2003-2004 hematopoiesis pharmacology review 28 august 2015 7:22 am
TRANSCRIPT
2003-2004Hematopoiesis
Pharmacology Review
April 19, 202310:05 AM
Abciximab
Antiplatelet
Anti-GPIIb/IIIa receptor antibody
Acetaminophen
Analgesic, Antipyretic
Adalimumab
TNF inhibitor
Anti-TNF antibodyUsed in rheumatoid arthritis
Alemtuzumab
Antineoplastic
Anti-CD52 antibody
Allopurinol
AntigoutAntineoplastic (supporting
agent)
Folic acid analogueXanthine oxidase inhibitor
Aminocaproic acid (EACA)
Procoagulant
Inhibitor of plasminogen activation
(decreases fibrinolysis)
Aminoglutethimide
AntineoplasticImmunosuppressive
Glucocorticoid antagonistAromatase inhibitor
(decreases steroid synthesis)
Angiostatin
Antineoplastic
Angiogenesis inhibitor
Anistreplase
Thrombolytic
Streptokinase + plasminogen
Anti-thymocyte globulin
Immunosuppressive
Anti-T cell antibody
Aprotinin
Procoagulant
Fibrinolytic inhibitorSerine protease inhibitor
(“serpin”)Streptokinase inhibitor
Argatroban
Anticoagulant
Direct thrombin inhibitor
L-asparaginase
Antineoplastic
Protein synthesis inhibitor
Aspirin(Acetylsalicylic acid, ASA)
NSAID (acetylsalicylate)Analgesic, Anti-inflammatory
Antipyretic, Antiplatelet
Irreversible cyclooxygenase inhibitor
Azathioprine
ImmunosuppressiveAntineoplastic
Antimetabolite(“pseudofeedback inhibition” of
HGPRT and PRP)
Basiliximab
Immunosuppressive
Anti-CD25 (interleukin 2 receptor)
Organ transplant (antirejection)
Betamethasone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidNot by inhalation
Bivalirudin
Anticoagulant
Direct thrombin inhibitor
Bortezomib
Antineoplastic
Proteosome inhibitor
Bradykinin
Inflammatory mediator
Plasma, hypotension, pain
C3a, C5a
Inflammatory mediators
Anaphylatoxins Low molecular weight
complement cleavage products
Celecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
Cetirizine
Antihistamine
H1 antagonist Non-sedating
Chlorpheniramine
Classical antihistamine
H1 antagonist
Clopidogrel
Antiplatelet
ADP receptor antagonist
Cobalamin(cyanocobalamin, hydroxocobalamin)
Vitamin
Treatment forvitamin B12 deficiency
Cortisol (Hydrocortisone)
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroid
Cyclosporine
ImmunosuppressiveAntineoplastic
Binds cyclophilinInhibits calcineurin
Cytarabine (AraC)
Antineoplastic
Antimetabolite
Daclizumab
Immunosuppressive
Anti-CD25 (interleukin 2 receptor) antibody
Organ transplant (anti-rejection)
Dalteparin
Anticoagulant
LMW HeparinATIII activator
Desmopressin acetate
Synthetic analogue ofarginine vasopressin
Used in treatment of bleeding disorders
Dexamethasone
AdrenocorticosteroidGlucocorticoidAntineoplastic
Antiemetic
Anti-inflammatory steroidNot by inhalation
Diflunisal
NSAIDAnalgesic, Anti-inflammatory
Antipyretic
Cyclooxygenase inhibitor
Diphenhydramine
Classical antihistamineAntiemetic
H1 antagonist
Dipyridamole
Antiplatelet
Phosphodiesterase inhibitor(increases cAMP)
Drotrecogin alfa(Activated Protein C)
Anticoagulant
Many actionsTreatment for septic shock
Edrecolomab
Antineoplastic
Anti-17-1A antibody
Enoxaparin
Anticoagulant
LMW HeparinATIII activator
Eptifibatide
Antiplatelet
GPIIb/IIIa antagonist
Erythropoietin (EPO)
Cytokine
Primary regulator of RBC synthesis
Etanercept
TNF inhibitor
Tumor necrosis factor receptor+ Fc portion of IgG
Used in rheumatoid arthritis
Fexofenadine
Antihistamine
H1 antagonistNon-sedating
5-Fluorouracil
Antineoplastic
AntimetaboliteThymidylate synthase inhibitor
Folic acid
Vitamin
Treatment for folicacid deficiency
Gefitinib
Antineoplastic
MiscellaneousTyrosine kinase inhibitor
Gemcitabine
Antineoplastic
Antimetabolite
Gemtuzumab
Antineoplastic
Anti-CD33 antibody
Heparin
Anticoagulant
ATIII activator
Hirudin
Anticoagulant
Direct thrombin inhibitor(DTI)
Histamine
Inflammatory mediator
Stored in mast cells and basophils
Hydrocortisone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroid
4-Hydroxycoumarin
Oral anticoagulant
Vitamin K synthesis inhibitor
Hydroxyurea
Antineoplastic
MiscellaneousRibonucleotide reductase
inhibitor
Hydroxyzine
Classical antihistamine
H1 antagonist
Ibritumomab
Antineoplastic
Anti-CD20 antibody
Ibuprofen
NSAIDAnalgesic, Anti-inflammatory
Antipyretic
Reversible cyclooxygenase inhibitor
Imatinib
Antineoplastic
MiscellaneousTyrosine kinase inhibitor
Indomethacin
