; diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) 22) Diagnose high grade urothelial cell carcinoma; urine 23) Solid pseudopapillary tumor 24) Endometrial cells that appear benign 25) Esophageal adenocarcinoma 26) Complications of a fine-needle aspiration in the thorax 27) Myelolipoma; diagnose from adrenal gland fine-needle aspirate 28) Recognition of malignant rhabdoid tumors 29) Cervicovaginal smear; classify as benign reactive/reparative change 30) Pelvic washing; interpret adenocarcinoma of the ovary 31) High-grade squamous intraepithelial lesion (HSIL); follow-up 32) Lymphoma in an effusion 33) Recognize polyomavirus 34) Intraductal papilloma from the breast; aspirate 35) Incidental brain parenchyma 36) Thyroid; recognize tracheal contamination 37) Cytomorphology of pleomorphic adenoma 38) Gastrointestinal stromal tumor (GIST) 39) Trichomonas vaginalis; identification from a cervical smear 40) Liquid based preparation; adequacy based on cellularity

AUTOPSY/FORENSIC PATHOLOGY 41) Potency of fentanyl analogs; carfentanil 42) Vehicular intrusion; blunt trauma in motor vehicle collisions 43) Recognize gunshot entrance wounds of the cranium 44) Recognize atrial septal defect-secundum type 45) Identification of patent ductus arteriosus 46) Manner of death; determination following trauma 47) Recognize cause of death related to calcific aortic stenosis due to congenitally bicuspid aortic valve 48) Postmortem heat-related epidural hemorrhage 49) Recognize insect predation; produce postmortem abrasions


AUTOPSY/FORENSIC PATHOLOGY (cont’d)

50) Cause of death statement; death certificate 51) Recognize hesitation marks/wounds 52) Characteristics of contact range gunshot wounds on skull 53) Detection of 6-MAM; heroin use 54) Positional asphyxia 55) CPAP (positive airway pressure); cause of death 56) Identify cardiac sarcoidosis 57) Decomposition; pattern in blood electrolytes 58) Vitreous fluid; hyperglycemia 59) Tache noire – postmortem change; identification and significance 60) Scene investigation in infant death 61) Identify cupping 62) Identify serrated edge knife injuries 63) Lung; changes due to lobar pneumonia 64) Identify; congenital Mongolian spot 65) Characteristics of Tardieu spots 66) Identify cerebral contusion from fixed brain 67) Pulmonary foreign body granulomas in intravenous drug users 68) Final stages of hypothermia; paradoxical undressing 69) Opioid overdose deaths; foam cone 70) Roles of the National Transportation Safety Board (NTSB) and The Federal Aviation Administration (FAA) in airline fatalities 71) Identify epidural hemorrhage 72) Early post mortem period; urea and creatinine concentrations 73) Deleted 74) Myocardial free-wall rupture; 3-7 days post myocardial infarction 75) Define adipocere 76) Recognize normal "brown fat" in infant

SURGICAL PATHOLOGY 77) Gastric-type endocervical adenocarcinoma features 78) Histologic appearance and clinical features of collagenous spherulosis 79) Schwann cell hamartoma 80) Acetaminophen overdose; hepatotoxicity 81) Identify chondroblastoma 82) Fabry disease 83) Low-grade appendiceal mucinous neoplasm 84) Clear cell carcinoma of endometrium 85) Findings in amebiasis 86) Clinicopathologic features of granular cell tumor 87) Identification of toxoplasma 88) Vacuolar interface change; lupus erythematosus, erythema multiforme 89) Focal segmental glomerulosclerosis; podocin 90) Characteristics of HPV-related squamous cell carcinoma 91) Juxtaglomerular cell tumor of the kidney; characteristics 92) Stromal lesion of the breast and CD34 staining 93) Immunoprofile of invasive micropapillary urothelial carcinoma 94) Recognize esophagitis dissecans superficialis histology in appropriate clinical context 95) Characteristics of hyperparathyroidism 96) Diagnose cryptosporidiosis; colon biopsy 97) Acute atherosis/fibrinoid necrosis in placenta 98) AJCC staging of lung cancer 99) Micromedullary carcinoma; identification from thyroid nodule 100) Rheumatoid nodule; identify 101) Immunohistochemical profile of mammary analogue secretory carcinoma 102) Prognostic factor for invasive breast carcinoma; axillary lymph node


