2017 advanced biomanufacturing sponsors - conferences @ wid – wisconsin … · 2017-08-18 ·...

2017ADVANCEDBIO

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UFACTU

RINGSPO

NSO

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ThankyouforourgrantsupportfromtheNationalScienceFoundation.

Gold

Silver

Bronze

ThankYouforourSponsors’GenerousSupport

MadisonIBMES-ABioM20171

TABLEOFCO

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Welcome………………………………….………………………………………. 2

ScientificCommitteeMembers………………………………………… 3

KeynoteSpeakers

StatusofAdvancedBiomanufacturingSession…………….. 5

EmergingConceptsSession…………………………………………. 7

FutureofAdvancedBiomanufacturingSessionI………….. 8

FutureofAdvancedBiomanufacturingSessionII............ 9

CurrentAdvancesinBiomanufacturingSession……………. 9

FutureAdvancesinBiomanufacturingSession……………… 11

2017ABioMAwardRecipients………………………………………….. 12

AbstractReviewers………………………………………………………….. 13

GeneralInformation………………………………………………………… 13

PosterSession…………………………………………………………………. 15

ProgramataGlance……………………………………………………….. 19


LETTERFROMTHECHAIRS

RandolphS.Ashton,PhDAnnualMeetingCo-Chair

AssistantProfessorBiomedicalEngineering

WisconsinInstituteforDiscoveryUniversityofWisconsin-Madison

WilliamMurphy,PhDAnnualMeetingCo-ChairHarveyD.SpanglerProfessor

BiomedicalEngineering

WisconsinInstituteforMedicalResearchUniversityofWisconsin-Madison

elcometotheinauguralmeetingoftheBiomedicalEngineeringSociety’sAdvancedBiomanufacturingSpecialInterestGroup(ABioM-SIG).Youractiveparticipationinthe

conferenceishighlyencouragedasweseektodefinethecurrentstateandfuturegoalsoftheABioMfield.Consistentwiththeconference’stheme,weaimtoidentifyopportunitiesandchallengesassociatedwithtranslatingthepharmaceuticalindustry’ssuccessfulclinicalmanufactureofsmallmoleculeandbiologictherapeuticstotheadvancedbiomanufactureofgenetherapiesandhumancell,tissueandtissue-relatedtechnologies.Thisincludesconsiderationofrequisitelogistical/supportiveinfrastructureandworkforcedevelopment.Tofacilitatethisprocess,wehaveassembledheadsofbiomanufacturingcorporations,leadersofrelevantindustry/academicinitiatives,manufacturesofclinicalcellandtissuetherapies,innovatorsofnext-generationregenerativeapproaches,anddirectorsofrelatedworkforcetraininginitiativestoparticipateinahighlyinteractiveprogram.WehopethatthepresentedinformationanddiscussionsprovideaconciseoverviewoftheABioMfield,forecastnoveladvancements,andevokeproductivecollaborationsandpartnerships.ThisconferencewouldnothavebeenpossiblewithouttheassistanceofmanystakeholdersintheABioMfield,andweofferthemoursincerestgratitude.TheWisconsinInstituteforDiscoveryservingbothasourmeetinghostandasponsorisatransdisciplinaryresearchinstitutewithABioMasoneofitscoreresearchfoci.TheconferenceisalsosponsoredbytheNationalScienceFoundation(#1743396),WiCell®,WorcesterPolytechnicInstitute,WaismanBiomanufacturing,theGraingerInstituteforEngineeringandtheBiomedicalEngineeringDepartmentintheCollegeofEngineeringatUW-Madison,andW.NuhsbaumIncorporated.DedicatedfacultymembersofboththeABioM-SIGandUW-Madison’sStemCellandRegenerativeMedicineCenterprovidedtheirtimetoassistwithabstractreviewsandawardselections.Also,specialthanksareduetomembersoftheorganizingscientificcommitteefortheirserviceanddedicationtothisendeavor.Mayyouhaveanenjoyableandproductivemeeting!

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SCIENTIFICCO

MMITTEEM

EMBERS

KaimingYe,PhDAnnualMeetingProgramCo-Chair

ProfessorandChairBiomedicalEngineering

SUNYBinghamton

GlennR.Gaudette,PhDAnnualMeetingProgramCo-Chair

ProfessorBiomedicalEngineering

WorcesterPolytechnicInstitute

RolandKaunas,PhD

ScientificCommitteeMemberAssociateProfessor

BiomedicalEngineering

TexasA&MUniversity

ElizabethLipke,PhD

ScientificCommitteeMemberMaryandJohnH.SandersAssociate

ProfessorChemicalEngineeringAubrunUniversity


KEYNOTESPEAKERS

PaulGoodwinistheScienceDirectorforGEHealthcare’sLifeSciencesbusiness,locatedintheSeattle,WAarea.PaulreceivedhisBachelor’sdegreeinBiologyfromtheUniversityofCalifornia,SanDiegoandcontinuedhiseducationintheDepartmentofPhysiologyandBiophysicsattheUniversityofWashington,Seattle,WAwhereheobtainedaMaster’sdegree.HethenbeganworkasaResearchTechnicianintheDepartmentofPathologyattheUniversityofWashingtoninthelaboratoryofDr.RussellRoss.Itwasherethathewasintroducedtotheuseofdigitalimageprocessingandimageanalysiswithlightandelectronmicroscopy.PaulwasrecruitedbytheFredHutchinsonCancerResearchCentertocreateandmanagetheImageAnalysisCoreFacilitywherehedevelopedanumberofnewimagingtechniques.

