2003.2 LTAlphacarcidol 0.5 μg/day

Adefovir 10 mg/day

Lamivudine 100 mg/dayEntecavir 1 mg/day

Hospitalization

P (

mg

/dL

)

AL

P (

U/L

)

P

ALP

Bone pain

Years after LT Months after hospitalization

1 2 3 4 5 2 4 6 8

1 mg/day

Supplemental Digital Content 1 - Figure 1. Serum phosphate and alkaline phosphatase levels in the patients with hypophosphatemic osteomalacia before and after hospitalization. Figures A, B and C represent the clinical courses of Patients 1, 2 and 3, respectively. Filled circles with solid lines in the graphs show the levels of serum phosphate and open squares with broken lines show the levels of serum alkaline phosphatase. The striped boxes indicate periods of hospitalization for each patient. The gray zones in the graphs correspond to the normal serum phosphate level. Arrowheads show the time of liver transplantation (LT).

Tacrolimus 2 mg/dayFig 1A

2002.7 LT

Alphacarcidol 0.5 μg/day

Adefovir dipivoxil 10 mg/day

Lamivudine 100 mg/day

Bone pain

Phosphate 1 mg/day

P (

mg

/dL

)

AL

P (

U/L

)

HospitalizationYears after LT Months after hospitalization

2 3 64 5 1 2 3 4

1 mg/day1.5 mg/day

Supplemental Fig. 1B

P

ALP

Tacrolimus 2 mg/day

2001.7 LT

Tacrolimus 2 mg/day

P (

mg

/dL

)

AL

P (

U/L

)

Bone pain

Prednisolone 5 mg/day

HospitalizationYears after LT Months after

hospitalization

3 4 75 6 1 2 3 4 5 6 7 8

Supplemental Fig. 1C

P

ALP

Alphacarcidol 2 μg/day