2008 cv cole v03 (for tom and irb) · 2001 andrea osvath – doctoral student (rotation), ucla...

PERSONAL:

Business Address: Department of Molecular Biology and Microbiology Biomolecular Science Center University of Central Florida Bldg. 20, Room 236 4000 Central Florida Blvd. Orlando, FL 32816-2364

Telephone: (407) 823-3633Laboratory: (407) 823-3634Fax: (407) 823-3635E-mail: [email protected]

Citizenship: USA

EDUCATION:

1989-1993 The College of William and Mary, Williamsburg, VA B.S. with Honors, Biology, 1993

1994-1998 The University of Medicine and Dentistry of New Jersey, Graduate School of Biomedical Sciences, Newark, NJ

Ph.D., Biomedical Sciences/Cell Biology, 1998

PROFESSIONAL EXPERIENCE:

1996-1998 Adjunct Professor, Department of Biology, Passaic County Community College, Patterson, NJ

1998-2001 Postgraduate Researcher, Department of Medicine, University of California, Los Angeles

Laboratory of Tomas Ganz, Ph.D., M.D.

2001-2003 Assistant Professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles*

2003-2006 Assistant Professor, Department of Molecular Biology and Microbiology, University of Central Florida, Orlando

2004-2006 Assistant Professor (Joint Appointment), Biomolecular Science Center, University of Central Florida, Orlando

2006-pr. Associate Professor (with tenure), Department of Molecular Biology and Microbiology and the Biomolecular Science Center, University of Central Florida, Orlando

Alexander M. Cole, Ph.D.Curriculum Vitae

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PROFESSIONAL ACTIVITIES:

Grant Peer Review:

2001 - NIH Review Panel, RFA HD-00-018: “Microbicide Preclinical Development Program”- Reviewer, NSF grant application

2002 - Member, NIH-NHLBI Special Emphasis Review Panel, “Innovative Research Grant Program” – (2 review panel meetings in 2002)

- NIH Review Panel, ZRG-AARR1: unsolicited P01

2003 - Reviewer, Swiss National Science Foundation - NIH Review Panel, RFA ID-02-026 “Cooperative Research for the

Development of Vaccines, Adjuvants, Therapeutics, Immunotherapeutics, and Diagnostics for Biodefense (VATID).”

- Three (3) NIH Review Panels, RFA AI-02-031 “Regional Centers of Excellence in Biodefense and Emerging Diseases.” – (three separate subcommittees)

- NIH Review Panel, ZRG1-AARR (52): unsolicited P01 - NIH Review Panel, ZRG-AARR-A (51): “Integrated Preclinical/Clinical

Program for Topical Microbicides”

2004 - Reviewer, Ireland Health Research Board (HRB), Research Funding and Policy Division, Research Project Grants

- Reviewer, Pittsburgh Life Sciences Greenhouse (PLSG) proposals - NIH Review Panel, RFA AI-03-045 (NIAID enhancement awards) - Reviewer, The Wellcome Trust

2005 - Reviewer (twice in 2005), Scottish Hospital Endowments Research Trust (SHERT) Research Project Grants

- NIH Review Panel, temporary member, HIBP study section (Host Interactions and Bacterial Pathogenesis)

- Reviewer, Italian Cystic Fibrosis Research Foundation - NIH Review Panel, RFA HL-04-031: “Mechanisms of HIV-related

pulmonary complications” (declined invitation due to schedule conflict) - NIH Review Panel, RFA HL-05-015: “Mentored career award” - NIH Review Panel, Special emphasis panel: “Preclinical/Clinical

Development of Topical Microbicides” (P01/U19 mechanisms)

2006 - Two (2) NIH Special Emphasis Review Panels: AIDS Clinical Trials Units (two separate panels)

- NIH Review Panel, RFA-AI06-005, Microbicides Innovation Program - Reviewer, Israel Science Foundation (ISF) - NIH Review Panel, IDM – M02, Bacterial Pathogenesis Study Section - NIH Review Panel, RFA HL-05-015 and RFA HL-05-016: “Mentored

career awards”

2007 - NIH Review Panel, RFA 06-036 “Partnerships to improve diagnosis and treatment of selected drug-resistant healthcare-associated infections” (U01 mechanism)


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- NIH Review Panel, ADDT study section, ad hoc member (invited – declined due to schedule conflict)

- Reviewer, Army Research Office Life Science Division, Department of Defense

- NIH Review Panel, RFA-AI06-042, Microbicides Innovation Program II - Reviewer, Italian Cystic Fibrosis Research Foundation - NIH Review Panel, RFA-07-001 “Integrated Preclinical/Clinical Program

for HIV Topical Microbicides” (U19 mechanism)- Reviewer, Swiss National Science Foundation- Three (3) NIH Review Panels – ADDT study section, RFP 08-09 “Non-human primate models to evaluate therapeutic strategies and topical microbicides for HIV”, and PAR-05-031 “Multidisciplinary Research on Oral manifestations associated with HIV/AIDS” (invited – declined due to schedule conflicts)- Reviewer, Seed grants for the Florida D-CFAR (Developmental Center for AIDS Research)

2008 - NIH Review Panel, IDM-A 90S, “Bacterial Pathogenesis” - Reviewer, The Wellcome Trust - Reviewer, grants for the UCSD Center for AIDS Research - NIH Review Panel, BAA AI20080022 BARDA “Application of Platform

Technologies for the Development of Therapeutics for Bio-defense” (invited - declined due to schedule conflict)

Editorial:

2003-2005 Guest Editor, Combinatorial Chemistry and High Throughput Screening. Vol. 8, No. 3, pp. 207-281. Commissioned and edited review articles for a special issue called “Antimicrobial peptides”. Editorial also written by A.M. Cole.

2005-present Editorial Board Member, Protein and Peptide Letters

2006-present Editorial Board Member, Drug Target Insights

2007-present Editorial Board Member (3 journals):The Open Medicinal Chemistry JournalCurrent ProteomicsVirology: Research and Treatment

2008-present Editorial Board Member, Probiotics and Antimicrobial Proteins

Manuscript Peer Review: (note: multiple reviews for most journals)

2000-2005 Journal of Experimental Medicine Journal of Clinical Investigation

Journal of Immunology, and JI: Cutting Edge Biochemistry Infection and Immunity Journal of Leukocyte Biology American Journal of Physiology Antimicrobial Agents and Chemotherapy


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Journal of Acquired Immune Deficiency Syndromes (JAIDS)European Respiratory Journal

FEBS Letters Peptides American Journal of Respiratory Cell and Molecular Biology

Journal of Clinical Drug InvestigationCombinatorial Chemistry & High-throughput ScreeningEvidence-Based Complementary and Alternative MedicineOral DiseasesLung Biopolymers: Peptide Science

Expert Opinion on Therapeutic Patents Expert Opinion on Investigational Drugs

Expert Opinion on PharmacotherapyJournal of Pharmacy and PharmacologyProtein and Peptide LettersProceedings of the Royal Society: Biological SciencesRespiratory Research