Aftertenyears,hewasrecruitedtoAppliedPrecision,Inc.inIssaquah,WAwherehehasservedvariousrolesinadvancedapplicationdevelopment,productmanagement,andR&D.AsScienceDirector,heworkswithteamsacrosstheLifeSciencesbusinesstoidentifyandsolvetechnicalchallengesthataffectourcustomersandourbusiness.Healsosupportsinnovationandprovidesbothvisionandstrategicplanningfortheorganization.PaulisanAffiliateTeachingAssociateintheDepartmentofComparativeMedicineattheUniversityofWashington,Seattle,WA.Heisanexpertinthree-dimensionaloptics,deconvolution,super-resolutionmicroscopy,andinstrumentdevelopment.HelecturesfrequentlyandservesasfacultyformicroscopycoursesattheMarineBiologicalLaboratory,WoodsHole,MAincludingtheImmunohistochemistryandMicroscopycoursesupportedbytheHistochemicalSociety.HehasbeenaCounciloroftheSocietysince2013andiscurrentlythePresident-ElectoftheHistochemicalSociety.GeorgeJ.ChrististheProfessorofBMEandOrthopaedicSurgery,MaryMuilenbrrgStampProfessorofOrthopaedicSurgery,andDirectorofBasicScience&TranslationalResearchforOrthopaedicSurgery,UninversityofVirginia.HeistheCo-DirectoroftheCenterforAdvancedBiomanufacturingattheUniversity

StatusofAdvancedBiomanufacturingSessionFriday–8:40AM

PaulGoodwin,PhD

ScienceDirector,LifeScienceDivisionGEHealthcare

Friday,August18,20178:40–9:15AM

GeorgeJ.Christ,PhDMaryMuilenbrrgStampProfessor,

BiomedicalEngineering&OrthopaedicSurgeryUniversityofVirginia



KEYNOTESPEAKERS

ofVirginia.Dr.ChristisamemberofAIMBE,thePastChairmanoftheDivisionofSystemsandIntegrativePharmacologyoftheAmericanSocietyofPharmacologyandExperimentalTherapeutics(ASPET),andPastPresidentoftheNorthCarolinaTissueEngineeringandRegenerativeMedicine(NCTERM)group.HeisontheEditorialBoardoffivejournalsandisanad-hocreviewerfor2dozenothers.Dr.Christhasauthored222scientificpublicationsandisco-editorofabookonintegrativesmoothmusclephysiologyandanotheronregenerativepharmacology.Dr.Christhasservedonbothnationalandinternationalcommitteesrelatedtohisexpertiseinmusclephysiology,andonNIHstudysectionsintheNIDDK,NICHD,NCRRandNHLBI.HehaschairedworkinggroupsforboththeNIHandtheWorldHealthOrganization.Dr.Christisaco-inventoronmorethan26patents(nationalandinternational)thatareeitherissuedorpending,relatedtogenetherapyforthetreatmentofhumansmoothmuscledisordersandtissueengineeringtechnologies.Dr.ChristhasalsobeenthedrivingscientificforcebehindthepreclinicalstudiesandINDapprovalssupportingthreePhaseIclinicaltrialsforgenetherapyforbenignhumansmoothmuscledisorders.Thistechnologyhasbeenevaluatedin55patientsintheUSand21overseas.Heisalsospearheadingthemulti-institutionaldevelopmentofatissueengineeredmusclerepair(TEMR)technologyplatformforthetreatmentofWoundedWarriors.AnINDsubmissionfora5patientfirst-in-manpilotstudyisanticipatedin2017tofurtherdevelopthistechnologyplatformfortreatmentofcleftlip.ThatstudyisfundedbyDODandwillbeconductedatUT-Houston.Another5patientpilotstudyhasalsobeenfundedbyDODtoevaluateaproprietaryhydrogelforthetreatmentoflowerextremityvolumetricmusclelossinjuriestothetibialisanteriormuscleatUVA.AnIDEapplicationforthatindicationisalsoanticipatedin2017.Dr.Christhasbeenextensivelyinvolvedinbasicandtranslationalstudiesofregenerativemedicinedirectedtowardvesseltissueengineeringandbladderregeneration,andmostrecently,regenerativepharmacology.

MarkJ.TomishimaistheHeadoftheSKIStemCellResearchFacility,partoftheCenterforStemCellBiologyandtheDevelopmentalBiologyProgramatSloanKetteringInstituteinNewYorkCity.Dr.TomishimaearnedhisPh.D.atPrincetonUniversitywherehestudiedthemovementofalpha-herpesvirusesthroughneurons.Atthetime,thisworkrequiredprimaryneuronculturethatlimitedthroughput.AfterearninghisPh.D.,heperformedpostdoctoralworkwithLorenzStuderatSloanKetteringwherehelearnedtoconvertpluripotentstemcellstounlimitedamountsofneurons,bypassingtheneedfortheprimaryculture.IntheStuderLab,Dr.Tomishimapioneeredtheuseofbacterialartificialchromosomesthatwereusedtopurifypopulationsofneuralcells.Suchpurifiedpopulationsareusefulinunderstandingthetranscriptomeofdifferentneuralcellpopulations,andallowedfortransplantationofdifferentstagesofESC-derivedneuralcellsintoanimalmodelsof

Parkinson’sdisease.Hewasalsopartofaninternationalteamthatusednuclearcloningtechnologytocreateapluripotent,autologousmodelofParkinson’scelltherapy.Forthepastdecade,Dr.TomishimahasruntheSKIStemCellResearch

MarkJ.Tomishima,PhDHeadofSloanKetteringInstitute

StemCellResearchFacilitySloanKetteringInstitute



KEYNOTESPEAKERS

Facility,ahumanpluripotentstemcellsharedfacilitythatprovidesanumberofservicestothestemcellcommunity.Onefocusofhisgroupwastoperformtheprocess,assayandSOP/BRdevelopmentaroundMSKDA01,ahumanembryonicstemcell-derivedmidbrainfloorplateanddopamineneuronproductintendedtotreatParkinson’sdiseasepatients.Dr.TomishimaandhisgroupmanufacturedMSKDA01inacGMPcleanroomandtheproductiscurrentlyundergoingthefinalIND-enablingstudies.TheLorenzStuder-ledconsortiumhopestofiletheINDapplicationwiththeFDAinthesummerof2018.

