2003-2004 antibiotics review 10 august 2015 6:39 am
TRANSCRIPT
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2003-2004Antibiotics Review
April 19, 202304:13 AM
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Amikacin
Aminoglycoside antibioticBactericidal protein synthesis
inhibitor
30S ribosomeFreezes initiation
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Aminoglycosides
AntibioticsBactericidal protein synthesis
inhibitors
30S ribosomeFreeze initiation
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Ampicillin
Penicillin antibioticCell wall synthesis inhibitor
Amino penicillinInhibits peptidoglycan cross-
linking
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Amphotericin B
AntifungalPolyene antibiotic
Binds to ergosterol and alters permeability
Systemic
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Azithromycin
Macrolide antibioticBacteriostatic protein synthesis
inhibitor
50S ribosome Inhibits translocation
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Aztreonam
New lactam antibiotic
Monobactam
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Bacitracin
AntibioticCell wall synthesis inhibitor
Topical, not a lactam, Inhibits dephosphorylation of
bactoprenol
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Benzathine penicillin G
Penicillin antibioticCell wall synthesis inhibitor
Inhibits peptidoglycan cross-linking Repository preparation
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Carbenicillin
Penicillin antibioticCell wall synthesis inhibitor
Anti-pseudomonal penicillinInhibits peptidoglycan cross-
linking
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Cefaclor
Cephalosporin antibioticCell wall synthesis inhibitor
2nd generationOral
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Cefadroxil
Cephalosporin antibioticCell wall synthesis inhibitor
1st generationOral
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Cefepime
Cephalosporin antibioticCell wall synthesis inhibitor
4th generationCSF penetration
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Cefotaxime
Cephalosporin antibioticCell wall synthesis inhibitor
3rd generationCSF penetration
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Cefoxitin
Cephalosporin antibioticCell wall synthesis inhibitor
2nd generation
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Ceftazidime
Cephalosporin antibioticCell wall synthesis inhibitor
3rd generation
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Ceftriaxone
Cephalosporin antibioticCell wall synthesis inhibitor
3rd generationCSF penetration
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Cefuroxime
Cephalosporin antibioticCell wall synthesis inhibitor
2nd generationCSF penetration
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Cephalexin
Cephalosporin antibioticCell wall synthesis inhibitor
1st generationOral
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Cephalosporins
Antibiotics lactam
Cell wall synthesis inhibitorsInhibit cross-linking of
peptidoglycan
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Cephalothin
Cephalosporin antibioticCell wall synthesis inhibitor
1st generationOral
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Chloramphenicol
AntibioticBacteriostatic protein synthesis
inhibitor
50S ribosomeInhibits peptide bond formation
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Ciprofloxacin
Fluoroquinolone antibioticDNA replication inhibitor
Inhibits bacterial DNA gyrase
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Clarithromycin
Macrolide antibioticBacteriostatic protein synthesis
inhibitor Antiulcer
50S ribosomeInhibits translocation
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Clavulanic acid
-lactamase inhibitor
Combined with antibacterials
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Clindamycin
AntibioticBacteriostatic protein synthesis
inhibitor
50S ribosomeAnaerobic infections
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Cloxacillin
Penicillin antibioticCell wall synthesis inhibitor
Penicillinase resistant penicillinInhibits peptidoglycan cross-
linking
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Cycloserine
AntibioticCell wall synthesis inhibitor
Secondary TB drugInhibits formation of Park
nucleotide
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Dapsone
Sulfone antibioticNucleic acid and
protein synthesis inhibitor
Inhibits dihydropteroate synthetase
Leprosy
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Doxycycline
Tetracycline antibioticBacteriostatic protein synthesis
inhibitor
30S ribosomePrevents aminoacyl tRNA attachment
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Erythromycin
Macrolide antibioticBacteriostatic protein synthesis
inhibitor
50S ribosomeInhibits translocation
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Ethambutol
Antibiotic
Major drug for tuberculosis
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Ethionamide
Antibiotic
Secondary drug for tuberculosis
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Fluorinated Quinolonesciprofloxacin, norfloxacin
AntibioticsDNA replication inhibitors
Inhibit bacterial DNA gyrase
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Gentamicin
Aminoglycoside antibioticbactericidal protein synthesis inhibitor
30S ribosomeFreezes initiation
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Imipenem/Cilastatin
New lactam antibiotic
Cilastatin inhibits akidney dipeptidase that inactivates imipenem
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Isoniazid
Antibiotic
Inhibits biosynthesis of mycolic acids
Major drug for tuberculosis
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Linezolid