Comparative Medicine Molecular Human Reproduction

2006-present Nature Biotechnology Journal of Clinical Investigation

Journal of ImmunologyThe LancetPLoS Biology Trends in MicrobiologyInfection and ImmunityJournal of Infectious DiseasesJournal of Acquired Immunodeficiency Syndromes (JAIDS)AIDS Research and Human RetrovirusesInternational Journal of Biochemistry and Cell BiologyJournal of Cellular and Molecular MedicineMucosal ImmunologyAmerican Journal of Respiratory Cell and Molecular BiologyBiochimica et Biophysica Acta PeptidesBMC PharmacologyApplied and Environmental Microbiology (ASM press)Journal of Reproductive ImmunologyJournal of Viral EntryCurrent ProteomicsClinical Infectious DiseasesProtein and Peptide LettersExpert Opinion on Investigational DrugsMolecular Human ReproductionRoyal SocietyDrug Discovery Today

Scientific Administrative and Organizational Activities:

2000 Organizer and co-chair, Innate Host Defense Workshop, North American Cystic Fibrosis Conference, Baltimore, MD, November 9-12, 2000


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2006 Chair, Session VII “Development of Topical or External Microbicides”, World AIDS Day, Tianjin, China (Dec. 1-3)

2007-present Florida-CFAR (Center for AIDS Research) Executive Committee; multi-institute D-CFAR application to NIH

Committee and University Service (faculty service listed):

University (UCLA and UCF)

2002-2003 Biomedical Initiative Program, University-wide AIDS research program task force, Sacramento, California (UCLA)

2004-pr. Pre-health Professions Advisory Board

2004-pr. Faculty Library Representative

2004-2007 Graduate Course Review and New Programs Subcommittee of the Graduate Council, Faculty Senate

2005 Ad hoc committee for IRB review of human tissue banks at UCF (7/13/05)

2005-2007 Parking and Traffic Appeals Committee (note: 22-24 meetings per year, 2.5 hrs per meeting)

2005-pr. Library Advisory Committee, Faculty Senate

2005-pr. Member, I2Lab

2006-2007 Medical School Curriculum Planning Committee (University-wide, and COM) – initial curriculum committee for the COM.

College/School (Burnett College/School of Biomedical Sciences, UCF; College of Medicine, UCF)

2004 College Research Committee (Distinguished Researcher) – (while in College of Health and Public Affairs)

2004 Search committee, Associate Director of the Biomolecular Science Center

2004-pr. Ph.D. Admission and Recruitment Committee

2004-2005 Search committee, Joint positions in Nanoscience Technology Center and Biomolecular Science Center

2005-2006 Curriculum committee, BS, BS/MS, and MS programs in Biotechnology

2005-2006 Search committee for Chair of Molecular Biology and Microbiology and Associate Dean of the Burnett College of Biomedical Sciences

2005-pr. Course and Program Review Committee


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2006 Chairman, Molecular Microbiology & Tuberculosis Faculty Search Committee

2006-2007 Chairman, Molecular Microbiologist Faculty search committee (2nd search)

2006-pr. Burnett College Research Committee

2006-2007 Burnett College Committee to examine graduate curriculum

2007-pr. RIA standards and awards committee

2007 Committee to review Honors in the Major (HIM) scholarship applications

2007 Faculty Representative, COM – Fall graduation

2007-pr. M.D. Program Curriculum Committee – standing committee of the COM (and separate from the Curriculum Planning Committee)

2007-pr. M.D. Program Curriculum Planning Committee (ex officio member) – advisory to the Program Curriculum Committee

2007 LCME (Liaison Committee for Medical Education) Site Visit – 1st year Educational component, Course Director of HB3 – Human Body: Health and Disease

2008-pr. Tenure and Promotion and CPE committees (Unit-level review)

2008-pr. Core equipment committee

2008-pr. Chairman, Infectious Disease faculty search committee

2008-pr. Medical Education Department Chairman search committee

2008-pr. Search Committee - Faculty positions in Microbiology, Immunology and Virology

Departmental (Molecular Biology & Microbiology, BSBS, UCF)

2003-2004 Faculty Search Committee

2004-2005 Departmental selection committee, UCF In-house grants

2004-2008 M.S. Program Graduate Committee (admissions and curriculum)

2004-2005 Chairman, Bacterial Pathogenesis Faculty Search Committee

2005-2006 Chairman, Infectious Diseases Faculty Search Committee

2005 Committee to review MS program and curriculum

2005-2006 Departmental selection committee, UCF in-house grants


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2007 Tenure and Promotion Committee

2007-2008 non-thesis MS program committee

2007-2008 M&M Faculty Search Committee, Bacterial Pathogenesis position (3rd search)

Outreach and Community Service:

1997-1998 Chairman and Founder, Volunteer Outreach Program to tutor underprivileged high school students in the Newark Public School System, UMDNJ

2004 Judge, Microbiology section, Seminole County Regional Science Fair. Feb. 14, 2004.

2004-2007 Faculty Advisor, ASPIRE high school program, Lake Highland Prep High School

2005, 2006, and 2007– Award and recognition for service 2004-pr. Registered Faculty Reviewer – UCF Undergraduate Research Journal

2005-pr. Minority Mentoring Program Mentor (provide career advice, and advice and review of manuscripts and grant applications), American Society for Microbiology

2005 Contributor, National Library Week celebration at UCF (April 10-16)

2005-pr. Editorial Board, Undergraduate Research Journal, UCF

Professional Associations and Scholarly Societies:

1996-pr. American Society for Microbiology1997-pr. American Association for the Advancement of Science1999-2004 American Thoracic Society2000-pr. Society for Mucosal Immunology2003-pr. American Association of Immunology - Regular (elected) member

Consulting:

2002-pr. National Institutes of Health2004-pr. MEDACorp, Boston, MA2006 Gencrest Division of Ajanta Pharmaceuticals, Raritan, NJ

Individuals Supervised:

Postdoctoral Fellows and Visiting Scientists:


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1999-2001 Alejandro Ceccarelli, D.V.M., Ph.D., Postdoctoral Research, Department of Laboratory Animal Medicine, UCLA – School of Medicine

2001 Heiman Wertheim, M.D., Visiting Postdoctoral Researcher (University of Rotterdam, The Netherlands)

2001-2002 V. Cuneyt Kalfa, M.D., Postdoctoral Research, Allergy and Rheumatology, UCLA – School of Medicine

- Dr. Kalfa was awarded a $10,000 fellowship from the American College of Allergy, Asthma and Immunology on “Protein determinants of recurrent and/or chronic rhinosinusitis”. 11/1/01-10/31/02

2003-pr. Amy Liese Cole, Ph.D. – Research Assistant Professor (Assistant Scientist), UCLA and UCF

2003-2004 S. Vasudeva Murthy, Ph.D. - Visiting Scholar at UCF (Kakatiya University, Warangal, India)- Dr. Murthy was awarded a $4,000 fellowship from the FIP Foundation

for Education and Research (The Hague) on “Host defense factors in nasal fluid from leprosy patients”.

2005-2006 Philip Arlen, Ph.D., postdoctoral fellow (co-mentor with Dr. Henry Daniell, UCF – Interferon project)

2005-pr. Gerry Quinn, Ph.D., postdoctoral fellow

2006-pr. Karthikeyen Sivaraman, Ph.D., postdoctoral fellow

Doctoral students:

2001 Andrea Osvath – doctoral student (rotation), UCLA ACCESS Program

2002 Lan Lin – doctoral student (rotation), UCLA ACCESS Program

2004-pr. Nitya Venkataraman – doctoral candidate, Biomolecular Sciences PhD Program, UCF. Dissertation title “Retrocyclin, a human theta-defensin with potent anti-HIV-1 activity”

2005 Charambalos “Bambos” Kaittanis – doctoral student (rotation, UCF)

2005-pr. Julie Martellini – doctoral student, Biomolecular Sciences PhD Program, UCF. Dissertation title “The anti-HIV-1 activity of human seminal plasma” (UCF)

2008-pr. Matthew Wood, doctoral student, Biomolecular Sciences PhD Program, UCF.