SURGICAL PATHOLOGY (cont’d)

103) Patterns of placental infections 104) Liver mass; identification of focal nodular hyperplasia 105) HER2 by immunohistochemical staining 106) Recognition of normal colonic mucosa 107) Characteristics of allergic fungal rhinosinusitis 108) Cytomegalovirus; cells infected 109) Meningioma; epithelial membrane antigen immunoreactivity 110) Characteristics of yolk sac tumor 111) Myelin stain 112) Adrenal nodule; adrenal cortical adenoma 113) Intracytoplasmic Negri and Lyssa bodies; rabies encephalitis 114) Microsatellite instability in colorectal adenocarcinoma 115) Nonspecific interstitial pneumonia; characteristics 116) Recognition of autoimmune pancreatitis 117) Characteristics of acquired cystic disease; renal cell carcinoma 118) Recognize Wilms tumor and distinguish it from other primitive pediatric neoplasms 119) Gross appearance; hydatid cyst 120) Ductal carcinoma in situ features and risk of recurrence 121) Features of tall cell variant of papillary thyroid carcinoma 122) Significance and diagnostic criteria for urothelial carcinoma in situ 123) Features of basal-like breast cancers 124) Recognition of granuloma annulare 125) Metastatic carcinoma; myelophthisic anemia 126) Eosinophilic neuronal degeneration 127) Staining C4d in kidney peritubular capillaries; acute humoral rejection 128) Immunohistochemistry in olfactory neuroblastoma 129) Definitions and significance of prostate cancer grade groups 130) Association of SDHB and paraganglioma 131) Mucinous cystic neoplasm with ovarian like stroma 132) Identification of eosinophilic esophagitis 133) Lymphangioleiomyomatosis associations 134) Adult granulosa cell tumor 135) Metastatic patterns of nasopharyngeal carcinoma 136) CPT billing codes in surgical pathology 137) Immunohistochemical profile of primary lung adenocarcinoma 138) Characteristics of complete mole 139) Identification of pancreatic serous cystadenoma 140) Kaposi sarcoma with HHV-8 LANA immunostain positivity 141) Ependymoma; identification 142) Synovial sarcoma; cytogenetics 143) Common causes of atrophic gastritis 144) Characteristics of MEN1 145) Perineum; cytologic atypia in nevi, special site nevi 146) Diagnosis of malignant phyllodes tumor

CLINICAL PATHOLOGY

CLINICAL CHEMISTRY 147) Negative predictive value; calculation 148) History of hemoptysis and hematuria; anti-glomerular basement membrane antibody; Goodpasture syndrome 149) Tumor marker; prostate specific antigen 150) Major intracellular cation 151) Hemolytic anemia; bilirubin and urinalysis findings 152) Acid-base balance, high total bicarbonate


CLINICAL CHEMISTRY (cont’d)

153) Folate testing 154) Fecal occult blood testing; methodologies and associated false positives 155) Candidate biomarkers should have a long half-life 156) Negative acute phase reactant; transferrin 157) Deleted 158) Pheochromocytoma; diagnostic tests; plasma free metanephrines 159) Methanol ingestion; serum osmol gap 160) Protein content in lipid fractions 161) Marker for pancreatic carcinoma; CA19-9 162) Methanol; toxic metabolite 163) Glomerular filtration rate; age, sex, height, serum creatinine 164) Ethyl alcohol and cocaine; cocaethylene 165) Autoantibodies and immunoassays 166) IgD and IgE myeloma 167) Diagnosis of diabetes 168) Calculated LDL 169) Determination of reference intervals 170) Calculated positive predictive value 171) Understand volume of distribution and half life 172) Testing for risk of Down syndrome 173) Celiac disease diagnosis; test most sensitive and specific 174) Elevated urinary telopeptides and deoxypyridinoline; osteoporosis and Padget disease 175) Alpha-1 hydroxylation; kidneys 176) False positive pregnancy tests 177) Anti-Jo-1; inflammatory myositis 178) Critical value importance in clinical laboratory 179) Sulfonylurea; type II diabetes therapy; insulin testing 180) Allergic bronchopulmonary mycosis; total IgE and IgE against Aspergillus 181) Acute porphyria; diagnostic testing 182) Deleted 183) Transthyretin; nutritional status 184) Positive interferences in sandwich immunoassays; circulating human anti-mouse antibodies 185) Phenytoin therapeutic drug monitoring 186) Compensated respiratory acidosis; increased serum bicarbonate