DeepakVashishthistheDirectoroftheRensselaerPolytechnicInstituteCenterforBiotechnology&InterdisciplinaryStudies(CBIS),conductingbreakthroughresearchonbonesandworkingtoredefinetheroleofatoptierresearchuniversity:onethatisengagedinpublicandprivatepartnerships,involvedininterdisciplinaryresearch,andprovidingqualityeducation,alltodriveentrepreneurial,sustainable,sociallyresponsiblescientificdiscoveryandtechnologicalinnovation.ThroughhisworkasaUniversityCenterDirectorsince2013,previouslyasaSchoolofEngineeringDepartmenthead(2009-2013),andinprofessionalsocietieshehassuccessfullydevelopedpartnerships,programsandplatforms,todrivetranslationalscientificresearchacrossdisciplines,sectors,andgeographicboundaries.HeearnedhisB.EngwithhonorsfromMalaviyaNationalInstituteofTechnology(India),MSfrom

WestVirginiaUniversity(USA)andPhDfromtheUniversityofLondon(UK).Hethenconductedpost-doctoralresearchattheBoneandJointCenter,DepartmentofOrthopaedicSurgery,HenryFordHospitalbeforejoiningRensselaerasanAssistantProfessorinBiomedicalEngineeringin1999.Hisresearchinterestsareintheareaofbiomolecularscienceandengineeringofextracellularmatrixwithparticularemphasisonbonetissueengineeringanddiagnosisandtreatmentofosteoporosis.Workingincollaborationwithothers,hisresearchgrouphasidentifiednewstructuralrolesforboneproteinsanddevelopednewbiomimickry-basedstrategiesfortissueengineeringscaffolds.Heisbringinghisbreakthroughresearchtomarket,co-foundingacompany(Orthograftplc),toproducetheacellularbiomimeticgraftsforbonerepair.ProfessorVashishthandhisresearchgrouphavepublishedmorethan200peer-reviewedjournalpublicationsandconferenceproceedingsintopjournalsincludingPNAS,MolecularandCellularProteomics,Langmuirandothers.HeisfellowoftheAIMBEandservesasAcademicEditorforPloSOneandeditorialboardmemberforBoneandtheJournaloftheMechanicalBehaviorofBiomedicalMaterials.HeisamemberoftheBiomedicalEngineering

EmergingConceptsSessionFriday–10:50AM

DeepakVashishth,PhDProfessor,BiomedicalEngineeringDirector,CenterforBiotechnology

andInterdisciplinaryStudiesRensselaerPolytechnicInstitute



KEYNOTESPEAKERS

Society,AmericanSocietyofBoneandMineralResearch,AmericanAssociaionforAdvancementofScience,andtheOrthopaedicResearchSociety.

Dr.Krishnendu(Krish)RoyreceivedhisundergraduatedegreefromtheIndianInstituteofTechnology(India)followedbyhisMSfromBostonUniversityandhisPhDinBiomedicalEngineeringfromJohnsHopkinsUniversity.FollowinghisPhD,hejoinedZycosInc.,astart-upbiotechnologycompanywhereheservedfirstasaScientistandthenasaSeniorScientistintheDrugDeliveryResearchgroup.Dr.RoylefthisindustrialpositiontojoinTheUniversityofTexasatAustinin2002,wherehewasmostrecentlyProfessorandFellowoftheCockrellChairinEngineeringExcellence.HeleftUT-AustininJulyof2013tomovetoGeorgiaTech.whereheiscurrentlytheRobertA.MiltonChair.AtGeorgiaTech,healsoservesastheDirectorofthenewlyestablishedMarcusCenterforCell-TherapyCharacterizationandManufacturingaswellastheDirectoroftheCenterforImmunoEngineering,aconsortiumof30+facultyfocusedonusingengineeringtoolsandmethodologiestounderstandandmodulatetheimmunesysteminhealthanddisease.HeisalsotheTechnicalLeadoftheNIST/AMTechNationalCell

ManufacturingConsortium(NCMC),anationalpublic-privatepartnership,focusedonaddressingthechallengesandsolutionsforlargescalemanufacturingoftherapeuticcells.Dr.Roy’sresearchinterestsareintheareasofscalablecellmanufacturing,Immuno-engineering,stem-cellengineeringandcontrolleddrugandvaccinedeliverytechnologies,withparticularfocusinbiomedicalmaterials.Inrecognitionofhisseminalcontributiontothesefields,Dr.RoyhasbeenelectedFellowoftheAmericanInstituteforMedicalandBiologicalEngineering(AIMBE)andFellowoftheBiomedicalEngineeringSociety(BMES).Inaddition,Dr.RoyhasreceivednumerousawardsandhonorsincludingYoungInvestigatorAwardsfromboththeControlledReleaseSociety(CRS)andTheSocietyforBiomaterials(SFB),theYoungScientistAwardfromHSEMB,NSFCAREERaward,GlobalIndusTechnovatorAwardfromMIT,theCRSCygnusAwardetc.HeisalsotherecipientofBestTeacherAwardgivenbytheBiomedicalEngineeringStudentsatTheUniversityofTexasandthebestadvisorawardgivenbybioengineeringstudentsatGeorgiaTech.HeservesasamemberoftheEditorialBoardsoftheJournalofControlledReleaseandtheEuropeanJournalofPharmaceuticsandBiopharmaceutics.HealsoservesasamemberoftheForumonRegenerativeMedicineoftheNationalAcademiesandasco-ChairoftheWorkingGroupoftheStandardsCoordinatingBody(SCB)forCellandRegenerativeTherapies.

FutureofAdvancedBiomanufacturingSessionIFriday–1:25PM

KrishnenduRoy,PhD

RobertA.MiltonChairandProfessor,BiomedicalEngineering

Director,MarcusCenterforCell-TherapyCharacterizationand

Manufacturing(MC3M)GeorgiaInstituteofTechnology

Friday,August18,20171:25–2:00PM


KEYNOTESPEAKERS

RichardMcFarland,PhD,MDistheChiefRegulatoryOfficerofARMI/BioFabUSA,aninstitutewithintheManufacturingUSAnetwork.Theinstitute’sgoalsincludecreatinganindustrialcommonswiththeaimstocoalescethefieldandprovidearoutefornascentproductconceptsinTE/RMtoreachthemarketplace.PriortoARMI,Dr.McFarlandwasAssociateDirectorforPolicyoftheOfficeofTissuesandAdvancedTherapiesattheFoodandDrugAdministration’sCenterforBiologicsEvaluationandResearch(FDA/CBER).HeservedattheFDAinvariouspositions,andwasheavilyinvolvedinpolicydevelopmentfortissueengineering,regenerativemedicine,andalternativestoanimaluseinregulatorydecisionmaking.Inadditiontodevelopmentofrisk-basedregulatoryoversightparadigmswithinFDA,hisinterestsincludedbroadereffortstocreateaninterlockingnetworkofinteragencyeffortstofostergrowthofbasicandtranslationalsciencetosupportmaturationoftheoverlappingfieldsoftissueengineeringandregenerativemedicinefrom

primarilydiscoverysciencetowardastageofcommercialdevelopment.Dr.McFarland,Ph.D.,M.D.receivedhisB.S.,Ph.D.,andM.D.fromtheUniversityofNorthCarolinaatChapelHill,andcompletedhisanatomic/clinicalpathologyresidencyandimmunopathologyfellowshiptrainingatUTSouthwesterninDallas.ImmediatelypriortojoiningtheFDA,hewasonthefacultyofthePathologyDepartmentoftheUniversityofTexasSouthwesterninDallas.InadditiontoFDApolicydocumentshehasco-authoredover25articlesinpeer-reviewedarticlesjournalsincludingNature,theProceedingsoftheNationalAcademyofScience(PNAS),andBlood.