2008-pr. Colleen Eade, doctoral student, Biomolecular Sciences PhD Program, UCF.

2008-pr. Gowrishankar Muthukrishnan, doctoral student, Biomolecular Sciences PhD Program, UCF.


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Masters students:

2005-2007 Christopher “Kit” Fuhrman – masters student, Dept. of Molecular Biology and Microbiology, UCF. Thesis title: “The Retrocyclin RC101 overcomes cationic mutations on the heptad repeat 2 of HIV-1 gp41” – defended 6/26/07

- Received Scholarship grant for the 2006 NBCR Summer Institute ($550) - Received Rudy Wodzinski Memorial Scholarship ($1250) - Awarded Order of Pegasus, 2007 – the most prestigious and

significant student award at UCF

2005-2007 Abirami Muthukrishnan - masters student (co-mentor with Dr. Henry Daniell, UCF) – resigned from program in early 2007 due to a family emergency in India

Other PhD and MS thesis committees:

2004 John Rumsey (M.S.)2004-2006 Amy Grenier (M.S.)2004-pr. Christina Kittipatarin (Ph.D.)2005-2006 Sushama Kamarajugadda (M.S.)2007-pr. Mary Jones (M.S., Biology)2007-pr. Melissa Donigan (Ph.D.)

Undergraduate students:

1999-2001 Albert Park, Student Research Program (SRP), UCLA

1999-2001 Dawn Yoshioka, Student Research Program (SRP), UCLA

2001 Jeffery Kwon, M-199 research project, UCLA

2001 Amie Chen, M-199 research project, UCLA

2003-2007 Miriam Vandermey, National Merit Scholar – Mentor Program, Honors College, UCF

2004-2005 Heidi Finkelstein – Undergraduate Research Initiative, UCF

2005 Christopher Fuhrman – Directed Independent Study; and, Undergraduate Research Initiative, UCF

2005-2007 Nick Felts – Undergraduate Research Initiative, UCF

2007-pr. Arantzazu Cruz – Undergraduate Research Initiative, UCF

2008-pr. Allen Seba – Undergraduate Research Initiative, UCF

High school students:


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2004-2007 Andrew Warren – high school student, ASPIRE program, Lake Highland Prep School

- 1st place, oral presentation, Junior Science EHS at University of Florida (Feb. 6-8, 2005)- 1st place, Medicine and Health, Senior Category, Orange County Regional Science and Engineering Fair (Feb 22-24, 2005)- Grand Prize - 2005, Senior Category, Orange County Regional Science and Engineering Fair (Automatic qualification to International Science Fair, including free airfare, room & board, and $1000 cash prize)- 3rd place, Microbiology, Florida State Science and Engineering Fair (April 6-8, 2005)- 2nd place Grand Award Winner - Microbiology, Intel International Science and Engineering Fair (Phoenix, AZ, May 8-14, 2005) - $1500 cash prize, and an asteroid named after him.- 1st place, Microbiology, Senior Category, Orange County Regional Science and Engineering Fair (Feb 21-23, 2006)- Grand Prize - 2006, Senior Category, Orange County Regional Science and Engineering Fair (Automatic qualification to International Science Fair, including free airfare, room & board, and $1050 cash prize)- 1st place, Microbiology, Senior Category, 51st annual State Science and Engineering Fair (Florida), April 19-21, 2006 ($1000 cash prize)- Best in Fair, Senior Category, 51st annual State Science and Engineering Fair (Florida), April 19-21, 2006 ($1000 cash prize)- 1st place and Best of Category Grand Award Winner – Microbiology, Intel International Science and Engineering Fair (ISEF; Indianapolis, IN, May 8-12, 2006) - $8000 cash prize, a laptop, and two $1000 grants to his high school and regional science fair- Semifinalist, Siemens-Westinghouse Competition, Oct. 20, 2006- 1st place, Microbiology, Senior Category, and backup trip winner to ISEF, Orange County Science and Engineering Fair (Feb 20-22, 2007)- Johns Hopkins University Early Admission – Biomedical Engineering Program (#1 program in the country for biomedical engineering)

Teaching Activities:

1991 Instructor, Developmental Biology Laboratory, Virginia Governor’s School

1996-1998 Adjunct Faculty Member, Anatomy and Physiology Lecture and Laboratory, Passaic County Community College

1997-1998 Instructor, Explorations of Biomedical Research laboratory program for underprivileged high school students, UMDNJ

1998 Instructor, Medical Gross Anatomy Laboratory, UMDNJ

1999-2000 Mentor, Undergraduate Student Research Program (2 students), UCLA

2000-2001 Mentor, 199 Independent Research (2 students), UCLA


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2001-2003 Faculty Advisor, “Pre-medical Peer Association”

2003 MCB 6938 (Seminar and Journal Club), Master’s Program, Dept. of M&M, UCF (Fall)

NOTE: Due to Departmental need, volunteered to start teaching 1 year ahead of contractual schedule

2004 PCB 5238 (Immunopathology), Spring – designed and developed this new course in immunobiology, linking innate and adaptive immunity.

Course satisfies Gordon Rule Composition Requirement (3000 words of composition in final term paper)

NOTE: Due to Departmental need, volunteered to start teaching 1 year ahead of contractual schedule

2004 PCB 5238 (Immunopathology), 3 credits, Fall Course satisfies Gordon Rule Composition Requirement (3000 words of

composition in final term paper)

2004 MCB 5527 (Genetic Engineering and Biotechnology), 3 credits (team-taught with Dr. Henry Daniell), Fall

2004 MCB 4312 (Molecular Biotechnology), 3 credits, team-taught with Dr. Henry Daniell, Fall

NOTE: Overload for Fall semester

2004 M.S. Comprehensive examinations (3 exams)

2004 Ph.D. Comprehensive examination

2005 PCB 4234 (Cellular Immunology), 3 credits, team-taught with Dr. Annette Khaled, Spring

2005 MCB 4906 (Directed Independent Study); 2 credits, Spring

2005 MCB 5527 (Genetic Engineering and Biotechnology), 3 credits (team-taught with Dr. Ken Teter), Fall

2005 MCB 4312 (Molecular Biotechnology), 3 credits, team-taught with Dr. Ken Teter, Fall

2005 M.S. Comprehensive examination


2006 PCB 5238 (Immunobiology), 3 credits, Spring Course satisfies Gordon Rule Composition Requirement (3000 words of

composition in final term paper) NOTE: Overload for Spring semester

2006 PCB 4234 (Molecular Immunology), 3 credits, team-taught with Dr. Annette Khaled, Spring

NOTE: Overload for Spring semester

2006 M.S. Comprehensive examinations (2)


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2006 BSC 6431 (Practice of Biomolecular Science), 2 credits, team taught with Dr. Pappachan Kolattukudy (25% of course)

NOTE: volunteered to teach this course

2007 PCB 5238 (Immunobiology), 3 credits, Spring Revamped over half of the course to encompass discussions of peer-

reviewed articles from top-tier journals. Course satisfies Gordon Rule Composition Requirement (3000 words of composition in final term paper)

2007 BSC 6431 (Practice of Biomolecular Science), 2 credits, team taught with Dr. Pappachan Kolattukudy (20% of course) - additional teaching assignment