HEMATOLOGY 187) B-lymphoblastic leukemia; immunophenotype and morphology 188) Resistant to the effects of activated protein C; abnormality of factor V 189) Prognosis in chronic lymphocytic leukemia 190) Mechanism of target cell formation 191) Vitamin K deficiency versus liver disease; Factor V 192) Metastatic carcinoma; appearance in effusion 193) Red blood cell agglutination; effect on automated cell count 194) Testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency 195) Automated hematology analyzers; instrument flags 196) Warm auto-immune hemolytic anemia 197) Ringed sideroblasts; iron stain 198) Acute promyelocytic leukemia; morphology and genetics 199) Inhibitor of the ADAMTS 13 enzyme; clinical characteristics of thrombotic thrombocytopenic purpura (TTP) 200) Histoplasmosis; bone marrow morphologic features 201) Flow cytometry; lymphocyte light scatter techniques 202) Red cell morphology; thermal injury 203) Aspirin; effect on platelet aggregation 204) Morphologic features of parvovirus infection 205) Paroxysmal nocturnal hemoglobinuria; fluorescein-labeled proaerolysin (FLAER)


HEMATOLOGY (cont’d)

206) Initial choice of anticoagulation in heparin-induced thrombocytopenia 207) Molecular basis for inherited Pelger-Huët abnormality 208) Laboratory diagnosis of anemia; beta thalassemia minor 209) Laboratory findings; hemolytic anemia 210) Automated hematology analyzers; nucleated red blood cells 211) Gaucher disease; enzyme deficiency 212) Automated cell counters; falsely high platelet count 213) Chronic myelomonocytic leukemia; absolute monocytosis, dysplasia, blasts 214) Transient abnormal myelopoiesis, molecular findings 215) Evans syndrome; clinical characteristics 216) Chronic granulomatous disease 217) Morphology and immunophenotype of acute myeloid leukemia with mutated NPM1 218) Factor XII deficiency; association with bleeding 219) Hemoglobin S/C disease; clinical and morphologic findings 220) Metastatic adenocarcinoma; bone marrow 221) Red blood cell inclusions; associated precipitated substance 222) Diagnosis of antiphospholipid syndrome; antiphospholipid antibodies over time 223) Effects of anticoagulant therapy on prothrombin time (PT) and activated partial thromboplastin time (aPTT) 224) Dysplastic megakaryocytes; identification 225) Anticoagulants that prolong thrombin time 226) Morphologic features of cystine crystals

MICROBIOLOGY 227) Gram stain; reagent effects 228) Identification of vector of tick-borne relapsing fever in the United States 229) Extended spectrum beta-lactamase; Klebsiella 230) Candida albicans; positive germ tube 231) Staphylococcus aureus; D test interpretation 232) Members of the Mycobacterium tuberculosis complex 233) Serological diagnosis of chronic hepatitis B infection 234) Intrinsic resistance in Candida species 235) Identification of helminth eggs and knowledge of helminth life cycles 236) Legionella culture method 237) Microscopic appearance of organisms associated with phaeohyphomycosis 238) Diagnosis of parvovirus infection from bone marrow 239) Influenza A vaccine subtypes 240) Nocardia species 241) Nontreponemal test for diagnosis of syphilis 242) Testing for human papillomavirus (HPV) in cervical cancer screening 243) Morphology of Charcot-Leyden crystal in a clinical specimen 244) Staphylococcus saprophyticus in urine; growth characteristics 245) Microscopic identification of Pneumocystis 246) Plasmodium vivax; treatment of the hypnozoite stage 247) Salmonella infection 248) Intrinsic resistance to vancomycin 249) Strongyloides larva; clinical symptoms and identification 250) Maxillary sinus infection; Rhizopus 251) Stains for acid fast bacilli 252) Virulence factors of Streptococcus pneumoniae 253) Acceptance criteria for sputum cultures 254) Fusobacterium in Lemierre’s syndrome 255) Mycobacterium marinum; clinical presentation and growth characteristics; photochromogens 256) Identify Proteus mirabilis; growth characteristics on agar plate 257) Anisakiasis; clinical characteristics and morphology 258) Aspergillus species microscopic and macroscopic morphology 259) Deleted


