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    2008H I G H E R S C H O O L C E R T I F I C A T E

    E X A M I N A T I O N

    Biology

    GeneralInstructions

    •Readingtime–5minutes

    •Workingtime–3hours

    •Writeusingblackorbluepen

    •Drawdiagramsusingpencil

    •Board-approvedcalculatorsmay

    beused

    •WriteyourCentreNumberand

    StudentNumberatthetopof

    pages9,13,17and21

    Totalmarks–100

    SectionI Pages2–24

    75marks

    Thissectionhastwoparts,PartAandPartB

    PartA–15marks•AttemptQuestions1–15

    •Allowabout30minutesforthispart

    PartB–60marks

    •AttemptQuestions16–28

    •Allowabout1hourand45minutesforthispart

    SectionII Pages25–30

    25marks•AttemptONEquestionfromQuestions29–33

    •Allowabout45minutesforthissection

    104

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    SectionI75marks

    PartA–15marks

    AttemptQuestions1–15

    Allowabout30minutesforthispart

    Usethemultiple-choiceanswersheetforQuestions1–15.

    1 Whichbloodvesselsinhumanscontainstructuresthatallowbloodtoflowinonlyone

    direction?

    (A) Arteries

    (B) Capillaries

    (C) Lymphvessels

    (D) Veins

    2 Which of the following pathogen types cause diseases that can be treated with

    antibiotics?

    (A) Bacteria

    (B) Macro-parasites

    (C) Prions

    (D) Viruses

    3 To protect a farm animal from a plant toxin, a gene for resistance to the toxin was

    transferredtothefarmanimal.

    Whichtermbestdescribesthisprocess?

    (A) Cloning

    (B) Geneticengineering

    (C) Artificialpollination

    (D) Artificialinsemination

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    4 Whichprocessinvolvesdetectingchangesfromastablestatethencounteractingthese

    changes?

    (A) Enantiostasis

    (B) Homeostasis

    (C) Osmosis

    (D) Phagocytosis

    5 Whyarepoliovaccinationseffective?

    (A) Theycauseaninflammationresponseresultingintheproductionofantibodiesthat

    engulfthepoliovirusifitentersthebody.

    (B) Theycausean immune responseresultingin theproductionofcytotoxic(killer)

    Tcellsthatremaininthebloodattackingallvirusesthatenterthebody.

    (C) TheycauseanimmuneresponseresultingintheproductionofmemoryBcellsthat

    providearapidresponseifinfectedbythepoliovirus.

    (D) TheycauseaninflammationresponseresultingintheproductionofmemoryTcells

    thatprovidealimitedresponseifinfectedbythepoliovirus.

    6 Somestudentscarriedoutinvestigationstodeterminewhetheranewlydiscoveredanimal

    wasanectothermoranendotherm.Eachstudentmadeoneobservationandconclusion.

    Whichisthecorrectconclusionbasedontheobservation?

    (A)

    (B)

    (C)

    (D)

    Observation Conclusion

    Itwasnotamammal. Theanimalisanectotherm.

    Itsbodytemperaturewas37°C. Theanimalisanendotherm.

    Itstemperaturewaslessthanthe

    temperatureofthecage.

    Theanimalisanendotherm.

    Itstemperatureandmetabolismincreased

    whenthecagetemperatureincreased.

    Theanimalisanectotherm.

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    7 Whichprocessesresultingeneticvariationofoffspring?

    (A) DNAmutationandgameteformation

    (B) Celldifferentiationandgameteformation

    (C) DNAmutationandpolypeptideproduction(D) Celldifferentiationandpolypeptideproduction

    8 Somestudentswanttodetermineifthecolouroflightaffectsplantgrowth.

    Whichofthefollowingisasuitablehypothesistobetestedbythestudents?

    (A) Allplantswillgrowbetterinredlight.

    (B) Allplantswillgrowbiggerflowersinsunlight.

    (C) Peaplantswillgrowtallerinredlightthaninbluelight.

    (D) Peaplantswillgrowfasterthanbeanplantsincolouredlight.

    9 Whatistheroleofantigensinthebody’sdefenceagainstdisease?

    (A) Theybindtoinvadingpathogens.

    (B) Theytriggertheimmuneresponse.

    (C) Theyinactivateinvadingantibodies.(D) Theysuppresstheinflammationresponse.

    10 Whichscientistimprovedtheunderstandingoftheimmuneresponse?

    (A) GeorgeBeadle

    (B) FrankMacfarlaneBurnet

    (C) RobertKoch

    (D) WalterSutton

    11 What finding from the study of comparative embryology supports the theory of

    evolution?

    (A) Embryosareeasilyfossilised.

    (B) Theembryosoffishandmammalslookverysimilar.

    (C) Thedominantchromosomesarepassedontoembryos.