2007-pr. HB-3 Human Body: Health and Disease – Course Director (course development, LCME preparation, faculty recruitment, etc), College of Medicine, M-1 year

2008 PCB 5238 (Immunobiology), 3 credits, Spring (first offered of Immunobiology as a Mixed-mode course)

State salary (teaching) buy-back from grants: (all summers funded 100% by research grants)

2004 Fall2005 Spring and Fall2008 Spring

RESEARCH GRANTS, FELLOWSHIPS, and OTHER FUNDING RECEIVED:

Ongoing:

2002-2011 NIH R01 AI052017, Retrocyclins: circular defensins active against HIV-1, ~$3,120,000 total costs (~$1.3M years 01-04; ~$1.8M years 05-09), Principal Investigator

2005-2010 NIH R01 AI060753, Nasal carriage of S. aureus: host-pathogen interactions, $1,608,750 total costs, Principal Investigator

2005-2009 NIH U19 AI065430, Project 2: Development of Retrocyclin microbicides. ~$715,000 total costs, Project Leader – in: CV-N-secreting lactobacilli and retrocyclin microbicides (PI: Gupta, U Pitt; co-PI: Cole)

2004-pr. Unrestricted research funds, HelixBiomedix Inc. $15,000 total costs, Principal Investigator

Completed:


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1999-2000 NIH (NHLBI) NRSA F32 Fellowship, Antimicrobial factors in cystic fibrosis airways, $32,416/yr, Principal Investigator

2000-2001 American Lung Association Research Training Grant, Determinants of airways colonization, $32,500, Principal Investigator

2000-2001 Cystic Fibrosis Research, Inc., Antimicrobial deficiency of CF airways secretions, $54,000 TDC, Co-principal Investigator (with Tomas Ganz, Ph.D., M.D., UCLA – Dept. of Medicine)

2001-2003 Cystic Fibrosis Foundation, Proteomic analysis of CF airways secretions. $120,000 TDC, Co-principal Investigator (with Tomas Ganz, Ph.D., M.D., UCLA – Dept. of Medicine)

2001-2002 Competitive renewal: American Lung Association Research Training Grant, Determinants of airways colonization, $32,500, Principal Investigator

2001-2002 IDEA grant, University-wide AIDS Research Program, Retrocyclin, a novel antimicrobial peptide with anti-HIV-1 activity, $50,200 TDC, Principal Investigator

2002-2005 Parker B. Francis Fellowship in Pulmonary Research, The role of lysozyme in airway host defense and inflammation, $120,000 TDC, Principal Investigator (declined award to accept two R01 grants)

2000-2003 NIH R21 AI48167, Innovation Grant, Nasal carriage of Staphylococcus aureus, $300,000 TDC, Co-investigator (PI: Tomas Ganz, Ph.D., M.D., UCLA - Department of Medicine)

2003 FIP Foundation for Education and Research (The Hague) on “Host defense factors in nasal fluid from leprosy patients”, $4,000 TDC. Principal Investigator and Mentor

2002-2005 NIH R01 HL70876, Proteomics of Staphylococcus aureus nasal carriage, $200,000 TDC, Principal Investigator

2006-2007 NIH R01 GM063879, Expression of human therapeutic proteins in transgenic chloroplasts, $178,750 total costs to Dr. Cole, co-investigator.

2006-2007 Gencrest/Ajanta Pharmaceuticals. $125k/yr (PI: Henry Daniell; co-PI: Cole - 20% effort and budget)

PATENTS:

2004 R.I. Lehrer, A.J. Waring, A.M. Cole, and T. Hong. “Retrocyclin: an antiretroviral circular minidefensin”. Patent # 6,713,078Issued March 30, 2004.

2008 R.I. Lehrer, A.J. Waring, A.M. Cole, and T. Hong. “Retrocyclins: antiviral and antimicrobial peptides”. Patent # 7,314,858

Issued January 1, 2008


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OTHER HONORS AND AWARDS (selected):

1993 Honors in Biology, The College of William and Mary

1994-1997 Fellowship, UMDNJ

1995-1996 Honorary Award Recognition, The National Dean’s List

1996 First Place, Poster Session, Graduate Student Research Forum, UMDNJ

1996-1997 Research Residency, The New York State Library

1997 Semifinalist, Educational Communications Scholarship Foundation

1997 First Place, Oral Presentation, Graduate Student Research Forum, UMDNJ

1997-1998 Scholarship, Champions of UMDNJ

1998 Honored by UMDNJ President, University Day, January 28, 1998.

1999 Medal of Excellence, President Stanley S. Bergen, Jr., M.D. Top graduate award, UMDNJ- Graduate School of Biomedical Sciences, May 23, 1999.

1999 Fellowship, Cystic Fibrosis Foundation (awarded)

1999 Travel Award, National Academy of Sciences Colloquium, Irvine, CA, December 1999.

2000 McLaughlin Award in Infectious Disease and Immunology, 41st Annual National Student Research Forum, Galveston, TX, April 6-8, 2000.

2000 Travel Award, Aegean Conference on Innate Immunity, Santorini, Greece, October 11-15, 2000.

2001 Chancellor ’s Award for Postdoctoral Research, Exceptional accomplishments in research, certificate of nomination, UCLA, March 20, 2001.

2002 Janis Giorgi Award, University-wide AIDS Research Program (UARP), 4th Annual Conference on AIDS Research in California, February 22, 2002. ($1500 honorarium and plaque).

LECTURES AND PRESENTATIONS:

1997 Invited Lecturer, New Jersey Sea Grant College Program Workshop on Marine Biotechnology, Rider University, NJ, May 19, 1997: “Pleurocidin - a novel mucosal antimicrobial peptide”


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1999 Invited Lecturer, Gordon Research Conference, Barga, Italy, April 25-30, 1999: “Antimicrobial properties of nasal secretions – an overview”

1999 Invited Lecturer, Williamsburg Meeting for Cystic Fibrosis, Williamsburg, VA, June 4-9, 1999: “Polymorphic protein expression and nasal Staphylococcus aureus colonization”

2000 Invited Lecturer, Innate Immunity Workshop, Santorini, Greece, October 11-15, 2000: “Calcitermin, a novel antimicrobial peptide from human nasal secretions”

2000 Participant, Roundtable, North American Cystic Fibrosis Conference, Baltimore, MD, November 9-12, 2000: “Antimicrobial properties of airways secretions”

2001 Lecturer, 23rd Southern California Pulmonary and Critical Care Medicine Research Conference, Palm Springs, CA, February 9-11, 2001: “Defective antimicrobial properties of cystic fibrosis airway secretions”

2001 Lecturer, Pulmonary Research Grand Rounds, UCLA, Dept. of Medicine, Pulmonary Division – February 15, 2001: “Antimicrobial properties of human airway secretions”

2001 Invited Lecturer (short talk), Gordon Research Conference, Ventura, CA, March 18-23, 2001: “Inhibition of cathelicidin processing impairs bacteria clearance in wounds”

2001 Invited Lecturer, Williamsburg Meeting for Cystic Fibrosis, Williamsburg, VA, June 1-5, 2001. “A defect in the natural antimicrobial activity of CF airway fluid”

2002 Invited Lecturer, NIAID Topical Microbicides Meeting, January 9-10, 2002: “Antimicrobial components of vaginal fluid”

2002 Invited Lecturer, NIAID Topical Microbicides Meeting, January 9-10, 2002: “Retrocyclins: novel primate peptides that protect cells from infection by HIV-1”