MICROBIOLOGY (cont’d)

260) Identification of helminth eggs and knowledge of intestinal helminth complications 261) Infections requiring airborne isolation precautions 262) Nitrofurantoin; uncomplicated cystitis 263) Antibody to hepatitis C virus; HCV RNA test 264) Mycobacterium fortuitum; clinical and microscopic characteristics 265) Recognition of morphologic forms of Coccidioides immitis/C. posadasii on fluorescent stain 266) Characteristics of Erysipelothrix rhusiopathiae

TRANSFUSION MEDICINE 267) Appropriate blood products modifications for stem cell transplant 268) Postnatal treatment of fetal and neonatal alloimmune thrombocytopenia (FNAIT) 269) Kinetics of plasma volume exchange and residual plasma components after exchange 270) Transfusion reaction; transfusion-associated graft vs. host disease 271) Bacterial contamination of platelets 272) Relationship between one-hour post transfusion count and platelet refractoriness 273) Non-immune causes for hemolysis during transfusion 274) Dosage effect of antibodies; delayed hemolytic transfusion reaction (DHTR) 275) Albumin characteristics and function 276) Calculation of plasma volume 277) Massive transfusion protocol guidelines 278) Appropriate test ordering and blood product replacement for coagulopathy 279) Transfusion related acute lung injury (TRALI) transfusion reaction work-up 280) Measles vaccine deferral 281) Antineutrophil antibodies; transfusion-related acute lung injury 282) Additive solution Red Blood Cells; storage and preparation 283) The definition of a leukoreduced blood product 284) Passenger lymphocyte syndrome; causes of hemolysis in transplant settings, antibody types 285) Intraoperative blood recovery 286) Pathophysiology of an aplastic crisis in hemoglobin SS disease 287) HLA system and transfusion; transplantation 288) Thrombocytopenia and microangiopathy 289) Arterial puncture during collection of whole blood 290) Hematopoietic progenitor cell collection yield 291) HIV lookback protocol 292) Platelet transfusion dose increment 293) Volunteer and directed blood donor criteria; exceptions 294) Foundation for the Accreditation of Cellular Therapy (FACT) purview 295) HIV infection; lupus anticoagulant 296) Cryoprecipitate; indications for transfusion 297) Appropriate therapy for FXII deficiency; a non-coagulopathic condition 298) ABO incompatible hematopoietic progenitor cell (HPC) transplants 299) Characteristics of anti-E and anti-K 300) Rh haplotypes 301) Autoantibody; antibody panel presentation 302) Interpretation of gel-based ABO and Rh typing 303) Significance of antibody titers in pregnancy 304) Haemovigilance program; transfusion related adverse events reporting 305) Irradiated Red Blood Cell unit; shelf life 306) Deferral interval after 2-unit red cell donation by apheresis