    (D) Mutationingametesiscommonandthisleadstodifferentembryos.

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    12 After an infection was treated with a new drug, inflammation decreased. In a few

    patients,inflammationreturnedafteroneweek.Inthesepatients,thepathogenscausing

    theinfectionwereshowntoberesistanttothedrug.

    Whatconclusioncanbedrawnfromtheseobservations?

    (A) Thesepatientsdevelopedresistancetothedrug.

    (B) Thedecreaseininflammationallowedthepathogenstobecomeresistanttothedrug.

    (C) The white blood cells were not functioning properly and therefore the

    inflammationreturned.

    (D) Afewpathogensresistanttothedrugswerepresentat thestartoftreatmentand

    naturalselectionincreasedtheirnumbers.

    13 Whatdoesmitosisproducetoassistinthemaintenanceofhealth?

    (A) Gametestoensurereproduction

    (B) Polypeptidestoensurecellgrowth

    (C) Prionstoprotectcellsagainstcancer

    (D) Cellstoreplacethosethataredamaged

    14 Whatisthemostimportantdifferencebetweenactiveandpassivetransport?

    (A) Activetransportrequiresenergyinput,passivetransportdoesnot.

    (B) Activetransportoccursinanimals,passivetransportoccursonlyinplants.

    (C) Active transport does not use membranes, passive transport always uses

    membranes.

    (D) Activetransportoccurswheneveranorganismmoves,passivetransportdoesnot

    involvemovementoftheorganism.

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    15 In a particular sex-linkeddisease, progressive weakening of the muscles and loss of

    coordinationleadtodeathbeforetheageoffive.

    1 2

    3

    Female

    Male

    Affectedfemale

    Affectedmale

    Usingthispedigree,whatisthegenotypeoftheindividualsnumbered1,2and3?

    (A)

    (B)

    (C)

    (D)

     Individual 1 Individual 2 Individual 3

    Normal Normal Normal

    Carrier Normal Carrier

    Normal Carrier Normal

    Normal Carrier Carrier

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    BLANKPAGE

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    ©BoardofStudiesNSW2008 

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    2008 HIGHER SCHOOL CERTIFICATE EXAMINATION

    BiologyCentreNumber

    SectionI(continued)

    PartB–60marks StudentNumberAttemptQuestions16–28

    Allowabout1hourand45minutesforthispart

    Answerthequestionsinthespacesprovided.

    Marks

    3

    Question16(3marks)

    Aplantspeciesmayhaveredorwhiteflowers.Twored-floweredplantswerecrossed.Mostoftheoffspringhadredflowers,butsomehadwhiteflowers.

    Explainthepresenceofbothred-andwhite-floweredoffspring.

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    105 –9 –

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    Marks

    1

    3

    Question17(4marks)

    (a) LabeltheTWOcomponentsofphloemtissueindicatedinthediagram.

    (b) Describe ONE theory about the processes responsible for the movement of

    materialsthroughphloemtissue.

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    whitebloodcell

    platelet

    redbloodcell

    10mm

    Marks

    3

    1

    Question18(4marks)

    Usingalightmicroscope,astudentlookedatapreparedslideofhumanblood,and

    drewascaleddiagram.

    Thediagramshownisarepresentationofthestudent’sscaleddiagram.

    (a) Assesstheaccuracyofthediagram.

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    (b) Whyisitsafertousepreparedslidesinsteadoffreshblood?

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    Marks

    4

    Question19(4marks)

    Anewproducthasbeendevelopedtokillpathogensindrinkingwater.

    Designanexperimenttotesttheeffectivenessoftheproduct.

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    2008 HIGHER SCHOOL CERTIFICATE EXAMINATION

    BiologyCentreNumber

    SectionI–PartB(continued)

    StudentNumber

    Marks

    5

    Question20(5marks)

    Describe theoccurrence, symptoms, cause and treatment/management of a named

    non-infectiousdisease.

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    106 –13 –

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    Question 21 (3 marks)

    Both the Australian marsupial bilby and the North American placental jack rabbit are

    found in hot, dry environments.

    How would the Darwin/Wallace theory of evolution account for the similarity in ear

    size?

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    Marks

    3

    Awaiting copyright

    © EPA, Queensland reproduced

    by permission. Image supplied

    courtesy of the Environmental

    Protection Agency, Queensland

    Bilby

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    Marks

    5

    4

    Question22(5marks)

    Explainhowhormoneactivitymaintainswaterandsaltlevelsintheblood.

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    Question23(4marks)

    Comparethechangesinthechemicalcompositionofbloodasitpassesthroughthe

    lungs,thesmallintestine,andthebrain.