2002 Invited Plenary Speaker, 5th Annual UARP Conference on AIDS Research in California, February 21-22, 2002: “Retrocyclins: novel primate peptides that protect cells from infection by HIV-1”

2002 Speaker, The Second Collaborative Research Seminar on HIV and other Viral Entry Inhibitors, May 3-5, New York, NY: “Retrocyclins: circular minidefensins active against HIV-1”

2002 Speaker, Microbicides 2002, May 12-15, Antwerp, Belgium: “Retrocyclins: circular minidefensins with potent activity against HIV-1”

2003 Invited Speaker, 4th Gordon Research Conference on Antimicrobial Peptides, April 27-May 2, Il Ciocco, Italy, “Retrocyclins: circular minidefensins active against HIV”


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2005 Invited Speaker, 10th International Meeting of the Institute of Human Virology, August 28-September 2, Baltimore, MD, “Retrocyclins: novel circular peptides active against HIV-1”

2006 Invited Speaker, World AIDS Day – China 2006, Tianjin, China (Dec. 1-3), “Repairing a broken anti-HIV theta-defensin”

2007 Speaker, Integrated Program on Topical Microbicides, NIH program session, Pittsburgh, PA, April 10-11, “Progress on developing Retrocyclins as topical intravaginal microbicides”

2007 Invited Plenary Speaker, Annual Meeting of the American Society of Reproductive Immunology, Toronto, Canada, May 14-16, “Retrocyclins, topical microbicides to prevent HIV-1 transmission”

2007 Invited Speaker, Luminary Speaker Series, Burnett College of Biomedical Sciences, Dr. Philips House, Orlando, FL, July 18, “Topical Microbicides: a new category of drugs to prevent HIV infection”

2007 Invited Speaker, Second International Symposium, Molecular Mechanisms of Epithelial Host Defense. Kiel, Germany, August 30-September 1, “Retrocyclins: antiviral peptides”

2008 Speaker, Integrated Program on Topical Microbicides, NIH program session, Pittsburgh, PA, May 21-22, “Developing Retrocyclins as topical microbicides”

2008 Invited Speaker, The 5th Key Symposium, Mucosal Immunity and Novel HIV-Vaccine Concepts, Stockholm, Sweden, September 11-13, “Innate host defense of human genital mucosae”


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Bibliography

RESEARCH PAPERS – PEER-REVIEWED:

(*** = corresponding author)

1. Yarus, S., J.M. Rosen, A.M. Cole, and G. Diamond. (1996). Production of active bovine trachea antimicrobial peptide in milk of transgenic mice. Proc Natl Acad Sci. USA, 93: 14118-14121.

2. Cole, A.M., P. Weis, and G. Diamond. (1997). Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J Biol Chem., 272(18):12008-12013.

3. Cole, A.M. and S.A. Ware. (1997). Forest vegetation, edaphic factors, and successional direction in the central Piedmont of Virginia. Castanea, 62(2):100-111.

4. Cole, A.M., P. Dewan, and T. Ganz. (1999). Innate antimicrobial activity of nasal secretions. Infect Immun. 67(7): 3267-3275.

5. Cole, A.M., R. Darouiche, D. Legarda, N. Connell, and G. Diamond. (2000). Pleurocidin: molecular cloning and characterization of a novel antimicrobial peptide gene. Antimicr Agents Chemother. 44(8): 2039-2045.

6. Cole, A.M., M. Wu, Y-H. Kim, and T. Ganz. (2000). Microanalysis of antimicrobial properties of human fluids. J Microbiol Methods. 41:135-143.

7. Cole, A.M., J. Shi, A. Ceccarelli, Y-H. Kim, A. Park, and T. Ganz. (2001). Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. Blood. 97(1): 297-304.

8. Ceccarelli, A.V., ***A.M. Cole, A.K. Park, S. Tahk, D. Yoshioka, and T. Ganz. (2001). The therapeutic effect of a pig-derived peptide antibiotic on porcine wound infections. Comparative Medicine. 51(1):75-79.

9. ***Cole, A.M., T. Ganz, A.M. Liese, M. Burdick, L. Liu, and R.M. Strieter. (2001). Cutting Edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol. 167: 623-627.

10. ***Cole, A.M., Y-H. Kim, S. Tahk, T. Hong, P. Weis, A. Waring, and T. Ganz. (2001). Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. FEBS Lett. 504(1-2): 5-10.

11. Cole, A.M., S. Tahk, A. Oren, D. Yoshioka, Y-H. Kim, A. Park, T. Ganz. (2001). Determinants of Staphylococcus aureus nasal carriage. Clin Diagn Lab Immunol. 8(6): 1064-1069.

12. Cole, A.M., T. Hong, L.M. Boo, T. Nguyen, C. Zhao, G. Bristol, J.A. Zack, A.J. Waring, O.O. Yang, and R.I. Lehrer. (2002). Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci USA. 99(4): 1813-1818.

13. ***Cole, A.M., H-I. Liao, O. Stuchlik, J. Tilan, J. Pohl, and T. Ganz. (2002). Cationic polypeptides are required for antimicrobial activity of human airway fluid. J Immunol. 169(12): 6985-6991.

14. Ganz, T., V. Gabayan, H.-I. Liao, L. Liu, A. Oren, T. Graf, and A.M. Cole. (2003). Increased pathogenicity of Micrococcus luteus in lysozyme M-deficient mice. Blood. 101(6): 2388-2392.


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15. ***Cole, A.M., H-I. Liao, T. Ganz, and O.O. Yang. (2003). Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Lett. 535 (1-3): 195-199.

16. Wang, W., A.M. Cole, T. Hong, A.J. Waring, and R.I. Lehrer. (2003). Retrocyclin, an antiretroviral theta-defensin, is a lectin. J Immunol. 170(9): 4708-16.

17. Milner, S.M., A. Cole, M.R. Ortega, M.H. Bakir, S. Gulati, S. Bhat and T. Ganz. (2003). Inducibility of HBD-2 in acute burns and chronic conditions of the lung. Burns. 29(6): 553-5.

18. Münk, C., G. Wei, O.O. Yang, A.J. Waring, W. Wang, T. Hong, R.I. Lehrer, N.R. Landau and ***A.M. Cole. (2003). The theta-defensin, Retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses. 19(10): 875-882.

19. Nguyen, T.X., A.M. Cole and R.I. Lehrer. (2003). Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides. 24(11): 1647-1654.

20. Owen, S.M., D.L. Rudolph, W. Wang, A.M. Cole, M.A. Sherman, A.J. Waring, R.I. Lehrer, and R.B. Lal. (2004). A θ-defensin composed exclusively of D-amino acids is active against HIV-1. J Pept Res. 63(6): 469-476.

21. Wang, W., S.M. Owen, D.L. Rudolph, A.M. Cole, T. Hong, A.J. Waring, R.B. Lal. and R.I. Lehrer. (2004). Activity of alpha and theta defensins against primary isolates of HIV-1. J Immunol. 173(1): 515-520.

22. Kalfa, V.C., S.L. Spector, T. Ganz, and ***A.M. Cole. (2004). Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. Ann Allergy Asthma Immunol. 93(3): 288-292.

23. Ross, D.J., A.M. Cole, D. Yoshioka, A.K. Park, J.A. Belperio, H. Laks, R.M. Strieter, J.P. Lynch III, B. Kubak, A. Ardehali, and T. Ganz. (2004). Increased BAL Human β-defensin Type 2 in Bronchiolitis Obliterans Syndrome after Lung Transplantation. Transplantation 78(8): 1222-4.