SPECIAL TOPICS

HEMATOPATHOLOGY 307) Follicular dendritic cell proliferation; angioimmunoblastic T-cell lymphoma 308) Changes in the bone marrow trabecula in patients with renal failure 309) Diagnose; acute monocytic leukemia 310) Nasal T/NK lymphoma; necrosis 311) Clinical, morphologic, and immunophenotypic findings in breast implant-associated anaplastic large-cell lymphoma 312) Origin of Reed-Sternberg cells 313) Mast cell disease; non-mast cell hematopoietic malignancy 314) Distinction between plasma cell myeloma and monoclonal gammopathy of undetermined significance 315) Clinicopathologic features of Rosai Dorfman Disease 316) Mantle cell lymphoma; immunophenotype 317) Sarcoidosis 318) Nodular lymphocyte, predominant Hodgkin lymphoma; identification 319) Bone marrow involvement by follicular lymphoma 320) Morphology and phenotype for the differential of hairy cell leukemia 321) Cytologic findings in follicular lymphoma

LABORATORY ADMINISTRATION 322) Blood products; large expense item 323) Prohibition of clinical laboratory self-referral 324) Principles of calibration 325) Proficiency testing 326) CLIA storage requirements for slides 327) Logical observation identifiers, names and codes (LOINC®); purpose 328) College of American Pathologists Phase II deficiency 329) Productivity; measure of outputs per input resources 330) Proficiency testing treated like patient sample 331) Obtain laboratory analyzer; reagent rental agreement 332) Types of indirect costs 333) Root cause analysis; retrospective process 334) Care and payment models 335) Accounts receivables 336) Know data required for regressive analysis for method comparison 337) CLIA certificate of waiver 338) Instrument precision; coefficient of variation 339) Deleted

MOLECULAR PATHOLOGY 340) DNA measurements 341) Communication of patient medical results 342) Cytogenomic array interpretation 343) Genomic databases 344) Define sequencing coverage 345) Interpretation of EGFR molecular testing in non-small cell lung adenocarcinoma 346) Mutation confirmation approaches in next-generation sequencing 347) DNA double helix bonds; hydrogen bonds 348) Isothermal amplification for transcription mediated amplification and nucleic acid sequence based amplification 349) New prenatal testing; fetal circulating DNA in the mother's blood 350) Fanconi’s anemia; chromosomal instability 351) Sensitive detection of common oncogene mutations 352) Dominant gene expressed in hetero and homozygous states 353) Genome translated into protein; exon


MOLECULAR PATHOLOGY (cont’d)

354) Exome sequencing; mutations in the coding regions of genes 355) Interpretation of B-cell receptor gene rearrangement 356) HLA loci tested for allogeneic transplantation 357) Prognostic factors in chronic myelogenous leukemia 358) Cystic fibrosis associated with absent vas deferens 359) DNA identity testing; short tandem repeats (STR) 360) Karyotype; interpretation 361) Microsatellite stability in colon cancer 362) Heavy chain CDR3 length; V, D, and J segments

American Society for Clinical Pathology 2018 Resident In-Service Examination Item References

ANATOMIC PATHOLOGY

CYTOPATHOLOGY

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CYTOPATHOLOGY (cont’d)


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2451. 261) CDC. Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings. 2007:94.

Jorgensen JH, Pfaller MA, Carroll KC, et al, eds. Manual of Clinical Microbiology. 11th ed. Washington, DC: ASM Press; 2015:1519-1535.

262) Jorgensen JH, Pfaller MA, Carroll KC, et al, eds. Manual of Clinical Microbiology. 11th ed. Washington, DC: ASM Press; 2015:1195-1196.



265) Jorgensen JH, Pfaller MA, Carroll KC, et al, eds. Manual of Clinical Microbiology. 11th ed. Washington, DC: ASM Press; 2015:2116. 266) Jorgensen JH, Pfaller MA, Carroll KC, et al, eds. Manual of Clinical Microbiology. 11th ed. Washington, DC: ASM Press; 2015:462-

473.