B.LynnAllen-Hoffmann,PhDisaProfessor,DepartmentofPathologyandDepartmentofSurgery,UniversityofWisconsin-Madison,andSeniorVicePresidentofRegenerativeMedicine,StratatechCorporationaSubsidiaryofMallinckrodt.Dr.Allen-Hoffmannreceivedherbachelor’sdegreefromtheUniversityofIllinoisandreceivedherPh.D.fromCornellUniversityinIthaca,NewYork.Dr.Allen-HoffmannwasaDamon-RunyonWalter-WinchellPostdoctoralFellowattheDana-FarberCancerInstituteatHarvardMedicalSchoolwhereshestudiedhumankeratinocytegrowthanddifferentiation.Sheisatenured,fullProfessorintheDepartmentsof

FutureofAdvancedBiomanufacturingSessionIIFriday–7:00PM

CurrentAdvancesinBiomanufacturingSessionSaturday–8:00AM

RichardMcFarland,MD,

PhDChiefRegulatoryOfficer,

AdvancedRegenerativeMedicineInstitute/BioFabUSA

Friday,August18,20177:35–8:10PM


KEYNOTESPEAKERS

PathologyandLaboratoryMedicineandSurgeryattheUWSchoolofMedicineandPublicHealth.Sheisinternationallyrecognizedforherinnovativeresearchandclinicaldevelopmentofhumanskinreplacementsincludingtheworld’sfirstgenetically-enhancedhumanskinreplacements.TheNIKScells,discoveredinherU.W.laboratory,areaconsistentsourceofgeneticallyuniform,non-tumorigenic,pathogenfreehumankeratinocytesamenabletogeneticmanipulation.Asaresultofthediscoveryinherlaboratory,Dr.Allen-HoffmannfoundedStratatechCorporationtodelivercell-basedtherapiestopatientswithcomplexskinloss.ShehasreceivednumerousstateandnationalawardsandisthefirstwomanattheUWtostartabiotechnologycompany.Dr.Allen-Hoffmannhascontributedtonumerouspeer-reviewedpublicationsandpatents.Dr.Allen-Hoffmann’sbasicandclinicalresearchhasreceivedcontinuousresearchsupport,includinggrantsfromtheNIH,NIST,AFIRM,BARDA,andDOD.RecentlyStratatechCorporationhasbeenoneofthetop10companiestoreceiveSBIRandSTTRfundingintheUnitedStates.In2015,BARDAreleasedasolicitationthroughProjectBioShieldforthelatestageclinicaldevelopmentanduseofcell-basedtherapiesforskinreplacementcausedbythermalburnsintheeventofamasscasualtyeventresultingfromthedetonationofanimprovisednucleardevice.StratatechwastheonlyacademicorprivatesectororganizationintheUnitedStatestosuccessfullycompeteforaBioShieldaward.The$247millionProjectBioShieldawardwillenabletheNIKStechnologytobeusedpriortoFDAapprovalthroughtheFDA’sPre-EmergencyUseAuthorizationmechanism.Stratatechreceived

a2016TibbittsAwardwhichwasacceptedbyDr.Allen-HoffmannataWhiteHouseceremony.StratatechCorporationwasacquiredbyMallinckrodtSpecialtyPharmaceuticalsonAugust31,2016.DavidSmithjoinedCambrexBioproductsinJanuary2012astheBusinessUnitDirectoroftheemergingcelltherapycontractmanufacturingbusiness.In2004,hewaspromotedtoVicePresident,BusinessDevelopment,andinDecember2005toVicePresident,CellularTherapeutics.Inthisrole,heassumedresponsibilityforcontractmanufacturing,processdevelopment,andclinical/commercialdevelopmentofCambrex-ownedEngineeredSkinSubstitute(ESS)forcatastrophicburns.In2009,twoyearsfollowingLonza’sacquisitionofCambrexBioproducts,Mr.SmithbecameHeadofTherapeuticCellSolutionswithadditionalresponsibilitiesforbiotherapeuticmedia,processdevelopment,viralvaccinesandgenetherapies.In2015,Mr.Smithbecame

B.LynnAllen-Hoffmann,PhD

ProfessorofPathology&SurgeryUniversityofWisconsinMadison

SeniorVicePresidentStratatechCorporation

Saturday,August19,20178:00–8:35AM

DavidSmith,MBA

VicePresident,GlobalBusinessDevelopment

Lonza



KEYNOTESPEAKERS

VicePresident,GlobalBusinessDevelopment,focusingonstrategicagreementsandalliancesfortheEmergingTechnologiesBusinessUnit,whichincludescellandviraltherapy.Heisanactivememberofnumerousgovernmentexpertpanels;companyexecutivecommitteesandadvisoryboards.UnderMr.Smith’sleadershipthecelltherapycontractmanufactacturingbusinessasgrownfromstart-uptomarketleader.PriortojoiningCambrex,Mr.SmithwasVicePresident,CorporateDevelopmentatClaragen,Inc.andBusinessUnitDirectoratInvitrogen.

Mr.DavidSmithholdsaB.S.inPharmacyfromDuquesneUniversityinPittsburgh,PennsylvaniaandaM.B.A.fromWheelingJesuitUniversityinWheeling,WestVirginia.Dr.WeiSuniscurrentlyappointedAlbertSoffaChairProfessorofMechanicalEngineeringatDrexelUniversity,USA,andNational“Thousand-Talent”DistinguishedProfessorandDirectorofBiomanufacturingResearchCenteratTsinghuaUniversity,China.HisresearchhasbeenonBiofabrication,3DBio-Printing,Computer-AidedTissueEngineering,andAdditiveManufacturing.HisresearchhasbeensponsoredbyNationalScienceFoundation(NSF),DefenseAdvancedResearchProjectsAgency(DARPA),NationalAeronauticsandSpaceAdministration(NASA),ChineseNaturalScienceFoundation(CNSF)andChineseMinistryofScienceandTechnology.Hehaspublishedover350journalandconferencepapers/abstractsandconductedover250nationalandinternationalinvited

presentationsinthefieldofhisresearch.HeiscurrentlyservingEditor-in-ChiefforjournalBiofabrication.