24. Owen, S.M., D. Rudolph, W. Wang, A.M. Cole, A.J. Waring, R.B. Lal, and R.I. Lehrer. (2004). RC-101, a Retrocylin-1 analogue with enhanced activity against primary HIV-1 isolates. AIDS Res Hum Retroviruses. 20(11): 1157-1165.

25. Yang, C., L. Boone, T.X. Nguyen, D. Rudolph, K. Limpakarnjanarat, T.D. Mastro, J. Tappero, A.M. Cole, and R.B. Lal. (2005). θ-Defensin pseudogenes in HIV-1-exposed, persistently seronegative female sex-workers from Thailand. Infect Genet Evol. 5(1): 11-15.

26. ***Cole, A.M., D. Thapa, V. Gabayan, H.-I. Liao, L. Liu, and T. Ganz. (2005). Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M. J Leuk Biol. 78(5): 1081-1085.

27. Venkataraman, N.*, A.L. Cole*, P. Svoboda, O. Stuchlik, J. Pohl, and ***A.M. Cole. (2005). Cationic polypeptides are required for the innate anti-HIV-1 activity of human vaginal fluid. J Immunol. 175: 7560-7567. * = equal contribution.

28. Gallo, S.A., W. Wang, S.S. Rawat, G. Jung, A.J. Waring, A.M. Cole, H. Lu, X. Yan, N.L. Daly, D.J. Craik, S. Jiang, R.I. Lehrer, and R. Blumenthal. (2006). Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem. 281(27): 18787-92.

29. Cole, A.L., O.O. Yang, A. Warren, A.J. Waring, R.I. Lehrer, and ***A.M. Cole. (2006). HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41. J Immunol. 176(11): 6900-6905.


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30. Keller, M.J., E. Guzman, E. Hazrati, A. Kasowitz, N. Cheshenko, S. Wallenstein, A.L. Cole, A.M. Cole, A.T. Profy, C.R. Wira, K. Hogarty, and B.C. Herold. (2007). PRO2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity. AIDS. 21(4): 476-476.

31. Cole, A.L., A. Herasimtschuk, P. Gupta, A.J. Waring, R.I. Lehrer, and ***A.M. Cole. (2007). The retrocyclin analog RC-101 prevents HIV-1 infection of a model human cervicovaginal tissue construct. Immunology. 121(1): 140-145.

32. Liu, H., S. Guo, R. Roll, J. Li, Z. Diao, N. Shao, M.R. Riley, A.M. Cole, J.P. Robinson, G. Shen, and P. Guo. (2007). Bacteriophage phi29 pRNA/ribozyme chimera targeting survivin for induction of apoptosis in various cancer cells. Cancer Biol Ther. 6(5): 697-704.

33. Quinn, G.A. and ***A.M. Cole. (2007). Suppression of innate immunity by a nasal carriage strain of Staphylococcus aureus increases its colonization on nasal epithelium. Immunology. 122(1): 80-9.

34. Arlen, P.A., R. Falconer, S. Cherukumilli, A.(L.) Cole, A.M. Cole, K.K. Oishi, and H. Daniell. (2007). Field Production and Functional Evaluation of Chloroplast-Derived Interferon alpha 2b. Plant Biotechnol J. 5(4): 511-525.

35. van Belkum, A., M. Emonts, H. Wertheim, C. de Jongh, J. Nouwen, H. Bartels, A.(M.) Cole, A.(L.) Cole, P. Hermans, H. Boelens, N. Lemmens-den Toom, S. Snijders, H. Verbrugh and W. van Leeuwen. (2007). The role of human innate immune factors in nasal colonization by Staphylococcus aureus. Microbes Infect. 9(12-13): 1471-77.

36. Fuhrman, C.A., A.D. Warren, A.J. Waring, S.M. Dutz, S. Sharma, R.I. Lehrer, A.L. Cole, and ***A.M. Cole. (2007). Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41. FEBS J 274(24): 6477-6487. NOTE: Featured Cover Article

37. Sivaraman, K., A. Seshasayee, P.M. Tarwater, and ***A.M. Cole. (2008). Codon choice in genes depends on flanking sequence information – implications for theoretical reverse translation. Nucleic Acids Research 36(3): e16.

38. Edström, A., J. Malm, B. Frohm, J. Martellini, A. Giwercman, M. Mörgelin, ***A.M. Cole, ***O.E. Sørensen. (2008). The major bactericidal activity of human seminal plasma is zinc-dependent and derived from degradation of the semenogelins. J Immunol. (in press) – Equal contribution and correspondence for A.M.C. and O.E.S. NIHMSID# 57416

39. Sivaraman, K., N. Venkataraman, J. Tsai, S. Dewell, and ***A.M. Cole. (2008). Complete genome sequencing and analyses of Staphylococcus aureus reveals determinants responsible for nasal carriage in humans. (in revision).

40. Quinn, G.A., P.M. Tarwater, and ***A.M. Cole. (2008). Subversion of IL-1-mediated host defense by a nasal carrier strain of Staphylococcus aureus. (in revision).

41. Venkataraman, N., A.L. Cole, P. Ruchula, A.J. Waring, R.I. Lehrer, O. Stuchlik, J. Pohl, and ***A.M. Cole. (2008). Reawakening retrocyclins: ancestral human theta-defensins with activity against HIV-1. (in revision).

INVITED REVIEWS and BOOK CHAPTERS:



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42. ***Cole, A.M. and T. Ganz. (2000). Human antimicrobial peptides: analysis and application. BioTechniques. 29(4): 822-831.

43. Cole, A.M. and T. Ganz. (2002). Antimicrobial Peptides and Proteins in the CF Airways. In: Cystic Fibrosis Methods and Protocols. John M. Walker, Editor. Methods Mol Med. 70: 447-464.

44. ***Cole, A.M. and A.J. Waring. (2002). The role of defensins in pulmonary medicine. Am J Respir Med. 1(4): 249-259.

45. ***Cole, A.M. and R.I. Lehrer. (2003). Minidefensins: antimicrobial peptides with activity against HIV-1. Curr Pharm Des. 9(18): 1463-1473. NOTE: Featured Cover Article.

46. ***Cole, A.M. (2003). Minidefensins and other antimicrobial peptides: candidate anti-HIV microbicides. Expert Opin Therapeut Targets. 7(3): 329-341.

47. Cole, A.M., W. Wang, A.J. Waring, and R.I. Lehrer. (2004). Retrocyclins: using past as prologue. Curr Prot & Peptide Sci. 5(5): 373-381.

48. ***Cole, A.M. and T. Ganz. (2005). Defensins and Other Antimicrobial Peptides: Innate Defense of Mucosal Surfaces. In: Colonization of Mucosal Surfaces. Ed. James Nataro et al., ASM Press. pp. 17-34.

49. ***Cole, A.M. (2005). Antimicrobial peptide microbicides targeting HIV. Protein Pept Lett. 12(1):41-7.

50. ***Cole, A.M. (2006). Innate host defense of vaginal and cervical mucosae. In: Antimicrobial peptides and human disease. Curr Top Microbiol Immunol. Ed. William M. Shafer, Springer-Verlag. 306: 199-230.

51. ***Cole, A.M. and A.L. Cole. (2008). Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense. Am J Reprod Immunol. 59(1): 27-34.