TRANSFUSION MEDICINE 267) Simon TL, Snyder El, Stowell CP, et al, eds. Rossi’s Principles of Transfusion Medicine. 4th ed. Oxford, England: Wiley-Blackwell;

2009:228-246, 852, 834. 268) Roback JD, et al, eds. AABB Technical Manual. 17th ed. Bethesda, MD: AABB; 2011:639-641. 269) Winters JL, et al, eds. Therapeutic Apheresis: A Physician''s Handbook. 4th ed. Bethesda, MD: AABB; 2013:14. 270) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethseda, MD: AABB; 2014: 686-688. 271) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:198-199. 272) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:458-59. 273) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:669. 274) Harmening D. Modern Blood Banking and Transfusion Practices. 6th ed. Philadelphia, PA: FA Davis; 2012:231-238. 275) Culler EE, Logdberg LE. Albumin. In: Hillyer CD, Silberstein LE, Ness MD, et al, eds. Blood Banking and Transfusion Medicine-

Basic Principles and Practice. 2nd ed. New York, NY :Churchill Livingstone; 2007:278-285. 276) Winters JL, Crookston KP, Delaney M, et al. Therapeutic Apheresis: A Physician’s Handbook. 4th ed. Bethesda, MD: AABB;

2013:16-17. 277) Sihler KC, Napolitano LM. Massive transfusion: insights. Chest. 2009;136:1654-1667. 278) Kitchens CS, Kessler CM, Konkle BA. Consultative Hemostasis and Thrombosis. 3rd ed. Philadelphia, PA: Elsevier Saunders;

2013:26. 279) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:668. 280) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:121-127.

Ooley PW, ed. AABB Standards for Blood Banks and Transfusion Services. 30th ed. Bethesda, MD: AABB; 2016:60-67.


TRANSFUSION MEDICINE (cont’d)

281) Fung Y, Silliman C. The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury. Trans Med Rev. 2009;23:266-283. Bux J. Antibody-Mediated (immune) Transfusion-Related Acute Lung Injury. Vox Sang. 2011;100, 122-138.

282) Ooley PW, ed. AABB Standards for Blood Banks and Transfusion Services. 30th ed. Bethesda, MD: AABB; 2016:51-53; Standard 5.1.8A.

283) AABB. Standards for Blood Banks and Transfusion Services. 29th ed. Bethesda, MD: AABB; 2014:24. Std. 5.7.3.1. 284) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:633. 285) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:606-607. 286) Randolph TR. Hemoglobinopathies (Structural Defects in Hemoglobin). In: Rodak BF, Fritsma GA, Doig K, eds. Hematology

Clinical Principles and Applications. 3rd ed. St. Louis, MO: Saunders; 2007:336-344. 287) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:481-484. 288) Shaz B, et al. Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects. 2nd ed. Waltham, MA. Elsevier; 2013:675-

680. 289) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethseda, MD: AABB; 2014:145. 290) AABB Press, McLeod B, Szczepiorkowski ZM, Weinstein R, Winters JL, eds. Apheresis Principles and Practice. 3rd ed. Bethesda,

MD: AABB Press; 2010:496. 291) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:187. 292) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:459. 293) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:130. 294) Snyder EL, Haley NR, ed. Cellular Therapy: A Physician’s Handbook. Bethesda, MD: AABB; 2004:236-241. 295) Roback JD, et al, eds. AABB Technical Manual. 17th ed. Bethesda, MD: AABB; 2011:594, 598-604. 296) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:522. 297) Kitchens CS, Kessler CM, Konkle BA. Consultative Hemostasis and Thrombosis. 3rd ed. Philadelphia, PA: Elsevier Saunders;

2013:70-71. 298) Hillyer CD, Shaz B, Zimring, Ashire, eds. Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects. New York:

Elsevier Inc; 2009:420-422. 299) Harmening D. Modern Blood Banking and Transfusion Practices. 5th ed. Philadelphia, PA: FA Davis; 2005:253-276. 300) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:329. 301) Roback JD, et al, eds. AABB Technical Manual. 17th ed. Bethesda, MD: AABB; 2011:448-455. 302) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:377. 303) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethesda, MD: AABB; 2014:563. 304) Roback JD, et al, eds. AABB Technical Manual. 17th ed. Bethesda, MD: AABB; 2011:727. 305) Ooley PW, ed. Standards for Blood Banks and Transfusion Services. 30th ed. Bethesda, MD: AABB; 2016:51-53. 306) Fung MK, et al, eds. AABB Technical Manual. 18th ed. Bethseda, MD: AABB; 2014:171.