Oxazolidinone antibioticProtein synthesis inhibitor
50S ribosomal subunit
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Macrolideserythromycin, azithromycin, clarithromycin
AntibioticsBacteriostatic protein synthesis
inhibitors
50S ribosome
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Methicillin
Penicillin antibioticCell wall synthesis inhibitor
Pencillinase resistant penicillin Inhibits peptidoglycan cross-
linking
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Metronidazole
AntibioticAntiparasitic
Antiulcer
AnaerobesReduction leads to intermediates
that damage DNA
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Minocycline
Tetracycline antibioticBacteriostatic protein synthesis
inhibitor
30S ribosomePrevents aminoacyl tRNA attachment
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Nafcillin
Penicillin antibioticCell wall synthesis inhibitor
Penicillinase resistant penicillinInhibits peptidoglycan cross-
linking
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Neomycin
Aminoglycoside antibioticBactericidal protein synthesis
inhibitor
30S ribosomeFreezes initiation
Topical
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Netilmicin
Aminoglycoside antibioticBactericidal protein synthesis
inhibitor
30S ribosomeFreezes initiation
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Norfloxacin
Fluoroquinolone antibioticDNA replication inhibitor
Inhibits bacterial DNA gyrase
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Nystatin
AntifungalPolyene antibiotic
Binds to ergosterol & alters permeability
Topical
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Oxacillin
Penicillin antibioticCell wall synthesis inhibitor
Pencillinase resistant penicillinInhibits peptidoglycan cross-
linking
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Oxytetracycline
Tetracycline antibioticBacteriostatic protein synthesis
inhibitor
30S ribosomePrevents aminoacyl tRNA attachment
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Para-aminosalicylic acid
AntibioticNucleic acid and
protein synthesis inhibitor
Inhibits dihydropteroate synthetase
Secondary TB drug
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Penicillins
lactam antibioticsCell wall synthesis inhibitors
Inhibit cross-linking of peptidoglycan
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Penicillin G
Penicillin antibioticCell wall synthesis inhibitor
Acid labileInhibits peptidoglycan cross-
linking
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Penicillin V
Penicillin antibioticCell wall synthesis inhibitor
More acid resistant than Penicillin G
Inhibits peptidoglycan cross-linking
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Piperacillin
Penicillin antibioticCell wall synthesis inhibitor
Anti-pseudomonal penicillinInhibits peptidoglycan cross-
linking
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Polymyxin B
AntibioticDisrupts gram negative cell
membrane
Binds phosphatidylethanolamineBactericidal
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Procaine Penicillin G
Penicillin antibioticCell wall synthesis inhibitor
Repository preparationInhibits peptidoglycan cross-
linking
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Pyrazinamide
Antibiotic
Major drug for tuberculosis
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Rifampin
AntibioticNucleic acid synthesis inhibitor
Inhibits DNA dependent RNA polymerase
Major drug for TB
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Silver sulfadiazine
Sulfonamide antibioticMicrobial nucleic acid
and protein synthesis inhibitor
Inhibits dihydropteroate synthetase
Topical
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Spectinomycin
AntibioticBacteriostatic protein synthesis
inhibitor
30S ribosome
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Streptomycin
Aminoglycoside antibioticBactericidal protein synthesis
inhibitor
30S ribosomeFreezes initiation
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Sulfacetamide
Sulfonamide antibioticMicrobial nucleic acid
and protein synthesis inhibitor
Inhibits dihydropteroate synthetase
Topical
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Sulfadoxine
Sulfonamide antibioticMicrobial nucleic acid
and protein synthesis inhibitor
Dihydropteroate synthetase inhibitor
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Sulfamethoxazole
Sulfonamide antibioticMicrobial nucleic acid
and protein synthesis inhibitor
Inhibits dihydropteroate synthetase
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Sulfisoxazole
Sulfonamide antibioticNucleic acid and
protein synthesis inhibitor
Inhibits dihydropteroate synthetase
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Sulfonamides
AntibioticsNucleic acid and
protein synthesis inhibitors
Inhibit dihydropteroate synthetase
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Tetracycline
AntibioticBacteriostatic protein synthesis
inhibitor Antiulcer
30S ribosomePrevents aminoacyl tRNA attachment
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Ticarcillin
Penicillin antibioticCell wall synthesis inhibitor
Anti-pseudomonal penicillinInhibits peptidoglycan cross-
linking
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Tobramycin
Aminoglycoside antibioticBactericidal protein synthesis
inhibitor
30S ribosomeFreezes initiation
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Trimethoprim
AntibioticProtein and nucleic acid
synthesis inhibitor
Inhibits bacterial dihydrofolate reductase
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Trimetrexate
Antibiotic
Folic acid antagonist Treatment for Pneumocystis
carinii
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Vancomycin
AntibioticInhibits cell wall synthesis
Not a lactam