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    BLANKPAGE

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    ©BoardofStudiesNSW2008 

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    2008 HIGHER SCHOOL CERTIFICATE EXAMINATION

    BiologyCentreNumber

    SectionI–PartB(continued)

    StudentNumber

    Question24(6marks)

    106a –17 –

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    Question24(6marks)

    Thedatainthetablearetheresultsfromaninvestigationmeasuringenzymeactivityusing

    different substrate concentrations. The experiment was carried out at pH 9.3 and the

    temperaturewaskeptconstantat37°C.

    Tubenumber Substrateconcentration

    (µ M)

    Enzymeactivity

    (µ M/sec/g)

    1 0 0

    2 5 0.7

    3 10 1.7

    4 15 2.5

    5 20 3.1

    6 25 3.4

    7 30 3.9

    8 35 4.1

    9 40 4.2

    10 45 4.3

    Question24continuesonpage19

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    Marks

    4

    2

    Question24(continued)

    Anappropriategraphistobedrawnandusedtopredicttheenzymeactivityforasubstrate

    concentrationof75µ M.

    (a) Usethedatatodrawanappropriategraph.

    (b) Extrapolateyourgraphandpredictwhat the enzymeactivitywouldbeif the

    substrateconcentrationwereincreasedto75µ M.

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    EndofQuestion24

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    Marks

    3

    2

    Question25(5marks)

    (a) HowcouldamutationinDNAaffectpolypeptideproduction?

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    (b) Howcouldachangeinapolypeptideaffectcellactivity?

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    2008 HIGHER SCHOOL CERTIFICATE EXAMINATION

    BiologyCentreNumber

    SectionI–PartB(continued)

    StudentNumber

    Question26(3marks)

    Marks

    3TheTasmaniandevilisindangerofbecomingextinctduetoaninfectiousdisease

    causingfacialtumours.Theanimalsslowlystarveandusuallydiewithinsixmonths

    ofshowing tumours.Populationsin thewesternthirdofTasmaniacurrentlyremain

    freeofthisdisease.

    Justify the steps you would take to ensure that a population ofTasmanian devils

    remainsdiseasefree.

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    106b –21 –

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    Marks

    8

    Question27(8marks)

    Somerecentdevelopmentsinbloodbanking

    Typesofdonation

    • Plasma donation – during collection, plasma is separated by

    centrifugationandtheotherbloodcomponentsarereturnedtothedonor

    • Wholeblooddonation–aftercollection,wholebloodiscentrifugedto

    separatebloodcomponentsandthecomponentsfromdifferentdonors

    arepooled

    Storageofbloodcomponents

    • Somebloodcomponentscanbefrozenforstorage

    • Somebloodcomponentscanberefrigeratedforuptoonemonth,but

    thisrequiresadditives

    – citrateisusedasananticoagulant

    – glucoseisusedasasourceofnutrients

    – mannitolisusedtomaintainosmolarityandpH

    Safety

    • Ensuringthatthedonordoesnotgetaninfectionduringdonation

    • Ensuringthat thedonatedbloodisnotcontaminatedbytesting itfor

    antibodiestoparticularmicrobesorforthepresenceofviralDNAor

    RNA

    • Ensuringthatthenumberofwhitebloodcells isdepletedbefore the

    bloodisgiventopatientswhohaveaweakenedimmunesystem

    • Bacterial contamination of platelets is still a problem because they

    cannotbeeasilyseparatedbyfiltration

    Withreferencetotheinformationabove,explainhowanunderstandingofbiologicalconcepts

    has led to the development of specificmethods inbloodbankingand the implications for

    society.

    Question27continuesonpage23

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    Question27(continued)

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    EndofQuestion27

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    Marks

    3

    3

    Question28(6marks)

    (a) ExplainhowONEnamedprocessthatoccursduringmeiosisresultsingenetic

    variation.

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    (b) Whyisgeneticvariationimportantinthesurvivalofaspecies?

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    2008 HIGHER SCHOOL CERTIFICATE EXAMINATION

    Biology

    SectionII

    25marksAttemptONEquestionfromQuestions29–33

    Allowabout45minutesforthissection

    Answerthequestioninawritingbooklet.Extrawritingbookletsareavailable.

    Pages

    Question29 Communication ..........................................................................26

    Question30 Biotechnology ............................................................................27

    Question31 Genetics:TheCodeBroken? .....................................................28

    Question32 TheHumanStory .......................................................................29

    Question33 Biochemistry ..............................................................................30

    106c –25 –

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    Marks

    2

    3

    6

    7

    3

    4

    Question29—Communication (25marks)

    (a) (i)

    (ii)

    NameTWOreceptorsusedforcommunicationinhumans.

    ForONEreceptor,outlinethestepsintheresponsetoastimulus.

    (b) Itwasobservedthatanewinsectspecieshadaflatdiskontheinnerkneeofeach

    foreleg.