SPECIAL TOPICS

HEMATOPATHOLOGY 307) Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and

Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC Press; 2017:408-410. 308) Foucar K, Reichard K, Czuchlewski D, eds. Bone Marrow Pathology. 3rd ed. Chicago, IL: ASCP Press; 2010:673-682. 309) Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and

Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC Press; 2017:156-166. 310) Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and

Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC Press; 2017:368-371. 311) Xu J, Wei S. Breast implant-associated anaplastic large cell lymphoma: review of a distinct clinicopathologic entity. Arch Pathol Lab

Med. 2014 Jun;138(6):842-846.


HEMATOPATHOLOGY (cont’d)

312) Stein H, Delsol G, Pileri SA, et al. Classical Hodgkin Lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC; 2017:424-430.

313) Foucar K, Reichard K, Czuchlewski D, eds. Bone Marrow Pathology. 3rd ed. Chicago, IL: ASCP Press; 2010:303. 314) Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and

Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC Press; 2017:241-254. 315) Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Fend L, et al, eds. Hematopathology: Expert Consult. 2nd ed. Philadelphia,

PA: Saunders Elsevier Press; 2016:957-959. 316) Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and

Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC Press; 2017:285-290. 317) O'Malley DP. Atlas of Spleen Pathology. New York, NY: Springer; 2012:138.

Cheuk W, Lee AK, Arora N, Ben-Arie Y, Chan JK. Splenic hamartoma with bizarre stromal cells. Am J Surg Pathol. 2005;29:109-114.

318) Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon, France: IARC; 2017:431-434.

319) Zhang QY, et al. Bone marrow involvement by hodgkin and non-hodgkin lymphoma. Hematol Oncol Clin North Am. 2009;23(4):873-902.

320) Venkataraman G, Aguhar C, Kreitman RJ, Yuan CM, Stetler-Stevenson M. Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia: usefulness of CD123 and CD103 in the diagnosis of mature B-cell lymphoproliferative disorders. Am J Clin Pathol. 2011;136(4):625-630.


LABORATORY ADMINISTRATION 322) McClatchey KD, Travers EM. Basic Laboratory Management. In: McClatchey KD. Clinical Laboratory Medicine. Philadelphia, PA:

Lippincott Williams & Wilkins; 2002:13. 323) Garcia LS, et al, eds. Clinical Laboratory Management. Herndon, VA: ASM Press; 2014:112. 324) Jhang JS. Evaluation of linearity in the clinical laboratory. Arch Pathol Lab Med. 2004;128:44-48. 325) McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. Philadelphia, PA:

Saunders Elsevier; 2017:125-129. 326) CLIA Regulations. 42 CFR 493.1105 - Standard: Retention requirements. 327) Logical Observation Identifiers Names and Codes (LOINC). Available at: www.loinc.org. Accessed February 10, 2017. 328) Sharkey F, ed. CAP Laboratory Accreditation Manual2012 October Edition. Northfield, IL: College of American Pathologists;

2012:103. 329) Wagar EA, Eltoum IA, Horowitz RE. Financial Management of the Laboratory. In: Wagar EA, Horowitz RE, Siegal GP, eds.

Laboratory Administration for Pathologists. Northfield, IL: CAP Press; 2011:160. 330) Schifman RB, Cembrowski G, Wolk D. Quality Management. In: Garcia LS, et al eds. Clinical Laboratory Management.

Washington, DC: ASM Press; 2004:380. 331) Harmening DM. Laboratory Management: Principles and Processes. 3rd ed. St. Petersburg, FL: DH Publishing and Consulting;

2013:285. 332) Harmening DM. Laboratory Management: Principles and Processes. 3rd ed. St. Petersburg, FL: DH Publishing and Consulting;

2013:273. 333) Garcia LS, et al, eds. Clinical Laboratory Management. Herndon, VA: ASM Press; 2004:79-134. 334) Garcia LS, et al, eds. Clinical Laboratory Management. Herndon, VA: ASM Press; 2014:211. 335) Garcia LS, et al, eds. Clinical Laboratory Management. Herndon, VA: ASM Press; 2004:525-550. 336) CLSI EP09-A3: Measurement Procedure Comparison and Bias Estimation Using Patient Samples. Approved Guideline - 3rd ed.