Dr.MichaelJ.YaszemskiistheJohnandPosyKrehbielEndowedProfessorofOrthopedicSurgeryandBiomedicalEngineeringattheMayoClinicanddirectorofitsPolymericBiomaterialsandTissueEngineeringLaboratory.HeisaretiredU.S.AirForceBrigadierGeneralandservedintheofficeoftheAirForceSurgeonGeneralandtheofficeofthePresidentoftheUniformedServicesUniversityoftheHealthSciencespriortoretiringin2013.Heservedas

FutureAdvancesinBiomanufacturingSession

Saturday–8:00AM

WeiSun,PhD

AlbertaSoffaChair&ProfessorofMechanicalEngineering

DrexelUniversity

National“Thousand-Talent”DistinguishedProfessorTsinghuaUniversity


MichaelYaszemski,

MD,PhDJohnandPosyKrehbielEndowedProfessorofOrthopedicSurgeryandBiomedicalEngineering

MayoClinic



2017ABIOMAW

ARDRECIPIENTS

presidentoftheMayoClinicmedicalstafffrom2013-2014,andhadservedfor10yearsastheChairoftheSpineSurgeryDivisionatMayopriortoenteringthepresidentialline.HereceivedbothBachelor’sandMaster’sdegreesinChemicalEngineeringfromLehighUniversityin1977and1978,anM.D.fromGeorgetownUniversityin1983andaPh.D.inChemicalEngineeringfromtheMassachusettsInstituteofTechnologyin1995.HeorganizedandthenservedasthefirstChairoftheMusculoskeletalTissueEngineeringstudysectionatNIH,andservedasamemberoftheAdvisoryCounciloftheNationalInstituteofBiomedicalImagingandBioengineeringfrom2010-2014.Hebegana4yeartermasamemberoftheAdvisoryCounciloftheNationalInstituteofArthritis,Musculoskeletal,andSkinDiseasesatNIHin2017.HeservedasChairoftheFDACenterforDevicesandRadiologicHealthAdvisoryCommittee,andiscurrentlyamemberoftheFDAScienceBoard.HecompletedasixyeartermontheLehighUniversityBoardofTrusteesin2017.Hisclinicalpracticeencompassesspinesurgeryandmusculoskeletaloncology.Hisresearchinterestsareinthesynthesisandcharacterizationofnoveldegradablepolymersforuseinboneregeneration,cartilageregeneration,nervoustissueregeneration,andcontrolleddeliveryofchemotherapeuticagentstomusculoskeletaltumors.

heABioM-SIGrecognizesthefollowingscientistfortheiroutstandingresearchdevelopingnext-generationbiomanufacturingproductsandprocesses.

JuniorInvestigatorAwardAndrewDias,PhD UniversityofWisconsinMadison

MinglinMa,PhD CornellUniversity

Jae-WonShin,PhD UniversityofIllinoisChicago

XiaojunLian,PhD ThePennsylvaniaStateUniversity

GraduateStudentTravelAwardAngelaXie,PhD UniversityofWisconsinMadisonEmergingConceptsAwardTiffanyHeaster UniversityofWisconsinMadison

FerdousFinklea AuburnUniversity

CarlosR.Marti-Figueroa UniversityofWisconsinMadison

T


ABSTRACTREVIEWERS

GENERALIN

FORM

ATION

SeanPalecek UniversityofWisconsinMadison

KrishanuSaha UniversityofWisconsinMadisonLih-ShengTurng UniversityofWisconsinMadisonKartikBalachandran UniversityofArkansas

KristenBilliar WorcesterPolytechnicInstitute

LesleyChow LehighUniversity

MatthewFisher NorthCarolinaStateUniversity

YiHong UniversityofTexasatArlington

DebanjanSarkar SUNYBuffalo

RandolphAshton UniversityofWisconsinMadisonWilliamMurphy UniversityofWisconsinMadisonKaimingYe SUNYBinghamton

RolandKaunas TexasA&MUniversity

GlennGaudette WorcesterPolytechnicInstituteElizabethLipke AuburnUniversity

MeetingLocationWisconsinInstitutesforDiscovery330N.OrchardStreetMadison,WI53715608.316.4300RegistrationPaidregistrationisrequiredforadmissiontoallmeetingfunctions.Registrationcanbecompletedonline,https://www.regonline.com/registration/Checkin.aspx?EventID=2004087,oronsitefrom7:30-5:00pmonFriday,August18.ExhibitsandPosterSessionExhibittablesandpostersshouldbeset-upby8:30amonFriday,August18andtakendownby1:30pmonSaturday,August19.Posterlocationswillbelabeledcorrespondingtoyourlistingnumber(p.15).

ThankYoutoourReviewersfortheirTimeandEffort


GENERALIN

FORM

ATION

PlatformPresenterInformationPresentationlecternwillbeequippedwithaPClaptoporpresenterswillbeabletoconnecttheirownlaptops.AVStaffwillbeonhandtoassist.Duringthebreakbeforeyoursessionbegins,pleaseuploadyourpresentationontothecomputerusingamemorystickorflashdrive.Ifusingapersonallaptop,youshouldtesttheconnectionandpresentationduringthistimeframeaswell.Allpresentationswillbedeletedattheendoftheconference.Apresentationcount-downtimerwillbepresentatthebackofthelecturehall.Pleaseremainwithinyourallottedtimeslots,andleavetimeforquestions.WIFIFreewifiisavailablethroughthe‘TownCenter’network.VenueMap


POSTERSESSIO

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1 Engineering2-DHumanCNSTissueSlicesfromHumanPluripotentStem

CellsAlirezaAghayee1,GavinKnight1,BradyLudin1,RandolphAshton11UniversityofWisconsinMadison,Madison,WI