52. Sorensen, O.E., N. Borregaard, and A.M. Cole. (2008). Antimicrobial peptides in the innate immune response. Contrib Microbiol. 15: 61-77.

53. ***Cole, A.M. (2008). Microbicides in the prevention of HIV transmission and acquisition: current status and future directions. Drugs. (invited Leading Article - in preparation, due October 2008)

54. ***Cole, A.M. (2009). Discovery of Peptide Drugs from Natural Sources. In: Peptide Drugs: Peptide chemistry and drug design. Ed. Ben M. Dunn, John Wiley & Sons, Inc. (invited book chapter - in preparation, due April 2009)

NON PEER-REVIEWED PAPERS:


1. Ganz, T. and A.M. Cole. (2002). Cystic fibrosis and airways secretions. Cystic Fibrosis Research Inc. News. Spring/Summer (cover article).

2. ***Cole, A.M. (2003). Cystic Fibrosis: a descriptive synopsis. Knowledgene perspectives database (http://www.knowledgene.com).

3. ***Cole, A.M. (2005). Antimicrobial peptides (Editorial). Combinat Chem & High-Throughput Screening. 8(3): 207-208.


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4. ***Cole, A.M. (2005). Antimicrobial peptides (Meet the guest editor). Combinat Chem & High-Throughput Screening. 8(3): 281.

MEDIA REPORTS:5. The amfAR Treatment insider. Vol 3., No. 4 August/September 2002. “New Research on

Blocking Sexual Transmission”.6. Windy City Times. Aug 14, 2002. “Microbicides for safer sex”. 7. Comment. CDC News. March 4, 2002. “CDC HIV/STD/TB Prevention News Update”.8. Comment. The Scientist. January 29, 2004. “[Zhang’s and Ho’s] 2002 defensins paper

retracted”. 9. “Defense peptide found in primates may block some human HIV transmissions” – UCF

News, Seminole County Chronicle, ASM Weekly Digest, Science Daily, EurekAlert, Scienceblog, Seed Magazine, New York Blade, Houston Voice, The Express, Southern Voice, Washington Blade, Drug Researcher.com, All Headline News, Therapeutics Daily, Medical Device and Diagnostic Industry, RedOrbit, Playfuls, The Post Chronicle, Political Gateway, UPI, PhysOrg, and others – August 9-25, 2006

ABSTRACTS and CONFERENCE PAPERS:

1. Cole, A.M., and S. A. Ware. Succession and Forest Vegetation in the Central Piedmont of Virginia. (Annual Meeting of the Virginia Academy of Science, Norfolk, VA, May 1993).

2. Cole, A.M., P. Weis and G. Diamond. A Novel Antimicrobial Peptide Discovered in the Skin Secretions of Winter Flounder. (Annual Graduate Student Research Conference - University of Medicine and Dentistry of New Jersey, Newark, NJ, June, 1996).

3. Cole, A.M., P. Weis and G. Diamond. Pleurocidin - an antimicrobial peptide from the skin of winter flounder (Keystone International Symposia on Innate Immunity: Non-clonal Host Defense Mechanisms, Park City, UT, January, 1997).

4. Cole, A.M., P. Weis and G. Diamond. Characterization of an antimicrobial peptide from fish skin (97th American Society for Microbiology General Meeting, Miami Beach, FL, May, 1997).

5. Cole, A.M., P. Weis and G. Diamond. Pleurocidin, a new peptide antibiotic from fish skin. (1997 Annual Graduate Student Research Conference - University of Medicine and Dentistry of New Jersey, Newark, NJ, June 13, 1997).

6. Cole, A.M., P. Weis, B. Hobbs, and G. Diamond. Functional characterization of pleurocidin, an antimicrobial peptide from the skin of winter flounder. (7th Congress of the International Society of Developmental and Comparative Immunology, Williamsburg, VA, July 21-25, 1997).

7. Cole, A.M., P. Weis, G. Diamond. Pleurocidin - Advances in marine innate immunity. (Winter Poster Session, Molecular Biosciences Graduate Student Association, UMDNJ - Piscataway, NJ, February 13, 1998).

8. Cole, A.M., P. Weis, G. Diamond. Molecular characterization, cellular localization, and bactericidal kinetics of pleurocidin, an antimicrobial peptide from winter flounder. (National Student Research Forum, Galveston, TX, April 16-18, 1998).


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9. Cole, A.M., P. Dewan, T. Kang, and T. Ganz. The antimicrobial (poly)peptides of human nasal secretions. (Gordon Research Conference, Barga, Italy, April 25-30, 1999).

10. Cole, A.M., T. Kang, A. Park, and T. Ganz. Human nasal innate immunity. (Benzon Symposium on Innate Immunity, Copenhagen, Denmark, August 22-26, 1999).

11. Cole, A.M., A. Oren, Y-H. Kim, A. Park, D. Yoshioka, and T. Ganz. Characteristics of nasal fluid in Staphylococcus aureus nasal carriers. (41st National Student Research Forum, Galveston, TX, April 6-8, 2000).

12. Cole, A.M., A. Oren, Y-H. Kim, A. Park, D. Yoshioka, and T. Ganz. Epithelial determinants Staphylococcus aureus nasal carriage. (100th General Meeting of the American Society for Microbiology, Los Angeles, CA, May 21-25, 2000).

13. Porter, E.M., A.M. Cole, Y-H. Kim, P. Dewan, A. Oren, J.S. Lee, M. Kurniawan, K. Cao and T. Ganz. Novel aspects of lysozyme activity against gram-negative rods. (100th General Meeting of the American Society for Microbiology, Los Angeles, CA, May 21-25, 2000).

14. Cole, A.M., N. Mehdi, Y-H. Kim, P.B. McCray, Jr., and T. Ganz. Innate antimicrobial activity of CF nasal secretions. (North American Cystic Fibrosis Conference, Baltimore, MD, Nov. 9-12, 2000).

15. T. Ganz, Y-H. Kim, N. Mehdi, P.B. McCray, Jr., and A.M. Cole. Defective Antimicrobial Function of Airways Secretions in CF. (North American Cystic Fibrosis Conference, Baltimore, MD, Nov. 9-12, 2000).

16. Cole, A.M., J. Shi, A. Ceccarelli, Y-H. Kim, S. Tahk, A. Park, and T. Ganz. Endogenous and exogenous protegrins exert antimicrobial activity in porcine skin wounds. (Gordon Research Conference on Antimicrobial Peptides, Ventura, CA, Mar. 18-21, 2001).

17. E.V. Valore, C.H. Park, S.L. Igreti, A.M. Cole, and T. Ganz. Antimicrobial components of vaginal fluid. (NIAID Topical Microbicides Meeting, January 9-10, 2002).

18. Cole, A.M., T. Hong, L.M. Boo, T. Nguyen, C. Zhao, G. Bristol, J. Zack, A.J. Waring, O.O. Yang, and RI Lehrer. Retrocyclins: novel primate peptides that protect cells from infection by HIV-1. (NIAID Topical Microbicides Meeting, January 9-10, 2002).

19. Cole, A.M., T. Hong, L.M. Boo, T. Nguyen, C. Zhao, G. Bristol, J. Zack, A.J. Waring, O.O. Yang, and RI Lehrer. Retrocyclins: novel primate peptides that protect cells from infection by HIV-1. (5th Annual UARP Conference on AIDS Research in California, February 21-22, 2002).