Wayne, PA: Clinical and Laboratory Standards Institute; 2013:CLIS EP09-A3. 337) https://wwwn.cdc.gov/clia/resources/waivedtests/default.aspx. Accessed October 2017. 338) McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. Philadelphia, PA:

Saunders Elsevier; 2017:102-104. 339) Deleted


MOLECULAR PATHOLOGY

340) Buckingham L, Flaws ML. Molecular Diagnostics: Fundamentals, Methods, and Clinical Applications. Philadelphia, PA: FA Davis; 2007:76-77.

341) Nussbaum RL, McInnes RR, Willard HF, eds. Thompson & Thompson Genetics in Medicine. 8th ed. Philadelphia, PA: Elsevier Saunders; 2016:386-388.

342) Nussbaum RL, McInnes RR, Willard HF, eds. Thompson & Thompson Genetics in Medicine. 8th ed. Philadelphia, PA: Elsevier Saunders; 2016:61-63.

343) Wheeler DL, Barrett T, Benson DA, et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 2007;35:D5–D12.

344) Haimovich AD. Methods, challenges, and promise of next-generation sequencing in cancer biology. Yale J Biol Med. 2011;84:439-446.

345) Buckingham L. Molecular Diagnostics. 2nd ed. Philadelphia, PA: FA Davis Company; 2012:373-375. 346) Schrijver I, Aziz N, Farkas DH, Furtado M, Ferreira-Gonzalez, A, Greiner TC, Grody WW, et al, eds. Opportunities and challenges

associated with clinical diagnostic genome sequencing: A report of the Association for Molecular Pathology. J Mol Diagn. 2012;14:525-540.

347) Burtis CA, Ashwood ER, Bruns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. Philadelphia, PA: Elsevier Saunders; 2005:1394.

348) McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2002:154. 349) Rifai N, Horvath AR, Wittwer CT. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. St Louis, MO: Elsevier;

2017:1152-1154. 350) Akkari Y, Olson S. Fanconi anemia: a decade of discoveries. J Assoc Genet Technol. 2004;30:48-53. 351) Siddiqui AD, Piperdi B. KRAS mutation in colon cancer: a marker of resistance to EGFR-I therapy. Ann Surg Oncol.

2010;17(4):1168-1176. 352) Nusbaum RL, McInnes RR, Willard HF. Thompson & Thompson Genetics in Medicine. 7th ed. Philadelphia, PA: WB Saunders;

2007:126-130. 353) Nusbaum RL, McInnes RR, Willard HF. Thompson & Thompson Genetics in Medicine. 6th ed. Philadelphia, PA: WB Saunders;

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Discov. 2013;3:224-237. 355) Grody WW, Nakamura RM, Kiechle FL, Strom C. Molecular diagnostics- Techniques and Applications for the Clinical Laboratory.

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Opinion of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). Biol Blood Marrow Transplant.2015;21(1):4–7. 357) Xu Y, Wahner AE, Nguyen PL. Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate. Arch

Pathol Lab Med. 2004 Sep;128(9):980-985. 358) Henry JB, ed. Clinical Diagnosis and Management by Laboratory Methods. 20th ed. Philadelphia, PA: Saunders; 2001:1377-1378. 359) Leonard DGB. Molecular Pathology in Clinical Practice. New York, NY: Springer; 2007:496-499. 360) An International System for Human Cytogenetic Nomenclature. Basel, Switzerland: Karger; 1995:50-74. 361) Sepulveda AR, Hamilton SR, Allegra CJ, et al. Molecular biomarkers for the evaluation of colorectal cancer: guideline from the

American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology. Arch Pathol Lab Med. 2017;141(5):625-657. doi: 10.5858/arpa.2016-0554-CP.

362) Janeway CA, Shlomchik MJ, Travers P, et al. Immunobiology. 5th ed. New York, NY: Garland Publishing; 2001:appendix I