2 MonitoringandmodelingofT-cellphenotypedistributionthroughisolationand50-foldexpansionAmritavaDas1,NicoleJPiscopo1,KatherinePMueller1,KirstiWalker1,ChristianCCapitini1,KrishanuSaha11UniversityofWisconsinMadison,Madison,WI

3 IntegrationofInkjetPrintedMicrovasculatureintoHostTissuesBeuOropeza1,LuisSolis1,MariaYanez2,ThomasBoland11UniversityofTexasatElPaso,ElPaso,TX,2UniversityofSouthCarolina,Columbia,SC

4 ScalableproductionofosteogenicdecellularizedtissuederivedfrommesenchymalstemcellsforbonetissueengineeringC.Sears1,E.McNeill2,B.Clough2,S.Jaligama1,J.Kameoka1,C.A.Gregory1,2,R.Kaunas1,21TexasA&MUniversity,2TexasA&MHealthScienceCenter,CollegeStation,TX

5 DevelopmentofBiomimeticThermoplasticPolyurethane/FibroinSmall-DiameterVascularGraftsviaNovelElectrospinningApproachEmilyYu1,JueZhang2,Hao-YangMi1,JamesA.Thomson1,2,Lih-ShengTurng11UniversityofWisconsinMadison,2MorgridgeInstituteforResearch,Madison,WI

6 Ahighthroughputtissue-modelmanufacturingsystemFrankBenesch-Lee1andKristenL.Billiar11WorcesterPolytechnicInstitute,Worcester,MA

7 Self-assemblyofhumanembryonicstemcell-derivedendothelialcellsinto

threedimensionalvascularscaffoldsindynamic,syntheticmicroenvironmentsGauravKaushik1,DanielA.Gil2,ElizabethTorr1,ElizabethS.Berge2,CherylSoref1,PeytonUhl1,GianlucaFontana1,JessicaAntosiewicz-Bourget2,CollinEdington3,MichaelP.Schwartz1,BrianJohnson1,LindaG.Griffith3,JamesA.Thomson2,MelissaC.Skala2,WilliamT.Daly1,WilliamL.Murphy11UniversityofWisconsinMadison,2MorgridgeInstituteforResearch,Madison,WI,3MassachusettesInstituteofTechnology,Cambridge,MA


POSTERSESSIO

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8 BiofunctionalizedPlantsasDiverseBiomaterialsforHumanCellCulture

GianlucaFontana1,JoshuaGershlak2,MichalAdamski1,Jae-SungLee1,ShionMatsumoto2,HauD.Le1,BernardBinder1,JohnWirth3,GlennGaudette2,WilliamL.Murphy11UniversityofWisconsinMadison,Madison,WI,2WorcesterPolytechnicInstitute,Worcester,MA,3OlbrichBotanicalGardens,Madison,WI

9 Three-dimensionaltissuesusinghumanpluripotentstemcellspheroidsasbiofabricationbuildingblocksHaishuangLin1,QiangLi1,YuguoLei11UniversityofNebraska,Lincoln,NE

10 Biocompatible,DegradableThermoplasticPolyurethaneBasedonPolycaprolactone-Block-Polytetrahydrofuran-Block-PolycaprolactoneCopolymerforSoftTissueEngineeringHao-YangMi1,XinJing1,2,BrettN.Napiwocki1,BreannaS.Hagerty1,GuojunChen1,Lih-ShengTurng11UniversityofWisconsinMadison,Madison,WI,2SouthChinaUniversityofTechnology,Guangzhou,China

11 PrecisegeneeditingofhumanstemcellsusingnovelnanoparticlescontainingCRISPRnucleaseswithDNArepairtemplatesJaredCarlson-Stevermer1,AmrA.Abdeen1,LucilleKohlenberg1,MadelynGoedland1,KaivalyaMolugu1,MengLou1,KrishanuSaha11UniversityofWisconsinMadison,Madison,WI

12 Leaf-inspiredArtificialMicrovascularNetworks(LIAMN)forThree-dimensionalCellCultureJiandiWan1,RongFan1,YihangSun11RochesterInstituteofTechnology,Rochester,NY

13 MaturationofhPSC-derivedCardiomyocytesviaCoculturewithEndothelialCellsKaitlinK.Dunn1,IsabellaReichardt1,SeanP.Palecek11UniversityofWisconsinMadison,Madison,WI

14 MicropatternedsubstratestopromoteanddissectreprogrammingofhumansomaticcellsTyHarkness1,JaredCarlson-Stevermer1,RyanPrestil1,StephanieSeymour1,GavinKnight1,KaivalyaMolugu1,RandolphAshton1,KrishanuSaha11UniversityofWisconsinMadison,Madison,WI


POSTERSESSIO

N

15 EngineeringAnisotropicJanus-typePolymerNanofiberScaffoldsvia

CentrifugalJetSpinningPrashanthRavishankar1,AlexKhang1,KartikBalachandran11UniversityofArkansas,Fayetteville,AR

16 AMicroscaleTestbedtoAssaytheManufactureofCART-Cell

ImmunotherapiesNicoleJPiscopo1,KatherinePMueller1,AmritavaDas1,KrishanuSaha11UniversityofWisconsinMadison,Madison,WI

17 GMPCas9Nuclease:manufacturingreproducibilityandavailabilityPeteLeland1,NicoleKavanaugh1,ShannonBrink11Aldevron,Fargo,NDandMadison,WI

18 BioprintingdefinedheterogeneouscellularmicroenvironmentsPeterNewman1,Jae-WonShin1,HalaZreiqat21UniversityofIllinoisChicago,Chicago,IL,2UniversityofSydney,Australia

19 BiofabricationofTissueEngineeredVesselGrafts

SebastianFreeman1,LuxiZhou1,KyleReeser1,ShaJin1,andKaimingYe11SUNYBinghamton,Binghamton,NY

20 DirectedDifferentiationofHumanPluripotentStemCellstoPodocytesvia

WntActivationTongchengQian1,EricV.Shusta1,SeanP.Palecek11UniversityofWisconsinMadison,Madison,WI

21 FabricationofStableCollagenScaffoldsforHumanPluripotentStemCellsXiangyangLyu1,KaimingYe1,ShaJin11SUNYBinghamton,Binghamton,NY

22 FabricationandCharacterizationofDirect-writeGelatin/PLGAMicro-fibersforPotentialMicrovascularTissueAngiogenesisXiaomingFan1,MarkCrain1,HanwenYuan1,RobertS.Keynton11UniversityofLouisville,Louisville,KY