20. Ross, D.J., A.M. Cole, D. Yoshioka, A.K. Park, R.M. Strieter, J. Belperio, B. Kubak, H. Laks, A. Ardehali, T. Ganz. Increased BAL Human beta-Defensin-2 in Bronchiolitis Obliterans Syndrome after Lung Transplantation. (International Society for Heart and Lung Transplant. April 10-13, 2002). Selected for oral presentation (by D.J.R.).

21. Cole, A.M., T. Hong, L.M. Boo, T. Nguyen, C. Zhao, G. Bristol, J. Zack, A.J. Waring, O.O. Yang, and R.I. Lehrer. Retrocyclins: circular minidefensins with potent activity against HIV-1. (Microbicides 2002. May 12-15, 2002, Antwerp, Belgium).

22. Cole, A.M., T. Hong, J. Jack, A.J. Waring, O.O. Yang and R.I. Lehrer. Retrocyclins, circular defensins active against HIV-1. (The second collaborative research seminar on HIV and other viral entry inhibitors, New York City, NY, May 3-5, 2002).

23. Wang, W., A.M. Cole, T. Hong, A.J. Waring, R.I. Lehrer. Mechanism of action of retrocyclin: a peptide inhibitor of HIV-1 infection. (Biacore Symposium 2002, Chicago, IL, May 5-8, 2002).


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24. Rudolph, D.L., Owen, S.M., Cole, A.M., Hong, T., Waring, A.J., Lehrer, R.I., and R.B. Lal. Synthetic theta-defensins inhibit replication of diverse primary HIV-1 isolates independently of co-receptor use. (Keystone symposium, 2003).

25. Yasin, B., W. Wang, N. Cheshenko, A.M. Cole, M. Pang, T. Hong, T.X. Nguyen, A. J. Waring, B. Herold, E. A. Wagar and R. I. Lehrer. Activity of θ-defensins against herpes simplex viruses. (Topical Microbicides Development and Evaluation Workshop, Washington, D.C. March 18-20, 2003).

26. Cole, A.M., C. Münk, G. Wei, O.O. Yang, A.J. Waring, W. Wang, T. Hong, R.I. Lehrer, and N.R. Landau. The θ-defensin, Retrocyclin, inhibits HIV-1 entry. (Topical Microbicides Development and Evaluation Workshop, Washington, D.C. March 18-20, 2003).

27. Wang, W., A.M. Cole, T. Hong, A. J. Waring and R. I. Lehrer. Theta (θ)-defensins are lectins that bind gp120 and CD4 with high affinity. (Topical Microbicides Development and Evaluation Workshop, Washington, D.C. March 18-20, 2003).

28. S. M. Owen, D. Rudolph, R. B. Lal, T. Hong, A.M. Cole and R. I. Lehrer. Activity of theta (θ)-defensins against primary isolates of HIV-1. (Topical Microbicides Development and Evaluation Workshop, Washington, D.C. March 18-20, 2003).

29. Wang, W., A.M. Cole, T. Hong, A.J. Waring, and R.I. Lehrer. Retrocyclin, an antiretroviral θ-defensin, is a lectin. (4th Gordon Research Conference on Antimicrobial Peptides. April 27-May 2, 2003, Barga, Italy).

30. C. Münk, G. Wei, O.O. Yang, A.J. Waring, W. Wang, T. Hong, R.I. Lehrer, N.R. Landau and A.M. Cole. The theta-defensin, Retrocyclin, inhibits HIV-1 entry. (9th German and 14th Austrian AIDS Congress, Hamburg, Germany, May 14-17 2003). Selected for oral presentation (by C.M.).

31. Murthy, S.V., and A.M. Cole. Nasal lavage proteins in patients with M. leprae colonization. (National symposium on 50 years of DNA double helix, Warangal, India, December 29-30, 2003). Selected for oral presentation (by S.V.M.).

32. Masciotra, S., W. Wang, S. Kennedy, D. Rudolph, A.M. Cole, A.J. Waring, R.B. Lal, R.I. Lehrer, and S.M. Owen. Synthetic θ-defensins which inhibit HIV-1 entry, exhibit different activity against HIV-2 and SIV isolates. (Conference on Retroviruses and Opportunistic Infections, Boston, MA, February 22-25, 2005).

33. N. Venkataraman*, A.L. Cole*, P. Svoboda, O. Stuchlik, A.J. Waring, J. Pohl, and A.M. Cole. Retrocyclins: candidate anti-HIV-1 topical microbicides. (Gordon Research Conference on Antimicrobial Peptides, Ventura, CA, March 6-11, 2005). *equal contribution

34. Cole, A.M., A.L. Cole, W. Wang, G. Jung, M.J. Lee, A.J. Waring, and R.I. Lehrer. Novel retrocyclin analogs with reduced toxicity and enhanced activity against HIV-1. (Experimental Biology, San Diego, CA, April 2-6, 2005).

35. Cole, A.M., N. Venkataraman, and A.L. Cole. Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. (Experimental Biology, San Diego, CA, April 2-6, 2005).

36. Zhang, L., J. Parente, S.M. Harris, A.M. Cole, G.F. Doncel, and T.J. Falla. Antimicrobial peptides as potential microbicide for prevention of STDs. Focus: in vitro antiviral activity against BaL (R5) and IIIB (X4) HIV-1 strains. (American Society for Microbiology General Meeting, Atlanta, GA, June 5-9, 2005).

37. Cole, A.L., O.O. Yang, A. Warren, A.J. Waring, R.I. Lehrer, and A.M. Cole. HIV-1 uses a bacterial stratagem in attempting to evade retrocyclin, a cationic host defense peptide. (American Society for Microbiology General Meeting, Orlando, FL, May 21-25, 2006).


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38. Cole, A.L., O.O. Yang, A. Warren, A.J. Waring, R.I. Lehrer, and A.M. Cole. HIV-1 remains susceptible to retrocyclin after prolonged passaging in its presence. (Microbicides 2006, Cape Town, South Africa, April 23-26, 2006).

39. Fuhrman, C.A., A.L. Cole, A. Warren, and A.M. Cole. Utilizing Autodock to examine molecular interactions of the antiviral retrocyclin, RC-101, with the gp41 fusion protein of HIV-1. (National Biomedical Computation Resource (NBCR) Summer Institute. Aug 7-11, 2006).

40. Fuhrman, C.A., A. Warren, A.J. Waring, R. I. Lehrer, A.L. Cole, and A.M. Cole. The Retrocyclin RC-101 does not induce significant mutations in HIV-1. (Gordon Research Conference on Antimicrobial Peptides, Il Ciocco, Barga, Italy, April 29-May 4, 2007).

41. Sivaraman, K. and A.M. Cole. SNP analysis reveals a role for polymorphisms in evolution of Staphylococcal pathogenicity. (International Society for Computational Biology, 5th Annual Rocky Mountain Bioinformatics Conference, Aspen/Snowmass, CO, Nov. 30-Dec. 2, 2007). Selected for both Oral and Poster presentations

42. Venkataraman, N. and A.M. Cole. Expression of the Retrocyclin RC-101 in human promyelocytic cells confers protection from entry of HIV-1. (Microbicides 2008, New Delhi, India, Feb. 24-27, 2008).

43. Sassi, A.B., A.L. Cole, M. Cost, D. Patton, P. Gupta, A.M. Cole and R.C. Rohan. RC-101 characterization, formulation, and tissue localization. (Microbicides 2008, New Delhi, India, Feb. 24-27, 2008).


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2008 cv cole v03 (for tom and irb) · 2001 andrea osvath – doctoral student (rotation), ucla...

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