    Howcouldyouusea first-handinvestigationandinformationfromsecondary

    sourcestodetermineifthisstructurefunctionsasatympanicmembrane?

    (c) People can have problemswithcommunicationbecauseofdifficulties in the

    sending,receivingorinterpretationofsomesignals.

    Howhasanincreasedunderstandingoftheprocessesofsightandhearingledto

    improvedassistanceforpeoplewithdifficultiesincommunicating?

    (d) Drawandlabeladiagramshowingthepathofsoundwavesthroughtheexternal,middleandinnerear.

    (e) Describe possible future research to overcome ONE current limitation in

    cochlearimplants.

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    Marks

    2

    3

    6

    7

    3

    4

    Question30—Biotechnology (25marks)

    (a) NameTWOorganiccompoundsproducedbybiotransformationtechnologies.

    (b) DescribeONEuseofbiotechnologybyanearlysociety.

    (c) Thesourdoughprocessofbreadmaking involvesretainingsomeofthedough

    eachtimeasa“starter”forthenextbreadmixture.

    Howcouldyouusea first-handinvestigationandinformationfromsecondary

    sources to develop methods to improve this process in order to ensure aconsistentbreadproduct?

    (d) How have developments in the understanding of modern biotechnological

    processesledtoimprovementsintreatingdisease?

    (e) Draw and label adiagramshowing the sequence of events that resultin theformationofrecombinantDNA.

    (f) Describe ONE possible area of future research based on a current use of

    recombinantDNAtechnology.

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    Marks

    2

    3

    6

    7

    3

    4

    Question31—Genetics:TheCodeBroken? (25marks)

    (a) (i)

    (ii)

    DescribeONE difference between gene cloning and whole organism

    cloning.

    Outlinethestepsthatcouldbetakentoverifythataparticularanimal

    wasaclone.

    (b) Ina studyofMendeliangenetics, small-wingedbutterflieswerecrossedwith

    butterflieswithnormalsizewings.

    Unexpectedly,oneoftheoffspringhadwingstwicethenormalsize.

    Howcouldyouuseafirst-handinvestigationandinformationfromsecondary

    sourcestodetermineifthisisageneticmutation?

    (c) Howhaveknowledgeofgeneticsandgeneticmutationsaffectedunderstanding

    ofhumanhealthanddisease?

    (d) DrawandlabeladiagramofamethodusedtoproducerecombinantDNA.

    (e) DescribeONEpossible area of future research arising from the limiteddata

    obtainedfromtheHumanGenomeProject.

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    Marks

    2

    3

    6

    7

    3

    4

    Question32—TheHumanStory (25marks)

    (a) Name TWO characteristics of humans that allow them to be classified as

    primates.

    (b) OutlineONEmethodthatcouldbeusedtodeterminetheageoffossils.

    (c) On a remote island, a whole Hominid skeleton was exposed by a recent

    landslide.

    Howcouldyouusea first-handinvestigationandinformationfromsecondarysourcestodetermineifthisisanew Homo species?

    (d) How have knowledge of cultural development and polymorphism led to an

    improved understanding of how the human species has adapted to the

    environment?

    (e) DrawandlabeladiagramtoshowtheprocessofDNA-DNAhybridisationthat

    isusedtodeterminerelationshipsbetweengroupsofprimates.

    (f) Describe possible implications of the Human Genome Project on our

    understandingofhumanevolution.

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    2

    CN

    C NO O O  X HC

    C CHN NO- P  O   P  O   P  O CH2

    O

    O- O- O H H

    Y H H

    triphosphategroup OH OH

    Marks

    2

    3

    6

    7

    3

    4

    Question33—Biochemistry (25marks)

    (a) ThestructureoftheATPmoleculeisshown.

    NH

    (i) NametheTWOcomponentsofATPthatarelabelled X andY .

    (ii) Why are the phosphate groups considered to be the biologically

    importantpartoftheATPmolecule?

    (b) Arareplantwasdiscoveredonthesideofavolcano.Thisplantexcretedpure

    sulfuratlevelsthatcouldbeusedcommercially.

    More sulfur was produced when the volcano was active and when theatmospherewasdeepred.

    Based onVan Niel’s findings it was thought that this was a photosynthetic

    reaction.

    Howcouldyouuseafirst-handinvestigationandinformationfromsecondary

    sourcestodetermineifthisisaphotosyntheticreaction?

    (c) How are developments in technologies and strategies for investigating plant

    biochemistryrelatedtothedevelopmentofunderstandingofphotosynthesis?

    (d) DrawandlabeladiagramtotracethemainstepsintheCalvincycle.

    (e) DescribeONEpossibleareaoffutureresearchinphotosynthesistoaddressthe

    continuingneedforenergysupplies.

    Endofpaper

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