23 Mussel-InspiredChitosan/GrapheneOxideHydrogelwithRapidSelf-HealingandRecoveryBehavioratRoomTemperatureXinJing1,Hao-YangMi1,BrettN.Napiwocki1,Lih-ShengTurng11UniversityofWisconsinMadison,Madison,WI


POSTERSESSIO

N

24 Micro-structuredphotoreceptorscaffoldsformodelingandtherapeutic

applicationsYeiHwanJung1,M.JosephPhillips2,JuhwanLee1,ShaoqinGong1,DavidM.Gamm1,ZhenqiangMa11UniversityofWisconsinMadison,Madison,WI

25 Endothelial-likeCellsDifferentiatedfromMesenchymalStemCellsModulatedbyStiffnessofCultureSubstratesYong-ChaoJiang1,2,Ming-SongLee2,Hong-LiJiao2,QianLi1,Lih-ShengTurng2,Wan-JuLi21ZhengzhouUniversity,Zhengzhou,China,2UniversityofWisconsinMadison,Madison,WI

26 EncapsulationofEquineEndothelialColonyFormingCellsinInjectableHydrogelMicrospheresusingaNovelMicrofluidicSystemYuanTian1,WenJ.Seeto1,RandolphL.Winter1,FredCaldwell1,AnneA.Wooldridge1,ElizabethA.Lipke11AuburnUniversity,Auburn,AL

27 AnIntegratedandAutomatedMiniatureDeviceforPersonalizedHumanInducedPluripotentStemCellExpansionandDifferentiationHaishuangLin1,QiangLi1,YuguoLei11UniversityofNebraska,Lincoln,NE

28 Designofa3DprintingsystemtofabricatetherapeuticallyloadedbiopolymermicrothreadscaffoldswhichfacilitateskeletalmuscleregenerationinamodelofvolumetricmusclelossMeaganCarnes1,ChristopherNycz1,JeremyShui1,JacquelineClaveaux1,AlexanderMarkoski1,RichardEberheim1,GregoryFischer1,RaymondL.Pins1,GeorgePins11WorcesterPolytechnicInstitute,Worcester,MA

29 CarbonNanotubeBasedOpticalSensorsforBiomanufacturingNigelF.Reuel1andNathanielKallmyer11IowaStateUniversityofScienceandTechnology,Ames,IA

30 MechanicalPropertiesTestingtoCharacterizeandDevelop3DCell

CultureTechnologies YiWenChai1,BethA.Lindborg1,2,JohnH.Brekke1

1BRTILifeSciences,TwoHarbors,MN,2UniversityofMinnesota,TwinCities,MN


PROGRAM

-AT-A-GLANCE

31 RapidStereolithographyPrintingofHuman-scaleVascularizedTissue NandithaAnandakrishnan1,HangYe1,ChiZhou1,RuogangZhao1

1SUNYBuffalo,Buffalo,NY

32 DevelopmentofanimplantablecontractilecardiacbundleusinghPS-CMandfibrinmicrothreads

KatrinaHansen1,EmilyRobbins1,GlennGaudette11WorcesterPolytechnicInstitute,Worcester,MA

33 Sustainedreleasefrommineral-coatedmicroparticlesreducesrequiredbFGFforhPSCculture

HunterJohnson1,AndrewKhalil1,AngelaXie1,andWilliamMurphy11UniversityofWisconsinMadison,Madison,WI

AllconferenceeventswillbeheldintheH.F.DeLucaForumandtheMainandCentralOpenCourt,exceptforABioMPlanningCommitteeBusinessMeetingsthatwillbeheldinconferenceroom1170.

Thursday,August17,2017

7:00pm-9:00pm ABioMPlanningCommitteeBusinessMeeting

Friday,August18,2017

7:30am-5:00pm Registration

8:00am-5:00pm ExhibitionTables

8:00am-8:30am Networking/LightBreakfastFare

8:30am-8:40am OpeningRemarks

StatusofAdvancedBiomanufacturingSession

8:40am-9:15am

TheDigitalTwin:TowardBioreactorModelingUsingDeepAnalyticsPaulGoodwin,PhD,ScienceDirector,LifeSciences–ChiefTechnologyOfficer,GEHealthcare

9:15am-9:50amBiomanufacturingforSkeletalMuscleRepair,RegenerationandReplacementGeorgeChrist,PhD,MaryMuilenbrrgStampProfessorof

Program-at-a-Glance


PROGRAM

-AT-A-GLANCE

OrthopaedicSurgery&Co-DirectoroftheCenterforAdvancedBiomanufacturing,UniversityofVirginia

9:50am-10:25am

Manufacturingaclinicallycompatiblehumanembryonicstemcell-derivedmidbraindopamineprogenitorandneuroncellproduct,MSK-DA01MarkJ.Tomishima,PhD,Head,SKIStemCellResearchFacility,SloanKetteringInstitute

10:25am-10:50am CoffeeBreakandNetworking

EmergingConceptsSession

10:50am-11:25am

BiofabricationandBiomanufacturing:WhereBiologyMeetsEngineeringDeepakVashishth,PhD,Professor&DirectoroftheCenterforBiotechnologyandInterdisciplinaryStudies,RensselaerPolytechnicInstitute

11:25am-11:40am

ChemicallyDefinedLabileSubstratesforControlledSelf-assemblyofStemCellAggregatesAngelaXie,UniversityofWisconsin-Madison(GraduateStudentTravelAwardWinner)

11:40am-11:55am

ImagingApproachesforQualityControlofAdoptiveImmuneCellTherapiesTiffanyHeaster,UniversityofWisconsin-Madison(EmergingConceptsAwardWinner)

11:55am-12:10pm

ANovelMicrofluidicDevicefortheProductionofEngineeredCardiacTissueSpheroidsFerdousFinklea,AuburnUniversity(EmergingConceptsAwardWinner)

12:10pm-12:25pm

Engineering3-DOrganoidMorphologyusingPVOH-CaSacrificialTemplatesCarlosMarti-Figueroa,UniversityofWisconsin–Madison(EmergingConceptsAwardWinner)