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitorTocolytic
Uterine relaxant
Infliximab
TNF inhibitor
Anti-TNF monoclonal antibodyTreatment of IBD
Interferon alpha
Antiviral for hepatitisAntineoplastic
Cytokine
Anti-angiogenesis
Interleukin 2
Cytokine Antineoplastic
Interleukin 11
Cytokine Antineoplastic (supporting
agent)
Interleukin 12
Cytokine Antineoplastic (supporting
agent)
Kallidin
Inflammatory mediator
Plasma, hypotension, pain
Ketoprofen
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Lepirudin
Anticoagulant
Direct thrombin inhibitor (DTI)
Leucovorin
Antineoplastic (supporting agent)
Folic acid analogue(used in methotrexate rescue)
Leukotriene B4 (LTB4)
Inflammatory mediator
Lipoxygenase productof arachidonate metabolism
Chemotactic
Leukotrienes C4, D4, E4
(LTC4, LTD4, LTE4)
Inflammatory mediators
Cysteinyl leukotrienesPeptidyl leukotrienes
SRS-ALipoxygenase products ofarachidonate metabolism
Loratidine
Antihistamine
H1 antagonistNon-sedating
Meclofenamate
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
6-Mercaptopurine
Antineoplastic
Antimetabolite(“pseudofeedback inhibition” of
HGPRT and PRP – purine synthesis)
Methotrexate
ImmunosuppressiveAntineoplastic
Folic acid antagonistDihydrofolate reductase
inhibitor
Methylprednisolone
AdrenocorticosteroidGlucocorticoid
Anti-inflammatory steroidNot by inhalation
Montelukast
Leukotriene inhibitor
LTR1 and LTD4 antagonistAsthma treatment
Muromonab-CD3
Immunosuppressive
Mouse monoclonal anti-CD3 antibody
Organ transplant (anti-rejection)
Mycophenolate
Immunosuppressive
Inhibits inosine monophosphate dehydrogenase activity
Naproxen
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Non-steroidalAnti-inflammatory Drugs
(NSAIDs)
Analgesic, Anti-inflammatory, Antipyretic
Cyclooxygenase inhibitors
Omalizumab
Anti-asthma
Anti-IgE antibody
Palivizumab
Antiviral
Monoclonal antibody againstthe surface of
respiratory syncytial virus
Pentostatin
Antineoplastic
MiscellaneousEnzyme inhibitor
(blocks purine synthesis)
Phytonadione
Vitamin K
Warfarin antagonist
Piroxicam
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Platelet Activating Factor (PAF)
Inflammatory mediator
LipidHypotensive
Prednisone
AdrenocorticosteroidGlucocorticoid Antineoplastic
Anti-inflammatoryNot by inhalation
Promethazine
Classical antihistamineAntipsychotic
Antiemetic
H1 antagonist
Prostaglandin D2 (PGD2)
Bronchoconstrictor
Cyclooxygenase product of arachidonate metabolism
Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)
Oxytocic prostaglandinInflammatory mediator
Cyclooxygenase product of arachidonate metabolism
Uterine stimulantCervical ripener
Prostaglandin F2 (PGF2)
Inflammatory mediator
Cyclooxygenase product of arachidonate metabolism
Prostaglandin I2 (PGI2)
Inflammatory mediator
Inhibits platelet aggregation
Cyclooxygenase product of arachidonate metabolism
Prostacyclin
Protamine Sulfate
Heparin antagonist
Rituxumab
Antineoplastic
Anti-CD20 antibody
Rofecoxib
NSAIDAnti-inflammatory
Cyclooxygenase 2 (COX-2) inhibitor
Sargramostim(GM-CSF)
Colony stimulating factor
WBC (granulocyte and macrophage)
stimulant
Sirolimus
Immunosuppressive
Binds FKBP, inhibits mTOR (mammalian kinase target of
rapamycin) & cell cycle progression
Rapamycin
Streptokinase
Thrombolytic
Sulindac
NSAIDAnalgesic, Anti-inflammatory,
Antipyretic
Cyclooxygenase inhibitor
Tacrolimus
ImmunosuppressiveAntineoplastic
Binds FKBP (FK506 binding protein)
Inhibits calcineurin
Thalidomide
AntineoplasticLeprosy treatment
Anti-angiogenicAnti-TNF
6-Thioguanine
Antineoplastic
Antimetabolite (“pseudofeedback inhibition” of
HGPRT and PRP – purine synthesis)
Thromboxane A2 (TXA2)
Autacoid
Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism
Ticlopidine
Antiplatelet
ADP receptor antagonist
Tissue plasminogen activators
Thrombolytics
alteplase, reteplase, tenecteplase
Tositumomab
Antineoplastic
Anti-CD20 antibody
Trastuzumab
Antineoplastic
Anti-HER2 antibody
Tripelennamine
Classical antihistamine
H1 antagonist
Tumor necrosis factor
CytokineAntineoplastic
Urokinase
Thrombolytic
Warfarin
Anticoagulant
Vitamin K synthesis inhibitor
Zafirlukast
Leukotriene inhibitor
LTR1 and LTD4 antagonistAsthma treatment
Zileuton
Leukotriene inhibitor
5-lipoxygenase inhibitorUsed in asthma