12:25pm-1:25pm NetworkingandLunch

FutureofAdvancedBiomanufacturingSessionI

1:25pm-2:00pm

KeyconsiderationsinLargeScale,Low-CostManufacturingofHighQualityTherapeuticCells:AperspectivefromtheNationalCellManufacturingConsortiumKrishnenduRoy,PhD,ProfessorandRobertA.Milton


PROGRAM

-AT-A-GLANCE

Chair&DirectorofMarcusCenterforCell-TherapyCharacterizationandManufacturing(MC3M),GeorgiaInstituteofTechnology

2:00pm-3:00pm

FutureofAdvancedBiomanufacturing‘Unconference’:TopicsincludeCellManufacturing,Organ/OrganoidEngineering,SustainableAdvancedBiomanufacturing,RegulatoryIssuesinBiomanufacturing.Moderator:GlennGaudette,PhD,Professor,WorcesterPolytechnicInstitute

3:00pm-3:30pm Unconferencereportout

3:30pm-3:45pm NetworkingandCoffeeBreak

Industry&AcademiaCollaborationsPanelDiscussion

3:45pm-4:45pm

“Howdowecreatecollaborationswithvalueforindustry&academia?”

§ Moderator:RolandKaunas,PhDAssociateProfessor,TexasA&MUniversity

§ Panelist:TomFoti,VicePresident&GeneralManager,Aldevron

§ Panelist:SteveKattman,Director,CardiacCellTherapy,CellularDynamicsInternational

§ Panelist:MarkPowers,PhD,SeniorDirector,R&DofCellBiology,ThermoFisherScientific

§ Panelist:GangBao,PhD,FoytFamilyProfessor,RiceUniversity

§ Panelist:ChengDong,PhD,DistinguishedProfessor&DepartmentofBiomedicalEngineeringHead,PennStateUniversity

PosterPresentationsSession

4:45pm-5:00pmPostersSpotlights:JaredCarlson-Stevermer,AlirezaAghayee,GauravKaushik,XiaomingFan

5:00pm-6:00pm PosterSession(HorsD’oeuvresandBeverages)

6:00pm-7:00pm NetworkingandDinner

FutureofAdvancedBiomanufacturingSessionII

7:00pm-9:00pm DessertsandCoffee


PROGRAM

-AT-A-GLANCE

7:00pm-7:35pm

Wisconsin’sFutureBiomanufacturingCenterofExcellenceLisaJohnson,ChiefExecutiveOfficer,BioForwardWilliamMurphy,PhD,HarveyD.SpanglerProfessor&Co-DirectorofStemCellandRegenerativeMedicineCenter,UniversityofWisconsin–Madison

7:35pm-8:10pm

TheBirthofBioFabUSA:ManufacturingtheFutureofBiofabricationRichardMcFarland,MD,PhD,ChiefRegulatoryOfficer,TheAdvancedRegenerativeManufacturingInstitute

Saturday,August19,2017

7:00am-8:00am ABioMPlanningCommitteeBusinessMeeting

7:30am-12:00pm ExhibitionTables

7:30am-8:00am NetworkingandLightBreakfast

CurrentAdvancesinBiomanufacturingSession

8:00am-8:35am

StrataGraft®BiomanufacturingFromDiscoverytoPhaseIIIClinicalTrialB.LynnAllen-Hoffmann,PhD,Founder/ChiefExecutiveOfficer/ChiefScientificOfficer,Stratatech&Professor,UniversityofWisconsin–Madison

8:35am-9:10amAPathtoSuccessfulCommercialManufacturingDavidSmith,PhD,VicePresidentforGlobalBusinessDevelopment,Lonza

9:10am-9:45am3DBioprintingforinvitroTissueModelsWeiSun,PhD,AlbertaSoffaChair&Professor,DrexelUniversity

9:45am-10:00am NetworkingandCoffeeBreak

FutureAdvancesinBiomanufacturingSession

10:00am-10:35am

BiofabricationofMusculoskeletalRegenerativeMedicineProductsMikeYaszemski,MD,PhD,ProfessorMayoClinics

10:35am-10:50amBiomimetic3DMicroenvironmentsInRegenerativeMedicine:MechanicalEngineeringMeetsBiochemistryAtTheMolecularLevel


PROGRAM

-AT-A-GLANCE

JohnH.Brekke,DDS,ChiefScientificOfficerofBRTILifeSciences-CellMate3D

10:50am-11:05am

SyntheticanddegradablehydrogelmicrocarriercoatingsforstemcellexpansionAndrewDias,PhD,UniversityofWisconsin-Madison(JuniorInvestigatorAwardWinner)

11:05am-11:20am

Organogenesisinmicrocapsules:AscalableplatformfororganoidcultureandmanufacturingMinglinMa,PhD,AssistantProfessor,CornellUniversity(JuniorInvestigatorAwardWinner)

11:20am-11:45amLeveragingbiomaterialmechanicstodesignmesenchymalstemcelltherapiesJae-WonShin,PhD,AssistantProfessor,UniversityofIllinoisatChicago(JuniorInvestigatorAwardWinner)

11:45am-12:00pm

BiomanufacturingHumanVentricularProgenitorsforinvivoorgan-on-organcardiactissueengineeringXiaojunLian,PhD,AssistantProfessor,PennStateUniversity(JuniorInvestigatorAwardWinner)

12:00pm-1:00pm

WorkforceTraininginAdvancedBiomanufacturingSession(BoxLunch)

§ Moderator:KaimingYe,PhD,Professor&ChairBinghamtonUniversity

§ Panelist:TomTubon,PhD,ProjectDirector/PI,NSFATEStemCellEducationInitiative.MadisonAreaTechnicalCollege

§ Panelist:WilliamMurphy,PhD,HarveyD.SpanglerProfessor&Co-DirectorofStemCellandRegenerativeMedicineCenter,UniversityofWisconsin–Madison

§ Panelist:SusanL.Woodard,PhD,NationalCenterforTherapeuticsManufacturing,SusanL.Woodard,PhD,TexasA&M

§ Panelist:KamalA.Rashid,Ph.D.Director,BiomanufacturingEducation&TrainingCenter,WorcesterPolytechnicInstitute

§ Panelist:WilliamJ.King,PhD,PrincipalResearchScientist,ZimmerBiomet

1:00pm-1:10pm ConclusionRemarks

2017 advanced biomanufacturing sponsors - conferences @ wid – wisconsin … · 2017-08-18 ·...

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